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Serpina1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Serpina1
Entrez Gene ID 24648
Full Name serpin family A member 1
Synonyms AAT,Pi,Spi1
General protein information
Preferred Names

serpin family A member 1

Names

alpha-1-antiproteinase
alpha-1-antitrypsin (protease inhibitor)
alpha-1-protease inhibitor
alpha-1-proteinase inhibitor
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
serine (or cysteine) proteinase inhibitor, clade A, member 1
serine protease inhibitor alpha 1
serpin A1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

6

6q32

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017594032.1 XP_017449521.1 alpha-1-antiproteinase isoform X1
XM_006240456.1 XP_006240518.1 alpha-1-antiproteinase isoform X1
NM_022519.2 NP_071964.2 alpha-1-antiproteinase precursor

Pathways from BioSystems


Homologies


Rattus norvegicus (Norway rat) Serpina1 NP_071964.2
Gallus gallus (chicken) SERPINA4 NP_001264421.1
Gallus gallus (chicken) SERPINA5 XP_004941954.1
Xenopus tropicalis (tropical clawed frog) serpina1 XP_002936109.1
Pan troglodytes (chimpanzee) SERPINA1 XP_522938.2
Mus musculus (house mouse) Serpina1e NP_033273.1
Gallus gallus (chicken) SERPINA1 NP_001264422.1
Danio rerio (zebrafish) serpina1l NP_001013277.3
Canis lupus familiaris (dog) SERPINA1 NP_001073578.1
Mus musculus (house mouse) Serpina1d NP_033272.1
Xenopus tropicalis (tropical clawed frog) serpina3k XP_002936116.2
Mus musculus (house mouse) Serpina1c NP_033271.1
Gallus gallus (chicken) SERPINA9 XP_004941955.1
Xenopus tropicalis (tropical clawed frog) LOC100488834 XP_002936115.2
Homo sapiens (human) SERPINA1 NP_001002236.1
SERPINA1 XP_001099255.1
Bos taurus (cattle) SERPINA1 NP_776307.1
Mus musculus (house mouse) Serpina1a NP_033269.1
Mus musculus (house mouse) Serpina1b NP_033270.3
Danio rerio (zebrafish) serpina1 NP_001071226.1

Gene Ontology


Bibliography

Related articles in PubMed

Identification of a new defective SERPINA1 allele (PI*Z
Hern?ndez-P?rez JM, Ramos-D?az R, P?rez JA
Respiratory medicine131114-117(2017 Oct)

Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.
Maicas N, van der Vlag J, Bublitz J, Florquin S, Bakker-van Bebber M, Dinarello CA, Verweij V, Masereeuw R, Joosten LA, Hilbrands LB
PloS one12(2)e0168981(2017)

Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection.
Ayala P, Meneses M, Olmos P, Montalva R, Droguett K, R?os M, Borzone G
Respiratory research17(1)71(2016 Jun)

Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis.
Wang Q, Du J, Yu P, Bai B, Zhao Z, Wang S, Zhu J, Feng Q, Gao Y, Zhao Q, Liu C
Scientific reports517833(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gastric contents-induced acute lung injury elicits a liver acute phase response characterized by increased mRNA expression of alpha 2 macroglobulin and alpha1-antitrypsin.
Title: Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection.

A1AT bidirectional uptake and secretion from lung endothelial cells towards the alveolar epithelium and airspaces
Title: Active trafficking of alpha 1 antitrypsin across the lung endothelium.

These results suggest that transfer of the N-terminal acidic extension of HCII to alpha1-PI M358R enhanced its inhibition of thrombin by conferring the ability to bind exosite 1 on HAPI M358R.
Title: The transferable tail: fusion of the N-terminal acidic extension of heparin cofactor II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition.

The following Serpina1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa05824 NM_022519.2
Latest version!		 Rattus norvegicus serpin family A member 1 (Serpina1), mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $188.30
$269.00
ORa05824 XM_017594032.1
Latest version!		 Rattus norvegicus serpin family A member 1 (Serpina1), transcript variant X2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $188.30
$269.00
ORa05824 XM_006240456.1
Latest version!		 Rattus norvegicus serpin family A member 1 (Serpina1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $188.30
$269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa05824
Clone ID Related Accession (Same CDS sequence) XM_017594032.1 , XM_006240456.1 , NM_022519.2
Accession Version NM_022519.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1236bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-24
Organism Rattus norvegicus(Norway rat)
Product alpha-1-antiproteinase precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078824.1. On Aug 8, 2004 this sequence version replaced NM_022519.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078824.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC 
AGCTTCCTGG CTGAGGATGC CCAGGAAACC GATACCTCCC AGCAGGACCA GAGTCCAACC 
TACCGTAAGA TTTCTTCAAA CCTGGCAGAC TTTGCCTTCA GCCTATACCG GGAGCTGGTC 
CATCAATCCA ATACATCCAA CATCTTCTTC TCCCCTATGA GCATCACCAC AGCCTTCGCC 
ATGCTCTCCC TGGGGAGCAA GGGTGACACT CGCAAACAGA TTCTAGAGGG CCTGGAGTTC 
AACCTCACAC AGATACCTGA GGCTGACATC CACAAGGCCT TCCATCACCT CCTCCAAACT 
CTCAACAGGC CAGACAGTGA GCTGCAGCTG AACACAGGCA ATGGCCTCTT TGTCAACAAG 
AATCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGTCAAGA ACAATTACCA CTCAGAAGCC 
TTCTCTGTCA ACTTTGCCGA CTCAGAAGAG GCTAAGAAAG TAATTAATGA TTATGTAGAG 
AAGGGAACCC AAGGAAAGAT AGTTGATTTG ATGAAACAGC TGGACGAAGA CACGGTTTTT 
GCCCTGGTGA ATTACATTTT CTTTAAAGGC AAGTGGAAGA GGCCATTCAA TCCTGAGCAC 
ACTAGGGATG CTGACTTCCA CGTAGACAAG TCCACCACGG TGAAGGTGCC CATGATGAAC 
CGCCTGGGCA TGTTTGACAT GCACTATTGC AGCACACTGT CCAGCTGGGT GCTGATGATG 
GATTACCTGG GCAACGCCAC TGCCATCTTC CTCCTGCCCG ATGATGGCAA GATGCAGCAT 
CTGGAGCAAA CTCTCACCAA GGATCTCATT TCCCGGTTCC TGCTAAACAG GCAAACAAGG 
TCAGCCATTC TCTACTTCCC CAAACTGTCC ATCTCTGGAA CCTATAACTT GAAGACACTC 
CTGAGCTCAC TGGGCATCAC CCGGGTCTTC AACAATGATG CTGATCTCTC TGGAATCACA 
GAGGATGCCC CCCTGAAGCT TAGCCAGGCT GTGCATAAGG CTGTGCTGAC CTTAGATGAG 
AGGGGAACAG AGGCTGCAGG AGCCACTGTG GTGGAGGCCG TCCCCATGTC TCTGCCCCCT 
CAAGTGAAGT TCGACCACCC TTTCATTTTC ATGATAGTTG AATCAGAAAC TCAGAGCCCC 
CTCTTTGTGG GAAAAGTGAT AGATCCCACA CGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_071964.2
CDS254..1489
Translation

Target ORF information:

RefSeq Version NM_022519.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus serpin family A member 1 (Serpina1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_022519.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC 
AGCTTCCTGG CTGAGGATGC CCAGGAAACC GATACCTCCC AGCAGGACCA GAGTCCAACC 
TACCGTAAGA TTTCTTCAAA CCTGGCAGAC TTTGCCTTCA GCCTATACCG GGAGCTGGTC 
CATCAATCCA ATACATCCAA CATCTTCTTC TCCCCTATGA GCATCACCAC AGCCTTCGCC 
ATGCTCTCCC TGGGGAGCAA GGGTGACACT CGCAAACAGA TTCTAGAGGG CCTGGAGTTC 
AACCTCACAC AGATACCTGA GGCTGACATC CACAAGGCCT TCCATCACCT CCTCCAAACT 
CTCAACAGGC CAGACAGTGA GCTGCAGCTG AACACAGGCA ATGGCCTCTT TGTCAACAAG 
AATCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGTCAAGA ACAATTACCA CTCAGAAGCC 
TTCTCTGTCA ACTTTGCCGA CTCAGAAGAG GCTAAGAAAG TAATTAATGA TTATGTAGAG 
AAGGGAACCC AAGGAAAGAT AGTTGATTTG ATGAAACAGC TGGACGAAGA CACGGTTTTT 
GCCCTGGTGA ATTACATTTT CTTTAAAGGC AAGTGGAAGA GGCCATTCAA TCCTGAGCAC 
ACTAGGGATG CTGACTTCCA CGTAGACAAG TCCACCACGG TGAAGGTGCC CATGATGAAC 
CGCCTGGGCA TGTTTGACAT GCACTATTGC AGCACACTGT CCAGCTGGGT GCTGATGATG 
GATTACCTGG GCAACGCCAC TGCCATCTTC CTCCTGCCCG ATGATGGCAA GATGCAGCAT 
CTGGAGCAAA CTCTCACCAA GGATCTCATT TCCCGGTTCC TGCTAAACAG GCAAACAAGG 
TCAGCCATTC TCTACTTCCC CAAACTGTCC ATCTCTGGAA CCTATAACTT GAAGACACTC 
CTGAGCTCAC TGGGCATCAC CCGGGTCTTC AACAATGATG CTGATCTCTC TGGAATCACA 
GAGGATGCCC CCCTGAAGCT TAGCCAGGCT GTGCATAAGG CTGTGCTGAC CTTAGATGAG 
AGGGGAACAG AGGCTGCAGG AGCCACTGTG GTGGAGGCCG TCCCCATGTC TCTGCCCCCT 
CAAGTGAAGT TCGACCACCC TTTCATTTTC ATGATAGTTG AATCAGAAAC TCAGAGCCCC 
CTCTTTGTGG GAAAAGTGAT AGATCCCACA CGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa05824
Clone ID Related Accession (Same CDS sequence) XM_017594032.1 , XM_006240456.1 , NM_022519.2
Accession Version XM_017594032.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1236bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product alpha-1-antiproteinase isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC 
AGCTTCCTGG CTGAGGATGC CCAGGAAACC GATACCTCCC AGCAGGACCA GAGTCCAACC 
TACCGTAAGA TTTCTTCAAA CCTGGCAGAC TTTGCCTTCA GCCTATACCG GGAGCTGGTC 
CATCAATCCA ATACATCCAA CATCTTCTTC TCCCCTATGA GCATCACCAC AGCCTTCGCC 
ATGCTCTCCC TGGGGAGCAA GGGTGACACT CGCAAACAGA TTCTAGAGGG CCTGGAGTTC 
AACCTCACAC AGATACCTGA GGCTGACATC CACAAGGCCT TCCATCACCT CCTCCAAACT 
CTCAACAGGC CAGACAGTGA GCTGCAGCTG AACACAGGCA ATGGCCTCTT TGTCAACAAG 
AATCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGTCAAGA ACAATTACCA CTCAGAAGCC 
TTCTCTGTCA ACTTTGCCGA CTCAGAAGAG GCTAAGAAAG TAATTAATGA TTATGTAGAG 
AAGGGAACCC AAGGAAAGAT AGTTGATTTG ATGAAACAGC TGGACGAAGA CACGGTTTTT 
GCCCTGGTGA ATTACATTTT CTTTAAAGGC AAGTGGAAGA GGCCATTCAA TCCTGAGCAC 
ACTAGGGATG CTGACTTCCA CGTAGACAAG TCCACCACGG TGAAGGTGCC CATGATGAAC 
CGCCTGGGCA TGTTTGACAT GCACTATTGC AGCACACTGT CCAGCTGGGT GCTGATGATG 
GATTACCTGG GCAACGCCAC TGCCATCTTC CTCCTGCCCG ATGATGGCAA GATGCAGCAT 
CTGGAGCAAA CTCTCACCAA GGATCTCATT TCCCGGTTCC TGCTAAACAG GCAAACAAGG 
TCAGCCATTC TCTACTTCCC CAAACTGTCC ATCTCTGGAA CCTATAACTT GAAGACACTC 
CTGAGCTCAC TGGGCATCAC CCGGGTCTTC AACAATGATG CTGATCTCTC TGGAATCACA 
GAGGATGCCC CCCTGAAGCT TAGCCAGGCT GTGCATAAGG CTGTGCTGAC CTTAGATGAG 
AGGGGAACAG AGGCTGCAGG AGCCACTGTG GTGGAGGCCG TCCCCATGTC TCTGCCCCCT 
CAAGTGAAGT TCGACCACCC TTTCATTTTC ATGATAGTTG AATCAGAAAC TCAGAGCCCC 
CTCTTTGTGG GAAAAGTGAT AGATCCCACA CGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017449521.1
CDS181..1416
Translation

Target ORF information:

RefSeq Version XM_017594032.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus serpin family A member 1 (Serpina1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017594032.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC 
AGCTTCCTGG CTGAGGATGC CCAGGAAACC GATACCTCCC AGCAGGACCA GAGTCCAACC 
TACCGTAAGA TTTCTTCAAA CCTGGCAGAC TTTGCCTTCA GCCTATACCG GGAGCTGGTC 
CATCAATCCA ATACATCCAA CATCTTCTTC TCCCCTATGA GCATCACCAC AGCCTTCGCC 
ATGCTCTCCC TGGGGAGCAA GGGTGACACT CGCAAACAGA TTCTAGAGGG CCTGGAGTTC 
AACCTCACAC AGATACCTGA GGCTGACATC CACAAGGCCT TCCATCACCT CCTCCAAACT 
CTCAACAGGC CAGACAGTGA GCTGCAGCTG AACACAGGCA ATGGCCTCTT TGTCAACAAG 
AATCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGTCAAGA ACAATTACCA CTCAGAAGCC 
TTCTCTGTCA ACTTTGCCGA CTCAGAAGAG GCTAAGAAAG TAATTAATGA TTATGTAGAG 
AAGGGAACCC AAGGAAAGAT AGTTGATTTG ATGAAACAGC TGGACGAAGA CACGGTTTTT 
GCCCTGGTGA ATTACATTTT CTTTAAAGGC AAGTGGAAGA GGCCATTCAA TCCTGAGCAC 
ACTAGGGATG CTGACTTCCA CGTAGACAAG TCCACCACGG TGAAGGTGCC CATGATGAAC 
CGCCTGGGCA TGTTTGACAT GCACTATTGC AGCACACTGT CCAGCTGGGT GCTGATGATG 
GATTACCTGG GCAACGCCAC TGCCATCTTC CTCCTGCCCG ATGATGGCAA GATGCAGCAT 
CTGGAGCAAA CTCTCACCAA GGATCTCATT TCCCGGTTCC TGCTAAACAG GCAAACAAGG 
TCAGCCATTC TCTACTTCCC CAAACTGTCC ATCTCTGGAA CCTATAACTT GAAGACACTC 
CTGAGCTCAC TGGGCATCAC CCGGGTCTTC AACAATGATG CTGATCTCTC TGGAATCACA 
GAGGATGCCC CCCTGAAGCT TAGCCAGGCT GTGCATAAGG CTGTGCTGAC CTTAGATGAG 
AGGGGAACAG AGGCTGCAGG AGCCACTGTG GTGGAGGCCG TCCCCATGTC TCTGCCCCCT 
CAAGTGAAGT TCGACCACCC TTTCATTTTC ATGATAGTTG AATCAGAAAC TCAGAGCCCC 
CTCTTTGTGG GAAAAGTGAT AGATCCCACA CGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa05824
Clone ID Related Accession (Same CDS sequence) XM_017594032.1 , XM_006240456.1 , NM_022519.2
Accession Version XM_006240456.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1236bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product alpha-1-antiproteinase isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC 
AGCTTCCTGG CTGAGGATGC CCAGGAAACC GATACCTCCC AGCAGGACCA GAGTCCAACC 
TACCGTAAGA TTTCTTCAAA CCTGGCAGAC TTTGCCTTCA GCCTATACCG GGAGCTGGTC 
CATCAATCCA ATACATCCAA CATCTTCTTC TCCCCTATGA GCATCACCAC AGCCTTCGCC 
ATGCTCTCCC TGGGGAGCAA GGGTGACACT CGCAAACAGA TTCTAGAGGG CCTGGAGTTC 
AACCTCACAC AGATACCTGA GGCTGACATC CACAAGGCCT TCCATCACCT CCTCCAAACT 
CTCAACAGGC CAGACAGTGA GCTGCAGCTG AACACAGGCA ATGGCCTCTT TGTCAACAAG 
AATCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGTCAAGA ACAATTACCA CTCAGAAGCC 
TTCTCTGTCA ACTTTGCCGA CTCAGAAGAG GCTAAGAAAG TAATTAATGA TTATGTAGAG 
AAGGGAACCC AAGGAAAGAT AGTTGATTTG ATGAAACAGC TGGACGAAGA CACGGTTTTT 
GCCCTGGTGA ATTACATTTT CTTTAAAGGC AAGTGGAAGA GGCCATTCAA TCCTGAGCAC 
ACTAGGGATG CTGACTTCCA CGTAGACAAG TCCACCACGG TGAAGGTGCC CATGATGAAC 
CGCCTGGGCA TGTTTGACAT GCACTATTGC AGCACACTGT CCAGCTGGGT GCTGATGATG 
GATTACCTGG GCAACGCCAC TGCCATCTTC CTCCTGCCCG ATGATGGCAA GATGCAGCAT 
CTGGAGCAAA CTCTCACCAA GGATCTCATT TCCCGGTTCC TGCTAAACAG GCAAACAAGG 
TCAGCCATTC TCTACTTCCC CAAACTGTCC ATCTCTGGAA CCTATAACTT GAAGACACTC 
CTGAGCTCAC TGGGCATCAC CCGGGTCTTC AACAATGATG CTGATCTCTC TGGAATCACA 
GAGGATGCCC CCCTGAAGCT TAGCCAGGCT GTGCATAAGG CTGTGCTGAC CTTAGATGAG 
AGGGGAACAG AGGCTGCAGG AGCCACTGTG GTGGAGGCCG TCCCCATGTC TCTGCCCCCT 
CAAGTGAAGT TCGACCACCC TTTCATTTTC ATGATAGTTG AATCAGAAAC TCAGAGCCCC 
CTCTTTGTGG GAAAAGTGAT AGATCCCACA CGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006240518.1
CDS111..1346
Translation

Target ORF information:

RefSeq Version XM_006240456.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus serpin family A member 1 (Serpina1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006240456.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCACCCT CCATCTCACG GGGGCTCCTG CTTCTGGCAG GCCTGTGTTG CCTGGCCCCC 
AGCTTCCTGG CTGAGGATGC CCAGGAAACC GATACCTCCC AGCAGGACCA GAGTCCAACC 
TACCGTAAGA TTTCTTCAAA CCTGGCAGAC TTTGCCTTCA GCCTATACCG GGAGCTGGTC 
CATCAATCCA ATACATCCAA CATCTTCTTC TCCCCTATGA GCATCACCAC AGCCTTCGCC 
ATGCTCTCCC TGGGGAGCAA GGGTGACACT CGCAAACAGA TTCTAGAGGG CCTGGAGTTC 
AACCTCACAC AGATACCTGA GGCTGACATC CACAAGGCCT TCCATCACCT CCTCCAAACT 
CTCAACAGGC CAGACAGTGA GCTGCAGCTG AACACAGGCA ATGGCCTCTT TGTCAACAAG 
AATCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGTCAAGA ACAATTACCA CTCAGAAGCC 
TTCTCTGTCA ACTTTGCCGA CTCAGAAGAG GCTAAGAAAG TAATTAATGA TTATGTAGAG 
AAGGGAACCC AAGGAAAGAT AGTTGATTTG ATGAAACAGC TGGACGAAGA CACGGTTTTT 
GCCCTGGTGA ATTACATTTT CTTTAAAGGC AAGTGGAAGA GGCCATTCAA TCCTGAGCAC 
ACTAGGGATG CTGACTTCCA CGTAGACAAG TCCACCACGG TGAAGGTGCC CATGATGAAC 
CGCCTGGGCA TGTTTGACAT GCACTATTGC AGCACACTGT CCAGCTGGGT GCTGATGATG 
GATTACCTGG GCAACGCCAC TGCCATCTTC CTCCTGCCCG ATGATGGCAA GATGCAGCAT 
CTGGAGCAAA CTCTCACCAA GGATCTCATT TCCCGGTTCC TGCTAAACAG GCAAACAAGG 
TCAGCCATTC TCTACTTCCC CAAACTGTCC ATCTCTGGAA CCTATAACTT GAAGACACTC 
CTGAGCTCAC TGGGCATCAC CCGGGTCTTC AACAATGATG CTGATCTCTC TGGAATCACA 
GAGGATGCCC CCCTGAAGCT TAGCCAGGCT GTGCATAAGG CTGTGCTGAC CTTAGATGAG 
AGGGGAACAG AGGCTGCAGG AGCCACTGTG GTGGAGGCCG TCCCCATGTC TCTGCCCCCT 
CAAGTGAAGT TCGACCACCC TTTCATTTTC ATGATAGTTG AATCAGAAAC TCAGAGCCCC 
CTCTTTGTGG GAAAAGTGAT AGATCCCACA CGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Identification of a new defective SERPINA1 allele (PI*Z
Respiratory medicine131114-117(2017 Oct)
Hern?ndez-P?rez JM,Ramos-D?az R,P?rez JA


book

Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.
PloS one12(2)e0168981(2017)
Maicas N,van der Vlag J,Bublitz J,Florquin S,Bakker-van Bebber M,Dinarello CA,Verweij V,Masereeuw R,Joosten LA,Hilbrands LB


book

Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection.
Respiratory research17(1)71(2016 Jun)
Ayala P,Meneses M,Olmos P,Montalva R,Droguett K,R?os M,Borzone G


book

Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis.
Scientific reports517833(2015 Dec)
Wang Q,Du J,Yu P,Bai B,Zhao Z,Wang S,Zhu J,Feng Q,Gao Y,Zhao Q,Liu C