This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
The following GBGT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GBGT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA397865.1, BI906086.1, AK307687.1, AY358175.1 and HY315485.1. On May 31, 2019 this sequence version replaced NM_001288572.1.
Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
##Evidence-Data-START##
Transcript exon combination :: BI906086.1, SRR7346977.1106675.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA397865.1, BI906086.1, AK307687.1, AY358175.1 and HY315485.1. On Dec 21, 2013 this sequence version replaced XM_005272182.1.
Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
##Evidence-Data-START##
Transcript exon combination :: BI906086.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA397865.1, AK307687.1, AY358175.1 and HY315485.1.
Transcript Variant: This variant (5) uses an alternate splice site in the 3' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus than isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AK307687.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2155371, SAMN01820701 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK307687.1, AY358175.1 and HY315485.1. On May 31, 2019 this sequence version replaced NM_001288573.1.
Transcript Variant: This variant (5) uses an alternate splice site in the 3' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus than isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AK307687.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2155371, SAMN01820701 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA397865.1, BC032499.1 and AL162417.23. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_021996.5.
Transcript Variant: This variant (1) encodes the longest isoform (1).
Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: AK291498.1, BC032499.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2155371, SAMEA2467150 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000372040.9/ ENSP00000361110.3
RefSeq Select criteria :: based on conservation, expression, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA397865.1, BC032499.1 and AL162417.23. This sequence is a reference standard in the RefSeqGene project. On Sep 17, 2013 this sequence version replaced NM_021996.4.
Transcript Variant: This variant (1) encodes the longest isoform (1).
Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: BC032499.1, AY358175.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2155371, SAMEA2467150 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA397865.1, AK303825.1 and AL162417.23. On Sep 17, 2013 this sequence version replaced XM_005272181.1.
Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK303825.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2145774, SAMEA2149398 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303825.1 and AL162417.23. On May 31, 2019 this sequence version replaced NM_001282632.1.
Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK303825.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2145774, SAMEA2149398 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA397865.1, AK074639.1, AL162417.23 and HY315485.1. On May 31, 2019 this sequence version replaced NM_001282629.1.
Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK074639.1, DA573087.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2155371, SAMN01820701 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA397865.1, AK074639.1, AL162417.23 and HY315485.1. On Sep 17, 2013 this sequence version replaced XM_005272183.1.
Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK074639.1, DA573087.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2155371, SAMN01820701 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
User Manual
NM_001288572.2
