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ADH6 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol ADH6
Entrez Gene ID 130
Full Name alcohol dehydrogenase 6 (class V)
Synonyms ADH-5
General protein information
Preferred Names

alcohol dehydrogenase 6 (class V)

Names

alcohol dehydrogenase 6
aldehyde reductase
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

4

4q23
Summary This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:

103735


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_000672.3 NP_000663.1 alcohol dehydrogenase 6 isoform 2
NM_000672.4 NP_000663.1 alcohol dehydrogenase 6 isoform 2
NM_001102470.2 NP_001095940.1 alcohol dehydrogenase 6 isoform 1
NM_001102470.1 NP_001095940.1 alcohol dehydrogenase 6 isoform 1

Pathways from BioSystems


Homologies


Homo sapiens (human) ADH6 NP_001095940.1
Bos taurus (cattle) ADH6 NP_001039522.1
Pan troglodytes (chimpanzee) ADH6 XP_517358.2
ADH6 XP_001106262.2
Gallus gallus (chicken) ADH6 NP_990423.1
Xenopus tropicalis (tropical clawed frog) LOC100487939 XP_002934816.1
Xenopus tropicalis (tropical clawed frog) LOC100488099 XP_002934817.1
Rattus norvegicus (Norway rat) Adh6 NP_001012084.1

Gene Ontology


Bibliography

Related articles in PubMed

Computational studies of human class V alcohol dehydrogenase - the odd sibling.
?stberg LJ, Persson B, H??g JO
BMC biochemistry17(1)16(2016 Jul)

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
Jeff JM, Ritchie MD, Denny JC, Kho AN, Ramirez AH, Crosslin D, Armstrong L, Basford MA, Wolf WA, Pacheco JA, Chisholm RL, Roden DM, Hayes MG, Crawford DC
Annals of human genetics77(4)321-32(2013 Jul)

Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.
Zuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X
Human genetics132(7)735-43(2013 Jul)

Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
Park BL, Kim JW, Cheong HS, Kim LH, Lee BC, Seo CH, Kang TC, Nam YW, Kim GB, Shin HD, Choi IG
Human genetics132(6)657-68(2013 Jun)

Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain).
Mu?oz X, Amiano P, Celorrio D, Dorronsoro M, S?nchez MJ, Huerta JM, Barricarte A, Arriola L, Navarro C, Molina-Montes E, Chirlaque MD, Ardanaz E, Rodriguez L, Duell EJ, Hijona E, Herreros-Villanueva M, Sala N, Bujanda L
Addiction (Abingdon, England)107(12)2117-27(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Local structural differences between human class V ADH and other human ADHs includes a for class V ADH unique and conserved Lys51, a position directly involved in the catalytic mechanism in other ADHs, and nine other class V ADH-specific residues.
Title: Computational studies of human class V alcohol dehydrogenase - the odd sibling.

common ADH variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans.
Title: Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.

Results show that polymorphism of ADH6 gene leads to heavy drinking in women.
Title: Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain).

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetical genomic determinants of alcohol consumption in rats and humans.

The following ADH6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADH6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu31495 NM_000672.4
Latest version!		 Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $154.50-$216.30
$309.00
OHu32009 NM_001102470.2
Latest version!		 Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
View Old Accession Versions >>
OHu31495 NM_000672.3 Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $154.50-$216.30
$309.00
OHu32009 NM_001102470.1 Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu31495
Clone ID Related Accession (Same CDS sequence) NM_000672.3 , NM_000672.4
Accession Version NM_000672.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1107bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-17
Organism Homo sapiens(human)
Product alcohol dehydrogenase 6 isoform 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK092768.1 and BC039065.1. On Aug 28, 2007 this sequence version replaced NM_000672.2. Transcript Variant: This variant (2) has an alternate 3' sequence including the coding region, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.71214.1, SRR5189664.96757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. 

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721
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961
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ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA 
CCATTTTCTA TTGAAGAGGT AGAAGTGGCC CCACCAAAGG CAAAGGAAGT TCGCATAAAG 
GTTGTGGCCA CCGGACTGTG TGGTACAGAG ATGAAAGTGT TGGGGAGTAA ACACTTGGAC 
CTCTTGTATC CCACCATCTT GGGCCATGAA GGGGCTGGAA TCGTTGAGAG TATTGGAGAA 
GGAGTAAGCA CAGTGAAACC AGGTGACAAA GTTATCACAC TCTTTCTGCC ACAGTGTGGA 
GAATGTACCT CTTGCCTGAA TTCTGAGGGC AATTTTTGTA TACAATTCAA ACAGTCAAAA 
ACCCAACTGA TGTCTGATGG TACCAGCAGG TTTACCTGCA AGGGAAAATC AATATATCAC 
TTTGGTAATA CCAGCACCTT CTGTGAATAC ACAGTGATAA AGGAAATCTC AGTTGCCAAG 
ATTGATGCAG TCGCTCCTCT AGAGAAAGTA TGCCTAATTA GCTGTGGCTT TTCCACTGGG 
TTTGGTGCTG CAATCAATAC TGCCAAGGTG ACTCCAGGTT CTACCTGTGC TGTGTTTGGC 
CTGGGAGGAG TCGGCTTGTC TGTTGTCATG GGTTGTAAAG CAGCAGGAGC AGCCAGGATC 
ATTGGAGTGG ATGTCAACAA GGAGAAATTT AAGAAGGCAC AGGAATTGGG TGCTACTGAG 
TGCCTCAACC CTCAGGACTT AAAGAAACCC ATTCAAGAAG TTTTATTTGA TATGACAGAT 
GCTGGTATAG ACTTCTGCTT TGAGGCCATT GGAAATCTGG ACGTTCTGGC AGCTGCCCTC 
GCCTCCTGCA ATGAGAGCTA TGGGGTCTGT GTGGTTGTTG GGGTGTTGCC TGCCAGTGTT 
CAACTCAAAA TCAGTGGCCA GTTGTTCTTC TCAGGACGTT CTTTGAAGGG TTCTGTTTTT 
GGAGGCTGGA AGAGCAGACA GCACATCCCT AAACTGGTTG CTGATTATAT GGCAGAGAAG 
TTGAATCTAG ATCCACTAAT TACTCATACT CTGAATCTTG ATAAAATCAA TGAAGCAGTT 
GAATTAATGA AAACTGGAAA ATGGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000663.1
CDS95..1201
Translation

Target ORF information:

RefSeq Version NM_000672.3
Organism Homo sapiens(human)
Definition Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_000672.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA 
CCATTTTCTA TTGAAGAGGT AGAAGTGGCC CCACCAAAGG CAAAGGAAGT TCGCATAAAG 
GTTGTGGCCA CCGGACTGTG TGGTACAGAG ATGAAAGTGT TGGGGAGTAA ACACTTGGAC 
CTCTTGTATC CCACCATCTT GGGCCATGAA GGGGCTGGAA TCGTTGAGAG TATTGGAGAA 
GGAGTAAGCA CAGTGAAACC AGGTGACAAA GTTATCACAC TCTTTCTGCC ACAGTGTGGA 
GAATGTACCT CTTGCCTGAA TTCTGAGGGC AATTTTTGTA TACAATTCAA ACAGTCAAAA 
ACCCAACTGA TGTCTGATGG TACCAGCAGG TTTACCTGCA AGGGAAAATC AATATATCAC 
TTTGGTAATA CCAGCACCTT CTGTGAATAC ACAGTGATAA AGGAAATCTC AGTTGCCAAG 
ATTGATGCAG TCGCTCCTCT AGAGAAAGTA TGCCTAATTA GCTGTGGCTT TTCCACTGGG 
TTTGGTGCTG CAATCAATAC TGCCAAGGTG ACTCCAGGTT CTACCTGTGC TGTGTTTGGC 
CTGGGAGGAG TCGGCTTGTC TGTTGTCATG GGTTGTAAAG CAGCAGGAGC AGCCAGGATC 
ATTGGAGTGG ATGTCAACAA GGAGAAATTT AAGAAGGCAC AGGAATTGGG TGCTACTGAG 
TGCCTCAACC CTCAGGACTT AAAGAAACCC ATTCAAGAAG TTTTATTTGA TATGACAGAT 
GCTGGTATAG ACTTCTGCTT TGAGGCCATT GGAAATCTGG ACGTTCTGGC AGCTGCCCTC 
GCCTCCTGCA ATGAGAGCTA TGGGGTCTGT GTGGTTGTTG GGGTGTTGCC TGCCAGTGTT 
CAACTCAAAA TCAGTGGCCA GTTGTTCTTC TCAGGACGTT CTTTGAAGGG TTCTGTTTTT 
GGAGGCTGGA AGAGCAGACA GCACATCCCT AAACTGGTTG CTGATTATAT GGCAGAGAAG 
TTGAATCTAG ATCCACTAAT TACTCATACT CTGAATCTTG ATAAAATCAA TGAAGCAGTT 
GAATTAATGA AAACTGGAAA ATGGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu31495
Clone ID Related Accession (Same CDS sequence) NM_000672.3 , NM_000672.4
Accession Version NM_000672.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1107bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-27
Organism Homo sapiens(human)
Product alcohol dehydrogenase 6 isoform 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK092768.1, BC039065.1 and AP002026.2. On May 31, 2019 this sequence version replaced NM_000672.3. Transcript Variant: This variant (2) has an alternate 3' sequence including the coding region, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.71214.1, SRR5189664.96757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA 
CCATTTTCTA TTGAAGAGGT AGAAGTGGCC CCACCAAAGG CAAAGGAAGT TCGCATAAAG 
GTTGTGGCCA CCGGACTGTG TGGTACAGAG ATGAAAGTGT TGGGGAGTAA ACACTTGGAC 
CTCTTGTATC CCACCATCTT GGGCCATGAA GGGGCTGGAA TCGTTGAGAG TATTGGAGAA 
GGAGTAAGCA CAGTGAAACC AGGTGACAAA GTTATCACAC TCTTTCTGCC ACAGTGTGGA 
GAATGTACCT CTTGCCTGAA TTCTGAGGGC AATTTTTGTA TACAATTCAA ACAGTCAAAA 
ACCCAACTGA TGTCTGATGG TACCAGCAGG TTTACCTGCA AGGGAAAATC AATATATCAC 
TTTGGTAATA CCAGCACCTT CTGTGAATAC ACAGTGATAA AGGAAATCTC AGTTGCCAAG 
ATTGATGCAG TCGCTCCTCT AGAGAAAGTA TGCCTAATTA GCTGTGGCTT TTCCACTGGG 
TTTGGTGCTG CAATCAATAC TGCCAAGGTG ACTCCAGGTT CTACCTGTGC TGTGTTTGGC 
CTGGGAGGAG TCGGCTTGTC TGTTGTCATG GGTTGTAAAG CAGCAGGAGC AGCCAGGATC 
ATTGGAGTGG ATGTCAACAA GGAGAAATTT AAGAAGGCAC AGGAATTGGG TGCTACTGAG 
TGCCTCAACC CTCAGGACTT AAAGAAACCC ATTCAAGAAG TTTTATTTGA TATGACAGAT 
GCTGGTATAG ACTTCTGCTT TGAGGCCATT GGAAATCTGG ACGTTCTGGC AGCTGCCCTC 
GCCTCCTGCA ATGAGAGCTA TGGGGTCTGT GTGGTTGTTG GGGTGTTGCC TGCCAGTGTT 
CAACTCAAAA TCAGTGGCCA GTTGTTCTTC TCAGGACGTT CTTTGAAGGG TTCTGTTTTT 
GGAGGCTGGA AGAGCAGACA GCACATCCCT AAACTGGTTG CTGATTATAT GGCAGAGAAG 
TTGAATCTAG ATCCACTAAT TACTCATACT CTGAATCTTG ATAAAATCAA TGAAGCAGTT 
GAATTAATGA AAACTGGAAA ATGGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000663.1
CDS95..1201
Translation

Target ORF information:

RefSeq Version NM_000672.4
Organism Homo sapiens(human)
Definition Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_000672.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA 
CCATTTTCTA TTGAAGAGGT AGAAGTGGCC CCACCAAAGG CAAAGGAAGT TCGCATAAAG 
GTTGTGGCCA CCGGACTGTG TGGTACAGAG ATGAAAGTGT TGGGGAGTAA ACACTTGGAC 
CTCTTGTATC CCACCATCTT GGGCCATGAA GGGGCTGGAA TCGTTGAGAG TATTGGAGAA 
GGAGTAAGCA CAGTGAAACC AGGTGACAAA GTTATCACAC TCTTTCTGCC ACAGTGTGGA 
GAATGTACCT CTTGCCTGAA TTCTGAGGGC AATTTTTGTA TACAATTCAA ACAGTCAAAA 
ACCCAACTGA TGTCTGATGG TACCAGCAGG TTTACCTGCA AGGGAAAATC AATATATCAC 
TTTGGTAATA CCAGCACCTT CTGTGAATAC ACAGTGATAA AGGAAATCTC AGTTGCCAAG 
ATTGATGCAG TCGCTCCTCT AGAGAAAGTA TGCCTAATTA GCTGTGGCTT TTCCACTGGG 
TTTGGTGCTG CAATCAATAC TGCCAAGGTG ACTCCAGGTT CTACCTGTGC TGTGTTTGGC 
CTGGGAGGAG TCGGCTTGTC TGTTGTCATG GGTTGTAAAG CAGCAGGAGC AGCCAGGATC 
ATTGGAGTGG ATGTCAACAA GGAGAAATTT AAGAAGGCAC AGGAATTGGG TGCTACTGAG 
TGCCTCAACC CTCAGGACTT AAAGAAACCC ATTCAAGAAG TTTTATTTGA TATGACAGAT 
GCTGGTATAG ACTTCTGCTT TGAGGCCATT GGAAATCTGG ACGTTCTGGC AGCTGCCCTC 
GCCTCCTGCA ATGAGAGCTA TGGGGTCTGT GTGGTTGTTG GGGTGTTGCC TGCCAGTGTT 
CAACTCAAAA TCAGTGGCCA GTTGTTCTTC TCAGGACGTT CTTTGAAGGG TTCTGTTTTT 
GGAGGCTGGA AGAGCAGACA GCACATCCCT AAACTGGTTG CTGATTATAT GGCAGAGAAG 
TTGAATCTAG ATCCACTAAT TACTCATACT CTGAATCTTG ATAAAATCAA TGAAGCAGTT 
GAATTAATGA AAACTGGAAA ATGGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu32009
Clone ID Related Accession (Same CDS sequence) NM_001102470.2 , NM_001102470.1
Accession Version NM_001102470.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1128bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-30
Organism Homo sapiens(human)
Product alcohol dehydrogenase 6 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK092768.1, BC039065.1 and AP002026.2. On Nov 23, 2018 this sequence version replaced NM_001102470.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK092768.1, SRR5189664.128750.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000394899.6/ ENSP00000378359.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

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481
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721
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841
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961
1021
1081
ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA 
CCATTTTCTA TTGAAGAGGT AGAAGTGGCC CCACCAAAGG CAAAGGAAGT TCGCATAAAG 
GTTGTGGCCA CCGGACTGTG TGGTACAGAG ATGAAAGTGT TGGGGAGTAA ACACTTGGAC 
CTCTTGTATC CCACCATCTT GGGCCATGAA GGGGCTGGAA TCGTTGAGAG TATTGGAGAA 
GGAGTAAGCA CAGTGAAACC AGGTGACAAA GTTATCACAC TCTTTCTGCC ACAGTGTGGA 
GAATGTACCT CTTGCCTGAA TTCTGAGGGC AATTTTTGTA TACAATTCAA ACAGTCAAAA 
ACCCAACTGA TGTCTGATGG TACCAGCAGG TTTACCTGCA AGGGAAAATC AATATATCAC 
TTTGGTAATA CCAGCACCTT CTGTGAATAC ACAGTGATAA AGGAAATCTC AGTTGCCAAG 
ATTGATGCAG TCGCTCCTCT AGAGAAAGTA TGCCTAATTA GCTGTGGCTT TTCCACTGGG 
TTTGGTGCTG CAATCAATAC TGCCAAGGTG ACTCCAGGTT CTACCTGTGC TGTGTTTGGC 
CTGGGAGGAG TCGGCTTGTC TGTTGTCATG GGTTGTAAAG CAGCAGGAGC AGCCAGGATC 
ATTGGAGTGG ATGTCAACAA GGAGAAATTT AAGAAGGCAC AGGAATTGGG TGCTACTGAG 
TGCCTCAACC CTCAGGACTT AAAGAAACCC ATTCAAGAAG TTTTATTTGA TATGACAGAT 
GCTGGTATAG ACTTCTGCTT TGAGGCCATT GGAAATCTGG ACGTTCTGGC AGCTGCCCTC 
GCCTCCTGCA ATGAGAGCTA TGGGGTCTGT GTGGTTGTTG GGGTGTTGCC TGCCAGTGTT 
CAACTCAAAA TCAGTGGCCA GTTGTTCTTC TCAGGACGTT CTTTGAAGGG TTCTGTTTTT 
GGAGGCTGGA AGAGCAGACA GCACATCCCT AAACTGGTTG CTGATTATAT GGCAGAGAAG 
TTGAATCTAG ATCCACTAAT TACTCATACT CTGAATCTTG ATAAAATCAA TGAAGCAGTT 
GAATTAATGA AAACTGGAAA ATGTATCCGC TGTATCCTGT TACTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001095940.1
CDS95..1222
Translation

Target ORF information:

RefSeq Version NM_001102470.2
Organism Homo sapiens(human)
Definition Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001102470.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA 
CCATTTTCTA TTGAAGAGGT AGAAGTGGCC CCACCAAAGG CAAAGGAAGT TCGCATAAAG 
GTTGTGGCCA CCGGACTGTG TGGTACAGAG ATGAAAGTGT TGGGGAGTAA ACACTTGGAC 
CTCTTGTATC CCACCATCTT GGGCCATGAA GGGGCTGGAA TCGTTGAGAG TATTGGAGAA 
GGAGTAAGCA CAGTGAAACC AGGTGACAAA GTTATCACAC TCTTTCTGCC ACAGTGTGGA 
GAATGTACCT CTTGCCTGAA TTCTGAGGGC AATTTTTGTA TACAATTCAA ACAGTCAAAA 
ACCCAACTGA TGTCTGATGG TACCAGCAGG TTTACCTGCA AGGGAAAATC AATATATCAC 
TTTGGTAATA CCAGCACCTT CTGTGAATAC ACAGTGATAA AGGAAATCTC AGTTGCCAAG 
ATTGATGCAG TCGCTCCTCT AGAGAAAGTA TGCCTAATTA GCTGTGGCTT TTCCACTGGG 
TTTGGTGCTG CAATCAATAC TGCCAAGGTG ACTCCAGGTT CTACCTGTGC TGTGTTTGGC 
CTGGGAGGAG TCGGCTTGTC TGTTGTCATG GGTTGTAAAG CAGCAGGAGC AGCCAGGATC 
ATTGGAGTGG ATGTCAACAA GGAGAAATTT AAGAAGGCAC AGGAATTGGG TGCTACTGAG 
TGCCTCAACC CTCAGGACTT AAAGAAACCC ATTCAAGAAG TTTTATTTGA TATGACAGAT 
GCTGGTATAG ACTTCTGCTT TGAGGCCATT GGAAATCTGG ACGTTCTGGC AGCTGCCCTC 
GCCTCCTGCA ATGAGAGCTA TGGGGTCTGT GTGGTTGTTG GGGTGTTGCC TGCCAGTGTT 
CAACTCAAAA TCAGTGGCCA GTTGTTCTTC TCAGGACGTT CTTTGAAGGG TTCTGTTTTT 
GGAGGCTGGA AGAGCAGACA GCACATCCCT AAACTGGTTG CTGATTATAT GGCAGAGAAG 
TTGAATCTAG ATCCACTAAT TACTCATACT CTGAATCTTG ATAAAATCAA TGAAGCAGTT 
GAATTAATGA AAACTGGAAA ATGTATCCGC TGTATCCTGT TACTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu32009
Clone ID Related Accession (Same CDS sequence) NM_001102470.2 , NM_001102470.1
Accession Version NM_001102470.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1128bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-01
Organism Homo sapiens(human)
Product alcohol dehydrogenase 6 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK092768.1, BC039065.1 and AP002026.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK092768.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA 
CCATTTTCTA TTGAAGAGGT AGAAGTGGCC CCACCAAAGG CAAAGGAAGT TCGCATAAAG 
GTTGTGGCCA CCGGACTGTG TGGTACAGAG ATGAAAGTGT TGGGGAGTAA ACACTTGGAC 
CTCTTGTATC CCACCATCTT GGGCCATGAA GGGGCTGGAA TCGTTGAGAG TATTGGAGAA 
GGAGTAAGCA CAGTGAAACC AGGTGACAAA GTTATCACAC TCTTTCTGCC ACAGTGTGGA 
GAATGTACCT CTTGCCTGAA TTCTGAGGGC AATTTTTGTA TACAATTCAA ACAGTCAAAA 
ACCCAACTGA TGTCTGATGG TACCAGCAGG TTTACCTGCA AGGGAAAATC AATATATCAC 
TTTGGTAATA CCAGCACCTT CTGTGAATAC ACAGTGATAA AGGAAATCTC AGTTGCCAAG 
ATTGATGCAG TCGCTCCTCT AGAGAAAGTA TGCCTAATTA GCTGTGGCTT TTCCACTGGG 
TTTGGTGCTG CAATCAATAC TGCCAAGGTG ACTCCAGGTT CTACCTGTGC TGTGTTTGGC 
CTGGGAGGAG TCGGCTTGTC TGTTGTCATG GGTTGTAAAG CAGCAGGAGC AGCCAGGATC 
ATTGGAGTGG ATGTCAACAA GGAGAAATTT AAGAAGGCAC AGGAATTGGG TGCTACTGAG 
TGCCTCAACC CTCAGGACTT AAAGAAACCC ATTCAAGAAG TTTTATTTGA TATGACAGAT 
GCTGGTATAG ACTTCTGCTT TGAGGCCATT GGAAATCTGG ACGTTCTGGC AGCTGCCCTC 
GCCTCCTGCA ATGAGAGCTA TGGGGTCTGT GTGGTTGTTG GGGTGTTGCC TGCCAGTGTT 
CAACTCAAAA TCAGTGGCCA GTTGTTCTTC TCAGGACGTT CTTTGAAGGG TTCTGTTTTT 
GGAGGCTGGA AGAGCAGACA GCACATCCCT AAACTGGTTG CTGATTATAT GGCAGAGAAG 
TTGAATCTAG ATCCACTAAT TACTCATACT CTGAATCTTG ATAAAATCAA TGAAGCAGTT 
GAATTAATGA AAACTGGAAA ATGTATCCGC TGTATCCTGT TACTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001095940.1
CDS95..1222
Translation

Target ORF information:

RefSeq Version NM_001102470.1
Organism Homo sapiens(human)
Definition Homo sapiens alcohol dehydrogenase 6 (class V) (ADH6), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001102470.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA 
CCATTTTCTA TTGAAGAGGT AGAAGTGGCC CCACCAAAGG CAAAGGAAGT TCGCATAAAG 
GTTGTGGCCA CCGGACTGTG TGGTACAGAG ATGAAAGTGT TGGGGAGTAA ACACTTGGAC 
CTCTTGTATC CCACCATCTT GGGCCATGAA GGGGCTGGAA TCGTTGAGAG TATTGGAGAA 
GGAGTAAGCA CAGTGAAACC AGGTGACAAA GTTATCACAC TCTTTCTGCC ACAGTGTGGA 
GAATGTACCT CTTGCCTGAA TTCTGAGGGC AATTTTTGTA TACAATTCAA ACAGTCAAAA 
ACCCAACTGA TGTCTGATGG TACCAGCAGG TTTACCTGCA AGGGAAAATC AATATATCAC 
TTTGGTAATA CCAGCACCTT CTGTGAATAC ACAGTGATAA AGGAAATCTC AGTTGCCAAG 
ATTGATGCAG TCGCTCCTCT AGAGAAAGTA TGCCTAATTA GCTGTGGCTT TTCCACTGGG 
TTTGGTGCTG CAATCAATAC TGCCAAGGTG ACTCCAGGTT CTACCTGTGC TGTGTTTGGC 
CTGGGAGGAG TCGGCTTGTC TGTTGTCATG GGTTGTAAAG CAGCAGGAGC AGCCAGGATC 
ATTGGAGTGG ATGTCAACAA GGAGAAATTT AAGAAGGCAC AGGAATTGGG TGCTACTGAG 
TGCCTCAACC CTCAGGACTT AAAGAAACCC ATTCAAGAAG TTTTATTTGA TATGACAGAT 
GCTGGTATAG ACTTCTGCTT TGAGGCCATT GGAAATCTGG ACGTTCTGGC AGCTGCCCTC 
GCCTCCTGCA ATGAGAGCTA TGGGGTCTGT GTGGTTGTTG GGGTGTTGCC TGCCAGTGTT 
CAACTCAAAA TCAGTGGCCA GTTGTTCTTC TCAGGACGTT CTTTGAAGGG TTCTGTTTTT 
GGAGGCTGGA AGAGCAGACA GCACATCCCT AAACTGGTTG CTGATTATAT GGCAGAGAAG 
TTGAATCTAG ATCCACTAAT TACTCATACT CTGAATCTTG ATAAAATCAA TGAAGCAGTT 
GAATTAATGA AAACTGGAAA ATGTATCCGC TGTATCCTGT TACTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Computational studies of human class V alcohol dehydrogenase - the odd sibling.
BMC biochemistry17(1)16(2016 Jul)
?stberg LJ,Persson B,H??g JO


book

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
Annals of human genetics77(4)321-32(2013 Jul)
Jeff JM,Ritchie MD,Denny JC,Kho AN,Ramirez AH,Crosslin D,Armstrong L,Basford MA,Wolf WA,Pacheco JA,Chisholm RL,Roden DM,Hayes MG,Crawford DC


book

Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.
Human genetics132(7)735-43(2013 Jul)
Zuo L,Wang K,Zhang XY,Pan X,Wang G,Tan Y,Zhong C,Krystal JH,State M,Zhang H,Luo X


book

Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
Human genetics132(6)657-68(2013 Jun)
Park BL,Kim JW,Cheong HS,Kim LH,Lee BC,Seo CH,Kang TC,Nam YW,Kim GB,Shin HD,Choi IG


book

Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain).
Addiction (Abingdon, England)107(12)2117-27(2012 Dec)
Mu?oz X,Amiano P,Celorrio D,Dorronsoro M,S?nchez MJ,Huerta JM,Barricarte A,Arriola L,Navarro C,Molina-Montes E,Chirlaque MD,Ardanaz E,Rodriguez L,Duell EJ,Hijona E,Herreros-Villanueva M,Sala N,Bujanda L