GIP cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | GIP |
| Entrez Gene ID | 2695 |
| Full Name | gastric inhibitory polypeptide |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_004123.2 | NP_004114.1 | gastric inhibitory polypeptide preproprotein |
| NM_004123.3 | NP_004114.1 | gastric inhibitory polypeptide preproprotein |
| Homo sapiens (human) | GIP | NP_004114.1 |
| GIP | XP_001091383.1 | |
| Canis lupus familiaris (dog) | GIP | XP_003639320.2 |
| Bos taurus (cattle) | GIP | NP_001160077.1 |
| Pan troglodytes (chimpanzee) | GIP | XP_001172671.1 |
| Mus musculus (house mouse) | Gip | NP_032145.2 |
| Rattus norvegicus (Norway rat) | Gip | NP_062604.1 |
Related articles in PubMed
The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor.
Asmar M, Asmar A, Simonsen L, Gasbjerg LS, Sparre-Ulrich AH, Rosenkilde MM, Hartmann B, Dela F, Holst JJ, B?low J
Diabetes66(9)2363-2371(2017 09)
Incretin secretion in humans is under the influence of cannabinoid receptors.
Chia CW, Carlson OD, Liu DD, Gonz?lez-Mariscal I, Santa-Cruz Calvo S, Egan JM
American journal of physiology. Endocrinology and metabolism313(3)E359-E366(2017 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
GIP and PP plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls.
Title: Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss.
The ability of a truncated form of GIP, GIP(3-30)NH2, to antagonize the physiological actions of GIP in glucose metabolism, subcutaneous abdominal adipose tissue blood flow, and lipid metabolism in humans.
Title: The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor.
Compared with the lean group, the obese group had significantly higher fasting and post-OGTT GIP levels, but similar fasting GLP-1 and significantly lower post-OGTT GLP-1 levels.
Title: Incretin secretion in humans is under the influence of cannabinoid receptors.
the stimulatory effect of IGF-1 on GIP promoter support the hypothesis of a functional growth hormone-igf-1-GIP axis
Title: The GIP/GIPR axis is functionally linked to GH-secretion increase in a significant proportion of
Evening postprandial insulin and GIP responses and insulin resistance declined by over 30% after three meals that limited daily carbohydrate intake to 30% compared to no such changes after three 60%-carbohydrate meals, an effect that was independent of pre-meal exercise.
Title: Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance.
The following GIP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GIP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu10094 | |
| Clone ID Related Accession (Same CDS sequence) | NM_004123.2 , NM_004123.3 | |
| Accession Version | NM_004123.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-26 | |
| Organism | Homo sapiens(human) | |
| Product | gastric inhibitory polypeptide preproprotein | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M18185.1 and BC069100.1. On Apr 6, 2005 this sequence version replaced NM_004123.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069100.1, M18185.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGTGGCCA CGAAGACCTT TGCTCTGCTG CTGCTGTCCC TGTTCCTGGC AGTGGGACTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_004114.1 |
| CDS | 99..560 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_004123.2 |
ORF Insert Sequence:
1 | ATGGTGGCCA CGAAGACCTT TGCTCTGCTG CTGCTGTCCC TGTTCCTGGC AGTGGGACTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu10094 | |
| Clone ID Related Accession (Same CDS sequence) | NM_004123.2 , NM_004123.3 | |
| Accession Version | NM_004123.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-06 | |
| Organism | Homo sapiens(human) | |
| Product | gastric inhibitory polypeptide preproprotein | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091133.11, M18185.1 and BC069100.1. On Nov 23, 2018 this sequence version replaced NM_004123.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279836.3413.1, BC069100.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357424.2/ ENSP00000350005.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGTGGCCA CGAAGACCTT TGCTCTGCTG CTGCTGTCCC TGTTCCTGGC AGTGGGACTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_004114.1 |
| CDS | 102..563 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_004123.3 |
ORF Insert Sequence:
1 | ATGGTGGCCA CGAAGACCTT TGCTCTGCTG CTGCTGTCCC TGTTCCTGGC AGTGGGACTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor. |
|
Incretin secretion in humans is under the influence of cannabinoid receptors. |