Txn2 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Txn2 |
| Entrez Gene ID | 56551 |
| Full Name | thioredoxin 2 |
| Synonyms | 2510006J11Rik,AI788873,Trx2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_019913.5 | NP_064297.1 | thioredoxin, mitochondrial precursor |
| Mus musculus (house mouse) | Txn2 | NP_064297.1 |
| Homo sapiens (human) | TXN2 | NP_036605.2 |
| Bos taurus (cattle) | TXN2 | NP_776633.1 |
| Rattus norvegicus (Norway rat) | Txn2 | NP_445783.1 |
| Gallus gallus (chicken) | TXN2 | NP_001026581.1 |
| Danio rerio (zebrafish) | txn2 | NP_991204.1 |
| Drosophila melanogaster (fruit fly) | CG8993 | NP_647716.1 |
| Anopheles gambiae (African malaria mosquito) | TRX2 | XP_308583.2 |
| Caenorhabditis elegans (roundworm) | trx-2 | NP_001256207.1 |
| Canis lupus familiaris (dog) | TXN2 | XP_531748.3 |
| Xenopus tropicalis (tropical clawed frog) | txn2 | NP_001008161.1 |
Related articles in PubMed
Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD
Journal of molecular and cellular cardiology971-14(2016 Aug)
Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.
Liu Y, Yang Y, Dong H, Cutler RG, Strong R, Mattson MP
Experimental neurology275 Pt 1126-32(2016 Jan)
Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
Pirson M, Knoops B
The Journal of comparative neurology523(17)2599-617(2015 Dec)
Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.
Huang Q, Zhou HJ, Zhang H, Huang Y, Hinojosa-Kirschenbaum F, Fan P, Yao L, Belardinelli L, Tellides G, Giordano FJ, Budas GR, Min W
Circulation131(12)1082-97(2015 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity
Title: Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.
The ventral signal observed from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord.
Title: Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species.
Title: Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.
The SirT1 regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase, catalase, peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2, and uncoupling protein 2.
Title: SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1? complex.
This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver and upregulated thioredoxin-2 expression.
Title: Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiency.
The following Txn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Txn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu16235 | |
| Clone ID Related Accession (Same CDS sequence) | NM_019913.5 | |
| Accession Version | NM_019913.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-24 | |
| Organism | Mus musculus(house mouse) | |
| Product | thioredoxin, mitochondrial precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL583886.11. On Apr 29, 2007 this sequence version replaced NM_019913.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK010917.1, BC068182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## | |
1 | ATGGCTCAGC GGCTCCTCCT GGGGAGGTTC CTGACCTCAG TCATCTCCAG GAAGCCTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_064297.1 |
| CDS | 89..589 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_019913.5 |
ORF Insert Sequence:
1 | ATGGCTCAGC GGCTCCTCCT GGGGAGGTTC CTGACCTCAG TCATCTCCAG GAAGCCTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress. |
|
Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction. |
|
Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development. |
|
Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function. |