ADH6 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | ADH6 |
Entrez Gene ID | 130 |
Full Name | alcohol dehydrogenase 6 (class V) |
Synonyms | ADH-5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_000672.3 | NP_000663.1 | alcohol dehydrogenase 6 isoform 2 |
NM_000672.4 | NP_000663.1 | alcohol dehydrogenase 6 isoform 2 |
NM_001102470.2 | NP_001095940.1 | alcohol dehydrogenase 6 isoform 1 |
NM_001102470.1 | NP_001095940.1 | alcohol dehydrogenase 6 isoform 1 |

Homo sapiens (human) | ADH6 | NP_001095940.1 |
Bos taurus (cattle) | ADH6 | NP_001039522.1 |
Pan troglodytes (chimpanzee) | ADH6 | XP_517358.2 |
ADH6 | XP_001106262.2 | |
Gallus gallus (chicken) | ADH6 | NP_990423.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100487939 | XP_002934816.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100488099 | XP_002934817.1 |
Rattus norvegicus (Norway rat) | Adh6 | NP_001012084.1 |

Related articles in PubMed
Computational studies of human class V alcohol dehydrogenase - the odd sibling.
?stberg LJ, Persson B, H??g JO
BMC biochemistry17(1)16(2016 Jul)
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
Jeff JM, Ritchie MD, Denny JC, Kho AN, Ramirez AH, Crosslin D, Armstrong L, Basford MA, Wolf WA, Pacheco JA, Chisholm RL, Roden DM, Hayes MG, Crawford DC
Annals of human genetics77(4)321-32(2013 Jul)
Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.
Zuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X
Human genetics132(7)735-43(2013 Jul)
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
Park BL, Kim JW, Cheong HS, Kim LH, Lee BC, Seo CH, Kang TC, Nam YW, Kim GB, Shin HD, Choi IG
Human genetics132(6)657-68(2013 Jun)
Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain).
Mu?oz X, Amiano P, Celorrio D, Dorronsoro M, S?nchez MJ, Huerta JM, Barricarte A, Arriola L, Navarro C, Molina-Montes E, Chirlaque MD, Ardanaz E, Rodriguez L, Duell EJ, Hijona E, Herreros-Villanueva M, Sala N, Bujanda L
Addiction (Abingdon, England)107(12)2117-27(2012 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Local structural differences between human class V ADH and other human ADHs includes a for class V ADH unique and conserved Lys51, a position directly involved in the catalytic mechanism in other ADHs, and nine other class V ADH-specific residues.
Title: Computational studies of human class V alcohol dehydrogenase - the odd sibling.
common ADH variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans.
Title: Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.
Results show that polymorphism of ADH6 gene leads to heavy drinking in women.
Title: Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain).
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetical genomic determinants of alcohol consumption in rats and humans.
The following ADH6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADH6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu31495![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_000672.3 , NM_000672.4 | |
Accession Version | NM_000672.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-17 | |
Organism | Homo sapiens(human) | |
Product | alcohol dehydrogenase 6 isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK092768.1 and BC039065.1. On Aug 28, 2007 this sequence version replaced NM_000672.2. Transcript Variant: This variant (2) has an alternate 3' sequence including the coding region, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.71214.1, SRR5189664.96757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. |
1 | ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_000663.1 |
CDS | 95..1201 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31495![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_000672.3 , NM_000672.4 | |
Accession Version | NM_000672.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-27 | |
Organism | Homo sapiens(human) | |
Product | alcohol dehydrogenase 6 isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK092768.1, BC039065.1 and AP002026.2. On May 31, 2019 this sequence version replaced NM_000672.3. Transcript Variant: This variant (2) has an alternate 3' sequence including the coding region, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.71214.1, SRR5189664.96757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. |
1 | ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_000663.1 |
CDS | 95..1201 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu32009![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001102470.2 , NM_001102470.1 | |
Accession Version | NM_001102470.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Homo sapiens(human) | |
Product | alcohol dehydrogenase 6 isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK092768.1, BC039065.1 and AP002026.2. On Nov 23, 2018 this sequence version replaced NM_001102470.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK092768.1, SRR5189664.128750.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000394899.6/ ENSP00000378359.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001095940.1 |
CDS | 95..1222 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu32009![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001102470.2 , NM_001102470.1 | |
Accession Version | NM_001102470.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | alcohol dehydrogenase 6 isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK092768.1, BC039065.1 and AP002026.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK092768.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001095940.1 |
CDS | 95..1222 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAGTACTA CAGGCCAAGT CATCAGATGC AAAGCAGCCA TACTCTGGAA GCCTGGTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Computational studies of human class V alcohol dehydrogenase - the odd sibling. |
![]() |
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. |
![]() |
Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. |
![]() |
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. |
![]() |
Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain). |