Gene Symbol | Kdm8 |
Entrez Gene ID | 77035 |
Full Name | lysine (K)-specific demethylase 8 |
Synonyms | 3110005O21Rik,Jmjd5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Kdm8 cDNA ORF clone
Gene Symbol | Kdm8 |
Entrez Gene ID | 77035 |
Full Name | lysine (K)-specific demethylase 8 |
Synonyms | 3110005O21Rik,Jmjd5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_029842.5 | NP_084118.1 | bifunctional peptidase and arginyl-hydroxylase JMJD5 |
XM_017312384.1 | XP_017167873.1 | lysine-specific demethylase 8 isoform X1 |
XM_017312384.2 | XP_017167873.1 | bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform X1 |
Pan troglodytes (chimpanzee) | JMJD5 | XP_003315073.1 |
Danio rerio (zebrafish) | kdm8 | NP_001103339.2 |
Drosophila melanogaster (fruit fly) | CG13902 | NP_612063.2 |
JMJD5 | XP_001100489.1 | |
Xenopus tropicalis (tropical clawed frog) | kdm8 | NP_001121525.1 |
Homo sapiens (human) | KDM8 | NP_001138820.1 |
Canis lupus familiaris (dog) | KDM8 | XP_850038.1 |
Rattus norvegicus (Norway rat) | Kdm8 | NP_001032273.1 |
Arabidopsis thaliana (thale cress) | AT3G20810 | NP_850617.1 |
Oryza sativa (rice) | Os09g0489200 | NP_001063533.2 |
Mus musculus (house mouse) | Kdm8 | NP_084118.1 |
Oryza sativa (rice) | Os08g0508500 | NP_001175654.1 |
Bos taurus (cattle) | KDM8 | NP_001068807.1 |
Gallus gallus (chicken) | KDM8 | XP_414883.3 |
Caenorhabditis elegans (roundworm) | jmjd-5 | NP_505831.1 |
Miz1 controls Schwann cell proliferation via H3K36
Fuhrmann D, Mernberger M, Nist A, Stiewe T, Els?sser HP
The Journal of neuroscience : the official journal of the Society for Neuroscience(2017 Dec)
Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.
Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G
Proceedings of the National Academy of Sciences of the United States of America114(37)E7717-E7726(2017 Sep)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.
Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bj?r?s M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A
Nature537(7621)548-552(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Jmjd5 is involved in the transcriptional regulation of a subset of p53-regulated genes, possibly through the control of p53 recruitment at the gene loci.
Title: Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
Data suggest that Jmjd5 partially accumulates on mitotic spindles during mitosis; depletion of Jmjd5 results in significant mitotic arrest, spindle assembly defects, and sustained activation of spindle assembly checkpoint.
Title: JMJD5 (Jumonji Domain-containing 5) Associates with Spindle Microtubules and Is Required for Proper Mitosis.
Collectively, these data indicate that JMJD5 is essential during embryonal development and a repressor of p53 expression. The latter suggests that JMJD5 has oncogenic activity and accordingly JMJD5 is upregulated in leukemias and breast cancer.
Title: Histone demethylase JMJD5 is essential for embryonic development.
Results suggest that Jmjd5 physiologically moderates embryonic cell proliferation through the epigenetic control of Cdkn1a expression.
Title: Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression.
The following Kdm8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kdm8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu82254 | |
Clone ID Related Accession (Same CDS sequence) | XM_017312384.1 , XM_017312384.2 | |
Accession Version | XM_017312384.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | lysine-specific demethylase 8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAGAGC GGATGGTACC CAGGCTCCGC TGCCCACCTC TGCAGTACTT CAAGCAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017167873.1 |
CDS | 385..1101 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017312384.1 |
1 | ATGTTAGAGC GGATGGTACC CAGGCTCCGC TGCCCACCTC TGCAGTACTT CAAGCAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu07553 | |
Clone ID Related Accession (Same CDS sequence) | NM_029842.5 | |
Accession Version | NM_029842.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-20 | |
Organism | Mus musculus(house mouse) | |
Product | bifunctional peptidase and arginyl-hydroxylase JMJD5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC125187.4 and AK014006.1. On Mar 23, 2011 this sequence version replaced NM_029842.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014006.1, BC024807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCAGAGG ACACCACAGA GCCCCTGGTG GGGTCCAGCA CCCTCTGGAA GGAGCTCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_084118.1 |
CDS | 183..1427 |
Translation |
Target ORF information:
Target ORF information:
|
NM_029842.5 |
1 | ATGTCAGAGG ACACCACAGA GCCCCTGGTG GGGTCCAGCA CCCTCTGGAA GGAGCTCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu82254 | |
Clone ID Related Accession (Same CDS sequence) | XM_017312384.1 , XM_017312384.2 | |
Accession Version | XM_017312384.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017312384.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAGAGC GGATGGTACC CAGGCTCCGC TGCCCACCTC TGCAGTACTT CAAGCAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017167873.1 |
CDS | 205..921 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017312384.2 |
1 | ATGTTAGAGC GGATGGTACC CAGGCTCCGC TGCCCACCTC TGCAGTACTT CAAGCAGCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Miz1 controls Schwann cell proliferation via H3K36 |
Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. |
High-throughput discovery of novel developmental phenotypes. |
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. |