Gene Symbol | Otulin |
Entrez Gene ID | 100362554 |
Full Name | OTU deubiquitinase with linear linkage specificity |
Synonyms | Fam105b |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Otulin cDNA ORF clone
gRNAs
Gene Symbol | Otulin |
Entrez Gene ID | 100362554 |
Full Name | OTU deubiquitinase with linear linkage specificity |
Synonyms | Fam105b |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006232088.3 | XP_006232150.1 | ubiquitin thioesterase otulin isoform X1 |
NM_001302889.1 | NP_001289818.1 | ubiquitin thioesterase otulin |
FAM105B | XP_001087122.2 | |
Rattus norvegicus (Norway rat) | Fam105b | XP_006232150.1 |
Gallus gallus (chicken) | FAM105B | XP_004935161.1 |
Homo sapiens (human) | FAM105B | NP_612357.4 |
Danio rerio (zebrafish) | fam105bb | NP_001159487.1 |
Pan troglodytes (chimpanzee) | FAM105B | XP_517640.2 |
Canis lupus familiaris (dog) | FAM105B | XP_848253.2 |
Bos taurus (cattle) | FAM105B | NP_001093798.1 |
Mus musculus (house mouse) | Fam105b | NP_001013814.2 |
Danio rerio (zebrafish) | LOC100001665 | XP_001341618.4 |
Xenopus tropicalis (tropical clawed frog) | fam105b | XP_004915385.1 |
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.
Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai WL, Kuehn HS, Wang H, Yang D, Park YH, Ombrello AK, Blake M, Romeo T, Remmers EF, Chae JJ, Mullikin JC, G?zel F, Milner JD, Boehm M, Rosenzweig SD, Gadina M, Welch SB, ?zen S, Topaloglu R, Abinun M, Kastner DL, Aksentijevich I
Proceedings of the National Academy of Sciences of the United States of America113(36)10127-32(2016 09)
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ, Komander D
Cell166(5)1215-1230.e20(2016 Aug)
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling.
Hrdinka M, Fiil BK, Zucca M, Leske D, Bagola K, Yabal M, Elliott PR, Damgaard RB, Komander D, Jost PJ, Gyrd-Hansen M
Cell reports14(12)2846-58(2016 Mar)
Binding of OTULIN to the PUB domain of HOIP controls NF-?B signaling.
Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I
Molecular cell54(3)349-61(2014 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Otulin gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Otulin cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa15130 | |
Clone ID Related Accession (Same CDS sequence) | NM_001302889.1 | |
Accession Version | NM_001302889.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-18 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin thioesterase otulin | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07008940.1, BC158613.1, FM089678.1, BC158827.1 and FM122033.1. On or before Nov 27, 2014 this sequence version replaced XM_002725921.4, XM_002729016.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC158613.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGTCGGG GAATCATGCC CCAACCCGGA GCGTGGCCGG GAGCGGGCTG CGCGGAGACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001289818.1 |
CDS | 73..1134 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGTCGGG GAATCATGCC CCAACCCGGA GCGTGGCCGG GAGCGGGCTG CGCGGAGACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa15131 | |
Clone ID Related Accession (Same CDS sequence) | XM_006232088.3 | |
Accession Version | XM_006232088.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin thioesterase otulin isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006232088.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGTCGGG GAATCATGCC CCAACCCGGA GCGTGGCCGG GAGCGGGCTG CGCGGAGACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006232150.1 |
CDS | 91..1149 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGTCGGG GAATCATGCC CCAACCCGGA GCGTGGCCGG GAGCGGGCTG CGCGGAGACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. |
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. |
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling. |
Binding of OTULIN to the PUB domain of HOIP controls NF-?B signaling. |