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Klrc2 cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Klrc2
Entrez Gene ID 16642
Full Name killer cell lectin-like receptor subfamily C, member 2
Synonyms NKG2C
General protein information
Preferred Names

killer cell lectin-like receptor subfamily C, member 2

Names

killer cell lectin-like receptor subfamily C, member 2
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

6

6|6 F3

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001098669.1 NP_001092139.1 killer cell lectin-like receptor subfamily C, member 2 isoform 2
XM_017321419.1 XP_017176908.1 killer cell lectin-like receptor subfamily C, member 2 isoform X1
NM_010653.4 NP_034783.3 killer cell lectin-like receptor subfamily C, member 2 isoform 1

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Klrc3 NP_067353.1
Mus musculus (house mouse) Klrc2 NP_034783.3
Rattus norvegicus (Norway rat) Klrc3 NP_001025079.1

Gene Ontology


Bibliography

Related articles in PubMed

Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Saether PC, Hoelsbrekken SE, Fossum S, Dissen E
Journal of immunology (Baltimore, Md. : 1950)187(12)6365-73(2011 Dec)

Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells.
Vance RE, Jamieson AM, Raulet DH
The Journal of experimental medicine190(12)1801-12(1999 Dec)

Molecular cloning of mouse NKG2A and C.
Silver ET, Lau JC, Kane KP
Immunogenetics49(7-8)727-30(1999 Jul)

Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells.
Lohwasser S, Hande P, Mager DL, Takei F
European journal of immunology29(3)755-61(1999 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rat and mouse CD94/NKG2C heterodimers bind efficiently to both adadptor proteins DAP12 and DAP10; this binding activity is critically dependent on the transmembrane lysine residue of CD94.
Title: Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.

The following Klrc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klrc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu03212 NM_001098669.1
Latest version!		 Mus musculus killer cell lectin-like receptor subfamily C, member 2 (Klrc2), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $188.30
$269.00
OMu06541 NM_010653.4
Latest version!		 Mus musculus killer cell lectin-like receptor subfamily C, member 2 (Klrc2), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00
OMu36956 XM_017321419.1
Latest version!		 Mus musculus killer cell lectin-like receptor subfamily C, member 2 (Klrc2), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu03212
Clone ID Related Accession (Same CDS sequence) NM_001098669.1
Accession Version NM_001098669.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 642bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-05-25
Organism Mus musculus(house mouse)
Product killer cell lectin-like receptor subfamily C, member 2 isoform 2
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF106011.2. Transcript Variant: This variant (2) is missing one of the internal coding exons found in transcript variant 1. It maintains the same reading frame, and encodes a shorter isoform (2, also known as NKG2C2) lacking an internal protein segment compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AF106011.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849383, SAMN00849387 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
ATGAGTCACC TGCTTGGAAC TGAACAGGCC TCAGAACCCA GGAAAGCCAC AAAGAAAACC 
CAGGCGCAGT TCCGTTTCAG TAATGCAGCA GGAGATCGCC TGCTGGAGTT TAGCCTTCAA 
CATGCTTCCC AGAAGCATCT GAAGGCCAGC AGGCATGGCT ACTGCAAAAA TTTTGCATCA 
CCTCCAGAGA AGCTCATCGC TGGAATCCTG GGCACCATCT GGTTTACCTT ATTGATTGCT 
CTAGTAATCT CAACCAGAAT TGTTTCTCCA TCACAGCCTT GTCCTCATTG TCCAAAGGAG 
TGGATATCAT ATTCTCACAA TTGTTATTTC ATTGGTATGG AGAGAAAATC TTGGAATGAC 
AGTTTGGGGT CCTGCCTTTC CAAAAACTGT AGTCTGCTTC ACATAGATAG TGAAGAGGAG 
CAGGATTTTC TGCAATCTCT TTCACTGGTC TCATGGACTG GAATCCTTCG GAAGGGCAGA 
GGTCAGGCCT GGGACTGGAA AAAAGACTCA ATTTTCAAAC CAAAGATAGC AGAGATTTCC 
CATGATGAAT GTAACTGTGC CATGATGTCA GCTTCTGGTC TCACAGCAGA CAACTGTACA 
ACTTTACATC CATATCTTTG TAAGTGTAAA TTCCCCATCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001092139.1
CDS41..682
Translation

Target ORF information:

RefSeq Version NM_001098669.1
Organism Mus musculus(house mouse)
Definition Mus musculus killer cell lectin-like receptor subfamily C, member 2 (Klrc2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001098669.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGAGTCACC TGCTTGGAAC TGAACAGGCC TCAGAACCCA GGAAAGCCAC AAAGAAAACC 
CAGGCGCAGT TCCGTTTCAG TAATGCAGCA GGAGATCGCC TGCTGGAGTT TAGCCTTCAA 
CATGCTTCCC AGAAGCATCT GAAGGCCAGC AGGCATGGCT ACTGCAAAAA TTTTGCATCA 
CCTCCAGAGA AGCTCATCGC TGGAATCCTG GGCACCATCT GGTTTACCTT ATTGATTGCT 
CTAGTAATCT CAACCAGAAT TGTTTCTCCA TCACAGCCTT GTCCTCATTG TCCAAAGGAG 
TGGATATCAT ATTCTCACAA TTGTTATTTC ATTGGTATGG AGAGAAAATC TTGGAATGAC 
AGTTTGGGGT CCTGCCTTTC CAAAAACTGT AGTCTGCTTC ACATAGATAG TGAAGAGGAG 
CAGGATTTTC TGCAATCTCT TTCACTGGTC TCATGGACTG GAATCCTTCG GAAGGGCAGA 
GGTCAGGCCT GGGACTGGAA AAAAGACTCA ATTTTCAAAC CAAAGATAGC AGAGATTTCC 
CATGATGAAT GTAACTGTGC CATGATGTCA GCTTCTGGTC TCACAGCAGA CAACTGTACA 
ACTTTACATC CATATCTTTG TAAGTGTAAA TTCCCCATCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu06541
Clone ID Related Accession (Same CDS sequence) NM_010653.4
Accession Version NM_010653.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 717bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-05-25
Organism Mus musculus(house mouse)
Product killer cell lectin-like receptor subfamily C, member 2 isoform 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF109785.1. On Jun 16, 2007 this sequence version replaced NM_010653.3. Transcript Variant: This variant (1) encodes the longer isoform (1, also known as NKG2C1). ##Evidence-Data-START## Transcript exon combination :: AF109785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGAGTCACC TGCTTGGAAC TGAACAGGCC TCAGAACCCA GGAAAGCCAC AAAGAAAACC 
CAGGCGCAGT TCCGTTTCAG TAATGCAGCA GGAGATCGCC TGCTGGAGTT TAGCCTTCAA 
CATGCTTCCC AGAAGCATCT GAAGGCCAGC AGGCATGGCT ACTGCAAAAA TTTTGCATCA 
CCTCCAGAGA AGCTCATCGC TGGAATCCTG GGCACCATCT GGTTTACCTT ATTGATTGCT 
CTAGTAATCT CAACCAGAAT TGTTTCTCCA TATGCTGAAC TGAAGAAGCA GATCCACCCC 
TTCTTGGTTA GAACCCAGAA AGGCTCACAC GCCTTGCTCT CCAAAGCACA GCCTTGTCCT 
CATTGTCCAA AGGAGTGGAT ATCATATTCT CACAATTGTT ATTTCATTGG TATGGAGAGA 
AAATCTTGGA ATGACAGTTT GGGGTCCTGC CTTTCCAAAA ACTGTAGTCT GCTTCACATA 
GATAGTGAAG AGGAGCAGGA TTTTCTGCAA TCTCTTTCAC TGGTCTCATG GACTGGAATC 
CTTCGGAAGG GCAGAGGTCA GGCCTGGGAC TGGAAAAAAG ACTCAATTTT CAAACCAAAG 
ATAGCAGAGA TTTCCCATGA TGAATGTAAC TGTGCCATGA TGTCAGCTTC TGGTCTCACA 
GCAGACAACT GTACAACTTT ACATCCATAT CTTTGTAAGT GTAAATTCCC CATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_034783.3
CDS1..717
Translation

Target ORF information:

RefSeq Version NM_010653.4
Organism Mus musculus(house mouse)
Definition Mus musculus killer cell lectin-like receptor subfamily C, member 2 (Klrc2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_010653.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGAGTCACC TGCTTGGAAC TGAACAGGCC TCAGAACCCA GGAAAGCCAC AAAGAAAACC 
CAGGCGCAGT TCCGTTTCAG TAATGCAGCA GGAGATCGCC TGCTGGAGTT TAGCCTTCAA 
CATGCTTCCC AGAAGCATCT GAAGGCCAGC AGGCATGGCT ACTGCAAAAA TTTTGCATCA 
CCTCCAGAGA AGCTCATCGC TGGAATCCTG GGCACCATCT GGTTTACCTT ATTGATTGCT 
CTAGTAATCT CAACCAGAAT TGTTTCTCCA TATGCTGAAC TGAAGAAGCA GATCCACCCC 
TTCTTGGTTA GAACCCAGAA AGGCTCACAC GCCTTGCTCT CCAAAGCACA GCCTTGTCCT 
CATTGTCCAA AGGAGTGGAT ATCATATTCT CACAATTGTT ATTTCATTGG TATGGAGAGA 
AAATCTTGGA ATGACAGTTT GGGGTCCTGC CTTTCCAAAA ACTGTAGTCT GCTTCACATA 
GATAGTGAAG AGGAGCAGGA TTTTCTGCAA TCTCTTTCAC TGGTCTCATG GACTGGAATC 
CTTCGGAAGG GCAGAGGTCA GGCCTGGGAC TGGAAAAAAG ACTCAATTTT CAAACCAAAG 
ATAGCAGAGA TTTCCCATGA TGAATGTAAC TGTGCCATGA TGTCAGCTTC TGGTCTCACA 
GCAGACAACT GTACAACTTT ACATCCATAT CTTTGTAAGT GTAAATTCCC CATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu36956
Clone ID Related Accession (Same CDS sequence) XM_017321419.1
Accession Version XM_017321419.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 741bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Mus musculus(house mouse)
Product killer cell lectin-like receptor subfamily C, member 2 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAGTCACC TGCTTGGAAC TGAACAGGCC TCAGAACCCA GGAAAGCCAC AAAGAAAACC 
CAGGCGCAGT TCCGTTTCAG TAATGCAGCA GGAGATCGCC TGCTGGAGTT TAGCCTTCAA 
CATGCTTCCC AGAAGCATCT GAAGGCCAGC AGGCATGGCT ACTGCAAAAA TTTTGCATCA 
CCTCCAGAGA AGCTCATCGC TGGAATCCTG GGCACCATCT GGTTTACCTT ATTGATTGCT 
CTAGTAATCT CAACCAGAAT TGTTTCTCCA TATGCTGAAC TGAAGAAGCA GATCCACCCC 
TTCTTGGTTA GAACCCAGAA AGGCTCACAC GCCTTGCTCT CCAAAGATAT AAACTACACT 
CTATCTTCAG CACAGCCTTG TCCTCATTGT CCAAAGGAGT GGATATCATA TTCTCACAAT 
TGTTATTTCA TTGGTATGGA GAGAAAATCT TGGAATGACA GTTTGGGGTC CTGCCTTTCC 
AAAAACTGTA GTCTGCTTCA CATAGATAGT GAAGAGGAGC AGGATTTTCT GCAATCTCTT 
TCACTGGTCT CATGGACTGG AATCCTTCGG AAGGGCAGAG GTCAGGCCTG GGACTGGAAA 
AAAGACTCAA TTTTCAAACC AAAGATAGCA GAGATTTCCC ATGATGAATG TAACTGTGCC 
ATGATGTCAG CTTCTGGTCT CACAGCAGAC AACTGTACAA CTTTACATCC ATATCTTTGT 
AAGTGTAAAT TCCCCATCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017176908.1
CDS182..922
Translation

Target ORF information:

RefSeq Version XM_017321419.1
Organism Mus musculus(house mouse)
Definition Mus musculus killer cell lectin-like receptor subfamily C, member 2 (Klrc2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017321419.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAGTCACC TGCTTGGAAC TGAACAGGCC TCAGAACCCA GGAAAGCCAC AAAGAAAACC 
CAGGCGCAGT TCCGTTTCAG TAATGCAGCA GGAGATCGCC TGCTGGAGTT TAGCCTTCAA 
CATGCTTCCC AGAAGCATCT GAAGGCCAGC AGGCATGGCT ACTGCAAAAA TTTTGCATCA 
CCTCCAGAGA AGCTCATCGC TGGAATCCTG GGCACCATCT GGTTTACCTT ATTGATTGCT 
CTAGTAATCT CAACCAGAAT TGTTTCTCCA TATGCTGAAC TGAAGAAGCA GATCCACCCC 
TTCTTGGTTA GAACCCAGAA AGGCTCACAC GCCTTGCTCT CCAAAGATAT AAACTACACT 
CTATCTTCAG CACAGCCTTG TCCTCATTGT CCAAAGGAGT GGATATCATA TTCTCACAAT 
TGTTATTTCA TTGGTATGGA GAGAAAATCT TGGAATGACA GTTTGGGGTC CTGCCTTTCC 
AAAAACTGTA GTCTGCTTCA CATAGATAGT GAAGAGGAGC AGGATTTTCT GCAATCTCTT 
TCACTGGTCT CATGGACTGG AATCCTTCGG AAGGGCAGAG GTCAGGCCTG GGACTGGAAA 
AAAGACTCAA TTTTCAAACC AAAGATAGCA GAGATTTCCC ATGATGAATG TAACTGTGCC 
ATGATGTCAG CTTCTGGTCT CACAGCAGAC AACTGTACAA CTTTACATCC ATATCTTTGT 
AAGTGTAAAT TCCCCATCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950)187(12)6365-73(2011 Dec)
Saether PC,Hoelsbrekken SE,Fossum S,Dissen E


book

Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells.
The Journal of experimental medicine190(12)1801-12(1999 Dec)
Vance RE,Jamieson AM,Raulet DH


book

Molecular cloning of mouse NKG2A and C.
Immunogenetics49(7-8)727-30(1999 Jul)
Silver ET,Lau JC,Kane KP


book

Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells.
European journal of immunology29(3)755-61(1999 Mar)
Lohwasser S,Hande P,Mager DL,Takei F