HASPIN cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | HASPIN |
| Entrez Gene ID | 83903 |
| Full Name | histone H3 associated protein kinase |
| Synonyms | GSG2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_031965.2 | NP_114171.2 | serine/threonine-protein kinase haspin |
| Canis lupus familiaris (dog) | GSG2 | XP_854539.1 |
| Pan troglodytes (chimpanzee) | GSG2 | XP_001159222.1 |
| GSG2 | XP_001090778.1 | |
| Mus musculus (house mouse) | Gsg2 | NP_034483.1 |
| Rattus norvegicus (Norway rat) | Gsg2 | XP_003750897.1 |
| Bos taurus (cattle) | GSG2 | NP_001070012.1 |
| Homo sapiens (human) | GSG2 | NP_114171.2 |
Related articles in PubMed
High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration.
Lew YJ, Rinella N, Qin J, Chiang J, Moore AT, Porco TC, Roorda A, Duncan JL
American journal of ophthalmology18532-42(2018 Jan)
A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.
Liang C, Chen Q, Yi Q, Zhang M, Yan H, Zhang B, Zhou L, Zhang Z, Qi F, Ye S, Wang F
EMBO reports19(1)43-56(2018 Jan)
Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.
Goto Y, Yamagishi Y, Shintomi-Kawamura M, Abe M, Tanno Y, Watanabe Y
Current biology : CB27(7)1005-1012(2017 Apr)
The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis.
Zhou L, Liang C, Chen Q, Zhang Z, Zhang B, Yan H, Qi F, Zhang M, Yi Q, Guan Y, Xiang X, Zhang X, Ye S, Wang F
Current biology : CB27(7)992-1004(2017 Apr)
Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin.
Kestav K, Uri A, Lavogina D
Current medicinal chemistry24(21)2276-2293(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Autosomal recessive RP associated with mutations in the male germ cell-associated kinase (MAK) gene is associated with preservation of foveal vision even in advanced stages of retinal degeneration despite similar rates of peripheral visual field loss to other forms of autosomal recessive RP
Title: High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration.
This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors
Title: Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.
Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool.
Title: Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores.
Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing.
Title: Modulation of the chromatin phosphoproteome by the Haspin protein kinase.
Haspin inhibitors reveal centromeric roles of Aurora B in chromosome movement and spindle checkpoint signaling
Title: Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.
The following HASPIN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HASPIN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu31161 | |
| Clone ID Related Accession (Same CDS sequence) | NM_031965.2 | |
| Accession Version | NM_031965.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Homo sapiens(human) | |
| Product | serine/threonine-protein kinase haspin | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC036181.1, BC016626.1, BC047457.1 and AF289865.1. On Dec 23, 2004 this sequence version replaced NM_031965.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC036181.1, AB039834.3 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000325418.5/ ENSP00000325290.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## | |
1 | ATGGCGGCTT CGCTCCCGGG ACCTGGGAGC CGGCTTTTCC GCACATATGG GGCTGCGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_114171.2 |
| CDS | 34..2430 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_031965.2 |
ORF Insert Sequence:
1 | ATGGCGGCTT CGCTCCCGGG ACCTGGGAGC CGGCTTTTCC GCACATATGG GGCTGCGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
High-resolution Imaging in Male Germ Cell-Associated Kinase (MAK)-related Retinal Degeneration. |
|
A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion. |
|
Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module. |
|
The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis. |
|
Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin. |