SLC17A7 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | SLC17A7 |
| Entrez Gene ID | 57030 |
| Full Name | solute carrier family 17 member 7 |
| Synonyms | BNPI,VGLUT1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_020309.3 | NP_064705.1 | vesicular glutamate transporter 1 |
| NM_020309.4 | NP_064705.1 | vesicular glutamate transporter 1 |
| Canis lupus familiaris (dog) | SLC17A7 | XP_533621.4 |
| Danio rerio (zebrafish) | LOC100331980 | XP_002666767.2 |
| Arabidopsis thaliana (thale cress) | PHT4;1 | NP_180526.1 |
| Xenopus tropicalis (tropical clawed frog) | slc17a7 | NP_001072608.1 |
| Pan troglodytes (chimpanzee) | SLC17A7 | XP_003316593.2 |
| Mus musculus (house mouse) | Slc17a7 | NP_892038.2 |
| Caenorhabditis elegans (roundworm) | eat-4 | NP_499023.3 |
| Homo sapiens (human) | SLC17A7 | NP_064705.1 |
| Bos taurus (cattle) | SLC17A7 | NP_001091515.1 |
| Rattus norvegicus (Norway rat) | Slc17a7 | NP_446311.1 |
| Danio rerio (zebrafish) | slc17a7 | NP_001092225.1 |
| Oryza sativa (rice) | Os01g0279700 | NP_001042749.1 |
Related articles in PubMed
Down-regulation of glutamatergic terminals (VGLUT1) driven by A? in Alzheimer's disease.
Rodriguez-Perdigon M, Tordera RM, Gil-Bea FJ, Gerenu G, Ramirez MJ, Solas M
Hippocampus26(10)1303-12(2016 Oct)
Genetic variation in SLC17A7 promoter associated with response to sport-related concussions.
Madura SA, McDevitt JK, Tierney RT, Mansell JL, Hayes DJ, Gaughan JP, Krynetskiy E
Brain injury30(7)908-13(2016)
JNK: A Putative Link Between Insulin Signaling and VGLUT1 in Alzheimer's Disease.
Rodriguez-Perdigon M, Solas M, Ramirez MJ
Journal of Alzheimer's disease : JAD50(4)963-7(2016)
Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene.
Lin B, Lee H, Yoon JG, Madan A, Wayner E, Tonning S, Hothi P, Schroeder B, Ulasov I, Foltz G, Hood L, Cobbs C
Oncotarget6(7)5369-81(2015 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Study revealed susceptibility of glutamatergic nerve terminals to Abeta induced toxicity and underlined the importance of VGLUT1 in the progression of Alzheimer's disease, as the decrease of this protein levels could increase the susceptibility to subsequent deleterious inputs by exacerbating Abeta induced neuroinflammation and synaptic plasticity disruption.
Title: Down-regulation of glutamatergic terminals (VGLUT1) driven by A? in Alzheimer's disease.
This study was the first to demonstrate an association between genetic polymorphism at rs7417284 SNP in the promoter region of the SLC17A7 gene and concussion severity and duration. Based upon these findings, rs74174284 is a potential predictive genetic marker for identifying athletes who are more susceptible for altered recovery times and worse motor speed ImPACT scores after sport-related concussion.
Title: Genetic variation in SLC17A7 promoter associated with response to sport-related concussions.
Results suggest that activation of JNK in Alzheimer's disease (AD) inhibits insulin signaling which could lead to a decreased expression of VGLUT1, therefore contributing to the glutamatergic deficit in AD
Title: JNK: A Putative Link Between Insulin Signaling and VGLUT1 in Alzheimer's Disease.
Loss of SLC17A7 expression is associated with glioblastoma.
Title: Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene.
Depressed patients showed significant decreases in synaptophysin (SYN) and VGLUT1 expression, whereas in bipolar patients, decreases in VGLUT1 expression have also been found.
Title: Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients.
The following SLC17A7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC17A7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu11061 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_020309.3 , NM_020309.4 | |
| Accession Version | NM_020309.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-01 | |
| Organism | Homo sapiens(human) | |
| Product | vesicular glutamate transporter 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010619.7, BC059379.1, AB032436.1, BQ636968.1 and BU732143.1. On Jan 24, 2009 this sequence version replaced NM_020309.2. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059379.1, AB032436.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAGTTCC GCCAGGAGGA GTTTCGGAAG CTAGCGGGTC GTGCTCTCGG GAAGCTGCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_064705.1 |
| CDS | 173..1855 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_020309.3 |
ORF Insert Sequence:
1 | ATGGAGTTCC GCCAGGAGGA GTTTCGGAAG CTAGCGGGTC GTGCTCTCGG GAAGCTGCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu11061 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_020309.3 , NM_020309.4 | |
| Accession Version | NM_020309.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-06 | |
| Organism | Homo sapiens(human) | |
| Product | vesicular glutamate transporter 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010619.7, BC059379.1, AB032436.1, BQ636968.1 and BU732143.1. On Nov 23, 2018 this sequence version replaced NM_020309.3. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059379.1, SRR3476690.554678.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000221485.8/ ENSP00000221485.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGAGTTCC GCCAGGAGGA GTTTCGGAAG CTAGCGGGTC GTGCTCTCGG GAAGCTGCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_064705.1 |
| CDS | 149..1831 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_020309.4 |
ORF Insert Sequence:
1 | ATGGAGTTCC GCCAGGAGGA GTTTCGGAAG CTAGCGGGTC GTGCTCTCGG GAAGCTGCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Down-regulation of glutamatergic terminals (VGLUT1) driven by A? in Alzheimer's disease. |
|
Genetic variation in SLC17A7 promoter associated with response to sport-related concussions. |
|
JNK: A Putative Link Between Insulin Signaling and VGLUT1 in Alzheimer's Disease. |
|
Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene. |