Gene Symbol | Pcgf1 |
Entrez Gene ID | 69837 |
Full Name | polycomb group ring finger 1 |
Synonyms | 2010002K04Rik,AU024121,Nspc1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Pcgf1 cDNA ORF clone
gRNAs
Gene Symbol | Pcgf1 |
Entrez Gene ID | 69837 |
Full Name | polycomb group ring finger 1 |
Synonyms | 2010002K04Rik,AU024121,Nspc1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_030255588.1 | XP_030111448.1 | polycomb group RING finger protein 1 isoform X1 |
NM_197992.1 | NP_932109.1 | polycomb group RING finger protein 1 |
LOC715341 | XP_001105519.2 | |
Pan troglodytes (chimpanzee) | PCGF1 | XP_515562.2 |
Canis lupus familiaris (dog) | PCGF1 | XP_532995.2 |
Bos taurus (cattle) | PCGF1 | NP_001039912.2 |
Homo sapiens (human) | PCGF1 | NP_116062.2 |
Rattus norvegicus (Norway rat) | Pcgf1 | NP_001007001.1 |
Danio rerio (zebrafish) | pcgf1 | NP_001007159.1 |
Mus musculus (house mouse) | Pcgf1 | NP_932109.1 |
Gallus gallus (chicken) | PCGF1 | XP_003643507.2 |
PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.
Almeida M, Pintacuda G, Masui O, Koseki Y, Gdula M, Cerase A, Brown D, Mould A, Innocent C, Nakayama M, Schermelleh L, Nesterova TB, Koseki H, Brockdorff N
Science (New York, N.Y.)356(6342)1081-1084(2017 06)
Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells.
Yan Y, Zhao W, Huang Y, Tong H, Xia Y, Jiang Q, Qin J
Scientific reports746276(2017 Apr)
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
Rose NR, King HW, Blackledge NP, Fursova NA, Ember KJ, Fischer R, Kessler BM, Klose RJ
eLife5(2016 10)
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4.
Li H, Fan R, Sun M, Jiang T, Gong Y
Biochemical and biophysical research communications440(4)527-32(2013 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Nspc1 has a positive role in maintaining the pluripotency of P19 cells by directly regulating Oct4.
Title: Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4.
Pcgf1 is an epigenetic regulator of hematopoietic cell differentiation. Simultaneous depletion of Runx1 and Pcgf1 allows sustained self-renewal while blocking differentiation of lineage marker-negative cells in vitro.
Title: Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.
The following Pcgf1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pcgf1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu08756 | |
Clone ID Related Accession (Same CDS sequence) | NM_197992.1 | |
Accession Version | NM_197992.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Mus musculus(house mouse) | |
Product | polycomb group RING finger protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC028560.1. ##Evidence-Data-START## Transcript exon combination :: BC028560.1, DV064595.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGGCTTC GGAACCAGCT CCAGTCAGTG TACAAGATGG ACCCACTACG GAACGAGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_932109.1 |
CDS | 33..776 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGGCTTC GGAACCAGCT CCAGTCAGTG TACAAGATGG ACCCACTACG GAACGAGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu89268 | |
Clone ID Related Accession (Same CDS sequence) | XM_030255588.1 | |
Accession Version | XM_030255588.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | polycomb group RING finger protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTGCAACA TCAAGATCCA CGAGACGCAG CCGTTGCTCA ATCTCAAACT GGATCGGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030111448.1 |
CDS | 844..1374 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTGCAACA TCAAGATCCA CGAGACGCAG CCGTTGCTCA ATCTCAAACT GGATCGGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. |
Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells. |
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4. |