• English
  • Sign In
    Please Sign In
    Sign In
    New to GenScript?
    Register
  • Contact Us
×
Contact us now: +1-877-436-7274

CST3 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol CST3
Entrez Gene ID 1471
Full Name cystatin C
Synonyms ARMD11,HEL-S-2
General protein information
Preferred Names

cystatin C

Names

cystatin-C
bA218C14.4 (cystatin C)
cystatin 3
epididymis secretory protein Li 2
gamma-trace
neuroendocrine basic polypeptide
post-gamma-globulin
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

20

20p11.21
Summary The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014].
Disorder MIM:

604312

Disorder Html: Cerebral amyloid angiopathy, 105150 (3); {Macular degeneration, age-related, 11}, 611953 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_000099.4 NP_000090.1 cystatin-C precursor
NM_001288614.2 NP_001275543.1 cystatin-C precursor
NM_001288614.1 NP_001275543.1 cystatin-C precursor
NM_000099.3 NP_000090.1 cystatin-C precursor

Pathways from BioSystems


Homologies


Canis lupus familiaris (dog) LOC607874 XP_003639869.1
Pan troglodytes (chimpanzee) CST3 XP_001146702.2
CST3 NP_001028096.1
Gallus gallus (chicken) CST3 NP_990831.2
Homo sapiens (human) CST3 NP_000090.1
Xenopus tropicalis (tropical clawed frog) LOC100485774 XP_002934915.1
Bos taurus (cattle) CST3 NP_776454.1
Mus musculus (house mouse) Cst3 NP_034106.2
Rattus norvegicus (Norway rat) Cst3 NP_036969.1

Gene Ontology

The following CST3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CST3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu22520 NM_001288614.1
Latest version!		 Homo sapiens cystatin C (CST3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu22520 NM_000099.3
Latest version!		 Homo sapiens cystatin C (CST3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu107694 NM_001288614.2
Latest version!		 Homo sapiens cystatin C (CST3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu107694 NM_000099.4
Latest version!		 Homo sapiens cystatin C (CST3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu22520
Clone ID Related Accession (Same CDS sequence) NM_001288614.1 , NM_000099.3
Accession Version NM_001288614.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-23
Organism Homo sapiens(human)
Product cystatin-C precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY042866.1, BX647523.1 and BF509512.1. On Dec 24, 2013 this sequence version replaced XM_005260672.1. Transcript Variant: This variant (2) represents the longer variant. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX647523.1, SRR1803617.37771.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 2153254 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGGCCGGGC CCCTGCGCGC CCCGCTGCTC CTGCTGGCCA TCCTGGCCGT GGCCCTGGCC 
GTGAGCCCCG CGGCCGGCTC CAGTCCCGGC AAGCCGCCGC GCCTGGTGGG AGGCCCCATG 
GACGCCAGCG TGGAGGAGGA GGGTGTGCGG CGTGCACTGG ACTTTGCCGT CGGCGAGTAC 
AACAAAGCCA GCAACGACAT GTACCACAGC CGCGCGCTGC AGGTGGTGCG CGCCCGCAAG 
CAGATCGTAG CTGGGGTGAA CTACTTCTTG GACGTGGAGC TGGGCCGAAC CACGTGTACC 
AAGACCCAGC CCAACTTGGA CAACTGCCCC TTCCATGACC AGCCACATCT GAAAAGGAAA 
GCATTCTGCT CTTTCCAGAT CTACGCTGTG CCTTGGCAGG GCACAATGAC CTTGTCGAAA 
TCCACCTGTC AGGACGCCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001275543.1
CDS187..627
Translation

Target ORF information:

RefSeq Version NM_001288614.1
Organism Homo sapiens(human)
Definition Homo sapiens cystatin C (CST3), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001288614.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCCGGGC CCCTGCGCGC CCCGCTGCTC CTGCTGGCCA TCCTGGCCGT GGCCCTGGCC 
GTGAGCCCCG CGGCCGGCTC CAGTCCCGGC AAGCCGCCGC GCCTGGTGGG AGGCCCCATG 
GACGCCAGCG TGGAGGAGGA GGGTGTGCGG CGTGCACTGG ACTTTGCCGT CGGCGAGTAC 
AACAAAGCCA GCAACGACAT GTACCACAGC CGCGCGCTGC AGGTGGTGCG CGCCCGCAAG 
CAGATCGTAG CTGGGGTGAA CTACTTCTTG GACGTGGAGC TGGGCCGAAC CACGTGTACC 
AAGACCCAGC CCAACTTGGA CAACTGCCCC TTCCATGACC AGCCACATCT GAAAAGGAAA 
GCATTCTGCT CTTTCCAGAT CTACGCTGTG CCTTGGCAGG GCACAATGAC CTTGTCGAAA 
TCCACCTGTC AGGACGCCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22520
Clone ID Related Accession (Same CDS sequence) NM_001288614.1 , NM_000099.3
Accession Version NM_000099.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-05
Organism Homo sapiens(human)
Product cystatin-C precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY042866.1 and BC013083.1. This sequence is a reference standard in the RefSeqGene project. On Dec 24, 2013 this sequence version replaced NM_000099.2. Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.8751.1, ERR279832.232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 2153254 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGGCCGGGC CCCTGCGCGC CCCGCTGCTC CTGCTGGCCA TCCTGGCCGT GGCCCTGGCC 
GTGAGCCCCG CGGCCGGCTC CAGTCCCGGC AAGCCGCCGC GCCTGGTGGG AGGCCCCATG 
GACGCCAGCG TGGAGGAGGA GGGTGTGCGG CGTGCACTGG ACTTTGCCGT CGGCGAGTAC 
AACAAAGCCA GCAACGACAT GTACCACAGC CGCGCGCTGC AGGTGGTGCG CGCCCGCAAG 
CAGATCGTAG CTGGGGTGAA CTACTTCTTG GACGTGGAGC TGGGCCGAAC CACGTGTACC 
AAGACCCAGC CCAACTTGGA CAACTGCCCC TTCCATGACC AGCCACATCT GAAAAGGAAA 
GCATTCTGCT CTTTCCAGAT CTACGCTGTG CCTTGGCAGG GCACAATGAC CTTGTCGAAA 
TCCACCTGTC AGGACGCCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000090.1
CDS187..627
Translation

Target ORF information:

RefSeq Version NM_000099.3
Organism Homo sapiens(human)
Definition Homo sapiens cystatin C (CST3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_000099.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCCGGGC CCCTGCGCGC CCCGCTGCTC CTGCTGGCCA TCCTGGCCGT GGCCCTGGCC 
GTGAGCCCCG CGGCCGGCTC CAGTCCCGGC AAGCCGCCGC GCCTGGTGGG AGGCCCCATG 
GACGCCAGCG TGGAGGAGGA GGGTGTGCGG CGTGCACTGG ACTTTGCCGT CGGCGAGTAC 
AACAAAGCCA GCAACGACAT GTACCACAGC CGCGCGCTGC AGGTGGTGCG CGCCCGCAAG 
CAGATCGTAG CTGGGGTGAA CTACTTCTTG GACGTGGAGC TGGGCCGAAC CACGTGTACC 
AAGACCCAGC CCAACTTGGA CAACTGCCCC TTCCATGACC AGCCACATCT GAAAAGGAAA 
GCATTCTGCT CTTTCCAGAT CTACGCTGTG CCTTGGCAGG GCACAATGAC CTTGTCGAAA 
TCCACCTGTC AGGACGCCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu107694
Clone ID Related Accession (Same CDS sequence) NM_000099.4 , NM_001288614.2
Accession Version NM_000099.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2020-01-01
Organism Homo sapiens(human)
Product cystatin-C precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121894.26. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000099.3. Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.8751.1, SRR3476690.1069974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376925.8/ ENSP00000366124.3 Protein has antimicrobial activity :: PMID: 2153254 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
ATGGCCGGGC CCCTGCGCGC CCCGCTGCTC CTGCTGGCCA TCCTGGCCGT GGCCCTGGCC 
GTGAGCCCCG CGGCCGGCTC CAGTCCCGGC AAGCCGCCGC GCCTAGTGGG AGGCCCCATG 
GACGCCAGCG TGGAGGAGGA GGGTGTGCGG CGTGCACTGG ACTTTGCCGT CGGCGAGTAC 
AACAAAGCCA GCAACGACAT GTACCACAGC CGCGCGCTGC AGGTGGTGCG CGCCCGCAAG 
CAGATCGTAG CTGGGGTGAA CTACTTCTTG GACGTGGAGC TGGGCCGAAC CACGTGTACC 
AAGACCCAGC CCAACTTGGA CAACTGCCCC TTCCATGACC AGCCACATCT GAAAAGGAAA 
GCATTCTGCT CTTTCCAGAT CTACGCTGTG CCTTGGCAGG GCACAATGAC CTTGTCGAAA 
TCCACCTGTC AGGACGCCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000090.1
CDS94..534
Translation

Target ORF information:

RefSeq Version NM_000099.4
Organism Homo sapiens(human)
Definition Homo sapiens cystatin C (CST3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_000099.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCCGGGC CCCTGCGCGC CCCGCTGCTC CTGCTGGCCA TCCTGGCCGT GGCCCTGGCC 
GTGAGCCCCG CGGCCGGCTC CAGTCCCGGC AAGCCGCCGC GCCTAGTGGG AGGCCCCATG 
GACGCCAGCG TGGAGGAGGA GGGTGTGCGG CGTGCACTGG ACTTTGCCGT CGGCGAGTAC 
AACAAAGCCA GCAACGACAT GTACCACAGC CGCGCGCTGC AGGTGGTGCG CGCCCGCAAG 
CAGATCGTAG CTGGGGTGAA CTACTTCTTG GACGTGGAGC TGGGCCGAAC CACGTGTACC 
AAGACCCAGC CCAACTTGGA CAACTGCCCC TTCCATGACC AGCCACATCT GAAAAGGAAA 
GCATTCTGCT CTTTCCAGAT CTACGCTGTG CCTTGGCAGG GCACAATGAC CTTGTCGAAA 
TCCACCTGTC AGGACGCCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu107694
Clone ID Related Accession (Same CDS sequence) NM_000099.4 , NM_001288614.2
Accession Version NM_001288614.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2020-01-03
Organism Homo sapiens(human)
Product cystatin-C precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121894.26. On May 31, 2019 this sequence version replaced NM_001288614.1. Transcript Variant: This variant (2) represents the longer variant. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.23845.1, SRR1803617.37771.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 2153254 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGGCCGGGC CCCTGCGCGC CCCGCTGCTC CTGCTGGCCA TCCTGGCCGT GGCCCTGGCC 
GTGAGCCCCG CGGCCGGCTC CAGTCCCGGC AAGCCGCCGC GCCTAGTGGG AGGCCCCATG 
GACGCCAGCG TGGAGGAGGA GGGTGTGCGG CGTGCACTGG ACTTTGCCGT CGGCGAGTAC 
AACAAAGCCA GCAACGACAT GTACCACAGC CGCGCGCTGC AGGTGGTGCG CGCCCGCAAG 
CAGATCGTAG CTGGGGTGAA CTACTTCTTG GACGTGGAGC TGGGCCGAAC CACGTGTACC 
AAGACCCAGC CCAACTTGGA CAACTGCCCC TTCCATGACC AGCCACATCT GAAAAGGAAA 
GCATTCTGCT CTTTCCAGAT CTACGCTGTG CCTTGGCAGG GCACAATGAC CTTGTCGAAA 
TCCACCTGTC AGGACGCCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001275543.1
CDS94..534
Translation

Target ORF information:

RefSeq Version NM_001288614.2
Organism Homo sapiens(human)
Definition Homo sapiens cystatin C (CST3), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001288614.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCCGGGC CCCTGCGCGC CCCGCTGCTC CTGCTGGCCA TCCTGGCCGT GGCCCTGGCC 
GTGAGCCCCG CGGCCGGCTC CAGTCCCGGC AAGCCGCCGC GCCTAGTGGG AGGCCCCATG 
GACGCCAGCG TGGAGGAGGA GGGTGTGCGG CGTGCACTGG ACTTTGCCGT CGGCGAGTAC 
AACAAAGCCA GCAACGACAT GTACCACAGC CGCGCGCTGC AGGTGGTGCG CGCCCGCAAG 
CAGATCGTAG CTGGGGTGAA CTACTTCTTG GACGTGGAGC TGGGCCGAAC CACGTGTACC 
AAGACCCAGC CCAACTTGGA CAACTGCCCC TTCCATGACC AGCCACATCT GAAAAGGAAA 
GCATTCTGCT CTTTCCAGAT CTACGCTGTG CCTTGGCAGG GCACAATGAC CTTGTCGAAA 
TCCACCTGTC AGGACGCCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed