Klhdc2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Klhdc2
Entrez Gene ID	69554
Full Name	kelch domain containing 2
Synonyms	2310022K15Rik,D12Ertd522e,HCLP-1,LCP
General protein information	Preferred Names kelch domain containing 2 Names kelch domain-containing protein 2 endothelial differentiation inhibitory protein TNG
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 C2\|12 28.77 cM

mRNA and Protein(s)

mRNA Protein Name

NM_027117.3 NP_081393.2 kelch domain-containing protein 2
Pathways from BioSystems

mRNA	Protein	Name
NM_027117.3	NP_081393.2	kelch domain-containing protein 2

Homologies

Bos taurus (cattle)	KLHDC2	NP_001014948.1
Homo sapiens (human)	KLHDC2	NP_055130.1
Gallus gallus (chicken)	KLHDC2	NP_001012608.1
Xenopus tropicalis (tropical clawed frog)	klhdc2	NP_001096337.1
Pan troglodytes (chimpanzee)	KLHDC2	XP_509933.3
Mus musculus (house mouse)	Klhdc2	NP_081393.2
Rattus norvegicus (Norway rat)	Klhdc2	NP_001029305.1
Canis lupus familiaris (dog)	KLHDC2	XP_537436.2
Danio rerio (zebrafish)	zgc:162310	XP_005173625.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts.
Neuhaus P, Jaschinsky B, Schneider S, Neuhaus H, Wolter A, Ebelt H, Braun T
Experimental cell research312(16)3049-59(2006 Oct)

Differentially expressed genes in endothelial differentiation.
Ishii H, Mimori K, Mori M, Vecchione A
DNA and cell biology24(7)432-7(2005 Jul)

Protein-protein interaction panel using mouse full-length cDNAs.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y
Genome research11(10)1758-65(2001 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that a tightly controlled expression of mKlhdc2 is essential for a faithful execution of the myogenic differentiation and migration program.
Title: Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts.

A conserved but uncharacterized gene encoding Klhdc2, which was down-regulated during endothelial differentiation, was identified.
Title: Differentially expressed genes in endothelial differentiation.

The following Klhdc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klhdc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03644	NM_027117.3 Latest version!	Mus musculus kelch domain containing 2 (Klhdc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klhdc2 ( NM_027117.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081393.2 Mus musculus kelch domain containing 2 (Klhdc2), mRNA.

Price & Availability↑

CloneID	OMu03644
Clone ID Related Accession (Same CDS sequence)	NM_027117.3
Accession Version	NM_027117.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Mus musculus(house mouse)
Product	kelch domain-containing protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC099934.14 and AK009481.1. On Apr 2, 2009 this sequence version replaced NM_027117.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.218930.1, SRR1660815.169400.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGATG GCAACGAGGA TGCTCGAGCG GAGGATCTGC CGGGCCCGGC CTTCGAGAAC 
TACGAGGCCA TGGAGCTGGC CTGCCCGGCT GAACGCAGCG GCCACGTCGC TGTCAGCGAT 
GGGCGCCACA TGTTCGTCTG GGGCGGCTAC AAGAGTAATC AAGTGAGAGG ATTATATGAC 
TTTTATCTGC CCAGAGAAGA ACTGTGGATC TACAACATGG AGACTGGAAG ATGGAAGAAA 
ATCAACACTG AAGGTGACGT TCCCCCGTCT ATGTCTGGGA GCTGCGCTGT GTGCGTGGAC 
CGGGTGCTGT ACTTGTTTGG TGGGCACCAT TCCAGAGGCA ATACAAACAA GTTCTACATG 
CTGGATTCGA GGTCTGCAGA CAGAGGGTTA CAGTGGGAAA GGATCGACTG CCAAGGAATC 
CCTCCATCAT CAAAGGACAA ACTTGGCGTC TGGGTGTATA AAAACAAGTT AATATTTTTT 
GGAGGCTATG GATATTTACC TGAAGATAAA GTATTGGGAA CTTTTGAATT TGATGAAACA 
TCTTTTTGGA ATTCAAGTCA TCCAAGAGGA TGGAATGATC ATGTCCATAT TTTAGACACT 
GAAACATTTG CCTGGAGCCA GCCCATCACC ACTGGTAAGG CACCTTCACC TCGGGCTGCC 
CATGCCTGTG CAACTGTTGG AAACAAGGGC TTTGTGTTTG GTGGCAGATA CCGGGATGCT 
AGAATGAATG ATCTTCACTA TCTTAATCTG GATACGTGGG AGTGGAATGA ACTAATTCCA 
CAAGGTGTGT GCCCTGTTGG CAGATCCTGG CACTCACTGA CACCAGTCTC TTCAGACCAT 
CTTTTTCTCT TTGGAGGATT TACCACTGAA AAACAGCCAC TAAGTGATGC CTGGACTTAC 
TGCATCAGTA AAAATGAATG GATTCAGTTT AATCATCCTT ATGTTGAAAA ACCAAGATTA 
TGGCACACAG CTTGTGCGAG TGATGAAGGA GAAGTCATTG TTTTTGGTGG TTGTGCTAAC 
AATCTGCTGG TTCATCACAG AGCTGCACAC AGTAATGAAG TACTTATATT TTCAGTTCAA 
CCAAAATCTC TTGTACGGCT AAGCTTAGAA GCAGTCATCT GCTTTAAAGA GATGCTAGCC 
AACTCGTGGA GCTGCCTTCC AAAACACTTA CTTCACAGCG TTAATCAGAG GTTTGGTAGT 
AACAACACTT CTGGATCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081393.2
CDS	315..1535
Translation	MADGNEDARAEDLPGPAFENYEAMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSADRGLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEWIQFNHPYVEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEMLANSWSCLPKHLLHSVNQRFGSNNTSGS

Target ORF information:

RefSeq Version	NM_027117.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch domain containing 2 (Klhdc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027117.3

ORF Insert Sequence:

ATGGCTGATG GCAACGAGGA TGCTCGAGCG GAGGATCTGC CGGGCCCGGC CTTCGAGAAC 
TACGAGGCCA TGGAGCTGGC CTGCCCGGCT GAACGCAGCG GCCACGTCGC TGTCAGCGAT 
GGGCGCCACA TGTTCGTCTG GGGCGGCTAC AAGAGTAATC AAGTGAGAGG ATTATATGAC 
TTTTATCTGC CCAGAGAAGA ACTGTGGATC TACAACATGG AGACTGGAAG ATGGAAGAAA 
ATCAACACTG AAGGTGACGT TCCCCCGTCT ATGTCTGGGA GCTGCGCTGT GTGCGTGGAC 
CGGGTGCTGT ACTTGTTTGG TGGGCACCAT TCCAGAGGCA ATACAAACAA GTTCTACATG 
CTGGATTCGA GGTCTGCAGA CAGAGGGTTA CAGTGGGAAA GGATCGACTG CCAAGGAATC 
CCTCCATCAT CAAAGGACAA ACTTGGCGTC TGGGTGTATA AAAACAAGTT AATATTTTTT 
GGAGGCTATG GATATTTACC TGAAGATAAA GTATTGGGAA CTTTTGAATT TGATGAAACA 
TCTTTTTGGA ATTCAAGTCA TCCAAGAGGA TGGAATGATC ATGTCCATAT TTTAGACACT 
GAAACATTTG CCTGGAGCCA GCCCATCACC ACTGGTAAGG CACCTTCACC TCGGGCTGCC 
CATGCCTGTG CAACTGTTGG AAACAAGGGC TTTGTGTTTG GTGGCAGATA CCGGGATGCT 
AGAATGAATG ATCTTCACTA TCTTAATCTG GATACGTGGG AGTGGAATGA ACTAATTCCA 
CAAGGTGTGT GCCCTGTTGG CAGATCCTGG CACTCACTGA CACCAGTCTC TTCAGACCAT 
CTTTTTCTCT TTGGAGGATT TACCACTGAA AAACAGCCAC TAAGTGATGC CTGGACTTAC 
TGCATCAGTA AAAATGAATG GATTCAGTTT AATCATCCTT ATGTTGAAAA ACCAAGATTA 
TGGCACACAG CTTGTGCGAG TGATGAAGGA GAAGTCATTG TTTTTGGTGG TTGTGCTAAC 
AATCTGCTGG TTCATCACAG AGCTGCACAC AGTAATGAAG TACTTATATT TTCAGTTCAA 
CCAAAATCTC TTGTACGGCT AAGCTTAGAA GCAGTCATCT GCTTTAAAGA GATGCTAGCC 
AACTCGTGGA GCTGCCTTCC AAAACACTTA CTTCACAGCG TTAATCAGAG GTTTGGTAGT 
AACAACACTT CTGGATCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts.
Experimental cell research312(16)3049-59(2006 Oct)
Neuhaus P,Jaschinsky B,Schneider S,Neuhaus H,Wolter A,Ebelt H,Braun T

Differentially expressed genes in endothelial differentiation.
DNA and cell biology24(7)432-7(2005 Jul)
Ishii H,Mimori K,Mori M,Vecchione A

Protein-protein interaction panel using mouse full-length cDNAs.
Genome research11(10)1758-65(2001 Oct)
Suzuki H,Fukunishi Y,Kagawa I,Saito R,Oda H,Endo T,Kondo S,Bono H,Okazaki Y,Hayashizaki Y

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Klhdc2 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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