MT1H cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | MT1H |
| Entrez Gene ID | 4496 |
| Full Name | metallothionein 1H |
| Synonyms | MT-0,MT-1H,MT-IH,MT1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_005951.2 | NP_005942.1 | metallothionein-1H |
Related articles in PubMed
Metallothionein 1H (MT1H) functions as a tumor suppressor in hepatocellular carcinoma through regulating Wnt/?-catenin signaling pathway.
Zheng Y, Jiang L, Hu Y, Xiao C, Xu N, Zhou J, Zhou X
BMC cancer17(1)161(2017 02)
An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.
Alkamal I, Ikromov O, T?lle A, Fuller TF, Magheli A, Miller K, Krause H, Kempkensteffen C
Urologia internationalis94(1)99-110(2015)
Genome-wide association study of a quantitative disordered gambling trait.
Lind PA, Zhu G, Montgomery GW, Madden PA, Heath AC, Martin NG, Slutske WS
Addiction biology18(3)511-22(2013 May)
Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
Raymond AD, Gekonge B, Giri MS, Hancock A, Papasavvas E, Chehimi J, Kossenkov AV, Kossevkov AV, Nicols C, Yousef M, Mounzer K, Shull J, Kostman J, Showe L, Montaner LJ
Journal of leukocyte biology88(3)589-96(2010 Sep)
Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes.
Chang XL, Jin TY, Zhou YF
Biomedical and environmental sciences : BES19(2)104-9(2006 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results show that MT1H is downregulated in TCGA dataset and a panel of 12 paired tumor/non-tumor tissues. Ectopic overexpression of MT1H in HepG2 and Hep3B cells inhibited cell proliferation, invasion, and migration through inhibiting Wnt/beta-catenin pathway.
Title: Metallothionein 1H (MT1H) functions as a tumor suppressor in hepatocellular carcinoma through regulating Wnt/?-catenin signaling pathway.
MT1H was down-regulated in renal cell carcinogenesis.
Title: An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.
Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.
Title: Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity.
Title: Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.
S-nitrosothiols react preferentially with zinc thiolate clusters through transnitrosation.
Title: S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.
The following MT1H gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MT1H cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu24875 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_005951.2 | |
| Accession Version | NM_005951.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-26 | |
| Organism | Homo sapiens(human) | |
| Product | metallothionein-1H | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC008408.1 and BC059780.1. On or before Jan 27, 2007 this sequence version replaced XM_001124306.1, NM_005951.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005436.1, BP274852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGACCCCA ACTGCTCCTG CGAGGCTGGT GGCTCCTGCG CCTGCGCCGG CTCCTGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_005942.1 |
| CDS | 72..257 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_005951.2 |
ORF Insert Sequence:
1 | ATGGACCCCA ACTGCTCCTG CGAGGCTGGT GGCTCCTGCG CCTGCGCCGG CTCCTGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Metallothionein 1H (MT1H) functions as a tumor suppressor in hepatocellular carcinoma through regulating Wnt/?-catenin signaling pathway. |
|
An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis. |
|
Genome-wide association study of a quantitative disordered gambling trait. |
|
Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia. |
|
Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. |