Gene Symbol | Sp5 |
Entrez Gene ID | 64406 |
Full Name | trans-acting transcription factor 5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Sp5 cDNA ORF clone
Gene Symbol | Sp5 |
Entrez Gene ID | 64406 |
Full Name | trans-acting transcription factor 5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_022435.2 | NP_071880.1 | transcription factor Sp5 |
Homo sapiens (human) | SP5 | NP_001003845.1 |
Canis lupus familiaris (dog) | SP5 | XP_851518.2 |
Pan troglodytes (chimpanzee) | SP5 | XP_001135769.2 |
Rattus norvegicus (Norway rat) | Sp5 | NP_001100022.1 |
SP5 | XP_001082704.1 | |
Danio rerio (zebrafish) | sp5a | NP_851304.1 |
Bos taurus (cattle) | SP5 | XP_005202450.1 |
Mus musculus (house mouse) | Sp5 | NP_071880.1 |
Gallus gallus (chicken) | SP5 | NP_001038149.1 |
Xenopus tropicalis (tropical clawed frog) | sp5 | NP_989092.1 |
Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal.
Tang L, Wang M, Liu D, Gong M, Ying QL, Ye S
PloS one12(9)e0185714(2017)
Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.
Amin S, Neijts R, Simmini S, van Rooijen C, Tan SC, Kester L, van Oudenaarden A, Creyghton MP, Deschamps J
Cell reports17(12)3165-3177(2016 12)
A new gain-of-function mouse line to study the role of Wnt3a in development and disease.
Chalamalasetty RB, Ajima R, Garriock RJ, Kennedy MW, Tessarollo L, Yamaguchi TP
Genesis (New York, N.Y. : 2000)54(9)497-502(2016 Sep)
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.
Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E
PLoS genetics12(7)e1006151(2016 07)
Tcf7l1 protects the anterior neural fold from adopting the neural crest fate.
Ma?ek J, Macho? O, Ko??nek V, Taketo MM, Kozmik Z
Development (Cambridge, England)143(12)2206-16(2016 06)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Title: Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal.
Sp5/8 bind directly to GC boxes in Wnt target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin to target gene enhancers.
Title: Sp5 and Sp8 recruit ?-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
Sp5 is able to convert mouse epiblast stem cells into a naive pluripotent state.
Title: Wnt/?-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal.
Sp5 and Sp8 are pivotal downstream effectors of Wnt3a/beta-catenin that are essential for the self-renewal and differentiation of neuromesodermal stem cells.
Title: Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/?-catenin pathway in neuromesodermal stem cells.
Sp5 transcription factor mediates the downstream responses to Wnt/beta-catenin signaling by directly repressing Sp1 target genes
Title: Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5.
The following Sp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17528 | |
Clone ID Related Accession (Same CDS sequence) | NM_022435.2 | |
Accession Version | NM_022435.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-14 | |
Organism | Mus musculus(house mouse) | |
Product | transcription factor Sp5 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK036234.1. On Jun 19, 2003 this sequence version replaced NM_022435.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036234.1, AF279479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCGCTG TGGCCGTCCT CCGGAACGAC TCACTGCAGG CCTTCCTCCA GGACCGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_071880.1 |
CDS | 344..1540 |
Translation |
Target ORF information:
Target ORF information:
|
NM_022435.2 |
1 | ATGGCCGCTG TGGCCGTCCT CCGGAACGAC TCACTGCAGG CCTTCCTCCA GGACCGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal. |
Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche. |
A new gain-of-function mouse line to study the role of Wnt3a in development and disease. |
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. |
Tcf7l1 protects the anterior neural fold from adopting the neural crest fate. |