Derl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Derl1
Entrez Gene ID	67819
Full Name	Der1-like domain family, member 1
Synonyms	1110021N07Rik,AI195141,AW551338,Derlin-1
General protein information	Preferred Names Der1-like domain family, member 1 Names derlin-1 degradation in endoplasmic reticulum protein 1 der1-like protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 D1

mRNA and Protein(s)

mRNA Protein Name

NM_024207.4 NP_077169.1 derlin-1
Pathways from BioSystems

mRNA	Protein	Name
NM_024207.4	NP_077169.1	derlin-1

Homologies

	DERL1	XP_001099154.1
Mus musculus (house mouse)	Derl1	NP_077169.1
Rattus norvegicus (Norway rat)	Derl1	NP_001014224.1
Gallus gallus (chicken)	DERL1	NP_001006350.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009288	XP_320085.4
Caenorhabditis elegans (roundworm)	cup-2	NP_492721.1
Xenopus tropicalis (tropical clawed frog)	derl1	NP_001016723.1
Drosophila melanogaster (fruit fly)	Der-1	NP_608632.1
Homo sapiens (human)	DERL1	NP_077271.1
Pan troglodytes (chimpanzee)	DERL1	XP_519933.1
Danio rerio (zebrafish)	derl1	NP_998609.1
Canis lupus familiaris (dog)	DERL1	XP_532320.2
Bos taurus (cattle)	DERL1	NP_991358.1

Gene Ontology
Bibliography

Related articles in PubMed

Derlin-1 promotes ubiquitylation and degradation of the epithelial Na
You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, Huang Y, Li M, Qu S, Sun F, Liang X
Journal of cell science130(6)1027-1036(2017 03)

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
Osorio FG, Soria-Valles C, Santiago-Fern?ndez O, Bernal T, Mittelbrunn M, Colado E, Rodr?guez F, Bonzon-Kulichenko E, V?zquez J, Porta-de-la-Riva M, Cer?n J, Fueyo A, Li J, Green AR, Freije JM, L?pez-Ot?n C
Nature medicine22(1)91-6(2016 Jan)

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.
Yamamoto S, Yamazaki T, Komazaki S, Yamashita T, Osaki M, Matsubayashi M, Kidoya H, Takakura N, Yamazaki D, Kakizawa S
Developmental biology393(1)33-43(2014 Sep)

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.
Chen SF, Wu CH, Lee YM, Tam K, Tsai YC, Liou JY, Shyue SK
The Journal of biological chemistry288(46)33462-9(2013 Nov)

Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice.
Eura Y, Yanamoto H, Arai Y, Okuda T, Miyata T, Kokame K
PloS one7(3)e34298(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.
Title: Derlin-1 promotes ubiquitylation and degradation of the epithelial Na

Cav-1 may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation.
Title: Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.

Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
Title: Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice.

Derlin-1 regulates the turnover of superoxide dismutase 1 by promoting the proteasomal and autophagosomal degradation of SOD1 protein, but not by decreasing mutant SOD1 mRNA levels.
Title: Derlin-1 overexpression ameliorates mutant SOD1-induced endoplasmic reticulum stress by reducing mutant SOD1 accumulation.

Perturbation of binding between SOD1(mut) and Derlin-1 by Derlin-1-derived oligopeptide suppressed SOD1(mut)-induced ER stress, ASK1 activation, and motor neuron death.
Title: ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

The following Derl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Derl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02178	NM_024207.4 Latest version!	Mus musculus Der1-like domain family, member 1 (Derl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Derl1 ( NM_024207.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_077169.1 Mus musculus Der1-like domain family, member 1 (Derl1), mRNA.

Price & Availability↑

CloneID	OMu02178
Clone ID Related Accession (Same CDS sequence)	NM_024207.4
Accession Version	NM_024207.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	derlin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC154874.9. On Apr 29, 2007 this sequence version replaced NM_024207.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK043420.1, BC085490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164140 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGACA TCGGGGACTG GTTCAGGAGC ATCCCGGCCA TCACGCGCTA CTGGTTTGCT 
GCCACCGTTG CTGTCCCCTT GATCGGCAAG CTCGGCATCA TCAGCCCGGC CTACTTCTTC 
CTCTGGCCCG AAGCCTTCCT CTATCGCTTC CAGATATGGA GGCCGTTCAC TGCCACCTTT 
TACTTCCCCG TGGGCCCAGG GACTGGATTT CTGTATTTGG TCAATTTATA TTTCTTATAT 
CAGTATTCTA CTCGGCTTGA AGCAGGAGCT TTTGACGGGA GGCCAGCAGA CTATTTATTC 
ATGCTTCTCT TTAACTGGAT CTGCATCGTT ATTACTGGCT TAGCAATGGA TATGCAGCTG 
CTGATGATCC CTCTGATCAT GTCAGTGCTC TACGTCTGGG CCCAGCTGAA CAGAGACCTG 
ATCGTGTCGT TCTGGTTCGG AACGCGATTT AAGGCCTGTT ACTTACCTTG GGTTATCCTT 
GGATTCAACT ATATCATTGG AGGCTCGGTG ATCAATGAGC TCATTGGAAA CCTTGTCGGC 
CATCTTTATT TCTTCCTGAT GTTCAGATAC CCAATGGACT TGGGAGGAAG GAATTTTCTG 
TCCACACCTC AGTTTTTGTA CCGCTGGCTA CCCAGTAGGA GAGGAGGGGT GTCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTCCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077169.1
CDS	124..879
Translation	MSDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFPVGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDLIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ

Target ORF information:

RefSeq Version	NM_024207.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus Der1-like domain family, member 1 (Derl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024207.4

ORF Insert Sequence:

ATGTCGGACA TCGGGGACTG GTTCAGGAGC ATCCCGGCCA TCACGCGCTA CTGGTTTGCT 
GCCACCGTTG CTGTCCCCTT GATCGGCAAG CTCGGCATCA TCAGCCCGGC CTACTTCTTC 
CTCTGGCCCG AAGCCTTCCT CTATCGCTTC CAGATATGGA GGCCGTTCAC TGCCACCTTT 
TACTTCCCCG TGGGCCCAGG GACTGGATTT CTGTATTTGG TCAATTTATA TTTCTTATAT 
CAGTATTCTA CTCGGCTTGA AGCAGGAGCT TTTGACGGGA GGCCAGCAGA CTATTTATTC 
ATGCTTCTCT TTAACTGGAT CTGCATCGTT ATTACTGGCT TAGCAATGGA TATGCAGCTG 
CTGATGATCC CTCTGATCAT GTCAGTGCTC TACGTCTGGG CCCAGCTGAA CAGAGACCTG 
ATCGTGTCGT TCTGGTTCGG AACGCGATTT AAGGCCTGTT ACTTACCTTG GGTTATCCTT 
GGATTCAACT ATATCATTGG AGGCTCGGTG ATCAATGAGC TCATTGGAAA CCTTGTCGGC 
CATCTTTATT TCTTCCTGAT GTTCAGATAC CCAATGGACT TGGGAGGAAG GAATTTTCTG 
TCCACACCTC AGTTTTTGTA CCGCTGGCTA CCCAGTAGGA GAGGAGGGGT GTCAGGATTT 
GGTGTGCCCC CTGCTAGCAT GAGGCGAGCT GCTGATCAGA ATGGCGGAGG CGGGAGACAC 
AACTGGGGCC AGGGCTTCCG ACTTGGAGAC CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Derlin-1 promotes ubiquitylation and degradation of the epithelial Na
Journal of cell science130(6)1027-1036(2017 03)
You H,Ge Y,Zhang J,Cao Y,Xing J,Su D,Huang Y,Li M,Qu S,Sun F,Liang X

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
Nature medicine22(1)91-6(2016 Jan)
Osorio FG,Soria-Valles C,Santiago-Fern?ndez O,Bernal T,Mittelbrunn M,Colado E,Rodr?guez F,Bonzon-Kulichenko E,V?zquez J,Porta-de-la-Riva M,Cer?n J,Fueyo A,Li J,Green AR,Freije JM,L?pez-Ot?n C

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.
Developmental biology393(1)33-43(2014 Sep)
Yamamoto S,Yamazaki T,Komazaki S,Yamashita T,Osaki M,Matsubayashi M,Kidoya H,Takakura N,Yamazaki D,Kakizawa S

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.
The Journal of biological chemistry288(46)33462-9(2013 Nov)
Chen SF,Wu CH,Lee YM,Tam K,Tsai YC,Liou JY,Shyue SK

Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice.
PloS one7(3)e34298(2012)
Eura Y,Yanamoto H,Arai Y,Okuda T,Miyata T,Kokame K

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Derl1 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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