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ADM cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol ADM
Entrez Gene ID 133
Full Name adrenomedullin
Synonyms AM,PAMP
General protein information
Preferred Names

adrenomedullin

Names

ADM
preproadrenomedullin
proadrenomedullin N-20 terminal peptide
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

11

11p15.4
Summary The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014].
Disorder MIM:

103275


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001124.3 NP_001115.1 ADM precursor
NM_001124.2 NP_001115.1 ADM precursor

Pathways from BioSystems


Homologies


Canis lupus familiaris (dog) ADM NP_001003183.1
Rattus norvegicus (Norway rat) Adm NP_036847.1
ADM XP_001100827.1
Pan troglodytes (chimpanzee) ADM XP_001169702.1
Mus musculus (house mouse) Adm NP_033757.1
Bos taurus (cattle) ADM NP_776313.1
Homo sapiens (human) ADM NP_001115.1
Xenopus tropicalis (tropical clawed frog) adm XP_002936787.1

Gene Ontology

The following ADM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu27103 NM_001124.3
Latest version!		 Homo sapiens adrenomedullin (ADM), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
View Old Accession Versions >>
OHu27103 NM_001124.2 Homo sapiens adrenomedullin (ADM), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu27103
Clone ID Related Accession (Same CDS sequence) NM_001124.3 , NM_001124.2
Accession Version NM_001124.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 558bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-07-05
Organism Homo sapiens(human)
Product ADM precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY105655.1, D14874.1 and BQ021632.1. On Nov 23, 2018 this sequence version replaced NM_001124.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.638.1, SRR3476690.854615.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000278175.10/ ENSP00000278175.5 Protein has antimicrobial activity :: PMID: 10225288 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
ATGAAGCTGG TTTCCGTCGC CCTGATGTAC CTGGGTTCGC TCGCCTTCCT AGGCGCTGAC 
ACCGCTCGGT TGGATGTCGC GTCGGAGTTT CGAAAGAAGT GGAATAAGTG GGCTCTGAGT 
CGTGGGAAGA GGGAACTGCG GATGTCCAGC AGCTACCCCA CCGGGCTCGC TGACGTGAAG 
GCCGGGCCTG CCCAGACCCT TATTCGGCCC CAGGACATGA AGGGTGCCTC TCGAAGCCCC 
GAAGACAGCA GTCCGGATGC CGCCCGCATC CGAGTCAAGC GCTACCGCCA GAGCATGAAC 
AACTTCCAGG GCCTCCGGAG CTTTGGCTGC CGCTTCGGGA CGTGCACGGT GCAGAAGCTG 
GCACACCAGA TCTACCAGTT CACAGATAAG GACAAGGACA ACGTCGCCCC CAGGAGCAAG 
ATCAGCCCCC AGGGCTACGG CCGCCGGCGC CGGCGCTCCC TGCCCGAGGC CGGCCCGGGT 
CGGACTCTGG TGTCTTCTAA GCCACAAGCA CACGGGGCTC CAGCCCCCCC GAGTGGAAGT 
GCTCCCCACT TTCTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001115.1
CDS179..736
Translation

Target ORF information:

RefSeq Version NM_001124.3
Organism Homo sapiens(human)
Definition Homo sapiens adrenomedullin (ADM), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001124.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGAAGCTGG TTTCCGTCGC CCTGATGTAC CTGGGTTCGC TCGCCTTCCT AGGCGCTGAC 
ACCGCTCGGT TGGATGTCGC GTCGGAGTTT CGAAAGAAGT GGAATAAGTG GGCTCTGAGT 
CGTGGGAAGA GGGAACTGCG GATGTCCAGC AGCTACCCCA CCGGGCTCGC TGACGTGAAG 
GCCGGGCCTG CCCAGACCCT TATTCGGCCC CAGGACATGA AGGGTGCCTC TCGAAGCCCC 
GAAGACAGCA GTCCGGATGC CGCCCGCATC CGAGTCAAGC GCTACCGCCA GAGCATGAAC 
AACTTCCAGG GCCTCCGGAG CTTTGGCTGC CGCTTCGGGA CGTGCACGGT GCAGAAGCTG 
GCACACCAGA TCTACCAGTT CACAGATAAG GACAAGGACA ACGTCGCCCC CAGGAGCAAG 
ATCAGCCCCC AGGGCTACGG CCGCCGGCGC CGGCGCTCCC TGCCCGAGGC CGGCCCGGGT 
CGGACTCTGG TGTCTTCTAA GCCACAAGCA CACGGGGCTC CAGCCCCCCC GAGTGGAAGT 
GCTCCCCACT TTCTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27103
Clone ID Related Accession (Same CDS sequence) NM_001124.3 , NM_001124.2
Accession Version NM_001124.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 558bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-10
Organism Homo sapiens(human)
Product ADM precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY105655.1, D14874.1 and BQ021632.1. On Aug 27, 2014 this sequence version replaced NM_001124.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279843.3113.1, ERR279872.1022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 10225288 ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
ATGAAGCTGG TTTCCGTCGC CCTGATGTAC CTGGGTTCGC TCGCCTTCCT AGGCGCTGAC 
ACCGCTCGGT TGGATGTCGC GTCGGAGTTT CGAAAGAAGT GGAATAAGTG GGCTCTGAGT 
CGTGGGAAGA GGGAACTGCG GATGTCCAGC AGCTACCCCA CCGGGCTCGC TGACGTGAAG 
GCCGGGCCTG CCCAGACCCT TATTCGGCCC CAGGACATGA AGGGTGCCTC TCGAAGCCCC 
GAAGACAGCA GTCCGGATGC CGCCCGCATC CGAGTCAAGC GCTACCGCCA GAGCATGAAC 
AACTTCCAGG GCCTCCGGAG CTTTGGCTGC CGCTTCGGGA CGTGCACGGT GCAGAAGCTG 
GCACACCAGA TCTACCAGTT CACAGATAAG GACAAGGACA ACGTCGCCCC CAGGAGCAAG 
ATCAGCCCCC AGGGCTACGG CCGCCGGCGC CGGCGCTCCC TGCCCGAGGC CGGCCCGGGT 
CGGACTCTGG TGTCTTCTAA GCCACAAGCA CACGGGGCTC CAGCCCCCCC GAGTGGAAGT 
GCTCCCCACT TTCTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001115.1
CDS272..829
Translation

Target ORF information:

RefSeq Version NM_001124.2
Organism Homo sapiens(human)
Definition Homo sapiens adrenomedullin (ADM), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001124.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGAAGCTGG TTTCCGTCGC CCTGATGTAC CTGGGTTCGC TCGCCTTCCT AGGCGCTGAC 
ACCGCTCGGT TGGATGTCGC GTCGGAGTTT CGAAAGAAGT GGAATAAGTG GGCTCTGAGT 
CGTGGGAAGA GGGAACTGCG GATGTCCAGC AGCTACCCCA CCGGGCTCGC TGACGTGAAG 
GCCGGGCCTG CCCAGACCCT TATTCGGCCC CAGGACATGA AGGGTGCCTC TCGAAGCCCC 
GAAGACAGCA GTCCGGATGC CGCCCGCATC CGAGTCAAGC GCTACCGCCA GAGCATGAAC 
AACTTCCAGG GCCTCCGGAG CTTTGGCTGC CGCTTCGGGA CGTGCACGGT GCAGAAGCTG 
GCACACCAGA TCTACCAGTT CACAGATAAG GACAAGGACA ACGTCGCCCC CAGGAGCAAG 
ATCAGCCCCC AGGGCTACGG CCGCCGGCGC CGGCGCTCCC TGCCCGAGGC CGGCCCGGGT 
CGGACTCTGG TGTCTTCTAA GCCACAAGCA CACGGGGCTC CAGCCCCCCC GAGTGGAAGT 
GCTCCCCACT TTCTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed