Uqcrc2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Uqcrc2
Entrez Gene ID	67003
Full Name	ubiquinol cytochrome c reductase core protein 2
Synonyms	1500004O06Rik
General protein information	Preferred Names ubiquinol cytochrome c reductase core protein 2 Names cytochrome b-c1 complex subunit 2, mitochondrial complex III subunit 2 core protein II ubiquinol-cytochrome-c reductase complex core protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F2

mRNA and Protein(s)

mRNA	Protein	Name
NM_025899.2	NP_080175.1	cytochrome b-c1 complex subunit 2, mitochondrial precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Uqcrc2	NP_001006971.1
Canis lupus familiaris (dog)	UQCRC2	XP_536942.1
Gallus gallus (chicken)	UQCRC2	XP_424611.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006099	XP_316158.3
Arabidopsis thaliana (thale cress)	AT1G51980	NP_175610.1
Xenopus tropicalis (tropical clawed frog)	uqcrc2	NP_001016666.1
Pan troglodytes (chimpanzee)	UQCRC2	NP_001233459.1
	UQCRC2	XP_001092339.1
Mus musculus (house mouse)	Uqcrc2	NP_080175.1
Drosophila melanogaster (fruit fly)	CG4169	NP_001261955.1
Oryza sativa (rice)	Os01g0191500	NP_001042272.1
Bos taurus (cattle)	UQCRC2	NP_777055.1
Danio rerio (zebrafish)	uqcrc2b	NP_001001589.1
Oryza sativa (rice)	Os01g0739000	NP_001044193.1
Homo sapiens (human)	UQCRC2	NP_003357.2
Arabidopsis thaliana (thale cress)	MPPalpha	NP_566548.1
Oryza sativa (rice)	Os05g0524300	NP_001056089.1

Gene Ontology
Bibliography

Related articles in PubMed

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Fakruddin M, Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K
Cell reports22(2)482-496(2018 Jan)

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis.
Khacho M, Clark A, Svoboda DS, MacLaurin JG, Lagace DC, Park DS, Slack RS
Human molecular genetics26(17)3327-3341(2017 Sep)

Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.
Spitler KM, Ponce JM, Oudit GY, Hall DD, Grueter CE
American journal of physiology. Heart and circulatory physiology312(4)H768-H780(2017 Apr)

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology216(3)675-693(2017 Mar)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nutlin-3a decreases male fertility via UQCRC2
Title: Nutlin-3a decreases male fertility via UQCRC2.

The following Uqcrc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Uqcrc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01247	NM_025899.2 Latest version!	Mus musculus ubiquinol cytochrome c reductase core protein 2 (Uqcrc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Uqcrc2 ( NM_025899.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080175.1 Mus musculus ubiquinol cytochrome c reductase core protein 2 (Uqcrc2), mRNA.

Price & Availability↑

CloneID	OMu01247
Clone ID Related Accession (Same CDS sequence)	NM_025899.2
Accession Version	NM_025899.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	cytochrome b-c1 complex subunit 2, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ074691.1, AK005151.1 and AK075856.1. On Apr 18, 2006 this sequence version replaced NM_025899.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075856.1, SRR1660811.14551.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTCC TCAGCAGGGC CGGGTCCTTC TCGAGATTTT ATTCCCTCAA AGTTGCCCCG 
AAGGTTAAAA CTTCAGCAGC CCCTGGAGGA GTGCCTCTGC AGCCTCAGGA TCTTGAGTTT 
ACCAAATTAC CAAATGGTTT GGTGATTGCT TCTCTGGAAA ACTATGCTCC TCTGTCAAGA 
ATCGGCTTGT TCGTTAAAGC AGGCAGTAGA TATGAGGACT CCAACAACTT GGGAACCTCA 
CATTTACTAC GTCTTGCATC TAGTTTGACT ACCAAAGGAG CTTCATCTTT CAAGATAACC 
CGTGGGATTG AAGCAGTTGG TGGTAAATTA AGTGTGACTG CAACAAGGGA AAACATGGCG 
TACACTGTAG AAGGCATTCG GAGTGATATT GAGATCCTCA TGGAGTTCCT GCTCAATGTC 
ACCACAGCAC CCGAGTTTCG CCGTTGGGAA GTAGCTGCCC TGCGGTCTCA GCTAAAGATT 
GACAAAGCTG TTGCCTTTCA GAATTCACAG ACCCGTATCA TTGAGAACTT GCATGATGTT 
GCCTACAAGA ATGCCTTGGC TAATCCTTTG TACTGTCCTG ACTATAGGAT GGGGAAGATA 
ACATCAGAGG AATTACATTA CTTTGTTCAG AACCACTTCA CAAGTGCAAG AATGGCTCTG 
GTTGGACTTG GTGTGAGTCA TTCTGTCTTA AAGCAGGTGG CTGAACAATT TCTCAACATG 
AGGGGTGGCC TTGGTTTAGC TGGTGCAAAA GCCAAATACC GTGGAGGTGA AATTAGAGAG 
CAGAATGGAG ACAACCTGGT CCATGCTGCT ATTGTTGCAG AAAGTGCTGC CATTGGAAAT 
GCAGAGGCAA ATGCATTCAG TGTACTTCAG CATCTTCTTG GTGCTGGACC ACATATCAAA 
AGGGGCAACA ACACCACCAG CCTCCTGAGC CAGAGTGTTG CCAAAGGAAG TCACCAGCCT 
TTTGATGTTT CTGCATTTAA TGCCAGTTAC TCAGACTCTG GGCTCTTTGG AATTTACACT 
ATTTCCCAGG CTGCAGCTGC TGGAGAGGTT ATCAATGCTG CCTACAACCA AGTCAAAGCA 
GTTGCTCAAG GAAACCTTTC CAGTGCAGAT GTCCAAGCTG CCAAGAACAA GCTAAAAGCT 
GGATATCTAA TGTCTGTGGA GACGTCAGAG GGCTTCCTGA GTGAAATTGG GTCACAGGCT 
CTAGCTGCAG GTTCTTATAT GCCACCTTCT ACCGTCCTTC AACAGATTGA CTCCGTGGCT 
GATGCTGATG TTGTAAAGGC TGCAAAAAAG TTTGTTTCTG GCAAGAAGTC AATGGCAGCG 
AGTGGAAACT TGGGACATAC GCCTTTTCTC GACGAGTTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080175.1
CDS	102..1463
Translation	MKLLSRAGSFSRFYSLKVAPKVKTSAAPGGVPLQPQDLEFTKLPNGLVIASLENYAPLSRIGLFVKAGSRYEDSNNLGTSHLLRLASSLTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVEGIRSDIEILMEFLLNVTTAPEFRRWEVAALRSQLKIDKAVAFQNSQTRIIENLHDVAYKNALANPLYCPDYRMGKITSEELHYFVQNHFTSARMALVGLGVSHSVLKQVAEQFLNMRGGLGLAGAKAKYRGGEIREQNGDNLVHAAIVAESAAIGNAEANAFSVLQHLLGAGPHIKRGNNTTSLLSQSVAKGSHQPFDVSAFNASYSDSGLFGIYTISQAAAAGEVINAAYNQVKAVAQGNLSSADVQAAKNKLKAGYLMSVETSEGFLSEIGSQALAAGSYMPPSTVLQQIDSVADADVVKAAKKFVSGKKSMAASGNLGHTPFLDEL

Target ORF information:

RefSeq Version	NM_025899.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquinol cytochrome c reductase core protein 2 (Uqcrc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025899.2

ORF Insert Sequence:

ATGAAGCTCC TCAGCAGGGC CGGGTCCTTC TCGAGATTTT ATTCCCTCAA AGTTGCCCCG 
AAGGTTAAAA CTTCAGCAGC CCCTGGAGGA GTGCCTCTGC AGCCTCAGGA TCTTGAGTTT 
ACCAAATTAC CAAATGGTTT GGTGATTGCT TCTCTGGAAA ACTATGCTCC TCTGTCAAGA 
ATCGGCTTGT TCGTTAAAGC AGGCAGTAGA TATGAGGACT CCAACAACTT GGGAACCTCA 
CATTTACTAC GTCTTGCATC TAGTTTGACT ACCAAAGGAG CTTCATCTTT CAAGATAACC 
CGTGGGATTG AAGCAGTTGG TGGTAAATTA AGTGTGACTG CAACAAGGGA AAACATGGCG 
TACACTGTAG AAGGCATTCG GAGTGATATT GAGATCCTCA TGGAGTTCCT GCTCAATGTC 
ACCACAGCAC CCGAGTTTCG CCGTTGGGAA GTAGCTGCCC TGCGGTCTCA GCTAAAGATT 
GACAAAGCTG TTGCCTTTCA GAATTCACAG ACCCGTATCA TTGAGAACTT GCATGATGTT 
GCCTACAAGA ATGCCTTGGC TAATCCTTTG TACTGTCCTG ACTATAGGAT GGGGAAGATA 
ACATCAGAGG AATTACATTA CTTTGTTCAG AACCACTTCA CAAGTGCAAG AATGGCTCTG 
GTTGGACTTG GTGTGAGTCA TTCTGTCTTA AAGCAGGTGG CTGAACAATT TCTCAACATG 
AGGGGTGGCC TTGGTTTAGC TGGTGCAAAA GCCAAATACC GTGGAGGTGA AATTAGAGAG 
CAGAATGGAG ACAACCTGGT CCATGCTGCT ATTGTTGCAG AAAGTGCTGC CATTGGAAAT 
GCAGAGGCAA ATGCATTCAG TGTACTTCAG CATCTTCTTG GTGCTGGACC ACATATCAAA 
AGGGGCAACA ACACCACCAG CCTCCTGAGC CAGAGTGTTG CCAAAGGAAG TCACCAGCCT 
TTTGATGTTT CTGCATTTAA TGCCAGTTAC TCAGACTCTG GGCTCTTTGG AATTTACACT 
ATTTCCCAGG CTGCAGCTGC TGGAGAGGTT ATCAATGCTG CCTACAACCA AGTCAAAGCA 
GTTGCTCAAG GAAACCTTTC CAGTGCAGAT GTCCAAGCTG CCAAGAACAA GCTAAAAGCT 
GGATATCTAA TGTCTGTGGA GACGTCAGAG GGCTTCCTGA GTGAAATTGG GTCACAGGCT 
CTAGCTGCAG GTTCTTATAT GCCACCTTCT ACCGTCCTTC AACAGATTGA CTCCGTGGCT 
GATGCTGATG TTGTAAAGGC TGCAAAAAAG TTTGTTTCTG GCAAGAAGTC AATGGCAGCG 
AGTGGAAACT TGGGACATAC GCCTTTTCTC GACGAGTTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Cell reports22(2)482-496(2018 Jan)
Fakruddin M,Wei FY,Suzuki T,Asano K,Kaieda T,Omori A,Izumi R,Fujimura A,Kaitsuka T,Miyata K,Araki K,Oike Y,Scorrano L,Suzuki T,Tomizawa K

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis.
Human molecular genetics26(17)3327-3341(2017 Sep)
Khacho M,Clark A,Svoboda DS,MacLaurin JG,Lagace DC,Park DS,Slack RS

Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.
American journal of physiology. Heart and circulatory physiology312(4)H768-H780(2017 Apr)
Spitler KM,Ponce JM,Oudit GY,Hall DD,Grueter CE

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
The Journal of cell biology216(3)675-693(2017 Mar)
Schatton D,Pla-Martin D,Marx MC,Hansen H,Mourier A,Nemazanyy I,Pessia A,Zentis P,Corona T,Kondylis V,Barth E,Schauss AC,Velagapudi V,Rugarli EI

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K

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Uqcrc2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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