Gene Symbol | Mfap4 |
Entrez Gene ID | 76293 |
Full Name | microfibrillar-associated protein 4 |
Synonyms | 1110007F23Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Mfap4 cDNA ORF clone
gRNAs
Gene Symbol | Mfap4 |
Entrez Gene ID | 76293 |
Full Name | microfibrillar-associated protein 4 |
Synonyms | 1110007F23Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_029568.3 | NP_083844.1 | microfibril-associated glycoprotein 4 isoform 2 precursor |
NM_029568.2 | NP_083844.1 | microfibril-associated glycoprotein 4 isoform 2 precursor |
NM_001347545.1 | NP_001334474.1 | microfibril-associated glycoprotein 4 isoform 1 precursor |
XM_030246411.1 | XP_030102271.1 | microfibril-associated glycoprotein 4 isoform X1 |
NM_001361359.1 | NP_001348288.1 | microfibril-associated glycoprotein 4 isoform 3 |
Mus musculus (house mouse) | Mfap4 | NP_083844.1 |
Canis lupus familiaris (dog) | MFAP4 | XP_546650.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP007031 | XP_565171.3 |
Xenopus tropicalis (tropical clawed frog) | LOC100488644 | XP_002943442.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100488329 | XP_002943440.2 |
Bos taurus (cattle) | MFAP4 | NP_001073686.1 |
Rattus norvegicus (Norway rat) | Mfap4 | NP_001029296.1 |
Drosophila melanogaster (fruit fly) | sca | NP_725230.2 |
Homo sapiens (human) | MFAP4 | NP_001185624.1 |
Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.
Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR
Neuron91(6)1260-1275(2016 Sep)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)
Growth of Murine Splenic Tissue Is Suppressed by Lymphotoxin β-Receptor Signaling (LTβR) Originating from Splenic and Non-Splenic Tissues.
Milićević NM, Nohroudi K, Schmidt F, Schmidt H, Ringer C, Sorensen GL, Milićević Ž, Westermann J
PloS one11(12)e0166901(2016)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
MFAP4 promotes follicular dendritic cell development in regenerating splenic tissue.
Title: The role of microfibrillar-associated protein 4 (MFAP4) in the formation and function of splenic compartments during embryonic and adult life.
MFAP4 regulates integrin alphaVbeta3-induced VSMC proliferation and migration, as well as monocyte chemotaxis, and accelerates neointimal hyperplasia after vascular injury.
Title: MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation.
MFAP4 promoted the development of asthmatic airway disease in vivo and pro-asthmatic functions of bronchial smooth muscle cells in vitro
Title: Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.
Mfap4 knockout mice develop a spontaneous loss of lung function.
Title: Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4.
The following Mfap4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mfap4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu47058 | |
Clone ID Related Accession (Same CDS sequence) | NM_001347545.1 | |
Accession Version | NM_001347545.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | microfibril-associated glycoprotein 4 isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL604029.12 and AA270684.1. On Dec 1, 2016 this sequence version replaced XM_006534422.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ951052.1, BQ714681.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGGCCC TCCCAGCCCT GCCACTGATG CTGATGCTGC TCTCCATGCC TCCCCCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001334474.1 |
CDS | 50..895 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGGCCC TCCCAGCCCT GCCACTGATG CTGATGCTGC TCTCCATGCC TCCCCCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu71483 | |
Clone ID Related Accession (Same CDS sequence) | NM_001361359.1 | |
Accession Version | NM_001361359.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Mus musculus(house mouse) | |
Product | microfibril-associated glycoprotein 4 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL604029.12. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075659.1, BB609695.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGATGC TGCTCTCCAT GCCTCCCCCC TGCGCCCCGC AAGCCTCTGG GATCCGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001348288.1 |
CDS | 125..871 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGATGC TGCTCTCCAT GCCTCCCCCC TGCGCCCCGC AAGCCTCTGG GATCCGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16116 | |
Clone ID Related Accession (Same CDS sequence) | NM_029568.3 , NM_029568.2 | |
Accession Version | NM_029568.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Mus musculus(house mouse) | |
Product | microfibril-associated glycoprotein 4 isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL604029.12. On Mar 19, 2018 this sequence version replaced NM_029568.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022666.1, AK003537.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGGCCC TCCCAGCCCT GCCACTGATG CTGATGCTGC TCTCCATGCC TCCCCCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_083844.1 |
CDS | 50..823 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGGCCC TCCCAGCCCT GCCACTGATG CTGATGCTGC TCTCCATGCC TCCCCCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16116 | |
Clone ID Related Accession (Same CDS sequence) | NM_029568.3 , NM_029568.2 | |
Accession Version | NM_029568.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Mus musculus(house mouse) | |
Product | microfibril-associated glycoprotein 4 isoform 2 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL604029.12. On Nov 17, 2006 this sequence version replaced NM_029568.1. Transcript Variant: This variant (2) uses alternate in-frame splice sites in the coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment, and is shorter, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK003537.1, BC022666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAAGGCCC TCCCAGCCCT GCCACTGATG CTGATGCTGC TCTCCATGCC TCCCCCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_083844.1 |
CDS | 37..810 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGGCCC TCCCAGCCCT GCCACTGATG CTGATGCTGC TCTCCATGCC TCCCCCCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu85941 | |
Clone ID Related Accession (Same CDS sequence) | XM_030246411.1 | |
Accession Version | XM_030246411.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | microfibril-associated glycoprotein 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAACTG AGGGCGGCAA GTGGACGGTT TTCCAGAAAA GATTCAACGG CTCAGTGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030102271.1 |
CDS | 358..912 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACAACTG AGGGCGGCAA GTGGACGGTT TTCCAGAAAA GATTCAACGG CTCAGTGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. |
High-throughput discovery of novel developmental phenotypes. |
Growth of Murine Splenic Tissue Is Suppressed by Lymphotoxin β-Receptor Signaling (LTβR) Originating from Splenic and Non-Splenic Tissues. |