Fbxo32 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Fbxo32 |
| Entrez Gene ID | 67731 |
| Full Name | F-box protein 32 |
| Synonyms | 4833442G10Rik,AI430017,ATROGIN1,Gm20361,MAFbx |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_026346.3 | NP_080622.1 | F-box only protein 32 |
| Rattus norvegicus (Norway rat) | Fbxo32 | NP_598205.1 |
| FBXO32 | XP_001100697.2 | |
| Bos taurus (cattle) | FBXO32 | NP_001039620.1 |
| Danio rerio (zebrafish) | fbxo32 | NP_957211.1 |
| Xenopus tropicalis (tropical clawed frog) | fbxo32 | XP_002941443.1 |
| Canis lupus familiaris (dog) | FBXO32 | XP_532324.2 |
| Gallus gallus (chicken) | FBXO32 | NP_001026127.1 |
| Homo sapiens (human) | FBXO32 | NP_478136.1 |
| Pan troglodytes (chimpanzee) | FBXO32 | XP_519940.2 |
| Mus musculus (house mouse) | Fbxo32 | NP_080622.1 |
Related articles in PubMed
Atrogin-1 Increases Smooth Muscle Contractility Through Myocardin Degradation.
Singh P, Li D, Gui Y, Zheng XL
Journal of cellular physiology232(4)806-817(2017 Apr)
Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.
Cortez-Toledo O, Schnair C, Sangngern P, Metzger D, Chao LC
PloS one12(2)e0171268(2017)
Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth.
Shin JY, M?ndez-L?pez I, Hong M, Wang Y, Tanji K, Wu W, Shugol L, Krauss RS, Dauer WT, Worman HJ
Human molecular genetics26(1)65-78(2017 01)
Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.
Murdoch JD, Rostosky CM, Gowrisankaran S, Arora AS, Soukup SF, Vidal R, Capece V, Freytag S, Fischer A, Verstreken P, Bonn S, Raimundo N, Milosevic I
Cell reports17(4)1071-1086(2016 10)
Muscle dysfunction caused by loss of Magel2 in a mouse model of Prader-Willi and Schaaf-Yang syndromes.
Kamaludin AA, Smolarchuk C, Bischof JM, Eggert R, Greer JJ, Ren J, Lee JJ, Yokota T, Berry FB, Wevrick R
Human molecular genetics25(17)3798-3809(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity.
Title: Atrogin-1 Increases Smooth Muscle Contractility Through Myocardin Degradation.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase FBXO32/atrogin-1 and its transcription factor FOXO3A.
Title: Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.
Valproic acid attenuated muscle wasting and myotube atrophy and reduced C/EBPbeta binding to atrogin1 promoter locus in the myotubes.
Title: Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBP?-regulated atrogin1 expression in cancer cachexia.
Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase mediated by the reduction of Akt-FOXO3a signaling by oxidative stress.
Title: Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3-E3 ubiquitin ligase-dependent pathway.
educed PABPN1 levels caused a consistent decline in distal PAS utilization in the 3'-UTR of a subset of OPMD-dysregulated genes. This alternative PAS utilization led to up-regulation of Atrogin-1, a key muscle atrophy regulator, but down regulation of proteasomal genes. Additionally reduced PABPN1 levels caused a reduction in proteasomal activity, and transition in MyHC isotope expression pattern in myofibers.
Title: PABPN1-Dependent mRNA Processing Induces Muscle Wasting.
The following Fbxo32 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbxo32 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu18433 | |
| Clone ID Related Accession (Same CDS sequence) | NM_026346.3 | |
| Accession Version | NM_026346.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-18 | |
| Organism | Mus musculus(house mouse) | |
| Product | F-box only protein 32 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU921446.1, AK014793.1 and AC113292.6. On or before Jul 30, 2011 this sequence version replaced XR_105720.1, XR_106914.1, NM_026346.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.106836.1, SRR1660821.16966.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCGTTCC TTGGGCAGGA CTGGCGGTCC CCGGGCCAGA GCTGGGTGAA GACGGCGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_080622.1 |
| CDS | 282..1349 |
| Misc Feature(1) | 147..149 |
| Misc Feature(2) | 465..482 |
| Misc Feature(3) | 786..800 |
| Misc Feature(4) | <1050..>1187 |
| Misc Feature(5) | 1119..1166 |
| Exon (1) | 1..397 |
| Exon (2) | 398..510 |
| Exon (3) | 511..560 |
| Exon (4) | 561..653 |
| Exon (5) | 654..747 |
| Exon (6) | 748..932 |
| Exon (7) | 933..1115 |
| Exon (8) | 1116..1259 |
| Exon (9) | 1260..6936 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_026346.3 |
ORF Insert Sequence:
1 | ATGCCGTTCC TTGGGCAGGA CTGGCGGTCC CCGGGCCAGA GCTGGGTGAA GACGGCGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Atrogin-1 Increases Smooth Muscle Contractility Through Myocardin Degradation. |
|
Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. |
|
Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth. |
|
Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System. |
|
Muscle dysfunction caused by loss of Magel2 in a mouse model of Prader-Willi and Schaaf-Yang syndromes. |