Gene Symbol | Fosb |
Entrez Gene ID | 100360880 |
Full Name | FosB proto-oncogene, AP-1 transcription factor subunit |
Synonyms | fra-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Fosb cDNA ORF clone
Gene Symbol | Fosb |
Entrez Gene ID | 100360880 |
Full Name | FosB proto-oncogene, AP-1 transcription factor subunit |
Synonyms | fra-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001256509.1 | NP_001243438.1 | protein fosB |
Canis lupus familiaris (dog) | FOSB | NP_001013866.1 |
Bos taurus (cattle) | FOSB | NP_001095718.1 |
Rattus norvegicus (Norway rat) | Fosb | NP_001243438.1 |
Mus musculus (house mouse) | Fosb | NP_032062.1 |
Danio rerio (zebrafish) | fosb | NP_001007313.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100490871 | XP_002932681.2 |
Homo sapiens (human) | FOSB | NP_006723.2 |
Transcription factor ?FosB acts within the nucleus of the solitary tract to increase mean arterial pressure during exposures to intermittent hypoxia.
Wu Q, Cunningham JT, Mifflin SW
American journal of physiology. Heart and circulatory physiologyajpheart002682017(2017 Nov)
Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.
Faulk K, Shell B, Nedungadi TP, Cunningham JT
American journal of physiology. Regulatory, integrative and comparative physiology312(2)R245-R252(2017 Feb)
Impact of repeated asenapine treatment on FosB/?FosB expression in the forebrain structures under normal conditions and mild stress preconditioning in the rat.
Majercikova Z, Horvathova L, Osacka J, Pecenak J, Kiss A
Brain research bulletin12729-37(2016 Oct)
Repeated forced swim stress affects the expression of pCREB and ?FosB and the acetylation of histone H3 in the rostral ventromedial medulla and locus coeruleus.
Imbe H, Kimura A
Brain research bulletin12711-22(2016 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Chromatin immunoprecipitation (ChIP) assays demonstrated an increase in FosB/DeltaFosB association with the ACE1 gene within the MnPO following CIH. FosB/DeltaFosB may transcriptionally target ACE1 within the MnPO following CIH to affect the downstream PVN region, which may influence SNA and blood pressure.
Title: Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.
Results show that repeated administration of asenapine may elici long-lasting FosB/DeltaFosB-like transcription factors that could mediate some of the persistent and region-specific changes in brain function, interconnected with chronic drug exposure. interconnected with chronic drug exposure. However, it cannot be excluded that the impact of repeated asenapine exposure might be influenced by an ambient stressogen leve...
Title: Impact of repeated asenapine treatment on FosB/?FosB expression in the forebrain structures under normal conditions and mild stress preconditioning in the rat.
Forced swim stress induced a significant increase in the expression of pCREB and DeltaFosB and the acetylation of histone H3 in the rostral ventromedial medulla, whereas the forced swim stress induced a significant increase only in the acetylation of histone H3 in the locus coeruleus.
Title: Repeated forced swim stress affects the expression of pCREB and ?FosB and the acetylation of histone H3 in the rostral ventromedial medulla and locus coeruleus.
Results show that FosB gene products are induced throughout the brain by chronic exposure to fluoxetine, and that the specific gene products expressed vary by brain region and between chronic stress and antidepressant treatment
Title: Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress.
Significant increase in FosB/DeltaFosB-like immunostaining was observed in the dentate gyrus, basolateral amygdala and medial prefrontal cortex of rats exposed to chronic variable stress-shock.
Title: History of chronic stress modifies acute stress-evoked fear memory and acoustic startle in male rats.
The following Fosb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fosb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa09153 | |
Clone ID Related Accession (Same CDS sequence) | NM_001256509.1 | |
Accession Version | NM_001256509.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-07 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | protein fosB | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473979.2. On or before Feb 5, 2012 this sequence version replaced XM_002725539.1, XM_002725540.1, XM_002728698.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTTCAAG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGTAGCTC ATCACCCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001243438.1 |
CDS | 325..1341 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001256509.1 |
1 | ATGTTTCAAG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGTAGCTC ATCACCCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Transcription factor ?FosB acts within the nucleus of the solitary tract to increase mean arterial pressure during exposures to intermittent hypoxia. |
Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia. |
Impact of repeated asenapine treatment on FosB/?FosB expression in the forebrain structures under normal conditions and mild stress preconditioning in the rat. |
Repeated forced swim stress affects the expression of pCREB and ?FosB and the acetylation of histone H3 in the rostral ventromedial medulla and locus coeruleus. |