Gene Symbol | RUSC1 |
Entrez Gene ID | 23623 |
Full Name | RUN and SH3 domain containing 1 |
Synonyms | NESCA |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » RUSC1 cDNA ORF clone
gRNAs
Gene Symbol | RUSC1 |
Entrez Gene ID | 23623 |
Full Name | RUN and SH3 domain containing 1 |
Synonyms | NESCA |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001278230.1 | NP_001265159.1 | RUN and SH3 domain-containing protein 1 isoform d |
NM_001278230.2 | NP_001265159.1 | RUN and SH3 domain-containing protein 1 isoform d |
NM_001278227.1 | NP_001265156.1 | RUN and SH3 domain-containing protein 1 isoform e |
NM_001105203.2 | NP_001098673.1 | RUN and SH3 domain-containing protein 1 isoform a |
XM_006711258.1 | XP_006711321.1 | RUN and SH3 domain-containing protein 1 isoform X1 |
NM_001278229.1 | NP_001265158.1 | RUN and SH3 domain-containing protein 1 isoform g |
NM_001105205.1 | NP_001098675.1 | RUN and SH3 domain-containing protein 1 isoform c |
NM_001105203.1 | NP_001098673.1 | RUN and SH3 domain-containing protein 1 isoform a |
XM_006711254.1 | XP_006711317.1 | RUN and SH3 domain-containing protein 1 isoform X1 |
NM_001105204.2 | NP_001098674.1 | RUN and SH3 domain-containing protein 1 isoform b |
XM_017000891.1 | XP_016856380.1 | RUN and SH3 domain-containing protein 1 isoform X1 |
XM_006711257.1 | XP_006711320.1 | RUN and SH3 domain-containing protein 1 isoform X3 |
XM_006711256.1 | XP_006711319.1 | RUN and SH3 domain-containing protein 1 isoform X2 |
NM_001105204.1 | NP_001098674.1 | RUN and SH3 domain-containing protein 1 isoform b |
NM_001278228.1 | NP_001265157.1 | RUN and SH3 domain-containing protein 1 isoform f |
NM_014328.4 | NP_055143.2 | RUN and SH3 domain-containing protein 1 isoform d |
XM_006711254.2 | XP_006711317.1 | RUN and SH3 domain-containing protein 1 isoform X1 |
XM_006711256.2 | XP_006711319.1 | RUN and SH3 domain-containing protein 1 isoform X2 |
XM_017000892.1 | XP_016856381.1 | RUN and SH3 domain-containing protein 1 isoform X4 |
Crystal structure and functional implication of the RUN domain of human NESCA.
Sun Q, Han C, Liu L, Wang Y, Deng H, Bai L, Jiang T
Protein & cell3(8)609-17(2012 Aug)
Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.
MacDonald JI, Dietrich A, Gamble S, Hryciw T, Grant RI, Meakin SO
Journal of neurochemistry121(6)861-80(2012 Jun)
NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein.
Napolitano G, Mirra S, Monfregola J, Lavorgna A, Leonardi A, Ursini MV
Journal of cellular physiology220(2)410-7(2009 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
RUN domain of NESCA can bind H-Ras, a downstream signaling molecule of TrkA, with high affinity. Moreover, NESCA RUN can directly interact with TrkA.
Title: Crystal structure and functional implication of the RUN domain of human NESCA.
Nesca functions as an adapter involved in neuronal vesicular transport
Title: Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.
Data show that NESCA and NEMO interact by their N-terminal region, that NESCA directly associates with TRAF6, which in turn catalyzes NESCA polyubiquitination, and that NESCA overexpression strongly inhibits TRAF6-mediated polyubiquitination of NEMO.
Title: NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein.
The following RUSC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RUSC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu00528![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_001278230.1 , NM_001278230.2 , XM_006711258.1 , XM_006711257.1 , NM_014328.4 | |
Accession Version | NM_001278230.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-01-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform d | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN305634.1, DA751328.1, BX640612.1 and BQ004124.1. Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 1 and 8 encode the same isoform (d). ##Evidence-Data-START## Transcript exon combination :: BX640612.1, AL080083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265159.1 |
CDS | 501..1802 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu00528![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001278230.1 , NM_001278230.2 , XM_006711258.1 , XM_006711257.1 , NM_014328.4 | |
Accession Version | NM_001278230.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-06 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform d | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL139410.20. On May 31, 2019 this sequence version replaced NM_001278230.1. Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 1 and 8 encode the same isoform (d). ##Evidence-Data-START## Transcript exon combination :: BX640612.1, AL080083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265159.1 |
CDS | 389..1690 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu00528![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001278230.1 , NM_001278230.2 , XM_006711258.1 , XM_006711257.1 , NM_014328.4 | |
Accession Version | NM_014328.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform d | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052277.1, DA131200.1, AK074982.1 and BQ004124.1. On May 17, 2013 this sequence version replaced NM_014328.3. Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 1 and 8 encode the same isoform (d). ##Evidence-Data-START## Transcript exon combination :: AB026894.2, SRR1803614.270502.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055143.2 |
CDS | 702..2003 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06212![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001105205.1 | |
Accession Version | NM_001105205.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform c | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052277.1 and BQ004124.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: BC052277.1, BC001045.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGCCCA CGTGCTCCCC GGGGCTCCGC AGGCAGGACT GGGCCCCGGG GCGGTGCGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001098675.1 |
CDS | 482..1960 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCGCCCA CGTGCTCCCC GGGGCTCCGC AGGCAGGACT GGGCCCCGGG GCGGTGCGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu00528![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001278230.1 , NM_001278230.2 , XM_006711258.1 , XM_006711257.1 , NM_014328.4 | |
Accession Version | XM_006711258.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | RUN and SH3 domain-containing protein 1 isoform X1 | |
Comment |
1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006711321.1 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu00528![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001278230.1 , NM_001278230.2 , XM_006711258.1 , XM_006711257.1 , NM_014328.4 | |
Accession Version | XM_006711257.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006711320.1 |
CDS | 316..1617 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu00436 | |
Clone ID Related Accession (Same CDS sequence) | NM_001278229.1 , XM_017000892.1 | |
Accession Version | NM_001278229.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-04 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform g | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052277.1, AK298730.1, BX402179.2, AK074982.1 and BQ004124.1. Transcript Variant: This variant (7) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (g) is shorter and has a shorter N-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: BX402179.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265158.1 |
CDS | 702..1685 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu00513 | |
Clone ID Related Accession (Same CDS sequence) | NM_001278228.1 | |
Accession Version | NM_001278228.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1284bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform f | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052277.1, AK307736.1, AK074982.1 and BQ004124.1. Transcript Variant: This variant (6) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (f) is shorter and has a distinct N-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: AK307736.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGGAGAG TAATGGAGCT CCGCGGGGGG TGCGGGAATG GTTGGCGGGA GGTGGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265157.1 |
CDS | 857..2140 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGGAGAG TAATGGAGCT CCGCGGGGGG TGCGGGAATG GTTGGCGGGA GGTGGCTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu04368 | |
Clone ID Related Accession (Same CDS sequence) | NM_001278227.1 | |
Accession Version | NM_001278227.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform e | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC052277.1, AK298730.1 and BQ004124.1. Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (e) is shorter and has a shorter N-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: AK298730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001265156.1 |
CDS | 702..1904 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu00436 | |
Clone ID Related Accession (Same CDS sequence) | NM_001278229.1 , XM_017000892.1 | |
Accession Version | XM_017000892.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016856381.1 |
CDS | 316..1299 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAGAAG CCCAGAGTGG GACTGGTCAG CTGCAGGAGC AGAAGAAAGG TCTTCTGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06211 | |
Clone ID Related Accession (Same CDS sequence) | NM_001105204.2 , NM_001105204.1 | |
Accession Version | NM_001105204.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-06 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA099897.1, BC025680.1, AK125378.1 and BQ004124.1. On May 31, 2019 this sequence version replaced NM_001105204.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AK125378.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001098674.1 |
CDS | 185..2575 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06211 | |
Clone ID Related Accession (Same CDS sequence) | NM_001105204.2 , NM_001105204.1 | |
Accession Version | NM_001105204.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-01-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA099897.1, BC025680.1, AK125378.1 and BQ004124.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AK125378.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001098674.1 |
CDS | 230..2620 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31612 | |
Clone ID Related Accession (Same CDS sequence) | NM_001105203.2 , NM_001105203.1 | |
Accession Version | NM_001105203.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2709bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA099897.1 and BC025680.1. On Nov 22, 2018 this sequence version replaced NM_001105203.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC025680.1, SRR3476690.687070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368352.10/ ENSP00000357336.5 RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001098673.1 |
CDS | 185..2893 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31612 | |
Clone ID Related Accession (Same CDS sequence) | NM_001105203.2 , NM_001105203.1 | |
Accession Version | NM_001105203.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2709bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA099897.1, BC025680.1 and BQ004124.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC025680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001098673.1 |
CDS | 230..2938 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34282 | |
Clone ID Related Accession (Same CDS sequence) | XM_006711254.1 , XM_017000891.1 , XM_006711254.2 | |
Accession Version | XM_006711254.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3120bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006711317.1 |
CDS | 230..3349 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34282 | |
Clone ID Related Accession (Same CDS sequence) | XM_006711254.1 , XM_017000891.1 , XM_006711254.2 | |
Accession Version | XM_017000891.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3120bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016856380.1 |
CDS | 400..3519 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34282 | |
Clone ID Related Accession (Same CDS sequence) | XM_006711254.1 , XM_017000891.1 , XM_006711254.2 | |
Accession Version | XM_006711254.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3120bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006711254.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006711317.1 |
CDS | 185..3304 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34283 | |
Clone ID Related Accession (Same CDS sequence) | XM_006711256.1 , XM_006711256.2 | |
Accession Version | XM_006711256.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006711319.1 |
CDS | 230..3031 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34283 | |
Clone ID Related Accession (Same CDS sequence) | XM_006711256.1 , XM_006711256.2 | |
Accession Version | XM_006711256.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | RUN and SH3 domain-containing protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_006711256.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006711319.1 |
CDS | 185..2986 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTGTCCC CTCAGAGAGC TTTACTCTGC AACCTCAACC ACATCCACCT CCAGCACGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Crystal structure and functional implication of the RUN domain of human NESCA. |
Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons. |
NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein. |