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CD300C cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol CD300C
Entrez Gene ID 10871
Full Name CD300c molecule
Synonyms CLM-6,CMRF-35,CMRF-35A,CMRF35,CMRF35-A1,CMRF35A,CMRF35A1,IGSF16,LIR
General protein information
Preferred Names

CD300c molecule

Names

CMRF35-like molecule 6
CD300 antigen-like family member C
CD300c antigen
CMRF35 antigen
CMRF35 leukocyte immunoglobulin-like receptor
CMRF35A leukocyte immunoglobulin-like receptor
immunoglobulin superfamily member 16
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

17

17q25.1
Summary The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008].
Disorder MIM:

606786


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_006678.5 NP_006669.1 CMRF35-like molecule 6 precursor
XM_017024033.2 XP_016879522.1 CMRF35-like molecule 6 isoform X1
XM_017024034.2 XP_016879523.1 CMRF35-like molecule 6 isoform X2
XM_017024033.1 XP_016879522.1 CMRF35-like molecule 6 isoform X1
NM_006678.4 NP_006669.1 CMRF35-like molecule 6 precursor
XM_017024034.1 XP_016879523.1 CMRF35-like molecule 6 isoform X2

Pathways from BioSystems


Homologies


Bos taurus (cattle) LOC526163 XP_005221374.1
Mus musculus (house mouse) AF251705 NP_598919.1
Rattus norvegicus (Norway rat) RGD1559458 XP_006247807.1
CD300C XP_001089270.1
Canis lupus familiaris (dog) CD300C XP_852230.2
Mus musculus (house mouse) Cd300c NP_954695.1
Rattus norvegicus (Norway rat) RGD1559482 NP_001161757.1
Rattus norvegicus (Norway rat) Igsf7 XP_006247801.1
Rattus norvegicus (Norway rat) Cd300c XP_002727889.2
Homo sapiens (human) CD300C NP_006669.1
Pan troglodytes (chimpanzee) CD300C XP_003953227.1
Bos taurus (cattle) CD300C XP_002696262.3
Rattus norvegicus (Norway rat) RGD1561778 NP_001161756.1
Rattus norvegicus (Norway rat) LOC100909671 XP_003751005.1
Rattus norvegicus (Norway rat) RGD1562667 XP_577143.3

Gene Ontology


Bibliography

Related articles in PubMed

CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
Dimitrova M, Zenarruzabeitia O, Borrego F, Simhadri VR
Scientific reports623942(2016 Apr)

Human CD300C delivers an Fc receptor-?-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.
Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J
The Journal of biological chemistry288(11)7662-75(2013 Mar)

CD300c is an activating receptor expressed on human monocytes.
Simhadri VR, Mariano JL, Gil-Krzewska A, Zhou Q, Borrego F
Journal of innate immunity5(4)389-400(2013)

Differential expression of CD300a/c on human TH1 and TH17 cells.
Simhadri VR, Mariano JL, Zhou Q, DeBell KE, Borrego F
BMC immunology1262(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that CD300c is exclusively expressed on CD56bright natural killer cells and differentially binds to phosphatidylethanolamine and phosphatidylserine. This expression is under the regulation of STAT5 and Il-4.
Title: CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.

engagement of CD300C led to Fc receptor gamma-dependent activation of mast cells and monocytes
Title: Human CD300C delivers an Fc receptor-?-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.

potential role in inflammatory responses
Title: CD300c is an activating receptor expressed on human monocytes.

differential expression on human TH1 and TH17 cell memory subsets
Title: Differential expression of CD300a/c on human TH1 and TH17 cells.

CD300a and CD300c receptors are indistinguishable on the surface of natural killer (NK) cells. The tyrosine residue in the third ITIM motif, Tyr-267-Ala, is the most important residue for execution of the inhibitory signal.
Title: Expression and function of CD300 in NK cells.

The following CD300C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD300C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu07727 NM_006678.5
Latest version!		 Homo sapiens CD300c molecule (CD300C), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu86487 XM_017024033.2
Latest version!		 Homo sapiens CD300c molecule (CD300C), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00
OHu86488 XM_017024034.2
Latest version!		 Homo sapiens CD300c molecule (CD300C), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00
View Old Accession Versions >>
OHu86487 XM_017024033.1 Homo sapiens CD300c molecule (CD300C), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00
OHu07727 NM_006678.4 Homo sapiens CD300c molecule (CD300C), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu86488 XM_017024034.1 Homo sapiens CD300c molecule (CD300C), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu07727
Clone ID Related Accession (Same CDS sequence) NM_006678.5 , NM_006678.4
Accession Version NM_006678.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 675bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-07
Organism Homo sapiens(human)
Product CMRF35-like molecule 6 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC022279.1, AC079325.10 and BF508242.1. On May 17, 2019 this sequence version replaced NM_006678.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022279.1, SRR3476690.251893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2158569 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000330793.2/ ENSP00000329507.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG CCGGGACGAC CACAGCCTCC 
AGCCCCCAGA GCTCCATGGG CACCTCAGGT CCTCCCACGA AGCTGCCCGT GCACACCTGG 
CCCAGCGTGA CCAGAAAGGA CAGCCCCGAA CCCAGCCCAC ACCCTGGCTC CCTGTTCAGC 
AATGTCCGCT TCCTGCTCCT GGTCCTCTTG GAGCTGCCCC TGCTCCTGAG CATGCTGGGT 
GCCGTCCTCT GGGTGAACAG ACCTCAGAGA AGCTCTAGAA GCAGGCAGAA TTGGCCCAAG 
GGTGAGAACC AGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006669.1
CDS334..1008
Translation

Target ORF information:

RefSeq Version NM_006678.5
Organism Homo sapiens(human)
Definition Homo sapiens CD300c molecule (CD300C), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_006678.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG CCGGGACGAC CACAGCCTCC 
AGCCCCCAGA GCTCCATGGG CACCTCAGGT CCTCCCACGA AGCTGCCCGT GCACACCTGG 
CCCAGCGTGA CCAGAAAGGA CAGCCCCGAA CCCAGCCCAC ACCCTGGCTC CCTGTTCAGC 
AATGTCCGCT TCCTGCTCCT GGTCCTCTTG GAGCTGCCCC TGCTCCTGAG CATGCTGGGT 
GCCGTCCTCT GGGTGAACAG ACCTCAGAGA AGCTCTAGAA GCAGGCAGAA TTGGCCCAAG 
GGTGAGAACC AGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu07727
Clone ID Related Accession (Same CDS sequence) NM_006678.5 , NM_006678.4
Accession Version NM_006678.4 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 675bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-22
Organism Homo sapiens(human)
Product CMRF35-like molecule 6 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP298972.1, BC022279.1, AC079325.10 and BF508242.1. On Nov 30, 2012 this sequence version replaced NM_006678.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022279.1, BM922826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2158569 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG CCGGGACGAC CACAGCCTCC 
AGCCCCCAGA GCTCCATGGG CACCTCAGGT CCTCCCACGA AGCTGCCCGT GCACACCTGG 
CCCAGCGTGA CCAGAAAGGA CAGCCCCGAA CCCAGCCCAC ACCCTGGCTC CCTGTTCAGC 
AATGTCCGCT TCCTGCTCCT GGTCCTCTTG GAGCTGCCCC TGCTCCTGAG CATGCTGGGT 
GCCGTCCTCT GGGTGAACAG ACCTCAGAGA AGCTCTAGAA GCAGGCAGAA TTGGCCCAAG 
GGTGAGAACC AGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006669.1
CDS390..1064
Translation

Target ORF information:

RefSeq Version NM_006678.4
Organism Homo sapiens(human)
Definition Homo sapiens CD300c molecule (CD300C), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_006678.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG CCGGGACGAC CACAGCCTCC 
AGCCCCCAGA GCTCCATGGG CACCTCAGGT CCTCCCACGA AGCTGCCCGT GCACACCTGG 
CCCAGCGTGA CCAGAAAGGA CAGCCCCGAA CCCAGCCCAC ACCCTGGCTC CCTGTTCAGC 
AATGTCCGCT TCCTGCTCCT GGTCCTCTTG GAGCTGCCCC TGCTCCTGAG CATGCTGGGT 
GCCGTCCTCT GGGTGAACAG ACCTCAGAGA AGCTCTAGAA GCAGGCAGAA TTGGCCCAAG 
GGTGAGAACC AGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu86487
Clone ID Related Accession (Same CDS sequence) XM_017024033.2 , XM_017024033.1
Accession Version XM_017024033.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 810bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product CMRF35-like molecule 6 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017024033.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG CCGGGACGAC CACAGCCTCC 
AGCCCCCAGA GCTCCATGGG CACCTCAGGT CCTCCCACGA AGCTGCCCGT GCACACCTGG 
CCCAGCGTGA CCAGAAAGGA CAGCCCCGAA CCCAGCCCAC ACCCTGGAGA TGGGTCTTAC 
TATGTTACCC AGGCTGGATT TGAACTCCTG GGCTCAAGCC TTGGTCCTGT CTCAGCCTCT 
GGAGCAGCTG GGACTACAGG CATGCACCAC AGCACCTGGC TCACATTCCG ATTGTTATGT 
TCATCATCAT CTTGTTTTAA GGGATTTGCC ACATACATGC ATATGGATTT CCAAAGGATG 
AAGCCTCATT CTGTCACCCA GGTTGGAGTG CAGAGAAGAC GATCTGTTAC CCATCTAGAA 
AGAGAAGTGA GAATAAAAGC ATTATTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016879522.1
CDS326..1135
Translation

Target ORF information:

RefSeq Version XM_017024033.2
Organism Homo sapiens(human)
Definition Homo sapiens CD300c molecule (CD300C), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017024033.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG CCGGGACGAC CACAGCCTCC 
AGCCCCCAGA GCTCCATGGG CACCTCAGGT CCTCCCACGA AGCTGCCCGT GCACACCTGG 
CCCAGCGTGA CCAGAAAGGA CAGCCCCGAA CCCAGCCCAC ACCCTGGAGA TGGGTCTTAC 
TATGTTACCC AGGCTGGATT TGAACTCCTG GGCTCAAGCC TTGGTCCTGT CTCAGCCTCT 
GGAGCAGCTG GGACTACAGG CATGCACCAC AGCACCTGGC TCACATTCCG ATTGTTATGT 
TCATCATCAT CTTGTTTTAA GGGATTTGCC ACATACATGC ATATGGATTT CCAAAGGATG 
AAGCCTCATT CTGTCACCCA GGTTGGAGTG CAGAGAAGAC GATCTGTTAC CCATCTAGAA 
AGAGAAGTGA GAATAAAAGC ATTATTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu86487
Clone ID Related Accession (Same CDS sequence) XM_017024033.2 , XM_017024033.1
Accession Version XM_017024033.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 810bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product CMRF35-like molecule 6 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG CCGGGACGAC CACAGCCTCC 
AGCCCCCAGA GCTCCATGGG CACCTCAGGT CCTCCCACGA AGCTGCCCGT GCACACCTGG 
CCCAGCGTGA CCAGAAAGGA CAGCCCCGAA CCCAGCCCAC ACCCTGGAGA TGGGTCTTAC 
TATGTTACCC AGGCTGGATT TGAACTCCTG GGCTCAAGCC TTGGTCCTGT CTCAGCCTCT 
GGAGCAGCTG GGACTACAGG CATGCACCAC AGCACCTGGC TCACATTCCG ATTGTTATGT 
TCATCATCAT CTTGTTTTAA GGGATTTGCC ACATACATGC ATATGGATTT CCAAAGGATG 
AAGCCTCATT CTGTCACCCA GGTTGGAGTG CAGAGAAGAC GATCTGTTAC CCATCTAGAA 
AGAGAAGTGA GAATAAAAGC ATTATTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016879522.1
CDS385..1194
Translation

Target ORF information:

RefSeq Version XM_017024033.1
Organism Homo sapiens(human)
Definition Homo sapiens CD300c molecule (CD300C), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017024033.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG CCGGGACGAC CACAGCCTCC 
AGCCCCCAGA GCTCCATGGG CACCTCAGGT CCTCCCACGA AGCTGCCCGT GCACACCTGG 
CCCAGCGTGA CCAGAAAGGA CAGCCCCGAA CCCAGCCCAC ACCCTGGAGA TGGGTCTTAC 
TATGTTACCC AGGCTGGATT TGAACTCCTG GGCTCAAGCC TTGGTCCTGT CTCAGCCTCT 
GGAGCAGCTG GGACTACAGG CATGCACCAC AGCACCTGGC TCACATTCCG ATTGTTATGT 
TCATCATCAT CTTGTTTTAA GGGATTTGCC ACATACATGC ATATGGATTT CCAAAGGATG 
AAGCCTCATT CTGTCACCCA GGTTGGAGTG CAGAGAAGAC GATCTGTTAC CCATCTAGAA 
AGAGAAGTGA GAATAAAAGC ATTATTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu86488
Clone ID Related Accession (Same CDS sequence) XM_017024034.2 , XM_017024034.1
Accession Version XM_017024034.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 705bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product CMRF35-like molecule 6 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017024034.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG GTGAGCCCCT CCTTTTCTCA 
GCACCAGGCC TGCCTGAGCC TAGGGCTGGT CATTCTGTCC CTGAAGAAAG AAGTGGAACA 
GGAGGGTGTG AGCCTGGGGG TTGCCTCTCT CCAGCCACTG CTGTGCCCAG GGCCCTGGCT 
TCGCAGTCAC TCTGGGTCAC CCTTCGCAGA GTAAACATCA CCCCATTCCC CCAGGTCACC 
CTGTCCCTCC CTGGCTGGGG TGAAACCTGG AGACCCGTAC CTTTGCCACA GGTGAGCAGG 
GCAGCTCTCA CATCTGAAAT GGTGTCCTGG CTCTGCAGTA CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016879523.1
CDS326..1030
Translation

Target ORF information:

RefSeq Version XM_017024034.2
Organism Homo sapiens(human)
Definition Homo sapiens CD300c molecule (CD300C), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017024034.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG GTGAGCCCCT CCTTTTCTCA 
GCACCAGGCC TGCCTGAGCC TAGGGCTGGT CATTCTGTCC CTGAAGAAAG AAGTGGAACA 
GGAGGGTGTG AGCCTGGGGG TTGCCTCTCT CCAGCCACTG CTGTGCCCAG GGCCCTGGCT 
TCGCAGTCAC TCTGGGTCAC CCTTCGCAGA GTAAACATCA CCCCATTCCC CCAGGTCACC 
CTGTCCCTCC CTGGCTGGGG TGAAACCTGG AGACCCGTAC CTTTGCCACA GGTGAGCAGG 
GCAGCTCTCA CATCTGAAAT GGTGTCCTGG CTCTGCAGTA CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu86488
Clone ID Related Accession (Same CDS sequence) XM_017024034.2 , XM_017024034.1
Accession Version XM_017024034.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 705bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product CMRF35-like molecule 6 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG GTGAGCCCCT CCTTTTCTCA 
GCACCAGGCC TGCCTGAGCC TAGGGCTGGT CATTCTGTCC CTGAAGAAAG AAGTGGAACA 
GGAGGGTGTG AGCCTGGGGG TTGCCTCTCT CCAGCCACTG CTGTGCCCAG GGCCCTGGCT 
TCGCAGTCAC TCTGGGTCAC CCTTCGCAGA GTAAACATCA CCCCATTCCC CCAGGTCACC 
CTGTCCCTCC CTGGCTGGGG TGAAACCTGG AGACCCGTAC CTTTGCCACA GGTGAGCAGG 
GCAGCTCTCA CATCTGAAAT GGTGTCCTGG CTCTGCAGTA CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016879523.1
CDS385..1089
Translation

Target ORF information:

RefSeq Version XM_017024034.1
Organism Homo sapiens(human)
Definition Homo sapiens CD300c molecule (CD300C), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017024034.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGCCA GGGCCTGGGC CTCGTGGCGG TCTTCAGCTC TGCTCCTCCT GCTTGTCCCA 
GGCTATTTTC CTCTGAGCCA CCCCATGACC GTGGCGGGCC CCGTGGGGGG ATCCCTGAGT 
GTGCAGTGTC GCTATGAGAA GGAACACAGG ACCCTCAACA AATTCTGGTG CAGACCACCA 
CAGATTCTCC GATGTGACAA GATTGTGGAG ACCAAAGGGT CAGCAGGGAA AAGGAATGGC 
CGAGTGTCCA TCAGGGACAG TCCTGCAAAC CTCAGCTTCA CAGTGACCCT GGAGAATCTC 
ACAGAGGAGG ACGCAGGCAC CTACTGGTGT GGGGTGGATA CACCGTGGCT CCGAGACTTT 
CATGATCCCA TTGTCGAGGT TGAGGTGTCC GTGTTCCCGG GTGAGCCCCT CCTTTTCTCA 
GCACCAGGCC TGCCTGAGCC TAGGGCTGGT CATTCTGTCC CTGAAGAAAG AAGTGGAACA 
GGAGGGTGTG AGCCTGGGGG TTGCCTCTCT CCAGCCACTG CTGTGCCCAG GGCCCTGGCT 
TCGCAGTCAC TCTGGGTCAC CCTTCGCAGA GTAAACATCA CCCCATTCCC CCAGGTCACC 
CTGTCCCTCC CTGGCTGGGG TGAAACCTGG AGACCCGTAC CTTTGCCACA GGTGAGCAGG 
GCAGCTCTCA CATCTGAAAT GGTGTCCTGG CTCTGCAGTA CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.
Scientific reports623942(2016 Apr)
Dimitrova M,Zenarruzabeitia O,Borrego F,Simhadri VR


book

Human CD300C delivers an Fc receptor-?-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.
The Journal of biological chemistry288(11)7662-75(2013 Mar)
Takahashi M,Izawa K,Kashiwakura J,Yamanishi Y,Enomoto Y,Kaitani A,Maehara A,Isobe M,Ito S,Matsukawa T,Nakahara F,Oki T,Kajikawa M,Ra C,Okayama Y,Kitamura T,Kitaura J


book

CD300c is an activating receptor expressed on human monocytes.
Journal of innate immunity5(4)389-400(2013)
Simhadri VR,Mariano JL,Gil-Krzewska A,Zhou Q,Borrego F


book

Differential expression of CD300a/c on human TH1 and TH17 cells.
BMC immunology1262(2011 Nov)
Simhadri VR,Mariano JL,Zhou Q,DeBell KE,Borrego F