PLPP2 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | PLPP2 |
Entrez Gene ID | 8612 |
Full Name | phospholipid phosphatase 2 |
Synonyms | LPP2,PAP-2c,PAP2-g,PPAP2C |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_177543.3 | NP_808211.1 | phospholipid phosphatase 2 isoform 3 |
NM_177526.2 | NP_803545.1 | phospholipid phosphatase 2 isoform 2 |
NM_003712.3 | NP_003703.1 | phospholipid phosphatase 2 isoform 1 |
NM_177543.2 | NP_808211.1 | phospholipid phosphatase 2 isoform 3 |
NM_177526.3 | NP_803545.1 | phospholipid phosphatase 2 isoform 2 |
XM_011528396.2 | XP_011526698.1 | phospholipid phosphatase 2 isoform X1 |
NM_003712.4 | NP_003703.1 | phospholipid phosphatase 2 isoform 1 |

Gallus gallus (chicken) | LOC100858471 | XP_003642894.2 |
Pan troglodytes (chimpanzee) | PPAP2C | XP_003954502.1 |
Bos taurus (cattle) | PPAP2C | NP_001039355.1 |
Rattus norvegicus (Norway rat) | Ppap2c | NP_640345.1 |
LOC721004 | XP_001116998.1 | |
Homo sapiens (human) | PPAP2C | NP_808211.1 |
Canis lupus familiaris (dog) | PPAP2C | XP_003639797.1 |
Mus musculus (house mouse) | Ppap2c | NP_056632.2 |
Xenopus tropicalis (tropical clawed frog) | ppap2c | NP_989117.1 |
Danio rerio (zebrafish) | LOC563806 | XP_692261.6 |

Related articles in PubMed
Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.
Long JS, Pyne NJ, Pyne S
The Biochemical journal411(2)371-7(2008 Apr)
Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts.
Morris KE, Schang LM, Brindley DN
The Journal of biological chemistry281(14)9297-306(2006 Apr)
Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.
Nanjundan M, Possmayer F
American journal of physiology. Lung cellular and molecular physiology284(1)L1-23(2003 Jan)
Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile.
Zhang N, Sundberg JP, Gridley T
Genesis (New York, N.Y. : 2000)27(4)137-40(2000 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
endogenous LPP2 and LPP3 form homo- and hetero-oligomers, which differ in their subcellular localization and which may confer differing spatial regulation of phosphatidic acid and sphingosine 1-phosphate signalling
Title: Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.
identified a novel and specific role for LPP2 activity and bioactive lipids in regulating cell cycle progression
Title: Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts.
Functional study of the mouse homolog
Title: Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile.
The following PLPP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLPP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu03480![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_003712.3 , NM_003712.4 | |
Accession Version | NM_003712.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | phospholipid phosphatase 2 isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM050291.1, AF047760.1, BM982485.1 and AA428937.1. On Jul 12, 2013 this sequence version replaced NM_003712.2. Transcript Variant: This variant (1) differs in the 5' region, including the 5' UTR and 5' coding region, as compared to variant 3. The resulting isoform (1) has a distinct and shorter N-terminus, as compared to isoform 3. ##Evidence-Data-START## Transcript exon combination :: BC002806.2, AF035959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAGCGGA GGTGGGTCTT CGTGCTGCTC GACGTGCTGT GCTTACTGGT CGCCTCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003703.1 |
CDS | 100..966 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCAGCGGA GGTGGGTCTT CGTGCTGCTC GACGTGCTGT GCTTACTGGT CGCCTCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu03480![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_003712.3 , NM_003712.4 | |
Accession Version | NM_003712.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-29 | |
Organism | Homo sapiens(human) | |
Product | phospholipid phosphatase 2 isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM050291.1, AF047760.1, BM982485.1 and AA428937.1. On Nov 23, 2018 this sequence version replaced NM_003712.3. Transcript Variant: This variant (1) differs in the 5' region, including the 5' UTR and 5' coding region, as compared to variant 3. The resulting isoform (1) has a distinct and shorter N-terminus, as compared to isoform 3. ##Evidence-Data-START## Transcript exon combination :: AF035959.1, SRR5189658.51970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000434325.7/ ENSP00000388565.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCAGCGGA GGTGGGTCTT CGTGCTGCTC GACGTGCTGT GCTTACTGGT CGCCTCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003703.1 |
CDS | 68..934 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCAGCGGA GGTGGGTCTT CGTGCTGCTC GACGTGCTGT GCTTACTGGT CGCCTCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu07446![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_177526.2 , NM_177526.3 | |
Accession Version | NM_177526.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-29 | |
Organism | Homo sapiens(human) | |
Product | phospholipid phosphatase 2 isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM050291.1, HY160303.1, BC002806.2, BM982485.1 and AA428937.1. On Jul 12, 2013 this sequence version replaced NM_177526.1. Transcript Variant: This variant (2) has an alternate 5' terminal exon, which results in a downstream translation start codon, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3. ##Evidence-Data-START## Transcript exon combination :: BM047764.1, BI601893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2153946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGGGG TCACCATCAC GGCCACCGTC ATCCTTGTCT CGGCCGGGGA AGCCTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_803545.1 |
CDS | 227..925 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCTGGGG TCACCATCAC GGCCACCGTC ATCCTTGTCT CGGCCGGGGA AGCCTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu07446![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_177526.2 , NM_177526.3 | |
Accession Version | NM_177526.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-03 | |
Organism | Homo sapiens(human) | |
Product | phospholipid phosphatase 2 isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM050291.1, HY160303.1, BC002806.2, BM982485.1 and AA428937.1. On Jun 1, 2019 this sequence version replaced NM_177526.2. Transcript Variant: This variant (2) has an alternate 5' terminal exon, which results in a downstream translation start codon, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3. ##Evidence-Data-START## Transcript exon combination :: DRR138512.122177.1, SRR7410570.647641.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2153946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGGGG TCACCATCAC GGCCACCGTC ATCCTTGTCT CGGCCGGGGA AGCCTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_803545.1 |
CDS | 195..893 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCTGGGG TCACCATCAC GGCCACCGTC ATCCTTGTCT CGGCCGGGGA AGCCTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu62029 | |
Clone ID Related Accession (Same CDS sequence) | XM_011528396.2 | |
Accession Version | XM_011528396.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | phospholipid phosphatase 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528396.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGCGGA GGTGGGTCTT CGTGCTGCTC GACGTGCTGT GCTTACTGGT CGGCTTTTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011526698.1 |
CDS | 78..962 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCAGCGGA GGTGGGTCTT CGTGCTGCTC GACGTGCTGT GCTTACTGGT CGGCTTTTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu07451 | |
Clone ID Related Accession (Same CDS sequence) | NM_177543.3 , NM_177543.2 | |
Accession Version | NM_177543.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-03 | |
Organism | Homo sapiens(human) | |
Product | phospholipid phosphatase 2 isoform 3 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG831889.1, BE615792.1, AF047760.1, BM982485.1 and AA428937.1. On May 31, 2019 this sequence version replaced NM_177543.2. Transcript Variant: This variant (3) encodes the longest isoform (3). ##Evidence-Data-START## Transcript exon combination :: SRR7410570.647648.1, BI160067.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGGTCG CGAGAGGCCC GGGGAGCCGG GGCCAGCATC CCCCGCCCCG GCAGCAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_808211.1 |
CDS | 74..1003 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGGGGTCG CGAGAGGCCC GGGGAGCCGG GGCCAGCATC CCCCGCCCCG GCAGCAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu07451 | |
Clone ID Related Accession (Same CDS sequence) | NM_177543.3 , NM_177543.2 | |
Accession Version | NM_177543.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-29 | |
Organism | Homo sapiens(human) | |
Product | phospholipid phosphatase 2 isoform 3 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG831889.1, BE615792.1, AF047760.1, BM982485.1 and AA428937.1. On Jul 12, 2013 this sequence version replaced NM_177543.1. Transcript Variant: This variant (3) encodes the longest isoform (3). ##Evidence-Data-START## Transcript exon combination :: BI194438.1, BI160067.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGGTCG CGAGAGGCCC GGGGAGCCGG GGCCAGCATC CCCCGCCCCG GCAGCAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_808211.1 |
CDS | 104..1033 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGGGGTCG CGAGAGGCCC GGGGAGCCGG GGCCAGCATC CCCCGCCCCG GCAGCAGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Widespread macromolecular interaction perturbations in human genetic disorders. |
![]() |
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. |
![]() |
Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts. |
![]() |
Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. |
![]() |
Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. |