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MATK cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol MATK
Entrez Gene ID 4145
Full Name megakaryocyte-associated tyrosine kinase
Synonyms CHK,CTK,HHYLTK,HYL,HYLTK,Lsk
General protein information
Preferred Names

megakaryocyte-associated tyrosine kinase

Names

megakaryocyte-associated tyrosine-protein kinase
CSK homologous kinase
Csk-homologous kinase
Csk-type protein tyrosine kinase
HYL tyrosine kinase
hematopoietic consensus tyrosine-lacking kinase
hydroxyaryl-protein kinase
leukocyte carboxyl-terminal src kinase related
protein kinase HYL
tyrosine kinase MATK
tyrosine-protein kinase CTK
tyrosylprotein kinase
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

19

19p13.3
Summary The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:

600038


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_011528018.1 XP_011526320.1 megakaryocyte-associated tyrosine-protein kinase isoform X1
NM_139355.2 NP_647612.1 megakaryocyte-associated tyrosine-protein kinase isoform a
NM_002378.3 NP_002369.2 megakaryocyte-associated tyrosine-protein kinase isoform b
NM_139354.2 NP_647611.1 megakaryocyte-associated tyrosine-protein kinase isoform c

Pathways from BioSystems


Homologies


Canis lupus familiaris (dog) MATK XP_005633123.1
Mus musculus (house mouse) Matk NP_034898.1
Rattus norvegicus (Norway rat) Matk NP_068631.1
Danio rerio (zebrafish) matk XP_695792.1
Xenopus tropicalis (tropical clawed frog) matk XP_002941433.1
Homo sapiens (human) MATK NP_647612.1
Bos taurus (cattle) MATK NP_001030183.1
Gallus gallus (chicken) MATK XP_004948733.1
Pan troglodytes (chimpanzee) LOC455592 XP_512276.3

Gene Ontology


Bibliography

Related articles in PubMed

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Reyniers L, Del Giudice MG, Civiero L, Belluzzi E, Lobbestael E, Beilina A, Arrigoni G, Derua R, Waelkens E, Li Y, Crosio C, Iaccarino C, Cookson MR, Baekelandt V, Greggio E, Taymans JM
Journal of neurochemistry131(2)239-50(2014 Oct)

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Leung KK, Hause RJ Jr, Barkinge JL, Ciaccio MF, Chuu CP, Jones RB
Molecular & cellular proteomics : MCP13(7)1705-23(2014 Jul)

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA, , , Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR
Proceedings of the National Academy of Sciences of the United States of America111(7)2626-31(2014 Feb)

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S
Cell150(5)987-1001(2012 Aug)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1.
Title: IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells.

CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma.
Title: Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma.

These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells.
Title: Decreased CHK protein levels are associated with Src activation in colon cancer cells.

Progesterone increases MATK in mast cells and reducs cell proliferation.
Title: Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation.

Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation.
Title: Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus.

The following MATK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MATK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu06309 NM_139355.2
Latest version!		 Homo sapiens megakaryocyte-associated tyrosine kinase (MATK), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
OHu06310 NM_139354.2
Latest version!		 Homo sapiens megakaryocyte-associated tyrosine kinase (MATK), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu06309 XM_011528018.1
Latest version!		 Homo sapiens megakaryocyte-associated tyrosine kinase (MATK), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
OHu03046 NM_002378.3
Latest version!		 Homo sapiens megakaryocyte-associated tyrosine kinase (MATK), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu06309
Clone ID Related Accession (Same CDS sequence) XM_011528018.1 , NM_139355.2
Accession Version NM_139355.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1524bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-10-02
Organism Homo sapiens(human)
Product megakaryocyte-associated tyrosine-protein kinase isoform a
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG396388.1, BM925586.1, BC000114.1 and X77278.1. On Aug 4, 2006 this sequence version replaced NM_139355.1. Transcript Variant: This variant (1) encodes the predominant isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X77278.1, BC000114.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCGGGGC GAGGCTCTCT GGTTTCCTGG CGGGCATTTC ACGGCTGTGA TTCTGCTGAG 
GAACTTCCCC GGGTGAGCCC CCGCTTCCTC CGAGCCTGGC ACCCCCCTCC CGTCTCAGCC 
AGGATGCCAA CGAGGCGCTG GGCCCCGGGC ACCCAGTGTA TCACCAAATG CGAGCACACC 
CGCCCCAAGC CAGGGGAGCT GGCCTTCCGC AAGGGCGACG TGGTCACCAT CCTGGAGGCC 
TGCGAGAACA AGAGCTGGTA CCGCGTCAAG CACCACACCA GTGGACAGGA GGGGCTGCTG 
GCAGCTGGGG CGCTGCGGGA GCGGGAGGCC CTCTCCGCAG ACCCCAAGCT CAGCCTCATG 
CCGTGGTTCC ACGGGAAGAT CTCGGGCCAG GAGGCTGTCC AGCAGCTGCA GCCTCCCGAG 
GATGGGCTGT TCCTGGTGCG GGAGTCCGCG CGCCACCCCG GCGACTACGT CCTGTGCGTG 
AGCTTTGGCC GCGACGTCAT CCACTACCGC GTGCTGCACC GCGACGGCCA CCTCACAATC 
GATGAGGCCG TGTTCTTCTG CAACCTCATG GACATGGTGG AGCATTACAG CAAGGACAAG 
GGCGCTATCT GCACCAAGCT GGTGAGACCA AAGCGGAAAC ACGGGACCAA GTCGGCCGAG 
GAGGAGCTGG CCAGGGCGGG CTGGTTACTG AACCTGCAGC ATTTGACATT GGGAGCACAG 
ATCGGAGAGG GAGAGTTTGG AGCTGTCCTG CAGGGTGAGT ACCTGGGGCA AAAGGTGGCC 
GTGAAGAATA TCAAGTGTGA TGTGACAGCC CAGGCCTTCC TGGACGAGAC GGCCGTCATG 
ACGAAGATGC AACACGAGAA CCTGGTGCGT CTCCTGGGCG TGATCCTGCA CCAGGGGCTG 
TACATTGTCA TGGAGCACGT GAGCAAGGGC AACCTGGTGA ACTTTCTGCG GACCCGGGGT 
CGAGCCCTCG TGAACACCGC TCAGCTCCTG CAGTTTTCTC TGCACGTGGC CGAGGGCATG 
GAGTACCTGG AGAGCAAGAA GCTTGTGCAC CGCGACCTGG CCGCCCGCAA CATCCTGGTC 
TCAGAGGACC TGGTGGCCAA GGTCAGCGAC TTTGGCCTGG CCAAAGCCGA GCGGAAGGGG 
CTAGACTCAA GCCGGCTGCC CGTCAAGTGG ACGGCGCCCG AGGCTCTCAA ACACGGGAAG 
TTCACCAGCA AGTCGGATGT CTGGAGTTTT GGGGTGCTGC TCTGGGAGGT CTTCTCATAT 
GGACGGGCTC CGTACCCTAA AATGTCACTG AAAGAGGTGT CGGAGGCCGT GGAGAAGGGG 
TACCGCATGG AACCCCCCGA GGGCTGTCCA GGCCCCGTGC ACGTCCTCAT GAGCAGCTGC 
TGGGAGGCAG AGCCCGCCCG CCGGCCACCC TTCCGCAAAC TGGCCGAGAA GCTGGCCCGG 
GAGCTACGCA GTGCAGGTGC CCCAGCCTCC GTCTCAGGGC AGGACGCCGA CGGCTCCACC 
TCGCCCCGAA GCCAGGAGCC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_647612.1
CDS401..1924
Misc Feature(1)548..724
Misc Feature(2)560..715
Misc Feature(3)order(569..571,575..577,584..586,596..598,653..658,701..703,707..712)
Misc Feature(4)752..1045
Misc Feature(5)764..1036
Misc Feature(6)order(785..787,839..841,902..904,908..910)
Misc Feature(7)order(905..907,986..988)
Misc Feature(8)1082..1843
Misc Feature(9)1103..1834
Misc Feature(10)1103..1834
Misc Feature(11)order(1121..1129,1145..1147,1178..1180,1184..1186,1265..1267,1310..1321,1328..1333,1454..1456,1466..1471,1475..1477,1505..1510,1547..1561,1586..1588,1688..1690)
Misc Feature(12)order(1121..1129,1145..1147,1178..1180,1184..1186,1265..1267,1310..1321,1328..1333,1466..1471,1475..1477,1505..1510)
Misc Feature(13)order(1163..1165,1196..1198,1232..1234,1241..1246,1250..1252,1289..1291)
Misc Feature(14)order(1454..1456,1466..1468,1547..1561,1586..1588,1688..1690)
Misc Feature(15)1505..1567
Misc Feature(16)1901..1903
Exon (1)1..249
Exon (2)250..472
Exon (3)473..532
Exon (4)533..646
Exon (5)647..762
Exon (6)763..982
Exon (7)983..1076
Exon (8)1077..1142
Exon (9)1143..1242
Exon (10)1243..1327
Exon (11)1328..1401
Exon (12)1402..1597
Exon (13)1598..1684
Exon (14)1685..2138
Translation

Target ORF information:

RefSeq Version NM_139355.2
Organism Homo sapiens(human)
Definition Homo sapiens megakaryocyte-associated tyrosine kinase (MATK), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_139355.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCGGGGC GAGGCTCTCT GGTTTCCTGG CGGGCATTTC ACGGCTGTGA TTCTGCTGAG 
GAACTTCCCC GGGTGAGCCC CCGCTTCCTC CGAGCCTGGC ACCCCCCTCC CGTCTCAGCC 
AGGATGCCAA CGAGGCGCTG GGCCCCGGGC ACCCAGTGTA TCACCAAATG CGAGCACACC 
CGCCCCAAGC CAGGGGAGCT GGCCTTCCGC AAGGGCGACG TGGTCACCAT CCTGGAGGCC 
TGCGAGAACA AGAGCTGGTA CCGCGTCAAG CACCACACCA GTGGACAGGA GGGGCTGCTG 
GCAGCTGGGG CGCTGCGGGA GCGGGAGGCC CTCTCCGCAG ACCCCAAGCT CAGCCTCATG 
CCGTGGTTCC ACGGGAAGAT CTCGGGCCAG GAGGCTGTCC AGCAGCTGCA GCCTCCCGAG 
GATGGGCTGT TCCTGGTGCG GGAGTCCGCG CGCCACCCCG GCGACTACGT CCTGTGCGTG 
AGCTTTGGCC GCGACGTCAT CCACTACCGC GTGCTGCACC GCGACGGCCA CCTCACAATC 
GATGAGGCCG TGTTCTTCTG CAACCTCATG GACATGGTGG AGCATTACAG CAAGGACAAG 
GGCGCTATCT GCACCAAGCT GGTGAGACCA AAGCGGAAAC ACGGGACCAA GTCGGCCGAG 
GAGGAGCTGG CCAGGGCGGG CTGGTTACTG AACCTGCAGC ATTTGACATT GGGAGCACAG 
ATCGGAGAGG GAGAGTTTGG AGCTGTCCTG CAGGGTGAGT ACCTGGGGCA AAAGGTGGCC 
GTGAAGAATA TCAAGTGTGA TGTGACAGCC CAGGCCTTCC TGGACGAGAC GGCCGTCATG 
ACGAAGATGC AACACGAGAA CCTGGTGCGT CTCCTGGGCG TGATCCTGCA CCAGGGGCTG 
TACATTGTCA TGGAGCACGT GAGCAAGGGC AACCTGGTGA ACTTTCTGCG GACCCGGGGT 
CGAGCCCTCG TGAACACCGC TCAGCTCCTG CAGTTTTCTC TGCACGTGGC CGAGGGCATG 
GAGTACCTGG AGAGCAAGAA GCTTGTGCAC CGCGACCTGG CCGCCCGCAA CATCCTGGTC 
TCAGAGGACC TGGTGGCCAA GGTCAGCGAC TTTGGCCTGG CCAAAGCCGA GCGGAAGGGG 
CTAGACTCAA GCCGGCTGCC CGTCAAGTGG ACGGCGCCCG AGGCTCTCAA ACACGGGAAG 
TTCACCAGCA AGTCGGATGT CTGGAGTTTT GGGGTGCTGC TCTGGGAGGT CTTCTCATAT 
GGACGGGCTC CGTACCCTAA AATGTCACTG AAAGAGGTGT CGGAGGCCGT GGAGAAGGGG 
TACCGCATGG AACCCCCCGA GGGCTGTCCA GGCCCCGTGC ACGTCCTCAT GAGCAGCTGC 
TGGGAGGCAG AGCCCGCCCG CCGGCCACCC TTCCGCAAAC TGGCCGAGAA GCTGGCCCGG 
GAGCTACGCA GTGCAGGTGC CCCAGCCTCC GTCTCAGGGC AGGACGCCGA CGGCTCCACC 
TCGCCCCGAA GCCAGGAGCC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu06310
Clone ID Related Accession (Same CDS sequence) NM_139354.2
Accession Version NM_139354.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1401bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-10-02
Organism Homo sapiens(human)
Product megakaryocyte-associated tyrosine-protein kinase isoform c
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG396388.1, BQ109562.1, AL137754.1 and X77278.1. On Aug 4, 2006 this sequence version replaced NM_139354.1. Transcript Variant: This variant (3) lacks an exon in the coding region, and utilizes a downstream in-frame start codon, compared to variant 1. Isoform c has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL137754.1, AK225834.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCCAACGA GGCGCTGGGC CCCGGGCACC CAGTGTATCA CCAAATGCGA GCACACCCGC 
CCCAAGCCAG GGGAGCTGGC CTTCCGCAAG GGCGACGTGG TCACCATCCT GGAGGCCTGC 
GAGAACAAGA GCTGGTACCG CGTCAAGCAC CACACCAGTG GACAGGAGGG GCTGCTGGCA 
GCTGGGGCGC TGCGGGAGCG GGAGGCCCTC TCCGCAGACC CCAAGCTCAG CCTCATGCCG 
TGGTTCCACG GGAAGATCTC GGGCCAGGAG GCTGTCCAGC AGCTGCAGCC TCCCGAGGAT 
GGGCTGTTCC TGGTGCGGGA GTCCGCGCGC CACCCCGGCG ACTACGTCCT GTGCGTGAGC 
TTTGGCCGCG ACGTCATCCA CTACCGCGTG CTGCACCGCG ACGGCCACCT CACAATCGAT 
GAGGCCGTGT TCTTCTGCAA CCTCATGGAC ATGGTGGAGC ATTACAGCAA GGACAAGGGC 
GCTATCTGCA CCAAGCTGGT GAGACCAAAG CGGAAACACG GGACCAAGTC GGCCGAGGAG 
GAGCTGGCCA GGGCGGGCTG GTTACTGAAC CTGCAGCATT TGACATTGGG AGCACAGATC 
GGAGAGGGAG AGTTTGGAGC TGTCCTGCAG GGTGAGTACC TGGGGCAAAA GGTGGCCGTG 
AAGAATATCA AGTGTGATGT GACAGCCCAG GCCTTCCTGG ACGAGACGGC CGTCATGACG 
AAGATGCAAC ACGAGAACCT GGTGCGTCTC CTGGGCGTGA TCCTGCACCA GGGGCTGTAC 
ATTGTCATGG AGCACGTGAG CAAGGGCAAC CTGGTGAACT TTCTGCGGAC CCGGGGTCGA 
GCCCTCGTGA ACACCGCTCA GCTCCTGCAG TTTTCTCTGC ACGTGGCCGA GGGCATGGAG 
TACCTGGAGA GCAAGAAGCT TGTGCACCGC GACCTGGCCG CCCGCAACAT CCTGGTCTCA 
GAGGACCTGG TGGCCAAGGT CAGCGACTTT GGCCTGGCCA AAGCCGAGCG GAAGGGGCTA 
GACTCAAGCC GGCTGCCCGT CAAGTGGACG GCGCCCGAGG CTCTCAAACA CGGGAAGTTC 
ACCAGCAAGT CGGATGTCTG GAGTTTTGGG GTGCTGCTCT GGGAGGTCTT CTCATATGGA 
CGGGCTCCGT ACCCTAAAAT GTCACTGAAA GAGGTGTCGG AGGCCGTGGA GAAGGGGTAC 
CGCATGGAAC CCCCCGAGGG CTGTCCAGGC CCCGTGCACG TCCTCATGAG CAGCTGCTGG 
GAGGCAGAGC CCGCCCGCCG GCCACCCTTC CGCAAACTGG CCGAGAAGCT GGCCCGGGAG 
CTACGCAGTG CAGGTGCCCC AGCCTCCGTC TCAGGGCAGG ACGCCGACGG CTCCACCTCG 
CCCCGAAGCC AGGAGCCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_647611.1
CDS301..1701
Misc Feature(1)127..129
Misc Feature(2)325..501
Misc Feature(3)337..492
Misc Feature(4)order(346..348,352..354,361..363,373..375,430..435,478..480,484..489)
Misc Feature(5)529..822
Misc Feature(6)541..813
Misc Feature(7)order(562..564,616..618,679..681,685..687)
Misc Feature(8)order(682..684,763..765)
Misc Feature(9)859..1620
Misc Feature(10)880..1611
Misc Feature(11)880..1611
Misc Feature(12)order(898..906,922..924,955..957,961..963,1042..1044,1087..1098,1105..1110,1231..1233,1243..1248,1252..1254,1282..1287,1324..1338,1363..1365,1465..1467)
Misc Feature(13)order(898..906,922..924,955..957,961..963,1042..1044,1087..1098,1105..1110,1243..1248,1252..1254,1282..1287)
Misc Feature(14)order(940..942,973..975,1009..1011,1018..1023,1027..1029,1066..1068)
Misc Feature(15)order(1231..1233,1243..1245,1324..1338,1363..1365,1465..1467)
Misc Feature(16)1282..1344
Exon (1)1..249
Exon (2)250..309
Exon (3)310..423
Exon (4)424..539
Exon (5)540..759
Exon (6)760..853
Exon (7)854..919
Exon (8)920..1019
Exon (9)1020..1104
Exon (10)1105..1178
Exon (11)1179..1374
Exon (12)1375..1461
Exon (13)1462..1915
Translation

Target ORF information:

RefSeq Version NM_139354.2
Organism Homo sapiens(human)
Definition Homo sapiens megakaryocyte-associated tyrosine kinase (MATK), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_139354.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCCAACGA GGCGCTGGGC CCCGGGCACC CAGTGTATCA CCAAATGCGA GCACACCCGC 
CCCAAGCCAG GGGAGCTGGC CTTCCGCAAG GGCGACGTGG TCACCATCCT GGAGGCCTGC 
GAGAACAAGA GCTGGTACCG CGTCAAGCAC CACACCAGTG GACAGGAGGG GCTGCTGGCA 
GCTGGGGCGC TGCGGGAGCG GGAGGCCCTC TCCGCAGACC CCAAGCTCAG CCTCATGCCG 
TGGTTCCACG GGAAGATCTC GGGCCAGGAG GCTGTCCAGC AGCTGCAGCC TCCCGAGGAT 
GGGCTGTTCC TGGTGCGGGA GTCCGCGCGC CACCCCGGCG ACTACGTCCT GTGCGTGAGC 
TTTGGCCGCG ACGTCATCCA CTACCGCGTG CTGCACCGCG ACGGCCACCT CACAATCGAT 
GAGGCCGTGT TCTTCTGCAA CCTCATGGAC ATGGTGGAGC ATTACAGCAA GGACAAGGGC 
GCTATCTGCA CCAAGCTGGT GAGACCAAAG CGGAAACACG GGACCAAGTC GGCCGAGGAG 
GAGCTGGCCA GGGCGGGCTG GTTACTGAAC CTGCAGCATT TGACATTGGG AGCACAGATC 
GGAGAGGGAG AGTTTGGAGC TGTCCTGCAG GGTGAGTACC TGGGGCAAAA GGTGGCCGTG 
AAGAATATCA AGTGTGATGT GACAGCCCAG GCCTTCCTGG ACGAGACGGC CGTCATGACG 
AAGATGCAAC ACGAGAACCT GGTGCGTCTC CTGGGCGTGA TCCTGCACCA GGGGCTGTAC 
ATTGTCATGG AGCACGTGAG CAAGGGCAAC CTGGTGAACT TTCTGCGGAC CCGGGGTCGA 
GCCCTCGTGA ACACCGCTCA GCTCCTGCAG TTTTCTCTGC ACGTGGCCGA GGGCATGGAG 
TACCTGGAGA GCAAGAAGCT TGTGCACCGC GACCTGGCCG CCCGCAACAT CCTGGTCTCA 
GAGGACCTGG TGGCCAAGGT CAGCGACTTT GGCCTGGCCA AAGCCGAGCG GAAGGGGCTA 
GACTCAAGCC GGCTGCCCGT CAAGTGGACG GCGCCCGAGG CTCTCAAACA CGGGAAGTTC 
ACCAGCAAGT CGGATGTCTG GAGTTTTGGG GTGCTGCTCT GGGAGGTCTT CTCATATGGA 
CGGGCTCCGT ACCCTAAAAT GTCACTGAAA GAGGTGTCGG AGGCCGTGGA GAAGGGGTAC 
CGCATGGAAC CCCCCGAGGG CTGTCCAGGC CCCGTGCACG TCCTCATGAG CAGCTGCTGG 
GAGGCAGAGC CCGCCCGCCG GCCACCCTTC CGCAAACTGG CCGAGAAGCT GGCCCGGGAG 
CTACGCAGTG CAGGTGCCCC AGCCTCCGTC TCAGGGCAGG ACGCCGACGG CTCCACCTCG 
CCCCGAAGCC AGGAGCCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu06309
Clone ID Related Accession (Same CDS sequence) XM_011528018.1 , NM_139355.2
Accession Version XM_011528018.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1524bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(human)
Product megakaryocyte-associated tyrosine-protein kinase isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCGGGGC GAGGCTCTCT GGTTTCCTGG CGGGCATTTC ACGGCTGTGA TTCTGCTGAG 
GAACTTCCCC GGGTGAGCCC CCGCTTCCTC CGAGCCTGGC ACCCCCCTCC CGTCTCAGCC 
AGGATGCCAA CGAGGCGCTG GGCCCCGGGC ACCCAGTGTA TCACCAAATG CGAGCACACC 
CGCCCCAAGC CAGGGGAGCT GGCCTTCCGC AAGGGCGACG TGGTCACCAT CCTGGAGGCC 
TGCGAGAACA AGAGCTGGTA CCGCGTCAAG CACCACACCA GTGGACAGGA GGGGCTGCTG 
GCAGCTGGGG CGCTGCGGGA GCGGGAGGCC CTCTCCGCAG ACCCCAAGCT CAGCCTCATG 
CCGTGGTTCC ACGGGAAGAT CTCGGGCCAG GAGGCTGTCC AGCAGCTGCA GCCTCCCGAG 
GATGGGCTGT TCCTGGTGCG GGAGTCCGCG CGCCACCCCG GCGACTACGT CCTGTGCGTG 
AGCTTTGGCC GCGACGTCAT CCACTACCGC GTGCTGCACC GCGACGGCCA CCTCACAATC 
GATGAGGCCG TGTTCTTCTG CAACCTCATG GACATGGTGG AGCATTACAG CAAGGACAAG 
GGCGCTATCT GCACCAAGCT GGTGAGACCA AAGCGGAAAC ACGGGACCAA GTCGGCCGAG 
GAGGAGCTGG CCAGGGCGGG CTGGTTACTG AACCTGCAGC ATTTGACATT GGGAGCACAG 
ATCGGAGAGG GAGAGTTTGG AGCTGTCCTG CAGGGTGAGT ACCTGGGGCA AAAGGTGGCC 
GTGAAGAATA TCAAGTGTGA TGTGACAGCC CAGGCCTTCC TGGACGAGAC GGCCGTCATG 
ACGAAGATGC AACACGAGAA CCTGGTGCGT CTCCTGGGCG TGATCCTGCA CCAGGGGCTG 
TACATTGTCA TGGAGCACGT GAGCAAGGGC AACCTGGTGA ACTTTCTGCG GACCCGGGGT 
CGAGCCCTCG TGAACACCGC TCAGCTCCTG CAGTTTTCTC TGCACGTGGC CGAGGGCATG 
GAGTACCTGG AGAGCAAGAA GCTTGTGCAC CGCGACCTGG CCGCCCGCAA CATCCTGGTC 
TCAGAGGACC TGGTGGCCAA GGTCAGCGAC TTTGGCCTGG CCAAAGCCGA GCGGAAGGGG 
CTAGACTCAA GCCGGCTGCC CGTCAAGTGG ACGGCGCCCG AGGCTCTCAA ACACGGGAAG 
TTCACCAGCA AGTCGGATGT CTGGAGTTTT GGGGTGCTGC TCTGGGAGGT CTTCTCATAT 
GGACGGGCTC CGTACCCTAA AATGTCACTG AAAGAGGTGT CGGAGGCCGT GGAGAAGGGG 
TACCGCATGG AACCCCCCGA GGGCTGTCCA GGCCCCGTGC ACGTCCTCAT GAGCAGCTGC 
TGGGAGGCAG AGCCCGCCCG CCGGCCACCC TTCCGCAAAC TGGCCGAGAA GCTGGCCCGG 
GAGCTACGCA GTGCAGGTGC CCCAGCCTCC GTCTCAGGGC AGGACGCCGA CGGCTCCACC 
TCGCCCCGAA GCCAGGAGCC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011526320.1
CDS556..2079
Misc Feature(1)703..879
Misc Feature(2)order(724..726,730..732,739..741,751..753,808..813,856..858,862..867)
Misc Feature(3)907..1200
Misc Feature(4)order(940..942,994..996,1057..1059,1063..1065)
Misc Feature(5)order(1060..1062,1141..1143)
Misc Feature(6)1237..1998
Misc Feature(7)1258..1989
Misc Feature(8)order(1276..1284,1300..1302,1333..1335,1339..1341,1420..1422,1465..1476,1483..1488,1609..1611,1621..1626,1630..1632,1660..1665,1702..1716,1741..1743,1843..1845)
Misc Feature(9)order(1276..1284,1300..1302,1333..1335,1339..1341,1420..1422,1465..1476,1483..1488,1621..1626,1630..1632,1660..1665)
Misc Feature(10)order(1318..1320,1351..1353,1387..1389,1396..1401,1405..1407,1444..1446)
Misc Feature(11)order(1609..1611,1621..1623,1702..1716,1741..1743,1843..1845)
Misc Feature(12)1660..1722
Translation

Target ORF information:

RefSeq Version XM_011528018.1
Organism Homo sapiens(human)
Definition Homo sapiens megakaryocyte-associated tyrosine kinase (MATK), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011528018.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCGGGGC GAGGCTCTCT GGTTTCCTGG CGGGCATTTC ACGGCTGTGA TTCTGCTGAG 
GAACTTCCCC GGGTGAGCCC CCGCTTCCTC CGAGCCTGGC ACCCCCCTCC CGTCTCAGCC 
AGGATGCCAA CGAGGCGCTG GGCCCCGGGC ACCCAGTGTA TCACCAAATG CGAGCACACC 
CGCCCCAAGC CAGGGGAGCT GGCCTTCCGC AAGGGCGACG TGGTCACCAT CCTGGAGGCC 
TGCGAGAACA AGAGCTGGTA CCGCGTCAAG CACCACACCA GTGGACAGGA GGGGCTGCTG 
GCAGCTGGGG CGCTGCGGGA GCGGGAGGCC CTCTCCGCAG ACCCCAAGCT CAGCCTCATG 
CCGTGGTTCC ACGGGAAGAT CTCGGGCCAG GAGGCTGTCC AGCAGCTGCA GCCTCCCGAG 
GATGGGCTGT TCCTGGTGCG GGAGTCCGCG CGCCACCCCG GCGACTACGT CCTGTGCGTG 
AGCTTTGGCC GCGACGTCAT CCACTACCGC GTGCTGCACC GCGACGGCCA CCTCACAATC 
GATGAGGCCG TGTTCTTCTG CAACCTCATG GACATGGTGG AGCATTACAG CAAGGACAAG 
GGCGCTATCT GCACCAAGCT GGTGAGACCA AAGCGGAAAC ACGGGACCAA GTCGGCCGAG 
GAGGAGCTGG CCAGGGCGGG CTGGTTACTG AACCTGCAGC ATTTGACATT GGGAGCACAG 
ATCGGAGAGG GAGAGTTTGG AGCTGTCCTG CAGGGTGAGT ACCTGGGGCA AAAGGTGGCC 
GTGAAGAATA TCAAGTGTGA TGTGACAGCC CAGGCCTTCC TGGACGAGAC GGCCGTCATG 
ACGAAGATGC AACACGAGAA CCTGGTGCGT CTCCTGGGCG TGATCCTGCA CCAGGGGCTG 
TACATTGTCA TGGAGCACGT GAGCAAGGGC AACCTGGTGA ACTTTCTGCG GACCCGGGGT 
CGAGCCCTCG TGAACACCGC TCAGCTCCTG CAGTTTTCTC TGCACGTGGC CGAGGGCATG 
GAGTACCTGG AGAGCAAGAA GCTTGTGCAC CGCGACCTGG CCGCCCGCAA CATCCTGGTC 
TCAGAGGACC TGGTGGCCAA GGTCAGCGAC TTTGGCCTGG CCAAAGCCGA GCGGAAGGGG 
CTAGACTCAA GCCGGCTGCC CGTCAAGTGG ACGGCGCCCG AGGCTCTCAA ACACGGGAAG 
TTCACCAGCA AGTCGGATGT CTGGAGTTTT GGGGTGCTGC TCTGGGAGGT CTTCTCATAT 
GGACGGGCTC CGTACCCTAA AATGTCACTG AAAGAGGTGT CGGAGGCCGT GGAGAAGGGG 
TACCGCATGG AACCCCCCGA GGGCTGTCCA GGCCCCGTGC ACGTCCTCAT GAGCAGCTGC 
TGGGAGGCAG AGCCCGCCCG CCGGCCACCC TTCCGCAAAC TGGCCGAGAA GCTGGCCCGG 
GAGCTACGCA GTGCAGGTGC CCCAGCCTCC GTCTCAGGGC AGGACGCCGA CGGCTCCACC 
TCGCCCCGAA GCCAGGAGCC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03046
Clone ID Related Accession (Same CDS sequence) NM_002378.3
Accession Version NM_002378.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1527bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-10-02
Organism Homo sapiens(human)
Product megakaryocyte-associated tyrosine-protein kinase isoform b
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK055395.1, DA592994.1, BC000114.1 and X77278.1. On Aug 4, 2006 this sequence version replaced NM_002378.2. Transcript Variant: This variant (2) contains an alternate region at the 5' end of the coding region and lacks two exons in the coding region, as compared to variant 1. The encoded isoform b has a slightly longer and unique N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK055395.1, SRR1660805.125799.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCAGGGAC ATTTCCCTGC TGAACGAAGA GAAGGCAGAC CTCGGCGAGG GACCCGTGGT 
CAGCAGCAGC TTCTGGTGAG CCCCCGCTTC CTCCGAGCCT GGCACCCCCC TCCCGTCTCA 
GCCAGGATGC CAACGAGGCG CTGGGCCCCG GGCACCCAGT GTATCACCAA ATGCGAGCAC 
ACCCGCCCCA AGCCAGGGGA GCTGGCCTTC CGCAAGGGCG ACGTGGTCAC CATCCTGGAG 
GCCTGCGAGA ACAAGAGCTG GTACCGCGTC AAGCACCACA CCAGTGGACA GGAGGGGCTG 
CTGGCAGCTG GGGCGCTGCG GGAGCGGGAG GCCCTCTCCG CAGACCCCAA GCTCAGCCTC 
ATGCCGTGGT TCCACGGGAA GATCTCGGGC CAGGAGGCTG TCCAGCAGCT GCAGCCTCCC 
GAGGATGGGC TGTTCCTGGT GCGGGAGTCC GCGCGCCACC CCGGCGACTA CGTCCTGTGC 
GTGAGCTTTG GCCGCGACGT CATCCACTAC CGCGTGCTGC ACCGCGACGG CCACCTCACA 
ATCGATGAGG CCGTGTTCTT CTGCAACCTC ATGGACATGG TGGAGCATTA CAGCAAGGAC 
AAGGGCGCTA TCTGCACCAA GCTGGTGAGA CCAAAGCGGA AACACGGGAC CAAGTCGGCC 
GAGGAGGAGC TGGCCAGGGC GGGCTGGTTA CTGAACCTGC AGCATTTGAC ATTGGGAGCA 
CAGATCGGAG AGGGAGAGTT TGGAGCTGTC CTGCAGGGTG AGTACCTGGG GCAAAAGGTG 
GCCGTGAAGA ATATCAAGTG TGATGTGACA GCCCAGGCCT TCCTGGACGA GACGGCCGTC 
ATGACGAAGA TGCAACACGA GAACCTGGTG CGTCTCCTGG GCGTGATCCT GCACCAGGGG 
CTGTACATTG TCATGGAGCA CGTGAGCAAG GGCAACCTGG TGAACTTTCT GCGGACCCGG 
GGTCGAGCCC TCGTGAACAC CGCTCAGCTC CTGCAGTTTT CTCTGCACGT GGCCGAGGGC 
ATGGAGTACC TGGAGAGCAA GAAGCTTGTG CACCGCGACC TGGCCGCCCG CAACATCCTG 
GTCTCAGAGG ACCTGGTGGC CAAGGTCAGC GACTTTGGCC TGGCCAAAGC CGAGCGGAAG 
GGGCTAGACT CAAGCCGGCT GCCCGTCAAG TGGACGGCGC CCGAGGCTCT CAAACACGGG 
AAGTTCACCA GCAAGTCGGA TGTCTGGAGT TTTGGGGTGC TGCTCTGGGA GGTCTTCTCA 
TATGGACGGG CTCCGTACCC TAAAATGTCA CTGAAAGAGG TGTCGGAGGC CGTGGAGAAG 
GGGTACCGCA TGGAACCCCC CGAGGGCTGT CCAGGCCCCG TGCACGTCCT CATGAGCAGC 
TGCTGGGAGG CAGAGCCCGC CCGCCGGCCA CCCTTCCGCA AACTGGCCGA GAAGCTGGCC 
CGGGAGCTAC GCAGTGCAGG TGCCCCAGCC TCCGTCTCAG GGCAGGACGC CGACGGCTCC 
ACCTCGCCCC GAAGCCAGGA GCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002369.2
CDS339..1865
Misc Feature(1)1..413
Misc Feature(2)315..317
Misc Feature(3)489..665
Misc Feature(4)501..656
Misc Feature(5)order(510..512,516..518,525..527,537..539,594..599,642..644,648..653)
Misc Feature(6)693..986
Misc Feature(7)705..977
Misc Feature(8)order(726..728,780..782,843..845,849..851)
Misc Feature(9)order(846..848,927..929)
Misc Feature(10)1023..1784
Misc Feature(11)1044..1775
Misc Feature(12)1044..1775
Misc Feature(13)order(1062..1070,1086..1088,1119..1121,1125..1127,1206..1208,1251..1262,1269..1274,1395..1397,1407..1412,1416..1418,1446..1451,1488..1502,1527..1529,1629..1631)
Misc Feature(14)order(1062..1070,1086..1088,1119..1121,1125..1127,1206..1208,1251..1262,1269..1274,1407..1412,1416..1418,1446..1451)
Misc Feature(15)order(1104..1106,1137..1139,1173..1175,1182..1187,1191..1193,1230..1232)
Misc Feature(16)order(1395..1397,1407..1409,1488..1502,1527..1529,1629..1631)
Misc Feature(17)1446..1508
Exon (1)1..281
Exon (2)282..413
Exon (3)414..473
Exon (4)474..587
Exon (5)588..703
Exon (6)704..923
Exon (7)924..1017
Exon (8)1018..1083
Exon (9)1084..1183
Exon (10)1184..1268
Exon (11)1269..1342
Exon (12)1343..1538
Exon (13)1539..1625
Exon (14)1626..2079
Translation

Target ORF information:

RefSeq Version NM_002378.3
Organism Homo sapiens(human)
Definition Homo sapiens megakaryocyte-associated tyrosine kinase (MATK), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_002378.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCAGGGAC ATTTCCCTGC TGAACGAAGA GAAGGCAGAC CTCGGCGAGG GACCCGTGGT 
CAGCAGCAGC TTCTGGTGAG CCCCCGCTTC CTCCGAGCCT GGCACCCCCC TCCCGTCTCA 
GCCAGGATGC CAACGAGGCG CTGGGCCCCG GGCACCCAGT GTATCACCAA ATGCGAGCAC 
ACCCGCCCCA AGCCAGGGGA GCTGGCCTTC CGCAAGGGCG ACGTGGTCAC CATCCTGGAG 
GCCTGCGAGA ACAAGAGCTG GTACCGCGTC AAGCACCACA CCAGTGGACA GGAGGGGCTG 
CTGGCAGCTG GGGCGCTGCG GGAGCGGGAG GCCCTCTCCG CAGACCCCAA GCTCAGCCTC 
ATGCCGTGGT TCCACGGGAA GATCTCGGGC CAGGAGGCTG TCCAGCAGCT GCAGCCTCCC 
GAGGATGGGC TGTTCCTGGT GCGGGAGTCC GCGCGCCACC CCGGCGACTA CGTCCTGTGC 
GTGAGCTTTG GCCGCGACGT CATCCACTAC CGCGTGCTGC ACCGCGACGG CCACCTCACA 
ATCGATGAGG CCGTGTTCTT CTGCAACCTC ATGGACATGG TGGAGCATTA CAGCAAGGAC 
AAGGGCGCTA TCTGCACCAA GCTGGTGAGA CCAAAGCGGA AACACGGGAC CAAGTCGGCC 
GAGGAGGAGC TGGCCAGGGC GGGCTGGTTA CTGAACCTGC AGCATTTGAC ATTGGGAGCA 
CAGATCGGAG AGGGAGAGTT TGGAGCTGTC CTGCAGGGTG AGTACCTGGG GCAAAAGGTG 
GCCGTGAAGA ATATCAAGTG TGATGTGACA GCCCAGGCCT TCCTGGACGA GACGGCCGTC 
ATGACGAAGA TGCAACACGA GAACCTGGTG CGTCTCCTGG GCGTGATCCT GCACCAGGGG 
CTGTACATTG TCATGGAGCA CGTGAGCAAG GGCAACCTGG TGAACTTTCT GCGGACCCGG 
GGTCGAGCCC TCGTGAACAC CGCTCAGCTC CTGCAGTTTT CTCTGCACGT GGCCGAGGGC 
ATGGAGTACC TGGAGAGCAA GAAGCTTGTG CACCGCGACC TGGCCGCCCG CAACATCCTG 
GTCTCAGAGG ACCTGGTGGC CAAGGTCAGC GACTTTGGCC TGGCCAAAGC CGAGCGGAAG 
GGGCTAGACT CAAGCCGGCT GCCCGTCAAG TGGACGGCGC CCGAGGCTCT CAAACACGGG 
AAGTTCACCA GCAAGTCGGA TGTCTGGAGT TTTGGGGTGC TGCTCTGGGA GGTCTTCTCA 
TATGGACGGG CTCCGTACCC TAAAATGTCA CTGAAAGAGG TGTCGGAGGC CGTGGAGAAG 
GGGTACCGCA TGGAACCCCC CGAGGGCTGT CCAGGCCCCG TGCACGTCCT CATGAGCAGC 
TGCTGGGAGG CAGAGCCCGC CCGCCGGCCA CCCTTCCGCA AACTGGCCGA GAAGCTGGCC 
CGGGAGCTAC GCAGTGCAGG TGCCCCAGCC TCCGTCTCAG GGCAGGACGC CGACGGCTCC 
ACCTCGCCCC GAAGCCAGGA GCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Journal of neurochemistry131(2)239-50(2014 Oct)
Reyniers L,Del Giudice MG,Civiero L,Belluzzi E,Lobbestael E,Beilina A,Arrigoni G,Derua R,Waelkens E,Li Y,Crosio C,Iaccarino C,Cookson MR,Baekelandt V,Greggio E,Taymans JM


book

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Molecular & cellular proteomics : MCP13(7)1705-23(2014 Jul)
Leung KK,Hause RJ Jr,Barkinge JL,Ciaccio MF,Chuu CP,Jones RB


book

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America111(7)2626-31(2014 Feb)
Beilina A,Rudenko IN,Kaganovich A,Civiero L,Chau H,Kalia SK,Kalia LV,Lobbestael E,Chia R,Ndukwe K,Ding J,Nalls MA,,,Olszewski M,Hauser DN,Kumaran R,Lozano AM,Baekelandt V,Greene LE,Taymans JM,Greggio E,Cookson MR


book

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Cell150(5)987-1001(2012 Aug)
Taipale M,Krykbaeva I,Koeva M,Kayatekin C,Westover KD,Karras GI,Lindquist S


book

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF