Gene Symbol | Diaph2 |
Entrez Gene ID | 54004 |
Full Name | diaphanous related formin 2 |
Synonyms | Dia3,Diap2,Drf2,E430022I22Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Diaph2 cDNA ORF clone
gRNAs
Gene Symbol | Diaph2 |
Entrez Gene ID | 54004 |
Full Name | diaphanous related formin 2 |
Synonyms | Dia3,Diap2,Drf2,E430022I22Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_030251385.1 | XP_030107245.1 | protein diaphanous homolog 2 isoform X3 |
XM_006528581.3 | XP_006528644.1 | protein diaphanous homolog 2 isoform X1 |
XM_006528581.4 | XP_006528644.1 | protein diaphanous homolog 2 isoform X1 |
XM_006528582.4 | XP_006528645.1 | protein diaphanous homolog 2 isoform X2 |
NM_172493.2 | NP_766081.1 | protein diaphanous homolog 2 |
XM_006528582.3 | XP_006528645.1 | protein diaphanous homolog 2 isoform X2 |
mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.
Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D, Sekiguchi M, Watanabe D, Furuyashiki T, Narumiya S
Cell reports17(9)2405-2417(2016 11)
Expression of multiple formins in adult tissues and during developmental stages of mouse brain.
Dutta P, Maiti S
Gene expression patterns : GEP19(1-2)52-9(2015 Sep-Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
Title: mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.
study examined how mDia functions in axon guidance in vivo and in vitro; findings show mDia plays multiple roles in the proper formation of the neural network
Title: EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.
These results imply that RhoD activated by FGF signaling forms cytoneme-like protrusions through activation of mDia3C, which induces actin filament formation
Title: RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.
actin cytoskeleton regulated by Rho-mDia pathway is critical for the integrity of the adherens junctions and the polarity of neuroepithelial cells
Title: Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
analysis of interactions between mDia isoforms 1, 2, and 3 and RhoA, Rac1, and Cdc42
Title: Specificity of interactions between mDia isoforms and Rho proteins.
The following Diaph2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Diaph2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu90415 | |
Clone ID Related Accession (Same CDS sequence) | XM_030251385.1 | |
Accession Version | XM_030251385.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | protein diaphanous homolog 2 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030107245.1 |
CDS | 307..2430 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17576 | |
Clone ID Related Accession (Same CDS sequence) | NM_172493.2 | |
Accession Version | NM_172493.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3309bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | protein diaphanous homolog 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL683856.10, AY312280.1, AL807775.8 and BQ030953.1. On Aug 28, 2010 this sequence version replaced NM_172493.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY312280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_766081.1 |
CDS | 235..3543 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu56538 | |
Clone ID Related Accession (Same CDS sequence) | XM_006528581.3 , XM_006528581.4 | |
Accession Version | XM_006528581.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3330bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | protein diaphanous homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006528581.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006528644.1 |
CDS | 309..3638 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu56539 | |
Clone ID Related Accession (Same CDS sequence) | XM_006528582.4 , XM_006528582.3 | |
Accession Version | XM_006528582.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3297bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | protein diaphanous homolog 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006528582.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006528645.1 |
CDS | 309..3605 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu56538 | |
Clone ID Related Accession (Same CDS sequence) | XM_006528581.3 , XM_006528581.4 | |
Accession Version | XM_006528581.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3330bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | protein diaphanous homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006528581.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006528644.1 |
CDS | 312..3641 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu56539 | |
Clone ID Related Accession (Same CDS sequence) | XM_006528582.4 , XM_006528582.3 | |
Accession Version | XM_006528582.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3297bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | protein diaphanous homolog 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006528582.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006528645.1 |
CDS | 312..3608 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGAGC TCGGGGCGGC GGCGTCGGGA GCCGGAGGCG GCGGCGGTGG CGGCGAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. |
Expression of multiple formins in adult tissues and during developmental stages of mouse brain. |