Gene Symbol | Stx1b |
Entrez Gene ID | 56216 |
Full Name | syntaxin 1B |
Synonyms | Stx1b2,Stx1bl,Syn1b |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Stx1b cDNA ORF clone
Gene Symbol | Stx1b |
Entrez Gene ID | 56216 |
Full Name | syntaxin 1B |
Synonyms | Stx1b2,Stx1bl,Syn1b |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006508044.3 | XP_006508107.1 | syntaxin-1B isoform X1 |
XM_011241866.1 | XP_011240168.1 | syntaxin-1B isoform X2 |
NM_024414.2 | NP_077725.1 | syntaxin-1B |
XM_006508044.4 | XP_006508107.1 | syntaxin-1B isoform X1 |
Mus musculus (house mouse) | Stx1b | NP_077725.1 |
Xenopus tropicalis (tropical clawed frog) | stx1b | NP_001096346.1 |
Bos taurus (cattle) | STX1B | NP_777043.1 |
Danio rerio (zebrafish) | stx1b | NP_571598.1 |
Pan troglodytes (chimpanzee) | STX1B | XP_001145497.1 |
LOC714251 | XP_001103901.1 | |
Canis lupus familiaris (dog) | STX1B | XP_005621349.1 |
Homo sapiens (human) | STX1B | NP_443106.1 |
Rattus norvegicus (Norway rat) | Stx1b | NP_036832.1 |
Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.
Fujiwara T, Kofuji T, Mishima T, Akagawa K
The European journal of neuroscience46(12)2867-2874(2017 Dec)
Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.
Anderson DM, Cannavino J, Li H, Anderson KM, Nelson BR, McAnally J, Bezprozvannaya S, Liu Y, Lin W, Liu N, Bassel-Duby R, Olson EN
Proceedings of the National Academy of Sciences of the United States of America113(31)E4494-503(2016 08)
Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons.
Vardar G, Chang S, Arancillo M, Wu YJ, Trimbuch T, Rosenmund C
The Journal of neuroscience : the official journal of the Society for Neuroscience36(30)7911-24(2016 07)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results demonstrated that STX1B is essential for the survival of neurons in vitro and it is a critical syntaxin protein for the neurotransmission at the mouse neuromuscular junctions
Title: Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions.
STX1B was important for neuronal survival, possibly by regulating the secretion of neurotrophic factors
Title: HPC-1/syntaxin 1A and syntaxin 1B play distinct roles in neuronal survival.
Although STX1A and STX1B share a basic function as neuronal t-SNAREs, STX1B but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission.
Title: Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapses.
closed conformation of syntaxin-1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE-complex/Munc18-1 assemblies
Title: Conformational switch of syntaxin-1 controls synaptic vesicle fusion.
The following Stx1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stx1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu08176 | |
Clone ID Related Accession (Same CDS sequence) | NM_024414.2 | |
Accession Version | NM_024414.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-1B | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149222.4. On or before Feb 1, 2008 this sequence version replaced NM_019560.1, NM_024414.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D45207.1, SRR1660819.105615.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAAGGATC GGACTCAGGA GCTGCGGAGT GCGAAAGACA GTGATGATGA AGAGGAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_077725.1 |
CDS | 243..1109 |
Translation |
Target ORF information:
Target ORF information:
|
NM_024414.2 |
1 | ATGAAGGATC GGACTCAGGA GCTGCGGAGT GCGAAAGACA GTGATGATGA AGAGGAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu39782 | |
Clone ID Related Accession (Same CDS sequence) | XM_006508044.3 , XM_006508044.4 | |
Accession Version | XM_006508044.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-1B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006508044.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGAGC TCAACTTTAC CCTGAGAATT CTGTTCCAGG CAGAGAGGAA TGGGGATCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006508107.1 |
CDS | 505..1725 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006508044.3 |
1 | ATGGCTGAGC TCAACTTTAC CCTGAGAATT CTGTTCCAGG CAGAGAGGAA TGGGGATCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu69620 | |
Clone ID Related Accession (Same CDS sequence) | XM_011241866.1 | |
Accession Version | XM_011241866.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-1B isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTATGGA GGACACAGGC GAAAGACAGT GATGATGAAG AGGAGGTGGT CCACGTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011240168.1 |
CDS | 16..870 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011241866.1 |
1 | ATGCTATGGA GGACACAGGC GAAAGACAGT GATGATGAAG AGGAGGTGGT CCACGTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu39782 | |
Clone ID Related Accession (Same CDS sequence) | XM_006508044.3 , XM_006508044.4 | |
Accession Version | XM_006508044.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-1B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006508044.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGAGC TCAACTTTAC CCTGAGAATT CTGTTCCAGG CAGAGAGGAA TGGGGATCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006508107.1 |
CDS | 16..1236 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006508044.4 |
1 | ATGGCTGAGC TCAACTTTAC CCTGAGAATT CTGTTCCAGG CAGAGAGGAA TGGGGATCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS. |
Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. |
Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons. |