MICB cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | MICB |
| Entrez Gene ID | 4277 |
| Full Name | MHC class I polypeptide-related sequence B |
| Synonyms | PERB11.2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_005931.4 | NP_005922.2 | MHC class I polypeptide-related sequence B isoform 1 precursor |
| NM_001289160.1 | NP_001276089.1 | MHC class I polypeptide-related sequence B isoform 2 |
| NM_001289161.1 | NP_001276090.1 | MHC class I polypeptide-related sequence B isoform 3 precursor |
| Pan troglodytes (chimpanzee) | MICB | NP_001038959.1 |
| Mus musculus (house mouse) | Mill2 | NP_715641.1 |
| CD9 | NP_001108437.1 | |
| Bos taurus (cattle) | MIC1 | NP_001120789.1 |
| Rattus norvegicus (Norway rat) | Micb | NP_001017468.1 |
| Homo sapiens (human) | MICB | NP_005922.2 |
| MICB | NP_001108428.1 |
Related articles in PubMed
Association Between Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms and Susceptibility of Systemic Lupus Erythematosus.
Yu P, Zhu Q, Chen C, Fu X, Li Y, Liu L, Luo Q, Wang F, Wang Y
The American journal of the medical sciences354(4)430-435(2017 Oct)
Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue.
Whitehorn J, Kien DTH, Quyen NTH, Wills B, Van Vinh Chau N, Tam DTH, Tuan NM, Jaenisch T, Hibberd M, Khor CC, Simmons CP
BMC infectious diseases17(1)412(2017 06)
Vigilin Regulates the Expression of the Stress-Induced Ligand MICB by Interacting with Its 5' Untranslated Region.
Berhani O, Nachmani D, Yamin R, Schmiedel D, Bar-On Y, Mandelboim O
Journal of immunology (Baltimore, Md. : 1950)198(9)3662-3670(2017 May)
MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.
Ghadially H, Brown L, Lloyd C, Lewis L, Lewis A, Dillon J, Sainson R, Jovanovic J, Tigue NJ, Bannister D, Bamber L, Valge-Archer V, Wilkinson RW
British journal of cancer116(9)1208-1217(2017 Apr)
Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population.
Zhang YM, Zhou XJ, Cheng FJ, Qi YY, Hou P, Zhao MH, Zhang H
Journal of immunology research20161343760(2016)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The results of this study suggested that the MICB*009N allele might be a risk factor for SLE, whereas the MICB*014, MICA*010 and MICB*002 alleles were associated with reduced incidence of SLE in the study population.
Title: Association Between Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms and Susceptibility of Systemic Lupus Erythematosus.
No association between MICB genotype and early viremia level in dengue patients.
Title: Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue.
this study shows that vigilin (HDLBP) binds and negatively regulates MICB expression through its 5'UTR, and that vigilin downregulation in target cells leads to NK cell activation against said target cells
Title: Vigilin Regulates the Expression of the Stress-Induced Ligand MICB by Interacting with Its 5' Untranslated Region.
This demonstrates for the first time that MICA/B is more broadly expressed in normal tissue and that expression is mainly intracellular with only a small fraction appearing on the cell surface of some epithelia and tumour cells.
Title: MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.
we have found that the allele G of rs3828903 was significantly associated with risk susceptibility to SLE in the current population. These data together with the functional annotations of rs3828903 convert MICB into a main candidate for being an additional MHC gene associated with SLE susceptibility.
Title: Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population.
The following MICB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MICB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu15606 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001289160.1 | |
| Accession Version | NM_001289160.1 Latest version! | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-12 | |
| Organism | Homo sapiens(human) | |
| Product | MHC class I polypeptide-related sequence B isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB121254.1, AK300791.1, DC364717.1, AK303655.1, CN389975.1, BC044218.1 and BQ216247.1. On or before Jan 16, 2014 this sequence version replaced XM_005249125.1, XM_005272818.1, XM_005274863.1, XM_005275250.1, XM_005275408.1, XM_005275556.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300791.1, SRR1163658.57237.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGTGCTGT CCCAGGATGG ATCTGTGCAG TCAGGGTTTC TCGCTGAGGG ACATCTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001276089.1 |
| CDS | 142..1197 |
| Misc Feature(1) | 112..114 |
| Misc Feature(2) | 148..639 |
| Misc Feature(3) | 658..933 |
| Misc Feature(4) | order(715..717,721..723,805..810,814..822,838..840,844..846) |
| Misc Feature(5) | order(736..744,829..831,904..906) |
| Exon (1) | 1..115 |
| Exon (2) | 116..370 |
| Exon (3) | 371..658 |
| Exon (4) | 659..937 |
| Exon (5) | 938..1069 |
| Exon (6) | 1070..2412 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001289160.1 |
ORF Insert Sequence:
1 | ATGGTGCTGT CCCAGGATGG ATCTGTGCAG TCAGGGTTTC TCGCTGAGGG ACATCTGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu15629 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001289161.1 | |
| Accession Version | NM_001289161.1 Latest version! | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-12 | |
| Organism | Homo sapiens(human) | |
| Product | MHC class I polypeptide-related sequence B isoform 3 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL663061.8, BC044218.1, DC364717.1, CN389975.1 and BQ216247.1. On or before Jan 16, 2014 this sequence version replaced XM_005249126.1, XM_005272819.1, XM_005274864.1, XM_005274976.1, XM_005275251.1, XM_005275409.1, XM_005275557.1. Transcript Variant: This variant (3) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isofom 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC044218.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGGGCTGG GCCGGGTCCT GCTGTTTCTG GCCGTCGCCT TCCCTTTTGC ACCCCCGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001276090.1 |
| CDS | 145..1167 |
| Misc Feature(1) | 121..123 |
| Misc Feature(2) | 214..>444 |
| Misc Feature(3) | 628..903 |
| Misc Feature(4) | order(685..687,691..693,775..780,784..792,808..810,814..816) |
| Misc Feature(5) | order(706..714,799..801,874..876) |
| Exon (1) | 1..214 |
| Exon (2) | 215..469 |
| Exon (3) | 470..628 |
| Exon (4) | 629..907 |
| Exon (5) | 908..1039 |
| Exon (6) | 1040..2382 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001289161.1 |
ORF Insert Sequence:
1 | ATGGGGCTGG GCCGGGTCCT GCTGTTTCTG GCCGTCGCCT TCCCTTTTGC ACCCCCGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu21386 | |
| Clone ID Related Accession (Same CDS sequence) | NM_005931.4 | |
| Accession Version | NM_005931.4 Latest version! | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-12 | |
| Organism | Homo sapiens(human) | |
| Product | MHC class I polypeptide-related sequence B isoform 1 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL663061.8, AK314228.1, DC364717.1, CN389975.1, BC044218.1 and BQ216247.1. This sequence is a reference standard in the RefSeqGene project. On Jan 16, 2014 this sequence version replaced NM_005931.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291927.1, X91625.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGGGCTGG GCCGGGTCCT GCTGTTTCTG GCCGTCGCCT TCCCTTTTGC ACCCCCGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_005922.2 |
| CDS | 145..1296 |
| Misc Feature(1) | 121..123 |
| Misc Feature(2) | 214..738 |
| Misc Feature(3) | 757..1032 |
| Misc Feature(4) | order(814..816,820..822,904..909,913..921,937..939,943..945) |
| Misc Feature(5) | order(835..843,928..930,1003..1005) |
| Misc Feature(6) | 1072..1134 |
| Exon (1) | 1..214 |
| Exon (2) | 215..469 |
| Exon (3) | 470..757 |
| Exon (4) | 758..1036 |
| Exon (5) | 1037..1168 |
| Exon (6) | 1169..2511 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_005931.4 |
ORF Insert Sequence:
1 | ATGGGGCTGG GCCGGGTCCT GCTGTTTCTG GCCGTCGCCT TCCCTTTTGC ACCCCCGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Association Between Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms and Susceptibility of Systemic Lupus Erythematosus. |
|
Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue. |
|
Vigilin Regulates the Expression of the Stress-Induced Ligand MICB by Interacting with Its 5' Untranslated Region. |
|
MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue. |
|
Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population. |