GABRR3 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | GABRR3 |
| Entrez Gene ID | 200959 |
| Full Name | gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001105580.2 | NP_001099050.1 | gamma-aminobutyric acid receptor subunit rho-3 precursor |
| GABRR3 | XP_001087158.2 | |
| Xenopus tropicalis (tropical clawed frog) | gabrr3 | XP_002933116.2 |
| Danio rerio (zebrafish) | gabrr3a | NP_001122232.1 |
| Bos taurus (cattle) | GABRR3 | NP_001179448.1 |
| Rattus norvegicus (Norway rat) | Gabrr3 | NP_620252.1 |
| Pan troglodytes (chimpanzee) | GABRR3 | XP_526252.1 |
| Mus musculus (house mouse) | Gabrr3 | NP_001074659.1 |
| Danio rerio (zebrafish) | LOC561083 | XP_689576.5 |
| Homo sapiens (human) | GABRR3 | NP_001099050.1 |
| Gallus gallus (chicken) | GABRR3 | XP_428531.4 |
Related articles in PubMed
Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.
Garc?a-Mart?n E, Mart?nez C, Alonso-Navarro H, Benito-Le?n J, Lorenzo-Betancor O, Pastor P, Puertas I, Rubio L, L?pez-Alburquerque T, Ag?ndez JA, Jim?nez-Jim?nez FJ
Journal of neurology258(2)203-11(2011 Feb)
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.
Craddock N, Jones L, Jones IR, Kirov G, Green EK, Grozeva D, Moskvina V, Nikolov I, Hamshere ML, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Norton N, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P, Holmans PA, , Donnelly P, Owen MJ, O'Donovan MC
Molecular psychiatry15(2)146-53(2010 Feb)
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratac?s M, Costas J, de Cid R, Bay?s M, Gonz?lez JR, Baca-Garc?a E, de Diego Y, Fern?ndez-Aranda F, Fern?ndez-Piqueras J, Guitart M, Mart?n-Santos R, Martorell L, Mench?n JM, Roca M, S?iz-Ruiz J, Sanju?n J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A,
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(6)808-16(2009 Sep)
GABA receptor rho subunit expression in the developing rat brain.
Alakuijala A, Palgi M, Wegelius K, Schmidt M, Enz R, Paulin L, Saarma M, Pasternack M
Brain research. Developmental brain research154(1)15-23(2005 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
found no significant differences in either the frequencies of the GABRR1-M26V, GABRR1- H27R, GABRR2-T455M, and GABRR3-Y205X genotypes or in the frequencies of the allelic variants of these polymorphisms in patients with essential tremor
Title: Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.
Observational study of gene-disease association. (HuGE Navigator)
Title: Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.
Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
GABA(C) receptors are specifically involved in aspects of visual image motion processing in the rat brain
Title: GABA receptor rho subunit expression in the developing rat brain.
The following GABRR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GABRR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu13993 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001105580.2 | |
| Accession Version | NM_001105580.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-11-26 | |
| Organism | Homo sapiens(human) | |
| Product | gamma-aminobutyric acid receptor subunit rho-3 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC026100.19 and KF459624.1. On Aug 2, 2011 this sequence version replaced NM_001105580.1. Transcript Variant: This variant (1) represents the functional allele (SNP rs832032, has Tyr205 versus a stop codon) and encodes the supported protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single human transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on partial human and full-length orthologous transcript alignments, including mouse BC151105.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2147975 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 20820800 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## | |
1 | ATGGTCCTGG CTTTCCAGTT AGTCTCCTTC ACCTACATCT GGATCATATT GAAACCAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001099050.1 |
| CDS | 118..1521 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001105580.2 |
ORF Insert Sequence:
1 | ATGGTCCTGG CTTTCCAGTT AGTCTCCTTC ACCTACATCT GGATCATATT GAAACCAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor. |
|
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. |
|
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. |
|
GABA receptor rho subunit expression in the developing rat brain. |