Gene Symbol | Psenen |
Entrez Gene ID | 66340 |
Full Name | presenilin enhancer gamma secretase subunit |
Synonyms | 1700023M09Rik,Pen-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Psenen cDNA ORF clone
gRNAs
Gene Symbol | Psenen |
Entrez Gene ID | 66340 |
Full Name | presenilin enhancer gamma secretase subunit |
Synonyms | 1700023M09Rik,Pen-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001364016.1 | NP_001350945.1 | gamma-secretase subunit PEN-2 |
NM_025498.3 | NP_079774.1 | gamma-secretase subunit PEN-2 |
NM_001364017.1 | NP_001350946.1 | gamma-secretase subunit PEN-2 |
NM_025498.2 | NP_079774.1 | gamma-secretase subunit PEN-2 |
Homo sapiens (human) | PSENEN | NP_001268461.1 |
PSENEN | XP_002801231.1 | |
Drosophila melanogaster (fruit fly) | pen-2 | NP_788401.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008094 | XP_317362.2 |
Xenopus tropicalis (tropical clawed frog) | psenen | NP_001016336.1 |
Pan troglodytes (chimpanzee) | PSENEN | XP_512600.1 |
Mus musculus (house mouse) | Psenen | NP_079774.1 |
Canis lupus familiaris (dog) | PSENEN | XP_533689.1 |
Bos taurus (cattle) | PSENEN | NP_001008669.1 |
Rattus norvegicus (Norway rat) | Psenen | NP_001008764.1 |
Danio rerio (zebrafish) | psenen | NP_991139.1 |
Caenorhabditis elegans (roundworm) | pen-2 | NP_499459.1 |
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Lokau J, Flynn CM, Garbers C
Biochemical and biophysical research communications491(2)296-302(2017 09)
Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.
Hu C, Xu J, Zeng L, Li T, Cui MZ, Xu X
Journal of Alzheimer's disease : JAD56(4)1263-1269(2017)
Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.
Liu L, Watanabe N, Akatsu H, Nishimura M
Neuroscience330236-46(2016 Aug)
Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ 3rd
Neuron85(5)967-81(2015 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Title: Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
the G206D mutation reduced presenilin-1-presenilin enhancer 2 interaction, but did not abolish gamma-secretase formation and presenilin-1 endoproteolysis
Title: G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases A?42/A?40 Ratio and Elevates ER Ca(2+) Accumulation.
Data show that the expression level of presenilin enhancer-2 (Pen-2) is relatively high in central nervous system at the early stages of postnatal development, but declines, gradually in adult mice.
Title: Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice.
rather than solely being a catalyst for gamma-secretase endoproteolysis, Pen-2 may also stabilize the complex prior to PS1 endoproteolysis, allowing time for full assembly and proper trafficking.
Title: Pen-2 is essential for ?-secretase complex stability and trafficking but partially dispensable for endoproteolysis.
Pen-2, as well as nicastrin and Aph-1alpha, is dispensable for presenilin endoproteolysis
Title: Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both ?-secretase assembly and substrate recruitment.
The following Psenen gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psenen cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu00574 | |
Clone ID Related Accession (Same CDS sequence) | NM_001364016.1 , NM_025498.3 , NM_001364017.1 , NM_025498.2 | |
Accession Version | NM_001364016.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-26 | |
Organism | Mus musculus(house mouse) | |
Product | gamma-secretase subunit PEN-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167970.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV499861.1, AA061009.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001350945.1 |
CDS | 202..507 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu00574 | |
Clone ID Related Accession (Same CDS sequence) | NM_001364016.1 , NM_025498.3 , NM_001364017.1 , NM_025498.2 | |
Accession Version | NM_025498.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-26 | |
Organism | Mus musculus(house mouse) | |
Product | gamma-secretase subunit PEN-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167970.4 and BC081443.1. On Jun 5, 2018 this sequence version replaced NM_025498.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081443.1, CB595929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_079774.1 |
CDS | 236..541 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu00574 | |
Clone ID Related Accession (Same CDS sequence) | NM_001364016.1 , NM_025498.3 , NM_001364017.1 , NM_025498.2 | |
Accession Version | NM_001364017.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-26 | |
Organism | Mus musculus(house mouse) | |
Product | gamma-secretase subunit PEN-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167970.4, AV576632.1 and W65052.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.345503.1, AV576632.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001350946.1 |
CDS | 185..490 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu00574 | |
Clone ID Related Accession (Same CDS sequence) | NM_001364016.1 , NM_025498.3 , NM_001364017.1 , NM_025498.2 | |
Accession Version | NM_025498.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-30 | |
Organism | Mus musculus(house mouse) | |
Product | gamma-secretase subunit PEN-2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC024347.1. On Jun 19, 2003 this sequence version replaced NM_025498.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024347.1, BC081443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_079774.1 |
CDS | 216..521 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAACTTGG AGCGGGTATC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome. |
Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing. |
Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. |
Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. |