KLRC4-KLRK1 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | KLRC4-KLRK1 |
| Entrez Gene ID | 100528032 |
| Full Name | KLRC4-KLRK1 readthrough |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001199805.1 | NP_001186734.1 | NKG2-D type II integral membrane protein |
| Homo sapiens (human) | KLRC4-KLRK1 | NP_001186734.1 |
| Homo sapiens (human) | KLRK1 | NP_031386.2 |
Related articles in PubMed
A disease-linked
Zuo J, Willcox CR, Mohammed F, Davey M, Hunter S, Khan K, Antoun A, Katakia P, Croudace J, Inman C, Parry H, Briggs D, Malladi R, Willcox BE, Moss P
Science signaling10(481)(2017 May)
CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.
Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS
European journal of immunology43(9)2473-83(2013 Sep)
Genome-wide association analysis identifies new susceptibility loci for Beh?et's disease and epistasis between HLA-B*51 and ERAP1.
Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, G?l A, Remmers EF, Kastner DL
Nature genetics45(2)202-7(2013 Feb)
Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
Serrano-Pertierra E, Cernuda-Moroll?n E, L?pez-Larrea C
European journal of immunology42(8)2142-51(2012 Aug)
A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans.
Tsuboi S, Sutoh M, Hatakeyama S, Hiraoka N, Habuchi T, Horikawa Y, Hashimoto Y, Yoneyama T, Mori K, Koie T, Nakamura T, Saitoh H, Yamaya K, Funyu T, Fukuda M, Ohyama C
The EMBO journal30(15)3173-85(2011 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following KLRC4-KLRK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLRC4-KLRK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu07952 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001199805.1 | |
| Accession Version | NM_001199805.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-20 | |
| Organism | Homo sapiens(human) | |
| Product | NKG2-D type II integral membrane protein | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF461811.1 and AC022075.29. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF461811.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 8302, 22914 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGGGTGGA TTCGTGGTCG GAGGTCTCGA CACAGCTGGG AGATGAGTGA ATTTCATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001186734.1 |
| CDS | 536..1186 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001199805.1 |
ORF Insert Sequence:
1 | ATGGGGTGGA TTCGTGGTCG GAGGTCTCGA CACAGCTGGG AGATGAGTGA ATTTCATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
A disease-linked |
|
CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. |
|
Genome-wide association analysis identifies new susceptibility loci for Beh?et's disease and epistasis between HLA-B*51 and ERAP1. |
|
Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. |
|
A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans. |