SLC15A1 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | SLC15A1 |
| Entrez Gene ID | 6564 |
| Full Name | solute carrier family 15 member 1 |
| Synonyms | HPECT1,HPEPT1,PEPT1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_005073.3 | NP_005064.1 | solute carrier family 15 member 1 |
| NM_005073.4 | NP_005064.1 | solute carrier family 15 member 1 |
| Pan troglodytes (chimpanzee) | SLC15A1 | XP_522705.3 |
| Canis lupus familiaris (dog) | SLC15A1 | NP_001003036.1 |
| Schizosaccharomyces pombe (fission yeast) | SPBC13A2.04c | NP_596417.1 |
| SLC15A1 | NP_001028071.1 | |
| Danio rerio (zebrafish) | slc15a1b | NP_932330.1 |
| Saccharomyces cerevisiae (baker's yeast) | PTR2 | NP_013019.1 |
| Oryza sativa (rice) | Os03g0719900 | NP_001051098.1 |
| Rattus norvegicus (Norway rat) | Slc15a1 | NP_476462.1 |
| Gallus gallus (chicken) | SLC15A1 | NP_989696.1 |
| Danio rerio (zebrafish) | slc15a1a | XP_001919914.3 |
| Caenorhabditis elegans (roundworm) | pept-1 | NP_509087.1 |
| Xenopus tropicalis (tropical clawed frog) | slc15a1 | XP_002935692.2 |
| Bos taurus (cattle) | SLC15A1 | NP_001092848.1 |
| Drosophila melanogaster (fruit fly) | CG2930 | NP_788857.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010383 | XP_311562.3 |
| Kluyveromyces lactis | KLLA0E12915g | XP_454532.1 |
| Homo sapiens (human) | SLC15A1 | NP_005064.1 |
| Mus musculus (house mouse) | Slc15a1 | NP_444309.2 |
| Caenorhabditis elegans (roundworm) | pept-2 | NP_502002.1 |
| Arabidopsis thaliana (thale cress) | PTR2 | NP_178313.1 |
Related articles in PubMed
Regulation profile of the intestinal peptide transporter 1 (PepT1).
Wang CY, Liu S, Xie XN, Tan ZR
Drug design, development and therapy113511-3517(2017)
Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants.
Mooij MG, de Koning BE, Lindenbergh-Kortleve DJ, Simons-Oosterhuis Y, van Groen BD, Tibboel D, Samsom JN, de Wildt SN
Drug metabolism and disposition: the biological fate of chemicals44(7)1014-9(2016 Jul)
Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice.
Hu Y, Smith DE
Biochemical pharmacology10781-90(2016 May)
A new target ligand Ser-Glu for PEPT1-overexpressing cancer imaging.
Dai T, Li N, Zhang L, Zhang Y, Liu Q
International journal of nanomedicine11203-12(2016)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil.
Title: Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice.
PEPT1 overexpression is associated with pancreatic cancer.
Title: A new target ligand Ser-Glu for PEPT1-overexpressing cancer imaging.
miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation.
Title: MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1.
OSR1 has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 by decreasing the carrier protein abundance in the cell membrane
Title: Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.
Phe-Psi-Ala is a high-affinity, metabolically stable, non-radioactive probe for PEPT1.
Title: Evaluation of a thiodipeptide, L-phenylalanyl-?[CS-N]-L-alanine, as a novel probe for peptide transporter 1.
The following SLC15A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC15A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu19511 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_005073.3 , NM_005073.4 | |
| Accession Version | NM_005073.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2127bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-09-06 | |
| Organism | Homo sapiens(human) | |
| Product | solute carrier family 15 member 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL708816.1, U13173.1, CU445953.1, BC096329.3 and AW449979.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2009 this sequence version replaced NM_005073.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U21936.1, BC096329.3 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGGAATGT CCAAATCACA CAGTTTCTTT GGTTATCCCC TGAGCATCTT CTTCATCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_005064.1 |
| CDS | 78..2204 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_005073.3 |
ORF Insert Sequence:
1 | ATGGGAATGT CCAAATCACA CAGTTTCTTT GGTTATCCCC TGAGCATCTT CTTCATCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu19511 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_005073.3 , NM_005073.4 | |
| Accession Version | NM_005073.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2127bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-21 | |
| Organism | Homo sapiens(human) | |
| Product | solute carrier family 15 member 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL708816.1, U13173.1, CU445953.1, BC096329.3 and AW449979.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005073.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U21936.1, BC096329.3 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376503.10/ ENSP00000365686.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGGAATGT CCAAATCACA CAGTTTCTTT GGTTATCCCC TGAGCATCTT CTTCATCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_005064.1 |
| CDS | 75..2201 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_005073.4 |
ORF Insert Sequence:
1 | ATGGGAATGT CCAAATCACA CAGTTTCTTT GGTTATCCCC TGAGCATCTT CTTCATCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Regulation profile of the intestinal peptide transporter 1 (PepT1). |
|
Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants. |
|
Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice. |
|
A new target ligand Ser-Glu for PEPT1-overexpressing cancer imaging. |