Fbxo32 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Fbxo32 |
| Entrez Gene ID | 67731 |
| Full Name | F-box protein 32 |
| Synonyms | 4833442G10Rik,AI430017,ATROGIN1,Gm20361,MAFbx |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_026346.3 | NP_080622.1 | F-box only protein 32 |
| Rattus norvegicus (Norway rat) | Fbxo32 | NP_598205.1 |
| FBXO32 | XP_001100697.2 | |
| Bos taurus (cattle) | FBXO32 | NP_001039620.1 |
| Danio rerio (zebrafish) | fbxo32 | NP_957211.1 |
| Xenopus tropicalis (tropical clawed frog) | fbxo32 | XP_002941443.1 |
| Canis lupus familiaris (dog) | FBXO32 | XP_532324.2 |
| Gallus gallus (chicken) | FBXO32 | NP_001026127.1 |
| Homo sapiens (human) | FBXO32 | NP_478136.1 |
| Pan troglodytes (chimpanzee) | FBXO32 | XP_519940.2 |
| Mus musculus (house mouse) | Fbxo32 | NP_080622.1 |
Related articles in PubMed
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.
Sahu SK, Tiwari N, Pataskar A, Zhuang Y, Borisova M, Diken M, Strand S, Beli P, Tiwari VK
Nature communications8(1)1523(2017 Nov)
Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1.
Liu HW, Chen YJ, Chang YC, Chang SJ
Nutrients9(9)(2017 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity.
Title: Atrogin-1 Increases Smooth Muscle Contractility Through Myocardin Degradation.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase FBXO32/atrogin-1 and its transcription factor FOXO3A.
Title: Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.
Valproic acid attenuated muscle wasting and myotube atrophy and reduced C/EBPbeta binding to atrogin1 promoter locus in the myotubes.
Title: Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBP?-regulated atrogin1 expression in cancer cachexia.
Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase mediated by the reduction of Akt-FOXO3a signaling by oxidative stress.
Title: Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3-E3 ubiquitin ligase-dependent pathway.
educed PABPN1 levels caused a consistent decline in distal PAS utilization in the 3'-UTR of a subset of OPMD-dysregulated genes. This alternative PAS utilization led to up-regulation of Atrogin-1, a key muscle atrophy regulator, but down regulation of proteasomal genes. Additionally reduced PABPN1 levels caused a reduction in proteasomal activity, and transition in MyHC isotope expression pattern in myofibers.
Title: PABPN1-Dependent mRNA Processing Induces Muscle Wasting.
The following Fbxo32 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbxo32 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu18433 | |
| Clone ID Related Accession (Same CDS sequence) | NM_026346.3 | |
| Accession Version | NM_026346.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | F-box only protein 32 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU921446.1, AK014793.1 and AC113292.6. On or before Jul 30, 2011 this sequence version replaced XR_105720.1, XR_106914.1, NM_026346.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014793.1, BC027211.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCGTTCC TTGGGCAGGA CTGGCGGTCC CCGGGCCAGA GCTGGGTGAA GACGGCGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_080622.1 |
| CDS | 282..1349 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_026346.3 |
ORF Insert Sequence:
1 | ATGCCGTTCC TTGGGCAGGA CTGGCGGTCC CCGGGCCAGA GCTGGGTGAA GACGGCGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development. |
|
Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1. |