Mpi cDNA ORF clone, Mus musculus(house mouse)
Gene Symbol | Mpi |
Entrez Gene ID | 110119 |
Full Name | mannose phosphate isomerase |
Synonyms | 1110002E17Rik,AI315153,Mpi-1,Mpi1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
XM_006510771.2 | XP_006510834.1 | mannose-6-phosphate isomerase isoform X1 |
NM_025837.2 | NP_080113.1 | mannose-6-phosphate isomerase |
XM_006510771.3 | XP_006510834.1 | mannose-6-phosphate isomerase isoform X1 |

Danio rerio (zebrafish) | mpi | NP_001028282.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000053 | XP_311105.2 |
Caenorhabditis elegans (roundworm) | ZK632.4 | NP_499174.3 |
Eremothecium gossypii | AGOS_ADR003C | NP_984099.1 |
Oryza sativa (rice) | Os01g0127900 | NP_001041907.1 |
Rattus norvegicus (Norway rat) | Mpi | NP_001004081.1 |
Gallus gallus (chicken) | MPI | XP_001233064.3 |
Kluyveromyces lactis | KLLA0D13728g | XP_453675.1 |
Arabidopsis thaliana (thale cress) | MEE31 | NP_186906.1 |
Arabidopsis thaliana (thale cress) | DIN9 | NP_176878.1 |
Xenopus tropicalis (tropical clawed frog) | mpi | XP_002937526.2 |
Homo sapiens (human) | MPI | NP_002426.1 |
LOC709811 | XP_001098369.1 | |
Mus musculus (house mouse) | Mpi | NP_080113.1 |
Drosophila melanogaster (fruit fly) | CG8417 | NP_649940.1 |
Saccharomyces cerevisiae (baker's yeast) | PMI40 | NP_010918.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_10677 | XP_003715901.1 |
Oryza sativa (rice) | Os09g0389000 | NP_001063081.2 |
Pan troglodytes (chimpanzee) | MPI | NP_001092020.1 |
Canis lupus familiaris (dog) | MPI | XP_535543.3 |
Bos taurus (cattle) | MPI | NP_001030361.1 |
Schizosaccharomyces pombe (fission yeast) | SPBC2G2.16 | NP_596445.1 |
Neurospora crassa | NCU07165 | XP_957390.1 |

Related articles in PubMed
Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.
Sharma V, Nayak J, DeRossi C, Charbono A, Ichikawa M, Ng BG, Grajales-Esquivel E, Srivastava A, Wang L, He P, Scott DA, Russell J, Contreras E, Guess CM, Krajewski S, Del Rio-Tsonis K, Freeze HH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(4)1854-69(2014 Apr)
Metabolically programmed quality control system for dolichol-linked oligosaccharides.
Harada Y, Nakajima K, Masahara-Negishi Y, Freeze HH, Angata T, Taniguchi N, Suzuki T
Proceedings of the National Academy of Sciences of the United States of America110(48)19366-71(2013 Nov)
Ontogeny of D-mannose transport and metabolism in rat small intestine.
Cano M, Ilundain AA
The Journal of membrane biology235(2)101-8(2010 Jun)
Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9.
Liljander M, Andersson A, Holmdahl R, Mattsson R
Genetics research91(4)259-65(2009 Aug)
The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells.
Fujita N, Tamura A, Higashidani A, Tonozuka T, Freeze HH, Nishikawa A
The FEBS journal275(4)788-98(2008 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data indicate that reduced phosphomannose isomerase (MPI) alters mannose flux in hypomorphic mice.
Title: Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.
Phosphomannose isomerase activity and mRNA levels increased at 1 month, and the values in the ileum were lower than in jejunum.
Title: Ontogeny of D-mannose transport and metabolism in rat small intestine.
Data conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways.
Title: The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells.
Results suggest that mannose toxicity in phosphomannose isomerase(-/-) embryos is caused by mannose-6-P accumulation, which inhibits glucose metabolism and depletes intracellular ATP.
Title: Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality.
The following Mpi gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mpi cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu01131 | |
Clone ID Related Accession (Same CDS sequence) | NM_025837.2 | |
Accession Version | NM_025837.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | mannose-6-phosphate isomerase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132777.1. On Apr 6, 2007 this sequence version replaced NM_025837.1. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132777.1, AF244360.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGAGTC CGCGAGTGTT CCCACTTTCC TGTGTGGTGC AGCAGTATGC CTGGGGGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080113.1 |
CDS | 34..1305 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGCGAGTC CGCGAGTGTT CCCACTTTCC TGTGTGGTGC AGCAGTATGC CTGGGGGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu42516 | |
Clone ID Related Accession (Same CDS sequence) | XM_006510771.2 , XM_006510771.3 | |
Accession Version | XM_006510771.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | mannose-6-phosphate isomerase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006510771.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTTCTG CTCTGAGGAA CTGCTTTTCC CACCTGATGA AGAGTGAGAA GAAGGTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006510834.1 |
CDS | 433..1137 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCTTCTG CTCTGAGGAA CTGCTTTTCC CACCTGATGA AGAGTGAGAA GAAGGTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu42516 | |
Clone ID Related Accession (Same CDS sequence) | XM_006510771.2 , XM_006510771.3 | |
Accession Version | XM_006510771.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | mannose-6-phosphate isomerase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006510771.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTTCTG CTCTGAGGAA CTGCTTTTCC CACCTGATGA AGAGTGAGAA GAAGGTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006510834.1 |
CDS | 472..1176 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCTTCTG CTCTGAGGAA CTGCTTTTCC CACCTGATGA AGAGTGAGAA GAAGGTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice. |
![]() |
Metabolically programmed quality control system for dolichol-linked oligosaccharides. |
![]() |
Ontogeny of D-mannose transport and metabolism in rat small intestine. |
![]() |
Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9. |
![]() |
The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells. |