Psenen cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Psenen
Entrez Gene ID	66340
Full Name	presenilin enhancer gamma secretase subunit
Synonyms	1700023M09Rik,Pen-2
General protein information	Preferred Names presenilin enhancer gamma secretase subunit Names gamma-secretase subunit PEN-2 presenilin enhancer 2 homolog presenilin enhancer protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001364016.1	NP_001350945.1	gamma-secretase subunit PEN-2
NM_025498.3	NP_079774.1	gamma-secretase subunit PEN-2
NM_001364017.1	NP_001350946.1	gamma-secretase subunit PEN-2
NM_025498.2	NP_079774.1	gamma-secretase subunit PEN-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PSENEN	NP_001268461.1
	PSENEN	XP_002801231.1
Drosophila melanogaster (fruit fly)	pen-2	NP_788401.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008094	XP_317362.2
Xenopus tropicalis (tropical clawed frog)	psenen	NP_001016336.1
Pan troglodytes (chimpanzee)	PSENEN	XP_512600.1
Mus musculus (house mouse)	Psenen	NP_079774.1
Canis lupus familiaris (dog)	PSENEN	XP_533689.1
Bos taurus (cattle)	PSENEN	NP_001008669.1
Rattus norvegicus (Norway rat)	Psenen	NP_001008764.1
Danio rerio (zebrafish)	psenen	NP_991139.1
Caenorhabditis elegans (roundworm)	pen-2	NP_499459.1

Gene Ontology
Bibliography

Related articles in PubMed

Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Lokau J, Flynn CM, Garbers C
Biochemical and biophysical research communications491(2)296-302(2017 09)

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.
Hu C, Xu J, Zeng L, Li T, Cui MZ, Xu X
Journal of Alzheimer's disease : JAD56(4)1263-1269(2017)

Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.
Liu L, Watanabe N, Akatsu H, Nishimura M
Neuroscience330236-46(2016 Aug)

Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ 3rd
Neuron85(5)967-81(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Title: Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.

the G206D mutation reduced presenilin-1-presenilin enhancer 2 interaction, but did not abolish gamma-secretase formation and presenilin-1 endoproteolysis
Title: G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases A?42/A?40 Ratio and Elevates ER Ca(2+) Accumulation.

Data show that the expression level of presenilin enhancer-2 (Pen-2) is relatively high in central nervous system at the early stages of postnatal development, but declines, gradually in adult mice.
Title: Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice.

rather than solely being a catalyst for gamma-secretase endoproteolysis, Pen-2 may also stabilize the complex prior to PS1 endoproteolysis, allowing time for full assembly and proper trafficking.
Title: Pen-2 is essential for ?-secretase complex stability and trafficking but partially dispensable for endoproteolysis.

Pen-2, as well as nicastrin and Aph-1alpha, is dispensable for presenilin endoproteolysis
Title: Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both ?-secretase assembly and substrate recruitment.

The following Psenen gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psenen cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu00574	NM_001364016.1 Latest version!	Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu00574	NM_025498.3 Latest version!	Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu00574	NM_001364017.1 Latest version!	Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu00574	NM_025498.2	Mus musculus presenilin enhancer gamma secretase subunit (Psenen), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psenen ( NM_001364016.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350945.1 Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu00574
Clone ID Related Accession (Same CDS sequence)	NM_001364016.1 , NM_025498.3 , NM_001364017.1 , NM_025498.2
Accession Version	NM_001364016.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Mus musculus(house mouse)
Product	gamma-secretase subunit PEN-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167970.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV499861.1, AA061009.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT 
GGTGGATTTG CGTTCCTGCC TTTTCTTTGG TTAGTCAACA TTTTCTGGTT CTTCAGAGAG 
GCGTTCCTCG CCCCAGCCTA CACAGAGCAG AGCCAAATCA AAGGCTATGT TTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATCATT CTCGCCACCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGCGC TCTTGGGGAC TACCTCTCCT TCACCATTCC CCTGGGCACT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350945.1
CDS	202..507
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_001364016.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001364016.1

ORF Insert Sequence:

ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT 
GGTGGATTTG CGTTCCTGCC TTTTCTTTGG TTAGTCAACA TTTTCTGGTT CTTCAGAGAG 
GCGTTCCTCG CCCCAGCCTA CACAGAGCAG AGCCAAATCA AAGGCTATGT TTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATCATT CTCGCCACCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGCGC TCTTGGGGAC TACCTCTCCT TCACCATTCC CCTGGGCACT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psenen ( NM_025498.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079774.1 Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu00574
Clone ID Related Accession (Same CDS sequence)	NM_001364016.1 , NM_025498.3 , NM_001364017.1 , NM_025498.2
Accession Version	NM_025498.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Mus musculus(house mouse)
Product	gamma-secretase subunit PEN-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167970.4 and BC081443.1. On Jun 5, 2018 this sequence version replaced NM_025498.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081443.1, CB595929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT 
GGTGGATTTG CGTTCCTGCC TTTTCTTTGG TTAGTCAACA TTTTCTGGTT CTTCAGAGAG 
GCGTTCCTCG CCCCAGCCTA CACAGAGCAG AGCCAAATCA AAGGCTATGT TTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATCATT CTCGCCACCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGCGC TCTTGGGGAC TACCTCTCCT TCACCATTCC CCTGGGCACT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079774.1
CDS	236..541
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_025498.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025498.3

ORF Insert Sequence:

ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT 
GGTGGATTTG CGTTCCTGCC TTTTCTTTGG TTAGTCAACA TTTTCTGGTT CTTCAGAGAG 
GCGTTCCTCG CCCCAGCCTA CACAGAGCAG AGCCAAATCA AAGGCTATGT TTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATCATT CTCGCCACCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGCGC TCTTGGGGAC TACCTCTCCT TCACCATTCC CCTGGGCACT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psenen ( NM_001364017.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001350946.1 Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu00574
Clone ID Related Accession (Same CDS sequence)	NM_001364016.1 , NM_025498.3 , NM_001364017.1 , NM_025498.2
Accession Version	NM_001364017.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Mus musculus(house mouse)
Product	gamma-secretase subunit PEN-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167970.4, AV576632.1 and W65052.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.345503.1, AV576632.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT 
GGTGGATTTG CGTTCCTGCC TTTTCTTTGG TTAGTCAACA TTTTCTGGTT CTTCAGAGAG 
GCGTTCCTCG CCCCAGCCTA CACAGAGCAG AGCCAAATCA AAGGCTATGT TTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATCATT CTCGCCACCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGCGC TCTTGGGGAC TACCTCTCCT TCACCATTCC CCTGGGCACT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350946.1
CDS	185..490
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_001364017.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin enhancer gamma secretase subunit (Psenen), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001364017.1

ORF Insert Sequence:

ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT 
GGTGGATTTG CGTTCCTGCC TTTTCTTTGG TTAGTCAACA TTTTCTGGTT CTTCAGAGAG 
GCGTTCCTCG CCCCAGCCTA CACAGAGCAG AGCCAAATCA AAGGCTATGT TTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATCATT CTCGCCACCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGCGC TCTTGGGGAC TACCTCTCCT TCACCATTCC CCTGGGCACT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psenen ( NM_025498.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079774.1 Mus musculus presenilin enhancer gamma secretase subunit (Psenen), mRNA.

Price & Availability↑

CloneID	OMu00574
Clone ID Related Accession (Same CDS sequence)	NM_001364016.1 , NM_025498.3 , NM_001364017.1 , NM_025498.2
Accession Version	NM_025498.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Mus musculus(house mouse)
Product	gamma-secretase subunit PEN-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC024347.1. On Jun 19, 2003 this sequence version replaced NM_025498.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024347.1, BC081443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END##

ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT 
GGTGGATTTG CGTTCCTGCC TTTTCTTTGG TTAGTCAACA TTTTCTGGTT CTTCAGAGAG 
GCGTTCCTCG CCCCAGCCTA CACAGAGCAG AGCCAAATCA AAGGCTATGT TTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATCATT CTCGCCACCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGCGC TCTTGGGGAC TACCTCTCCT TCACCATTCC CCTGGGCACT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079774.1
CDS	216..521
Translation	MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLGTP

Target ORF information:

RefSeq Version	NM_025498.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus presenilin enhancer gamma secretase subunit (Psenen), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025498.2

ORF Insert Sequence:

ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT 
GGTGGATTTG CGTTCCTGCC TTTTCTTTGG TTAGTCAACA TTTTCTGGTT CTTCAGAGAG 
GCGTTCCTCG CCCCAGCCTA CACAGAGCAG AGCCAAATCA AAGGCTATGT TTGGCGCTCA 
GCTGTGGGCT TCCTCTTCTG GGTGATCATT CTCGCCACCT GGATCACCAT CTTCCAGATC 
TACCGGCCCC GCTGGGGCGC TCTTGGGGAC TACCTCTCCT TCACCATTCC CCTGGGCACT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Biochemical and biophysical research communications491(2)296-302(2017 09)
Lokau J,Flynn CM,Garbers C

Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.
Journal of Alzheimer's disease : JAD56(4)1263-1269(2017)
Hu C,Xu J,Zeng L,Li T,Cui MZ,Xu X

Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.
Neuroscience330236-46(2016 Aug)
Liu L,Watanabe N,Akatsu H,Nishimura M

Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Neuron85(5)967-81(2015 Mar)
Xia D,Watanabe H,Wu B,Lee SH,Li Y,Tsvetkov E,Bolshakov VY,Shen J,Kelleher RJ 3rd

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Psenen cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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