Gene Symbol | Serpina1 |
Entrez Gene ID | 24648 |
Full Name | serpin family A member 1 |
Synonyms | AAT,Pi,Spi1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Serpina1 cDNA ORF clone
gRNAs
Gene Symbol | Serpina1 |
Entrez Gene ID | 24648 |
Full Name | serpin family A member 1 |
Synonyms | AAT,Pi,Spi1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017594032.1 | XP_017449521.1 | alpha-1-antiproteinase isoform X1 |
XM_006240456.1 | XP_006240518.1 | alpha-1-antiproteinase isoform X1 |
NM_022519.2 | NP_071964.2 | alpha-1-antiproteinase precursor |
Rattus norvegicus (Norway rat) | Serpina1 | NP_071964.2 |
Gallus gallus (chicken) | SERPINA4 | NP_001264421.1 |
Gallus gallus (chicken) | SERPINA5 | XP_004941954.1 |
Xenopus tropicalis (tropical clawed frog) | serpina1 | XP_002936109.1 |
Pan troglodytes (chimpanzee) | SERPINA1 | XP_522938.2 |
Mus musculus (house mouse) | Serpina1e | NP_033273.1 |
Gallus gallus (chicken) | SERPINA1 | NP_001264422.1 |
Danio rerio (zebrafish) | serpina1l | NP_001013277.3 |
Canis lupus familiaris (dog) | SERPINA1 | NP_001073578.1 |
Mus musculus (house mouse) | Serpina1d | NP_033272.1 |
Xenopus tropicalis (tropical clawed frog) | serpina3k | XP_002936116.2 |
Mus musculus (house mouse) | Serpina1c | NP_033271.1 |
Gallus gallus (chicken) | SERPINA9 | XP_004941955.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100488834 | XP_002936115.2 |
Homo sapiens (human) | SERPINA1 | NP_001002236.1 |
SERPINA1 | XP_001099255.1 | |
Bos taurus (cattle) | SERPINA1 | NP_776307.1 |
Mus musculus (house mouse) | Serpina1a | NP_033269.1 |
Mus musculus (house mouse) | Serpina1b | NP_033270.3 |
Danio rerio (zebrafish) | serpina1 | NP_001071226.1 |
Identification of a new defective SERPINA1 allele (PI*Z
Hern?ndez-P?rez JM, Ramos-D?az R, P?rez JA
Respiratory medicine131114-117(2017 Oct)
Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.
Maicas N, van der Vlag J, Bublitz J, Florquin S, Bakker-van Bebber M, Dinarello CA, Verweij V, Masereeuw R, Joosten LA, Hilbrands LB
PloS one12(2)e0168981(2017)
Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection.
Ayala P, Meneses M, Olmos P, Montalva R, Droguett K, R?os M, Borzone G
Respiratory research17(1)71(2016 Jun)
Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis.
Wang Q, Du J, Yu P, Bai B, Zhao Z, Wang S, Zhu J, Feng Q, Gao Y, Zhao Q, Liu C
Scientific reports517833(2015 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Gastric contents-induced acute lung injury elicits a liver acute phase response characterized by increased mRNA expression of alpha 2 macroglobulin and alpha1-antitrypsin.
Title: Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection.
A1AT bidirectional uptake and secretion from lung endothelial cells towards the alveolar epithelium and airspaces
Title: Active trafficking of alpha 1 antitrypsin across the lung endothelium.
These results suggest that transfer of the N-terminal acidic extension of HCII to alpha1-PI M358R enhanced its inhibition of thrombin by conferring the ability to bind exosite 1 on HAPI M358R.
Title: The transferable tail: fusion of the N-terminal acidic extension of heparin cofactor II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition.
The following Serpina1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa05824 | |
Clone ID Related Accession (Same CDS sequence) | XM_017594032.1 , XM_006240456.1 , NM_022519.2 | |
Accession Version | NM_022519.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | alpha-1-antiproteinase precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078824.1. On Aug 8, 2004 this sequence version replaced NM_022519.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078824.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_071964.2 |
CDS | 254..1489 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa05824 | |
Clone ID Related Accession (Same CDS sequence) | XM_017594032.1 , XM_006240456.1 , NM_022519.2 | |
Accession Version | XM_017594032.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | alpha-1-antiproteinase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017449521.1 |
CDS | 181..1416 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa05824 | |
Clone ID Related Accession (Same CDS sequence) | XM_017594032.1 , XM_006240456.1 , NM_022519.2 | |
Accession Version | XM_006240456.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | alpha-1-antiproteinase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006240518.1 |
CDS | 111..1346 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Identification of a new defective SERPINA1 allele (PI*Z |
Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury. |
Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection. |
Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis. |