Gene Symbol | Fis1 |
Entrez Gene ID | 66437 |
Full Name | fission, mitochondrial 1 |
Synonyms | 2010003O14Rik,Ttc11 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Fis1 cDNA ORF clone
Gene Symbol | Fis1 |
Entrez Gene ID | 66437 |
Full Name | fission, mitochondrial 1 |
Synonyms | 2010003O14Rik,Ttc11 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001347504.1 | NP_001334433.1 | mitochondrial fission 1 protein isoform 3 |
NM_001163243.1 | NP_001156715.1 | mitochondrial fission 1 protein isoform 2 |
NM_025562.3 | NP_079838.1 | mitochondrial fission 1 protein isoform 1 |
Pan troglodytes (chimpanzee) | FIS1 | XP_001143081.2 |
Bos taurus (cattle) | FIS1 | NP_001029956.1 |
Danio rerio (zebrafish) | im:6905231 | XP_005172294.1 |
Caenorhabditis elegans (roundworm) | fis-2 | NP_001024560.1 |
Xenopus tropicalis (tropical clawed frog) | fis1 | NP_001123678.1 |
Canis lupus familiaris (dog) | FIS1 | XP_536854.1 |
Homo sapiens (human) | FIS1 | NP_057152.2 |
FIS1 | XP_001108062.1 | |
Mus musculus (house mouse) | Fis1 | NP_079838.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009852 | XP_318964.4 |
Drosophila melanogaster (fruit fly) | Fis1 | NP_001137607.1 |
Rattus norvegicus (Norway rat) | Fis1 | NP_001099389.1 |
Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1.
Rojansky R, Cha MY, Chan DC
eLife5(2016 11)
Precise expression of Fis1 is important for glucose responsiveness of beta cells.
Schultz J, Waterstradt R, Kantowski T, Rickmann A, Reinhardt F, Sharoyko V, Mulder H, Tiedge M, Baltrusch S
The Journal of endocrinology230(1)81-91(2016 Jul)
The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.
G?mez-Del Arco P, Perdiguero E, Yunes-Leites PS, Ac?n-P?rez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jim?nez-Alc?zar M, Segal?s J, L?pez-Maderuelo D, Orn?s B, Jim?nez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Mu?oz-C?noves P, Redondo JM
Cell metabolism23(5)881-92(2016 May)
Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.
Moriya M, Inoue S, Miyagawa-Tomita S, Nakashima Y, Oba D, Niihori T, Hashi M, Ohnishi H, Kure S, Matsubara Y, Aoki Y
Human molecular genetics24(25)7349-60(2015 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our data confirm that FIS1 is a key regulator in pancreatic beta cells, because both glucose-stimulated insulin secretion and mitochondrial dynamics were clearly adapted to precise expression levels of this fission protein.
Title: Precise expression of Fis1 is important for glucose responsiveness of beta cells.
MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria.
Title: Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.
we find that either MiD49 or MiD51 can mediate Drp1 recruitment and mitochondrial fission in the absence of Fis1 and Mff
Title: Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
miR-484 attenuate Fis1 and mitochondrial fission by binding to N-terminal of Fis1 and inhibiting its translation.
Title: miR-484 regulates mitochondrial network through targeting Fis1.
study provides the first evidence that homocysteine-induced ganglion cell loss involves the dysregulation of mitochondrial dynamics, both in vivo and in vitro.
Title: Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells.
The following Fis1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fis1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13241 | |
Clone ID Related Accession (Same CDS sequence) | NM_001163243.1 | |
Accession Version | NM_001163243.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-06 | |
Organism | Mus musculus(house mouse) | |
Product | mitochondrial fission 1 protein isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA322565.1, AK008078.1 and CD774298.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF583067.1, BI412194.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCCAGAG ACGAAGCTGC AAGGAATTTT GAAAGGAAAT TTCAGTCTGA GCAGGCAGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001156715.1 |
CDS | 293..730 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001163243.1 |
1 | ATGCCCAGAG ACGAAGCTGC AAGGAATTTT GAAAGGAAAT TTCAGTCTGA GCAGGCAGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu36186 | |
Clone ID Related Accession (Same CDS sequence) | NM_001347504.1 | |
Accession Version | NM_001347504.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-06 | |
Organism | Mus musculus(house mouse) | |
Product | mitochondrial fission 1 protein isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC147987.5. On Nov 30, 2016 this sequence version replaced XM_006504489.1. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV505347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGCCC AGAGACGAAG CTGCAAGGAG CTGTTGCCCA AAGGGAGCAA AGAGGAACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001334433.1 |
CDS | 289..597 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001347504.1 |
1 | ATGGATGCCC AGAGACGAAG CTGCAAGGAG CTGTTGCCCA AAGGGAGCAA AGAGGAACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13176 | |
Clone ID Related Accession (Same CDS sequence) | NM_025562.3 | |
Accession Version | NM_025562.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | mitochondrial fission 1 protein isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW988976.1, AK008078.1 and CD774298.1. On Jul 11, 2009 this sequence version replaced NM_025562.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010783.1, AK008078.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGGCCG TGCTGAACGA GCTGGTGTCT GTGGAGGATC TGAAGAATTT TGAAAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_079838.1 |
CDS | 108..566 |
Translation |
Target ORF information:
Target ORF information:
|
NM_025562.3 |
1 | ATGGAGGCCG TGCTGAACGA GCTGGTGTCT GTGGAGGATC TGAAGAATTT TGAAAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. |
Precise expression of Fis1 is important for glucose responsiveness of beta cells. |
The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. |
Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype. |