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PLSCR3 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol PLSCR3
Entrez Gene ID 57048
Full Name phospholipid scramblase 3
General protein information
Preferred Names

phospholipid scramblase 3

Names

phospholipid scramblase 3
PL scramblase 3
ca(2+)-dependent phospholipid scramblase 3
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

17

17p13.1
Disorder MIM:

607611


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001201576.2 NP_001188505.1 phospholipid scramblase 3 isoform 1
NM_001369421.1 NP_001356350.1 phospholipid scramblase 3 isoform 3
NM_001201576.1 NP_001188505.1 phospholipid scramblase 3
NM_001369420.1 NP_001356349.1 phospholipid scramblase 3 isoform 2
NM_020360.4 NP_065093.2 phospholipid scramblase 3 isoform 1
NM_020360.3 NP_065093.2 phospholipid scramblase 3
NM_001369422.1 NP_001356351.1 phospholipid scramblase 3 isoform 3
NM_001369407.1 NP_001356336.1 phospholipid scramblase 3 isoform 1

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) PLSCR3 XP_001174792.2
Bos taurus (cattle) PLSCR3 NP_001039518.1
Drosophila melanogaster (fruit fly) scramb2 NP_647761.1
Homo sapiens (human) PLSCR3 NP_001188505.1
Mus musculus (house mouse) Plscr3 NP_001161969.1
PLSCR3 XP_001118026.1
Canis lupus familiaris (dog) PLSCR3 XP_005620375.1
Rattus norvegicus (Norway rat) Plscr3 NP_001012139.1

Gene Ontology


Bibliography

Related articles in PubMed

In vitro reconstitution and biochemical characterization of human phospholipid scramblase 3: phospholipid specificity and metal ion binding studies.
Palanirajan SK, Sivagnanam U, Murugan S, Gummadi SN
Biological chemistry(2017 Jun)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells.
Inuzuka T, Inokawa A, Chen C, Kizu K, Narita H, Shibata H, Maki M
Bioscience reports33(2)e00026(2013 Mar)

Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell.
Sahu SK, Aradhyam GK, Gummadi SN
Biochimica et biophysica acta1790(10)1274-81(2009 Oct)

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane.
Py B, Basmaciogullari S, Bouchet J, Zarka M, Moura IC, Benhamou M, Monteiro RC, Hocini H, Madrid R, Benichou S
PloS one4(3)e5006(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Secreted Scr3 was taken up by HeLa cells, suggesting that Scr3 functions as a cell-to-cell transferable modulator carried by exosomes in a paracrine manner.
Title: ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells.

Results show that binding affinities of the peptides are in the order hPLSCR1>hPLSCR3>hPLSCR2>hPLSCR4 for Ca2+ and in the order hPLSCR1>hPLSCR2>hPLSCR3>hPLSCR4 for Mg2+.
Title: Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell.

TRAIL-induced activation of PKC-delta mediates regulation of the phospholipid scramblase3-induced changes in cardiolipin.
Title: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3.

Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants
Title: Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.

These findings indicate that phosphorylation of PLS3 by PKC-delta induces PLS3 activation to facilitate mitochondrial targeting of tBid and apoptosis.
Title: Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid.

The following PLSCR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLSCR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu03274 NM_020360.4
Latest version!		 Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu03274 NM_001369407.1
Latest version!		 Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu03274 NM_001201576.2
Latest version!		 Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu107997 NM_001369422.1
Latest version!		 Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu107997 NM_001369421.1
Latest version!		 Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu108000 NM_001369420.1
Latest version!		 Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00
View Old Accession Versions >>
OHu03274 NM_001201576.1 Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant w, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu03274 NM_020360.3 Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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2-4 Clone 40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu03274
Clone ID Related Accession (Same CDS sequence) NM_001201576.2 , NM_001201576.1 , NM_020360.4 , NM_020360.3 , NM_001369407.1
Accession Version NM_001201576.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 888bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-06
Organism Homo sapiens(human)
Product phospholipid scramblase 3 isoform 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113189.11. On Apr 9, 2019 this sequence version replaced NM_001201576.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.193638.1, AF159442.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001188505.1
CDS99..986
Translation

Target ORF information:

RefSeq Version NM_001201576.2
Organism Homo sapiens(human)
Definition Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001201576.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03274
Clone ID Related Accession (Same CDS sequence) NM_001201576.2 , NM_001201576.1 , NM_020360.4 , NM_020360.3 , NM_001369407.1
Accession Version NM_001201576.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 888bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-22
Organism Homo sapiens(human)
Product phospholipid scramblase 3
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG830095.1, CX785894.1, AF159442.1, BC093026.1 and BC011735.2. Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF159442.1, BX458893.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001188505.1
CDS417..1304
Translation

Target ORF information:

RefSeq Version NM_001201576.1
Organism Homo sapiens(human)
Definition Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant w, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001201576.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03274
Clone ID Related Accession (Same CDS sequence) NM_001201576.2 , NM_001201576.1 , NM_020360.4 , NM_020360.3 , NM_001369407.1
Accession Version NM_020360.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 888bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-05
Organism Homo sapiens(human)
Product phospholipid scramblase 3 isoform 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC093026.1 and BC011735.2. On Nov 22, 2018 this sequence version replaced NM_020360.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.703258.1, BC093026.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000619711.5/ ENSP00000483743.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_065093.2
CDS207..1094
Translation

Target ORF information:

RefSeq Version NM_020360.4
Organism Homo sapiens(human)
Definition Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_020360.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03274
Clone ID Related Accession (Same CDS sequence) NM_001201576.2 , NM_001201576.1 , NM_020360.4 , NM_020360.3 , NM_001369407.1
Accession Version NM_020360.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 888bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-11-27
Organism Homo sapiens(human)
Product phospholipid scramblase 3
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG830095.1, CX785894.1, BC093026.1 and BC011735.2. On Jan 27, 2011 this sequence version replaced NM_020360.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093026.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_065093.2
CDS525..1412
Translation

Target ORF information:

RefSeq Version NM_020360.3
Organism Homo sapiens(human)
Definition Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_020360.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03274
Clone ID Related Accession (Same CDS sequence) NM_001201576.2 , NM_001201576.1 , NM_020360.4 , NM_020360.3 , NM_001369407.1
Accession Version NM_001369407.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 888bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Homo sapiens(human)
Product phospholipid scramblase 3 isoform 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113189.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314643.1, DRR138524.1033042.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001356336.1
CDS211..1098
Translation

Target ORF information:

RefSeq Version NM_001369407.1
Organism Homo sapiens(human)
Definition Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001369407.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAACGTT CCTAGGCTGG 
GAGACCTGTA ATCGGTATGA ACTGCGCTCT GGGGCCGGGC AGCCCCTGGG TCAGGCGGCC 
GAGGAGAGCA ACTGCTGCGC CCGTCTGTGC TGTGGCGCCC GCCGGCCGCT GCGTGTCCGC 
CTGGCCGACC CCGGGGACCG TGAGGTGCTG CGTTTGCTCC GCCCGCTGCA CTGTGGCTGC 
AGCTGCTGCC CCTGTGGCCT CCAGGAGATG GAAGTACAGG CTCCACCAGG CACCACCATT 
GGCCACGTGC TACAGACCTG GCATCCCTTC CTCCCCAAGT TCTCCATCCA GGATGCCGAT 
CGCCAGACAG TCTTGCGAGT GGTGGGGCCC TGCTGGACCT GTGGCTGTGG CACAGACACC 
AACTTTGAGG TGAAGACTCG GGATGAATCC CGCAGTGTGG GCCGCATCAG CAAGCAGTGG 
GGGGGCCTGG TCCGAGAAGC CCTCACAGAT GCAGATGACT TTGGCCTACA GTTCCCGCTG 
GACCTGGATG TGAGGGTGAA GGCTGTGCTG CTGGGAGCCA CATTCCTCAT TGACTACATG 
TTCTTTGAGA AGCGAGGAGG CGCTGGGCCC TCTGCCGTCA CCAGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu107997
Clone ID Related Accession (Same CDS sequence) NM_001369421.1 , NM_001369422.1
Accession Version NM_001369421.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Homo sapiens(human)
Product phospholipid scramblase 3 isoform 3
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113189.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.167500.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
ATGGAAGTAC AGGCTCCACC AGGCACCACC ATTGGCCACG TGCTACAGAC CTGGCATCCC 
TTCCTCCCCA AGTTCTCCAT CCAGGATGCC GATCGCCAGA CAGTCTTGCG AGTGGTGGGG 
CCCTGCTGGA CCTGTGGCTG TGGCACAGAC ACCAACTTTG AGGTGAAGAC TCGGGATGAA 
TCCCGCAGTG TGGGCCGCAT CAGCAAGCAG TGGGGGGGCC TGGTCCGAGA AGCCCTCACA 
GATGCAGATG ACTTTGGCCT ACAGTTCCCG CTGGACCTGG ATGTGAGGGT GAAGGCTGTG 
CTGCTGGGAG CCACATTCCT CATTGACTAC ATGTTCTTTG AGAAGCGAGG AGGCGCTGGG 
CCCTCTGCCG TCACCAGTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001356350.1
CDS257..637
Translation

Target ORF information:

RefSeq Version NM_001369421.1
Organism Homo sapiens(human)
Definition Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001369421.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGAAGTAC AGGCTCCACC AGGCACCACC ATTGGCCACG TGCTACAGAC CTGGCATCCC 
TTCCTCCCCA AGTTCTCCAT CCAGGATGCC GATCGCCAGA CAGTCTTGCG AGTGGTGGGG 
CCCTGCTGGA CCTGTGGCTG TGGCACAGAC ACCAACTTTG AGGTGAAGAC TCGGGATGAA 
TCCCGCAGTG TGGGCCGCAT CAGCAAGCAG TGGGGGGGCC TGGTCCGAGA AGCCCTCACA 
GATGCAGATG ACTTTGGCCT ACAGTTCCCG CTGGACCTGG ATGTGAGGGT GAAGGCTGTG 
CTGCTGGGAG CCACATTCCT CATTGACTAC ATGTTCTTTG AGAAGCGAGG AGGCGCTGGG 
CCCTCTGCCG TCACCAGTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu107997
Clone ID Related Accession (Same CDS sequence) NM_001369421.1 , NM_001369422.1
Accession Version NM_001369422.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Homo sapiens(human)
Product phospholipid scramblase 3 isoform 3
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113189.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF185827.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
ATGGAAGTAC AGGCTCCACC AGGCACCACC ATTGGCCACG TGCTACAGAC CTGGCATCCC 
TTCCTCCCCA AGTTCTCCAT CCAGGATGCC GATCGCCAGA CAGTCTTGCG AGTGGTGGGG 
CCCTGCTGGA CCTGTGGCTG TGGCACAGAC ACCAACTTTG AGGTGAAGAC TCGGGATGAA 
TCCCGCAGTG TGGGCCGCAT CAGCAAGCAG TGGGGGGGCC TGGTCCGAGA AGCCCTCACA 
GATGCAGATG ACTTTGGCCT ACAGTTCCCG CTGGACCTGG ATGTGAGGGT GAAGGCTGTG 
CTGCTGGGAG CCACATTCCT CATTGACTAC ATGTTCTTTG AGAAGCGAGG AGGCGCTGGG 
CCCTCTGCCG TCACCAGTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001356351.1
CDS149..529
Translation

Target ORF information:

RefSeq Version NM_001369422.1
Organism Homo sapiens(human)
Definition Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001369422.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGAAGTAC AGGCTCCACC AGGCACCACC ATTGGCCACG TGCTACAGAC CTGGCATCCC 
TTCCTCCCCA AGTTCTCCAT CCAGGATGCC GATCGCCAGA CAGTCTTGCG AGTGGTGGGG 
CCCTGCTGGA CCTGTGGCTG TGGCACAGAC ACCAACTTTG AGGTGAAGAC TCGGGATGAA 
TCCCGCAGTG TGGGCCGCAT CAGCAAGCAG TGGGGGGGCC TGGTCCGAGA AGCCCTCACA 
GATGCAGATG ACTTTGGCCT ACAGTTCCCG CTGGACCTGG ATGTGAGGGT GAAGGCTGTG 
CTGCTGGGAG CCACATTCCT CATTGACTAC ATGTTCTTTG AGAAGCGAGG AGGCGCTGGG 
CCCTCTGCCG TCACCAGTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu108000
Clone ID Related Accession (Same CDS sequence) NM_001369420.1
Accession Version NM_001369420.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 693bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Homo sapiens(human)
Product phospholipid scramblase 3 isoform 2
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC113189.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.780392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAATGAC CCTGTCTGCT 
TCCCACTCCC AGATGGAAGT ACAGGCTCCA CCAGGCACCA CCATTGGCCA CGTGCTACAG 
ACCTGGCATC CCTTCCTCCC CAAGTTCTCC ATCCAGGATG CCGATCGCCA GACAGTCTTG 
CGAGTGGTGG GGCCCTGCTG GACCTGTGGC TGTGGCACAG ACACCAACTT TGAGGTGAAG 
ACTCGGGATG AATCCCGCAG TGTGGGCCGC ATCAGCAAGC AGTGGGGGGG CCTGGTCCGA 
GAAGCCCTCA CAGATGCAGA TGACTTTGGC CTACAGTTCC CGCTGGACCT GGATGTGAGG 
GTGAAGGCTG TGCTGCTGGG AGCCACATTC CTCATTGACT ACATGTTCTT TGAGAAGCGA 
GGAGGCGCTG GGCCCTCTGC CGTCACCAGT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001356349.1
CDS207..899
Translation

Target ORF information:

RefSeq Version NM_001369420.1
Organism Homo sapiens(human)
Definition Homo sapiens phospholipid scramblase 3 (PLSCR3), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001369420.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCAGGCT ACTTGCCCCC CAAAGGCTAC GCCCCTTCGC CCCCACCTCC CTACCCTGTC 
ACCCCTGGGT ACCCGGAGCC GGCGCTACAT CCTGGGCCCG GGCAGGCGCC AGTGCCCGCC 
CAGGTACCTG CCCCAGCTCC CGGCTTCGCC CTCTTCCCCT CGCCTGGCCC CGTGGCCTTG 
GGGTCTGCTG CCCCCTTCTT GCCACTGCCA GGGGTGCCTT CTGGCCTCGA ATTCCTGGTG 
CAGATTGATC AGATTTTGAT TCACCAGAAG GCTGAGCGAG TGGAAATGAC CCTGTCTGCT 
TCCCACTCCC AGATGGAAGT ACAGGCTCCA CCAGGCACCA CCATTGGCCA CGTGCTACAG 
ACCTGGCATC CCTTCCTCCC CAAGTTCTCC ATCCAGGATG CCGATCGCCA GACAGTCTTG 
CGAGTGGTGG GGCCCTGCTG GACCTGTGGC TGTGGCACAG ACACCAACTT TGAGGTGAAG 
ACTCGGGATG AATCCCGCAG TGTGGGCCGC ATCAGCAAGC AGTGGGGGGG CCTGGTCCGA 
GAAGCCCTCA CAGATGCAGA TGACTTTGGC CTACAGTTCC CGCTGGACCT GGATGTGAGG 
GTGAAGGCTG TGCTGCTGGG AGCCACATTC CTCATTGACT ACATGTTCTT TGAGAAGCGA 
GGAGGCGCTG GGCCCTCTGC CGTCACCAGT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

In vitro reconstitution and biochemical characterization of human phospholipid scramblase 3: phospholipid specificity and metal ion binding studies.
Biological chemistry(2017 Jun)
Palanirajan SK,Sivagnanam U,Murugan S,Gummadi SN


book

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M


book

ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells.
Bioscience reports33(2)e00026(2013 Mar)
Inuzuka T,Inokawa A,Chen C,Kizu K,Narita H,Shibata H,Maki M


book

Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell.
Biochimica et biophysica acta1790(10)1274-81(2009 Oct)
Sahu SK,Aradhyam GK,Gummadi SN


book

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane.
PloS one4(3)e5006(2009)
Py B,Basmaciogullari S,Bouchet J,Zarka M,Moura IC,Benhamou M,Monteiro RC,Hocini H,Madrid R,Benichou S