LALBA cDNA ORF clone, Homo sapiens(Human)
| Gene Symbol | LALBA |
| Entrez Gene ID | 3906 |
| Full Name | lactalbumin alpha |
| Synonyms | LYZG |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(Human) |
| Genome | |
| Summary | This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_002289.2 | NP_002280.1 | alpha-lactalbumin precursor |
| XM_006719395.3 | XP_006719458.1 | alpha-lactalbumin isoform X1 |
| XM_011538343.1 | XP_011536645.1 | alpha-lactalbumin isoform X1 |
| Bos taurus (cattle) | LALBA | NP_776803.1 |
| Homo sapiens (human) | LALBA | NP_002280.1 |
| Canis lupus familiaris (dog) | LALBA | NP_001003129.1 |
| Rattus norvegicus (Norway rat) | Lalba | NP_036726.1 |
| Pan troglodytes (chimpanzee) | LALBA | XP_001160401.1 |
| LALBA | XP_001102116.1 | |
| Mus musculus (house mouse) | Lalba | NP_034809.1 |
Related articles in PubMed
Disorder in Milk Proteins: ?-Lactalbumin. Part C. Peculiarities of Metal Binding.
Permyakov EA, Permyakov SE, Breydo L, Redwan EM, Almehdar HA, Uversky VN
Current protein & peptide science17(8)735-745(2016)
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
Wu Y, Gao H, Li H, Tabara Y, Nakatochi M, Chiu YF, Park EJ, Wen W, Adair LS, Borja JB, Cai Q, Chang YC, Chen P, Croteau-Chonka DC, Fogarty MP, Gan W, He CT, Hsiung CA, Hwu CM, Ichihara S, Igase M, Jo J, Kato N, Kawamoto R, Kuzawa CW, Lee JJ, Liu J, Lu L, McDade TW, Osawa H, Sheu WH, Teo Y, Vadlamudi S, Van Dam RM, Wang Y, Xiang YB, Yamamoto K, Ye X, Young TL, Zheng W, Zhu J, Shu XO, Shin C, Jee SH, Chuang LM, Miki T, Yokota M, Lin X, Mohlke KL, Tai ES
Human molecular genetics23(4)1108-19(2014 Feb)
The small heat-shock protein ?B-crystallin uses different mechanisms of chaperone action to prevent the amorphous versus fibrillar aggregation of ?-lactalbumin.
Kulig M, Ecroyd H
The Biochemical journal448(3)343-52(2012 Dec)
Effects of macromolecular crowding on the structural stability of human ?-lactalbumin.
Zhang DL, Wu LJ, Chen J, Liang Y
Acta biochimica et biophysica Sinica44(8)703-11(2012 Aug)
Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanch? H, Schreiber S, Nebel A
Mutation research694(1-2)13-9(2010 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Studies indicate that alpha-lactalbumin has two domains, a large alpha-helical domain and a small beta-sheet domain connected by a calcium binding loop.
Title: Disorder in Milk Proteins: ?-Lactalbumin. Part C. Peculiarities of Metal Binding.
High molecular mass complexes are formed with alpha-lactalbumin and alphaB-crystallin, preventing the amorphous aggregation of alpha-lactalbumin.
Title: The small heat-shock protein ?B-crystallin uses different mechanisms of chaperone action to prevent the amorphous versus fibrillar aggregation of ?-lactalbumin.
analysis of macromolecular crowding on the structural stability of human alpha-lactalbumin
Title: Effects of macromolecular crowding on the structural stability of human ?-lactalbumin.
Data show that alpha-lactalbumin and CD14 form a complex in the gut which alters degradation of CD14, suggesting a mechanism by which this key LPS receptor may remain functional in the neonatal gut.
Title: Alpha-lactalbumin in human milk alters the proteolytic degradation of soluble CD14 by forming a complex.
Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
The following LALBA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LALBA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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| CloneID | OHu17377 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_002289.2 , XM_011538343.1 | |
| Accession Version | NM_002289.2 Latest version! | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | COA |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-01 | |
| Organism | Homo sapiens(human) | |
| Product | alpha-lactalbumin precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069103.1 and BX281629.1. On Apr 19, 2005 this sequence version replaced NM_002289.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069103.1, J00270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. | |
1 | ATGAGGTTCT TTGTCCCTCT GTTCCTGGTG GGCATCCTGT TCCCTGCCAT CCTGGCCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_002280.1 |
| CDS | 27..455 |
| Misc Feature(1) | 84..440 |
| Misc Feature(2) | order(177..182,186..188,207..209,243..245,249..251,258..260,366..368,375..377,390..395) |
| Misc Feature(3) | order(180..182,228..230) |
| Misc Feature(4) | order(327..329,342..347) |
| Exon (1) | 1..159 |
| Exon (2) | 160..318 |
| Exon (3) | 319..394 |
| Exon (4) | 395..728 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_002289.2 |
ORF Insert Sequence:
1 | ATGAGGTTCT TTGTCCCTCT GTTCCTGGTG GGCATCCTGT TCCCTGCCAT CCTGGCCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu17377 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_002289.2 , XM_011538343.1 | |
| Accession Version | XM_011538343.1 Latest version! | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | COA |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-03-12 | |
| Organism | Homo sapiens(Human) | |
| Product | alpha-lactalbumin isoform X1 | |
| Comment | ||
1 | ATGAGGTTCT TTGTCCCTCT GTTCCTGGTG GGCATCCTGT TCCCTGCCAT CCTGGCCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011536645.1 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011538343.1 |
ORF Insert Sequence:
1 | ATGAGGTTCT TTGTCCCTCT GTTCCTGGTG GGCATCCTGT TCCCTGCCAT CCTGGCCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu46551 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006719395.3 | |
| Accession Version | XM_006719395.3 Latest version! | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-06 | |
| Organism | Homo sapiens(human) | |
| Product | alpha-lactalbumin isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006719395.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTTCTTGG GGGTAGCCAA AATGAGGTTC TTTGTCCCTC TGTTCCTGGT GGGCATCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006719458.1 |
| CDS | 84..533 |
| Misc Feature(1) | 162..518 |
| Misc Feature(2) | order(255..260,264..266,285..287,321..323,327..329,336..338,444..446,453..455,468..473) |
| Misc Feature(3) | order(258..260,306..308) |
| Misc Feature(4) | order(405..407,420..425) |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006719395.3 |
ORF Insert Sequence:
1 | ATGTTCTTGG GGGTAGCCAA AATGAGGTTC TTTGTCCCTC TGTTCCTGGT GGGCATCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Disorder in Milk Proteins: ?-Lactalbumin. Part C. Peculiarities of Metal Binding. |
|
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. |
|
The small heat-shock protein ?B-crystallin uses different mechanisms of chaperone action to prevent the amorphous versus fibrillar aggregation of ?-lactalbumin. |
|
Effects of macromolecular crowding on the structural stability of human ?-lactalbumin. |
|
Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. |