Cpe cDNA ORF clone, Rattus norvegicus(Norway rat)
Gene Symbol | Cpe |
Entrez Gene ID | 25669 |
Full Name | carboxypeptidase E |
Synonyms | CARBE,Cph |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | may play a role in post-translational processing of peptide hormones including preproopiomelanocortin [RGD, Feb 2006]. |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_013128.1 | NP_037260.1 | carboxypeptidase E precursor |

Rattus norvegicus (Norway rat) | Cpe | NP_037260.1 |
Xenopus tropicalis (tropical clawed frog) | cpe | NP_001106417.1 |
CPE | XP_001097378.2 | |
Danio rerio (zebrafish) | cpe | NP_999975.1 |
Pan troglodytes (chimpanzee) | CPE | NP_001092029.1 |
Caenorhabditis elegans (roundworm) | egl-21 | NP_501935.1 |
Homo sapiens (human) | CPE | NP_001864.1 |
Bos taurus (cattle) | CPE | NP_776328.2 |
Mus musculus (house mouse) | Cpe | NP_038522.2 |
Canis lupus familiaris (dog) | CPE | XP_005629450.1 |
Gallus gallus (chicken) | CPE | XP_420392.3 |

Related articles in PubMed
carboxypeptidase E-?N, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.
Qin XY, Cheng Y, Murthy SR, Selvaraj P, Loh YP
PloS one9(11)e112996(2014)
Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.
Murthy SRK, Dupart E, Al-Sweel N, Chen A, Cawley NX, Loh YP
Cancer letters341(2)204-13(2013 Dec)
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)
Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway.
Skalka N, Caspi M, Caspi E, Loh YP, Rosin-Arbesfeld R
Oncogene32(23)2836-47(2013 Jun)
Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study.
Arnett DK, Devereux RB, Rao DC, Li N, Tang W, Kraemer R, Claas SA, Leon JM, Broeckel U
Journal of hypertension27(8)1585-93(2009 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The neuroprotective effect of CPE-DeltaN against neuronal glutamate neurotoxicity was mediated by secreted FGF2.
Title: carboxypeptidase E-?N, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.
Data indicate that secreted carboxypeptidase E (CPE) promotes PC12 cell survival under metabolic stress.
Title: Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.
CPE mediates the effects of NOS1AP on dendrite morphology.
Title: NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway.
These results reveal a novel role for CPE in the regulation of DAT trafficking and DAT-mediated dopamine uptake.
Title: Regulation of dopamine transporter activity by carboxypeptidase E.
CPE expression levels were compared among mature retina tissue, RGC-5 cells and its differentiated cells; more CPE and preproNPY protein expression in the tumor cells or tumor tissue were observed
Title: PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues.
The following Cpe gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cpe cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa02082 | |
Clone ID Related Accession (Same CDS sequence) | NM_013128.1 | |
Accession Version | NM_013128.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-23 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | carboxypeptidase E precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X51406.1. On Apr 19, 2005 this sequence version replaced XM_224778.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X51406.1, BC085762.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCGGGC GCGGAGGACG GGTGCTGCTG GCGCTGTGTG CCGCGCTGGT GGCCGGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_037260.1 |
CDS | 89..1519 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCCGGGC GCGGAGGACG GGTGCTGCTG GCGCTGTGTG CCGCGCTGGT GGCCGGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
carboxypeptidase E-?N, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity. |
![]() |
Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion. |
![]() |
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. |
![]() |
Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. |
![]() |
Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. |