Pagr1a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Pagr1a
Entrez Gene ID	67278
Full Name	PAXIP1 associated glutamate rich protein 1A
Synonyms	2900092E17Rik,C77040,PA1,PAGR1
General protein information	Preferred Names PAXIP1 associated glutamate rich protein 1A Names PAXIP1-associated glutamate-rich protein 1A PAXIP1-associated glutamate-rich protein 1 PAXIP1-associated protein 1 PTIP-associated 1 PTIP-associated protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F3

mRNA and Protein(s)

mRNA Protein Name

NM_030240.1 NP_084516.1 PAXIP1-associated glutamate-rich protein 1A
Pathways from BioSystems

mRNA	Protein	Name
NM_030240.1	NP_084516.1	PAXIP1-associated glutamate-rich protein 1A

Homologies

	PAGR1	XP_001104747.1
Canis lupus familiaris (dog)	PAGR1	XP_849156.1
Danio rerio (zebrafish)	pagr1	XP_002663938.1
Xenopus tropicalis (tropical clawed frog)	pagr1	NP_001096347.1
Mus musculus (house mouse)	Pagr1a	NP_084516.1
Homo sapiens (human)	PAGR1	NP_078792.1
Pan troglodytes (chimpanzee)	PAGR1	XP_001144010.1
Bos taurus (cattle)	PAGR1	NP_001069100.1

Gene Ontology
Bibliography

Related articles in PubMed

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec H?jfeldt M, Vala A, Yang W, L?pez-M?ndez B, Lee JE, Peng W, Yuan J, Ge K, Montoya G, Nussenzweig A, Choudhary C, Daniel JA
Genes & development30(2)149-63(2016 Jan)

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet ?-Cell Function.
Scoville DW, Cyphert HA, Liao L, Xu J, Reynolds A, Guo S, Stein R
Diabetes64(11)3772-83(2015 Nov)

Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.
Kumar A, Lualdi M, Loncarek J, Cho YW, Lee JE, Ge K, Kuehn MR
Developmental dynamics : an official publication of the American Association of Anatomists243(7)937-47(2014 Jul)

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.
Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K
eLife2e01503(2013 Dec)

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.
Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K
Proceedings of the National Academy of Sciences of the United States of America109(38)15324-9(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR
Title: A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage.
Title: Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.

PA1 (also known as C16orf53 in human and 2900092E17Rik in mouse) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex.
Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

The following Pagr1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pagr1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08230	NM_030240.1 Latest version!	Mus musculus PAXIP1 associated glutamate rich protein 1A (Pagr1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pagr1a ( NM_030240.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084516.1 Mus musculus PAXIP1 associated glutamate rich protein 1A (Pagr1a), mRNA.

Price & Availability↑

CloneID	OMu08230
Clone ID Related Accession (Same CDS sequence)	NM_030240.1
Accession Version	NM_030240.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Mus musculus(house mouse)
Product	PAXIP1-associated glutamate-rich protein 1A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC003932.1. ##Evidence-Data-START## Transcript exon combination :: BC003932.1, SRR1660815.177766.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCTTG CCCTGGGCCA TGGAACCATT GCAGGCAGCA CAGCAGCGCC TCTGTCTGAA 
GAAGGGGAAG TGACTTCCGG CCTCCAAGCT CTGGCGGTGG AGGACACTGG AGGTCCCTCT 
GTCTCGGCTA GTAAGGCCGA GGAAGAGGGG AAAGGCAGTC AGGAGGAGGC CGGGCGTGAG 
GGATCCAGGC CTGAGGAGGC ACTAGAAGCT CCCAGCGCTG CGAGCGACGA GCGTGCGGAG 
GGAGAAGCCG AAGACTGGTG CGTGCCCTGC AGCGATGAGG AGGTGGAGCT GCCGGCCAAT 
GGGCAGTCCT GGATGCCCCC ACCCTCCGAG ATCCAGCGGC TCTATGAACT GCTGGCTACC 
CAAGGTACTC TGGAGCTTCA AGCAGAGATC CTACCCCGCC GGCCGCCTAC CCCAGAGGCC 
CAGAGTGAAG AGGAGAGATC AGACGAGGAG CCAGAGGCCA AAGAAGAGGA GGAGGAAAAG 
CCGCACATGC CTACAGAATT TGACTTTGAT GATGAGCCAA TGACACCAAA GGACTCACTG 
ATTGACAGGA GACGGACACC AGGAAGCTCA GCCCGGAGCC AGAAACGGGA GGCGCGTCTG 
GATAAGGTCC TCTCAGACAT GAAGCGCCAT AAGAAACTAG AGGAGCAAAT CCTCCGGACC 
GGGAGAGACC TCTTCAGCTT AGACTCAGAG GGCCCCAGCC CCACCAGCCC TCCACTCCGA 
TCCTCAGGAA ACAGTCTCTT TCCCAGACAG CGGAAGTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084516.1
CDS	432..1193
Translation	MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGKGSQEEAGREGSRPEEALEAPSAASDERAEGEAEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPMTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEGPSPTSPPLRSSGNSLFPRQRKY

Target ORF information:

RefSeq Version	NM_030240.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus PAXIP1 associated glutamate rich protein 1A (Pagr1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030240.1

ORF Insert Sequence:

ATGTCCCTTG CCCTGGGCCA TGGAACCATT GCAGGCAGCA CAGCAGCGCC TCTGTCTGAA 
GAAGGGGAAG TGACTTCCGG CCTCCAAGCT CTGGCGGTGG AGGACACTGG AGGTCCCTCT 
GTCTCGGCTA GTAAGGCCGA GGAAGAGGGG AAAGGCAGTC AGGAGGAGGC CGGGCGTGAG 
GGATCCAGGC CTGAGGAGGC ACTAGAAGCT CCCAGCGCTG CGAGCGACGA GCGTGCGGAG 
GGAGAAGCCG AAGACTGGTG CGTGCCCTGC AGCGATGAGG AGGTGGAGCT GCCGGCCAAT 
GGGCAGTCCT GGATGCCCCC ACCCTCCGAG ATCCAGCGGC TCTATGAACT GCTGGCTACC 
CAAGGTACTC TGGAGCTTCA AGCAGAGATC CTACCCCGCC GGCCGCCTAC CCCAGAGGCC 
CAGAGTGAAG AGGAGAGATC AGACGAGGAG CCAGAGGCCA AAGAAGAGGA GGAGGAAAAG 
CCGCACATGC CTACAGAATT TGACTTTGAT GATGAGCCAA TGACACCAAA GGACTCACTG 
ATTGACAGGA GACGGACACC AGGAAGCTCA GCCCGGAGCC AGAAACGGGA GGCGCGTCTG 
GATAAGGTCC TCTCAGACAT GAAGCGCCAT AAGAAACTAG AGGAGCAAAT CCTCCGGACC 
GGGAGAGACC TCTTCAGCTT AGACTCAGAG GGCCCCAGCC CCACCAGCCC TCCACTCCGA 
TCCTCAGGAA ACAGTCTCTT TCCCAGACAG CGGAAGTACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
Genes & development30(2)149-63(2016 Jan)
Starnes LM,Su D,Pikkupeura LM,Weinert BT,Santos MA,Mund A,Soria R,Cho YW,Pozdnyakova I,Kubec H?jfeldt M,Vala A,Yang W,L?pez-M?ndez B,Lee JE,Peng W,Yuan J,Ge K,Montoya G,Nussenzweig A,Choudhary C,Daniel JA

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet ?-Cell Function.
Diabetes64(11)3772-83(2015 Nov)
Scoville DW,Cyphert HA,Liao L,Xu J,Reynolds A,Guo S,Stein R

Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.
Developmental dynamics : an official publication of the American Association of Anatomists243(7)937-47(2014 Jul)
Kumar A,Lualdi M,Loncarek J,Cho YW,Lee JE,Ge K,Kuehn MR

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.
eLife2e01503(2013 Dec)
Lee JE,Wang C,Xu S,Cho YW,Wang L,Feng X,Baldridge A,Sartorelli V,Zhuang L,Peng W,Ge K

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.
Proceedings of the National Academy of Sciences of the United States of America109(38)15324-9(2012 Sep)
Wang C,Lee JE,Cho YW,Xiao Y,Jin Q,Liu C,Ge K

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Pagr1a cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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