Gene Symbol | Wipi2 |
Entrez Gene ID | 288498 |
Full Name | WD repeat domain, phosphoinositide interacting 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Wipi2 cDNA ORF clone
gRNAs
Gene Symbol | Wipi2 |
Entrez Gene ID | 288498 |
Full Name | WD repeat domain, phosphoinositide interacting 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001007615.1 | NP_001007616.1 | WD repeat domain phosphoinositide-interacting protein 2 |
Canis lupus familiaris (dog) | WIPI2 | XP_850630.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005910 | XP_315940.3 |
Eremothecium gossypii | AGOS_AAL119W | NP_982423.1 |
Pan troglodytes (chimpanzee) | WIPI2 | XP_003318335.1 |
Bos taurus (cattle) | WIPI2 | NP_001039594.1 |
Drosophila melanogaster (fruit fly) | Atg18 | NP_001261565.1 |
Kluyveromyces lactis | KLLA0D04664g | XP_453268.1 |
Schizosaccharomyces pombe (fission yeast) | atg18 | NP_594055.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03139 | XP_003716858.1 |
Mus musculus (house mouse) | Wipi2 | NP_848485.1 |
Rattus norvegicus (Norway rat) | Wipi2 | NP_001007616.1 |
Gallus gallus (chicken) | WIPI2 | NP_001006162.1 |
Neurospora crassa | NCU03441 | XP_956727.1 |
Oryza sativa (rice) | Os02g0791800 | NP_001048361.1 |
Homo sapiens (human) | WIPI2 | NP_057087.2 |
Saccharomyces cerevisiae (baker's yeast) | ATG18 | NP_444297.1 |
Arabidopsis thaliana (thale cress) | G18B | NP_194780.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100497399 | XP_004917971.1 |
Caenorhabditis elegans (roundworm) | atg-18 | NP_741576.1 |
WIPI3 and WIPI4 ?-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.
Bakula D, M?ller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B, Proikas-Cezanne T
Nature communications815637(2017 May)
PI(5)P regulates autophagosome biogenesis.
Vicinanza M, Korolchuk VI, Ashkenazi A, Puri C, Menzies FM, Clarke JH, Rubinsztein DC
Molecular cell57(2)219-34(2015 Jan)
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA
Molecular cell55(2)238-52(2014 Jul)
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
Orsi A, Razi M, Dooley HC, Robinson D, Weston AE, Collinson LM, Tooze SA
Molecular biology of the cell23(10)1860-73(2012 May)
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.
Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urb? S, Clague MJ, Tooze SA
Autophagy6(4)506-22(2010 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Wipi2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wipi2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa11160 | |
Clone ID Related Accession (Same CDS sequence) | NM_001007615.1 | |
Accession Version | NM_001007615.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-18 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | WD repeat domain phosphoinositide-interacting protein 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079184.1. On Nov 29, 2004 this sequence version replaced XM_213714.2. ##Evidence-Data-START## Transcript exon combination :: BC079184.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGAACCTGG CAAGCCAGAG CGGAGAGGCC GGCGCCGGCC AGCTGCTGTT CGCCAACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001007616.1 |
CDS | 193..1530 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAACCTGG CAAGCCAGAG CGGAGAGGCC GGCGCCGGCC AGCTGCTGTT CGCCAACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
WIPI3 and WIPI4 ?-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. |
PI(5)P regulates autophagosome biogenesis. |
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. |
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy. |
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. |