Des cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Des |
| Entrez Gene ID | 64362 |
| Full Name | desmin |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | class II intermediate filament protein, localized to muscle cells, may be a differentiation marker for muscle cells [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_022531.1 | NP_071976.1 | desmin |
| Pan troglodytes (chimpanzee) | DES | XP_526039.2 |
| Canis lupus familiaris (dog) | DES | NP_001012394.1 |
| Bos taurus (cattle) | DES | NP_001075044.1 |
| Rattus norvegicus (Norway rat) | Des | NP_071976.1 |
| Gallus gallus (chicken) | DES | XP_004942895.1 |
| Homo sapiens (human) | DES | NP_001918.3 |
| DES | XP_001104181.1 | |
| Xenopus tropicalis (tropical clawed frog) | des.1 | NP_989134.1 |
| Mus musculus (house mouse) | Des | NP_034173.1 |
Related articles in PubMed
The Novel Desmin Mutation p.Glu401Asp Impairs Filament Formation, Disrupts Cell Membrane Integrity and Causes Severe Arrhythmogenic Left Ventricular Cardiomyopathy/Dysplasia.
Berm?dez-Jim?nez FJ, Carriel V, Brodehl A, Alaminos M, Campos A, Schirmer I, Milting H, ?lvarez Abril B, ?lvarez M, L?pez-Fern?ndez S, Garc?a-Giustiniani D, Monserrat L, Tercedor L, Jim?nez-J?imez J
Circulation(2017 Dec)
Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.
Guichard JL, Rogowski M, Agnetti G, Fu L, Powell P, Wei CC, Collawn J, Dell'Italia LJ
American journal of physiology. Heart and circulatory physiology313(1)H32-H45(2017 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study provides new evidence of early onset (24 h) and continuous (4-12 wk) desmin misarrangement and disruption of the normal sarcomeric and mitochondrial architecture throughout the progression of volume overload heart failure, suggesting a causal link between desmin cleavage and mitochondrial disorganization and damage.
Title: Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.
Data indicte that desmin and h1-calponin are expressed in mesenchymal stem cells (MSC).
Title: Differentiated markers in undifferentiated cells: expression of smooth muscle contractile proteins in multipotent bone marrow mesenchymal stem cells.
Desmin and alpha-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.
Title: Desmin and ?-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.
Following phosphorylation at Ser15 during reloading and regrowing of soleus muscle, HSP25 contributes to desmin cytoskeletal organization.
Title: HSP25 can modulate myofibrillar desmin cytoskeleton following the phosphorylation at Ser15 in rat soleus muscle.
tetanic contractions induce an over-activation of calpains which lead to higher degrees of desmin degradation in unloaded soleus muscle
Title: Tetanic contractions impair sarcomeric Z-disk of atrophic soleus muscle via calpain pathway.
The following Des gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Des cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa05862 | |
| Clone ID Related Accession (Same CDS sequence) | NM_022531.1 | |
| Accession Version | NM_022531.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1410bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-11-10 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | desmin | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X73524.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ214848.1, BC061872.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGAGCCAGG CCTACTCGTC CAGCCAGCGC GTGTCCTCCT ACCGCCGCAC CTTCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_071976.1 |
| CDS | 79..1488 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_022531.1 |
ORF Insert Sequence:
1 | ATGAGCCAGG CCTACTCGTC CAGCCAGCGC GTGTCCTCCT ACCGCCGCAC CTTCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
The Novel Desmin Mutation p.Glu401Asp Impairs Filament Formation, Disrupts Cell Membrane Integrity and Causes Severe Arrhythmogenic Left Ventricular Cardiomyopathy/Dysplasia. |
|
Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure. |