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Pla2g1b cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Pla2g1b
Entrez Gene ID 18778
Full Name phospholipase A2, group IB, pancreas
Synonyms Pla2a,sPLA2IB
General protein information
Preferred Names

phospholipase A2, group IB, pancreas

Names

phospholipase A2
PLA2-Ib
group IB phospholipase A2
phosphatidylcholine 2-acylhydrolase 1B
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

5

5|5 F

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_011107.1 NP_035237.1 phospholipase A2 precursor
NM_001356587.1 NP_001343516.1 phospholipase A2 isoform 3 precursor
XM_006530199.2 XP_006530262.1 phospholipase A2 isoform X1
NM_011107.2 NP_035237.1 phospholipase A2 isoform 1 precursor
NM_001356586.1 NP_001343515.1 phospholipase A2 isoform 2 precursor

Pathways from BioSystems


Homologies


Rattus norvegicus (Norway rat) Pla2g1b NP_113773.1
Xenopus tropicalis (tropical clawed frog) pla2g1b XP_004910660.1
PLA2G1B XP_001088684.1
Canis lupus familiaris (dog) PLA2G1B NP_001003320.1
Mus musculus (house mouse) Pla2g1b NP_035237.1
Gallus gallus (chicken) PLA2G1B XP_001233627.2
Homo sapiens (human) PLA2G1B NP_000919.1
Pan troglodytes (chimpanzee) PLA2G1B XP_001160305.1
Bos taurus (cattle) PLA2G1B NP_777071.2
Danio rerio (zebrafish) pla2g1b XP_700448.2

Gene Ontology


Bibliography

Related articles in PubMed

Group 1B phospholipase A? inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice.
Hollie NI, Konaniah ES, Goodin C, Hui DY
Atherosclerosis234(2)377-80(2014 Jun)

cPLA2? knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons.
Qu BX, Gong Y, Sinclair D, Fu M, Perl D, Diaz-Arrastia R
Brain research1497101-5(2013 Feb)

Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A?, group VIA and secretory phospholipase A?, group IB.
Zhan C, Wang J, Kolko M
Current eye research37(10)930-40(2012 Oct)

Group 1B phospholipase A? deficiency protects against diet-induced hyperlipidemia in mice.
Hollie NI, Hui DY
Journal of lipid research52(11)2005-11(2011 Nov)

Cytosolic phospholipase A2? blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs.
Thakker P, Marusic S, Stedman NL, Lee KL, McKew JC, Wood A, Goldman SJ, Leach MW, Collins M, Kuchroo VK, Wolf SF, Clark JD, Hassan-Zahraee M
Journal of immunology (Baltimore, Md. : 1950)187(4)1986-97(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pla2g1b inactivation suppressed diet-induced body weight gain and reduced diabetes and atherosclerosis in LDL receptor-deficient mice.
Title: Group 1B phospholipase A? inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice.

Exogenously added sPLA(2)-IB decreases phagocytosis of outer retinal segments regardless of enzymatic activity.
Title: Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A?, group VIA and secretory phospholipase A?, group IB.

inhibition of Pla2g1b protects against diet-induced hyperlipidemia
Title: Group 1B phospholipase A? deficiency protects against diet-induced hyperlipidemia in mice.

Lysophospholipids produced by Pla2g1b hydrolysis suppress hepatic fat utilization and down-regulate energy expenditure, preventing metabolically beneficial adaptation to a high-fat diet exposure in promoting diet-induced obesity and type 2 diabetes.
Title: Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesity.

pro-inflammatory effects of Ps. aeruginosa involve release of an sPLA2 of epithelial origin that, in part, via distinct signalling molecules, transactivates the ABCA1 gene, leading to export of phospholipid.
Title: Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR.

The following Pla2g1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pla2g1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu35818 NM_001356586.1
Latest version!		 Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OMu35818 XM_006530199.2
Latest version!		 Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OMu07483 NM_011107.2
Latest version!		 Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OMu83835 NM_001356587.1
Latest version!		 Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
View Old Accession Versions >>
OMu07483 NM_011107.1 Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu35818
Clone ID Related Accession (Same CDS sequence) XM_006530199.2 , NM_001356586.1
Accession Version NM_001356586.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-24
Organism Mus musculus(house mouse)
Product phospholipase A2 isoform 2 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC117735.8 and BY088109.1. On Oct 11, 2017 this sequence version replaced XM_006530199.2. Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY093468.1, BY088109.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGGCGCTG CTGCACACAG CATCAGCCCT 
CGGGCTGTGT GGCAGTTCCG CAATATGATC AAGTGCACCA TCCCCGGGAG TGATCCCCTG 
AAGGATTACA ACAACTATGG CTGCTACTGT GGCTTGGGCG GCTGGGGCAC CCCAGTGGAC 
GACTTAGACA GGTGCTGCCA GACTCATGAC CACTGCTACA GTCAGGCCAA GAAGCTGGAA 
AGCTGTAAAT TCCTCATAGA CAACCCCTAC ACCAACACTT ACTCCTACTC ATGCTCCGGG 
AGCGAGATCA CCTGCAGCGC CAAAAACAAC AAATGCGAGG ACTTCATCTG CAACTGTGAC 
CGTGAGGCCG CCATCTGCTT CTCCAAGGTC CCGTACAACA AGGAATACAA AAACCTTGAC 
ACCGGGAAAT TCTGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001343515.1
CDS146..583
Translation

Target ORF information:

RefSeq Version NM_001356586.1
Organism Mus musculus(house mouse)
Definition Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001356586.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGGCGCTG CTGCACACAG CATCAGCCCT 
CGGGCTGTGT GGCAGTTCCG CAATATGATC AAGTGCACCA TCCCCGGGAG TGATCCCCTG 
AAGGATTACA ACAACTATGG CTGCTACTGT GGCTTGGGCG GCTGGGGCAC CCCAGTGGAC 
GACTTAGACA GGTGCTGCCA GACTCATGAC CACTGCTACA GTCAGGCCAA GAAGCTGGAA 
AGCTGTAAAT TCCTCATAGA CAACCCCTAC ACCAACACTT ACTCCTACTC ATGCTCCGGG 
AGCGAGATCA CCTGCAGCGC CAAAAACAAC AAATGCGAGG ACTTCATCTG CAACTGTGAC 
CGTGAGGCCG CCATCTGCTT CTCCAAGGTC CCGTACAACA AGGAATACAA AAACCTTGAC 
ACCGGGAAAT TCTGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu35818
Clone ID Related Accession (Same CDS sequence) XM_006530199.2 , NM_001356586.1
Accession Version XM_006530199.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-21
Organism Mus musculus(House mouse)
Product phospholipase A2 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006530199.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGGCGCTG CTGCACACAG CATCAGCCCT 
CGGGCTGTGT GGCAGTTCCG CAATATGATC AAGTGCACCA TCCCCGGGAG TGATCCCCTG 
AAGGATTACA ACAACTATGG CTGCTACTGT GGCTTGGGCG GCTGGGGCAC CCCAGTGGAC 
GACTTAGACA GGTGCTGCCA GACTCATGAC CACTGCTACA GTCAGGCCAA GAAGCTGGAA 
AGCTGTAAAT TCCTCATAGA CAACCCCTAC ACCAACACTT ACTCCTACTC ATGCTCCGGG 
AGCGAGATCA CCTGCAGCGC CAAAAACAAC AAATGCGAGG ACTTCATCTG CAACTGTGAC 
CGTGAGGCCG CCATCTGCTT CTCCAAGGTC CCGTACAACA AGGAATACAA AAACCTTGAC 
ACCGGGAAAT TCTGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006530262.1
CDS47..484
Translation

Target ORF information:

RefSeq Version XM_006530199.2
Organism Mus musculus(House mouse)
Definition Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006530199.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGGCGCTG CTGCACACAG CATCAGCCCT 
CGGGCTGTGT GGCAGTTCCG CAATATGATC AAGTGCACCA TCCCCGGGAG TGATCCCCTG 
AAGGATTACA ACAACTATGG CTGCTACTGT GGCTTGGGCG GCTGGGGCAC CCCAGTGGAC 
GACTTAGACA GGTGCTGCCA GACTCATGAC CACTGCTACA GTCAGGCCAA GAAGCTGGAA 
AGCTGTAAAT TCCTCATAGA CAACCCCTAC ACCAACACTT ACTCCTACTC ATGCTCCGGG 
AGCGAGATCA CCTGCAGCGC CAAAAACAAC AAATGCGAGG ACTTCATCTG CAACTGTGAC 
CGTGAGGCCG CCATCTGCTT CTCCAAGGTC CCGTACAACA AGGAATACAA AAACCTTGAC 
ACCGGGAAAT TCTGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu07483
Clone ID Related Accession (Same CDS sequence) NM_011107.1 , NM_011107.2
Accession Version NM_011107.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-04-24
Organism Mus musculus(House mouse)
Product phospholipase A2 precursor
Comment PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF162712.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF162712.1, AK007797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGCAGGCG CTGCTGCACA CAGCATCAGC 
CCTCGGGCTG TGTGGCAGTT CCGCAATATG ATCAAGTGCA CCATCCCCGG GAGTGATCCC 
CTGAAGGATT ACAACAACTA TGGCTGCTAC TGTGGCTTGG GCGGCTGGGG CACCCCAGTG 
GACGACTTAG ACAGGTGCTG CCAGACTCAT GACCACTGCT ACAGTCAGGC CAAGAAGCTG 
GAAAGCTGTA AATTCCTCAT AGACAACCCC TACACCAACA CTTACTCCTA CTCATGCTCC 
GGGAGCGAGA TCACCTGCAG CGCCAAAAAC AACAAATGCG AGGACTTCAT CTGCAACTGT 
GACCGTGAGG CCGCCATCTG CTTCTCCAAG GTCCCGTACA ACAAGGAATA CAAAAACCTT 
GACACCGGGA AATTCTGTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_035237.1
CDS22..462
Translation

Target ORF information:

RefSeq Version NM_011107.1
Organism Mus musculus(House mouse)
Definition Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_011107.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGCAGGCG CTGCTGCACA CAGCATCAGC 
CCTCGGGCTG TGTGGCAGTT CCGCAATATG ATCAAGTGCA CCATCCCCGG GAGTGATCCC 
CTGAAGGATT ACAACAACTA TGGCTGCTAC TGTGGCTTGG GCGGCTGGGG CACCCCAGTG 
GACGACTTAG ACAGGTGCTG CCAGACTCAT GACCACTGCT ACAGTCAGGC CAAGAAGCTG 
GAAAGCTGTA AATTCCTCAT AGACAACCCC TACACCAACA CTTACTCCTA CTCATGCTCC 
GGGAGCGAGA TCACCTGCAG CGCCAAAAAC AACAAATGCG AGGACTTCAT CTGCAACTGT 
GACCGTGAGG CCGCCATCTG CTTCTCCAAG GTCCCGTACA ACAAGGAATA CAAAAACCTT 
GACACCGGGA AATTCTGTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu07483
Clone ID Related Accession (Same CDS sequence) NM_011107.1 , NM_011107.2
Accession Version NM_011107.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-24
Organism Mus musculus(house mouse)
Product phospholipase A2 isoform 1 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC117735.8 and AK008668.1. On Oct 11, 2017 this sequence version replaced NM_011107.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF162712.1, AK007797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGCAGGCG CTGCTGCACA CAGCATCAGC 
CCTCGGGCTG TGTGGCAGTT CCGCAATATG ATCAAGTGCA CCATCCCCGG GAGTGATCCC 
CTGAAGGATT ACAACAACTA TGGCTGCTAC TGTGGCTTGG GCGGCTGGGG CACCCCAGTG 
GACGACTTAG ACAGGTGCTG CCAGACTCAT GACCACTGCT ACAGTCAGGC CAAGAAGCTG 
GAAAGCTGTA AATTCCTCAT AGACAACCCC TACACCAACA CTTACTCCTA CTCATGCTCC 
GGGAGCGAGA TCACCTGCAG CGCCAAAAAC AACAAATGCG AGGACTTCAT CTGCAACTGT 
GACCGTGAGG CCGCCATCTG CTTCTCCAAG GTCCCGTACA ACAAGGAATA CAAAAACCTT 
GACACCGGGA AATTCTGTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_035237.1
CDS146..586
Translation

Target ORF information:

RefSeq Version NM_011107.2
Organism Mus musculus(house mouse)
Definition Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_011107.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGCAGGCG CTGCTGCACA CAGCATCAGC 
CCTCGGGCTG TGTGGCAGTT CCGCAATATG ATCAAGTGCA CCATCCCCGG GAGTGATCCC 
CTGAAGGATT ACAACAACTA TGGCTGCTAC TGTGGCTTGG GCGGCTGGGG CACCCCAGTG 
GACGACTTAG ACAGGTGCTG CCAGACTCAT GACCACTGCT ACAGTCAGGC CAAGAAGCTG 
GAAAGCTGTA AATTCCTCAT AGACAACCCC TACACCAACA CTTACTCCTA CTCATGCTCC 
GGGAGCGAGA TCACCTGCAG CGCCAAAAAC AACAAATGCG AGGACTTCAT CTGCAACTGT 
GACCGTGAGG CCGCCATCTG CTTCTCCAAG GTCCCGTACA ACAAGGAATA CAAAAACCTT 
GACACCGGGA AATTCTGTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu83835
Clone ID Related Accession (Same CDS sequence) NM_001356587.1
Accession Version NM_001356587.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 249bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-24
Organism Mus musculus(house mouse)
Product phospholipase A2 isoform 3 precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC117735.8 and AK019009.1. Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK019009.1, CF587249.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGCAGGCG CTGCTGCACA CAGCATCAGC 
CCTCGGGCTG TGTGGCAGTT CCGCAATATG ATCAAGTGCA CCATCCCCGG GAGTGATCCC 
CTGAAGGATT ACAACAACTA TGGCTGCTAC TGTGGCTTGG GCGGCTGGGG CACCCCAGTG 
GACGACTTAG ACAGAGCTGA GGACCGAACC CACAGCCTTG TTCTTGCTAG GCAAGCACTC 
TACCACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001343516.1
CDS146..394
Translation

Target ORF information:

RefSeq Version NM_001356587.1
Organism Mus musculus(house mouse)
Definition Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001356587.1

ORF Insert Sequence:

1
61
121
181
241
ATGAAACTCC TTCTGCTGGC TGCTCTGCTC ACAGCAGGCG CTGCTGCACA CAGCATCAGC 
CCTCGGGCTG TGTGGCAGTT CCGCAATATG ATCAAGTGCA CCATCCCCGG GAGTGATCCC 
CTGAAGGATT ACAACAACTA TGGCTGCTAC TGTGGCTTGG GCGGCTGGGG CACCCCAGTG 
GACGACTTAG ACAGAGCTGA GGACCGAACC CACAGCCTTG TTCTTGCTAG GCAAGCACTC 
TACCACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Group 1B phospholipase A? inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice.
Atherosclerosis234(2)377-80(2014 Jun)
Hollie NI,Konaniah ES,Goodin C,Hui DY


book

cPLA2? knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons.
Brain research1497101-5(2013 Feb)
Qu BX,Gong Y,Sinclair D,Fu M,Perl D,Diaz-Arrastia R


book

Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A?, group VIA and secretory phospholipase A?, group IB.
Current eye research37(10)930-40(2012 Oct)
Zhan C,Wang J,Kolko M


book

Group 1B phospholipase A? deficiency protects against diet-induced hyperlipidemia in mice.
Journal of lipid research52(11)2005-11(2011 Nov)
Hollie NI,Hui DY


book

Cytosolic phospholipase A2? blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs.
Journal of immunology (Baltimore, Md. : 1950)187(4)1986-97(2011 Aug)
Thakker P,Marusic S,Stedman NL,Lee KL,McKew JC,Wood A,Goldman SJ,Leach MW,Collins M,Kuchroo VK,Wolf SF,Clark JD,Hassan-Zahraee M