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Cpe cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Cpe
Entrez Gene ID 25669
Full Name carboxypeptidase E
Synonyms CARBE,Cph
General protein information
Preferred Names

carboxypeptidase E

Names

carboxypeptidase E
carboxypeptidase H
enkephalin convertase
prohormone-processing carboxypeptidase
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

16

16p13
Summary may play a role in post-translational processing of peptide hormones including preproopiomelanocortin [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_013128.1 NP_037260.1 carboxypeptidase E precursor

Pathways from BioSystems


Homologies


Rattus norvegicus (Norway rat) Cpe NP_037260.1
Xenopus tropicalis (tropical clawed frog) cpe NP_001106417.1
CPE XP_001097378.2
Danio rerio (zebrafish) cpe NP_999975.1
Pan troglodytes (chimpanzee) CPE NP_001092029.1
Caenorhabditis elegans (roundworm) egl-21 NP_501935.1
Homo sapiens (human) CPE NP_001864.1
Bos taurus (cattle) CPE NP_776328.2
Mus musculus (house mouse) Cpe NP_038522.2
Canis lupus familiaris (dog) CPE XP_005629450.1
Gallus gallus (chicken) CPE XP_420392.3

Gene Ontology


Bibliography

Related articles in PubMed

carboxypeptidase E-?N, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.
Qin XY, Cheng Y, Murthy SR, Selvaraj P, Loh YP
PloS one9(11)e112996(2014)

Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.
Murthy SRK, Dupart E, Al-Sweel N, Chen A, Cawley NX, Loh YP
Cancer letters341(2)204-13(2013 Dec)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway.
Skalka N, Caspi M, Caspi E, Loh YP, Rosin-Arbesfeld R
Oncogene32(23)2836-47(2013 Jun)

Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study.
Arnett DK, Devereux RB, Rao DC, Li N, Tang W, Kraemer R, Claas SA, Leon JM, Broeckel U
Journal of hypertension27(8)1585-93(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The neuroprotective effect of CPE-DeltaN against neuronal glutamate neurotoxicity was mediated by secreted FGF2.
Title: carboxypeptidase E-?N, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.

Data indicate that secreted carboxypeptidase E (CPE) promotes PC12 cell survival under metabolic stress.
Title: Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.

CPE mediates the effects of NOS1AP on dendrite morphology.
Title: NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway.

These results reveal a novel role for CPE in the regulation of DAT trafficking and DAT-mediated dopamine uptake.
Title: Regulation of dopamine transporter activity by carboxypeptidase E.

CPE expression levels were compared among mature retina tissue, RGC-5 cells and its differentiated cells; more CPE and preproNPY protein expression in the tumor cells or tumor tissue were observed
Title: PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues.

The following Cpe gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cpe cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa02082 NM_013128.1
Latest version!		 Rattus norvegicus carboxypeptidase E (Cpe), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $279.30
$399.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa02082
Clone ID Related Accession (Same CDS sequence) NM_013128.1
Accession Version NM_013128.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1431bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-23
Organism Rattus norvegicus(Norway rat)
Product carboxypeptidase E precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X51406.1. On Apr 19, 2005 this sequence version replaced XM_224778.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X51406.1, BC085762.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGCCGGGC GCGGAGGACG GGTGCTGCTG GCGCTGTGTG CCGCGCTGGT GGCCGGCGGG 
TGGCTGTTAG CGGCTGAAGC CCAGGAGCCC GGGGCGCCAG CGGCTGGCAT GCGGCGGCGC 
CGGCGGCTGC AGCAGGAGGA CGGCATCTCC TTCGAGTACC ACCGCTATCC CGAGCTGCGC 
GAGGCGCTGG TGTCGGTATG GCTGCAGTGC ACCGCCATCA GCAGGATCTA CACGGTGGGG 
CGCAGCTTCG AGGGCCGGGA GCTCCTGGTC ATCGAGCTGT CTGACAACCC CGGGGTCCAT 
GAGCCCGGTG AACCTGAGTT TAAATACATT GGGAACATGC ATGGTAATGA GGCGGTTGGA 
CGGGAGCTGC TCATTTTCTT GGCCCAGTAC CTGTGTAACG AATACCAGAG AGGGAATGAG 
ACAATTGTCA ACCTGATCCA CAGCACACGA ATCCATATCA TGCCCTCCTT GAACCCCGAT 
GGCTTTGAGA AAGCAGCATC TCAGCCCGGT GAGCTGAAGG ACTGGTTCGT GGGCCGCAGC 
AATGCCCAGG GAATAGATCT GAACCGGAAC TTCCCAGACT TGGATAGGAT CGTGTATGTT 
AATGAGAAAG AAGGCGGTCC CAACAACCAC CTGCTGAAGA ATCTGAAGAA AATTGTGGAC 
CAAAATTCAA AGCTTGCCCC CGAGACCAAG GCTGTCATTC ACTGGATCAT GGACATCCCA 
TTTGTGCTCT CTGCCAACCT GCACGGAGGA GACCTCGTGG CTAATTACCC GTATGATGAG 
ACGCGGAGTG GTACTGCTCA CGAATACAGT TCCTGCCCTG ATGACGCAAT TTTCCAAAGC 
TTGGCTCGCG CATACTCTTC TTTCAACCCA GTCATGTCTG ACCCCAATCG ACCTCCCTGT 
CGCAAGAATG ATGATGACAG TAGCTTTGTA GATGGAACAA CCAATGGTGG TGCATGGTAC 
AGCGTCCCCG GTGGAATGCA AGACTTCAAT TACCTGAGCA GCAACTGCTT TGAGATCACT 
GTGGAGCTTA GCTGTGAGAA GTTCCCACCT GAAGAGACTC TCAAAAGCTA CTGGGAAGAT 
AACAAAAACT CCCTCATCAA CTACCTGGAG CAGATACACC GAGGTGTTAA AGGGTTTGTC 
CGTGACCTTC AAGGTAATCC GATTGCCAAC GCAACCATTT CCGTGGATGG GATAGACCAT 
GATGTCACCT CGGCTAAGGA TGGGGATTAC TGGCGATTGC TTGCGCCTGG AAACTATAAA 
CTTACAGCCT CAGCTCCCGG CTACCTGGCA ATCACAAAGA AAGTGGCAGT TCCTTTCAGC 
CCTGCTGTTG GGGTGGACTT TGAGCTGGAG TCTTTCTATG AAAGGAAGGA GGAGGAGAAG 
GAAGAATTGA TGGAGTGGTG GAAAATGATG TCAGAGACTT TGAATTTTTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_037260.1
CDS89..1519
Translation

Target ORF information:

RefSeq Version NM_013128.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus carboxypeptidase E (Cpe), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_013128.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGCCGGGC GCGGAGGACG GGTGCTGCTG GCGCTGTGTG CCGCGCTGGT GGCCGGCGGG 
TGGCTGTTAG CGGCTGAAGC CCAGGAGCCC GGGGCGCCAG CGGCTGGCAT GCGGCGGCGC 
CGGCGGCTGC AGCAGGAGGA CGGCATCTCC TTCGAGTACC ACCGCTATCC CGAGCTGCGC 
GAGGCGCTGG TGTCGGTATG GCTGCAGTGC ACCGCCATCA GCAGGATCTA CACGGTGGGG 
CGCAGCTTCG AGGGCCGGGA GCTCCTGGTC ATCGAGCTGT CTGACAACCC CGGGGTCCAT 
GAGCCCGGTG AACCTGAGTT TAAATACATT GGGAACATGC ATGGTAATGA GGCGGTTGGA 
CGGGAGCTGC TCATTTTCTT GGCCCAGTAC CTGTGTAACG AATACCAGAG AGGGAATGAG 
ACAATTGTCA ACCTGATCCA CAGCACACGA ATCCATATCA TGCCCTCCTT GAACCCCGAT 
GGCTTTGAGA AAGCAGCATC TCAGCCCGGT GAGCTGAAGG ACTGGTTCGT GGGCCGCAGC 
AATGCCCAGG GAATAGATCT GAACCGGAAC TTCCCAGACT TGGATAGGAT CGTGTATGTT 
AATGAGAAAG AAGGCGGTCC CAACAACCAC CTGCTGAAGA ATCTGAAGAA AATTGTGGAC 
CAAAATTCAA AGCTTGCCCC CGAGACCAAG GCTGTCATTC ACTGGATCAT GGACATCCCA 
TTTGTGCTCT CTGCCAACCT GCACGGAGGA GACCTCGTGG CTAATTACCC GTATGATGAG 
ACGCGGAGTG GTACTGCTCA CGAATACAGT TCCTGCCCTG ATGACGCAAT TTTCCAAAGC 
TTGGCTCGCG CATACTCTTC TTTCAACCCA GTCATGTCTG ACCCCAATCG ACCTCCCTGT 
CGCAAGAATG ATGATGACAG TAGCTTTGTA GATGGAACAA CCAATGGTGG TGCATGGTAC 
AGCGTCCCCG GTGGAATGCA AGACTTCAAT TACCTGAGCA GCAACTGCTT TGAGATCACT 
GTGGAGCTTA GCTGTGAGAA GTTCCCACCT GAAGAGACTC TCAAAAGCTA CTGGGAAGAT 
AACAAAAACT CCCTCATCAA CTACCTGGAG CAGATACACC GAGGTGTTAA AGGGTTTGTC 
CGTGACCTTC AAGGTAATCC GATTGCCAAC GCAACCATTT CCGTGGATGG GATAGACCAT 
GATGTCACCT CGGCTAAGGA TGGGGATTAC TGGCGATTGC TTGCGCCTGG AAACTATAAA 
CTTACAGCCT CAGCTCCCGG CTACCTGGCA ATCACAAAGA AAGTGGCAGT TCCTTTCAGC 
CCTGCTGTTG GGGTGGACTT TGAGCTGGAG TCTTTCTATG AAAGGAAGGA GGAGGAGAAG 
GAAGAATTGA TGGAGTGGTG GAAAATGATG TCAGAGACTT TGAATTTTTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

carboxypeptidase E-?N, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.
PloS one9(11)e112996(2014)
Qin XY,Cheng Y,Murthy SR,Selvaraj P,Loh YP


book

Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.
Cancer letters341(2)204-13(2013 Dec)
Murthy SRK,Dupart E,Al-Sweel N,Chen A,Cawley NX,Loh YP


book

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M


book

Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway.
Oncogene32(23)2836-47(2013 Jun)
Skalka N,Caspi M,Caspi E,Loh YP,Rosin-Arbesfeld R


book

Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study.
Journal of hypertension27(8)1585-93(2009 Aug)
Arnett DK,Devereux RB,Rao DC,Li N,Tang W,Kraemer R,Claas SA,Leon JM,Broeckel U