Gene Symbol | Hpn |
Entrez Gene ID | 29135 |
Full Name | hepsin |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | cell surface serine proteinase [RGD, Feb 2006]. |
ORF » Species Summary » Rattus norvegicus » Hpn cDNA ORF clone
Gene Symbol | Hpn |
Entrez Gene ID | 29135 |
Full Name | hepsin |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | cell surface serine proteinase [RGD, Feb 2006]. |
mRNA | Protein | Name |
---|---|---|
NM_017112.1 | NP_058808.1 | serine protease hepsin precursor |
Pan troglodytes (chimpanzee) | HPN | XP_001157575.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004552 | XP_313850.5 |
Canis lupus familiaris (dog) | HPN | XP_541697.2 |
Bos taurus (cattle) | HPN | NP_001073710.1 |
Danio rerio (zebrafish) | si:dkey-33i11.3 | NP_001091657.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008649 | XP_314746.4 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004568 | XP_313873.5 |
Homo sapiens (human) | HPN | NP_892028.1 |
Rattus norvegicus (Norway rat) | Hpn | NP_058808.1 |
Danio rerio (zebrafish) | LOC100536154 | XP_003200307.1 |
HPN | XP_001093699.2 | |
Mus musculus (house mouse) | Hpn | NP_032307.2 |
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, P?hlmann S
Journal of virology88(2)1293-307(2014 Jan)
Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol.
Aljakna A, Choi S, Savage H, Hageman Blair R, Gu T, Svenson KL, Churchill GA, Hibbs M, Korstanje R
PloS one7(8)e43139(2012)
Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period.
Rosewell K, Al-Alem L, Li F, Kelty B, Curry TE Jr
Biology of reproduction85(4)858-66(2011 Oct)
Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice.
Hanifa S, Scott HS, Crewther P, Guipponi M, Tan J
Neuroreport21(13)897-901(2010 Sep)
Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.
Chen M, Chen LM, Lin CY, Chai KX
Molecular and cellular biochemistry337(1-2)259-66(2010 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results suggest that hepsin and PDIA3 undergo proteolysis by MMP2/9 in ovarian granulosa cells during ovulation and/or luteinization.
Title: Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period.
Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility.
Title: Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression.
The following Hpn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hpn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa02895 | |
Clone ID Related Accession (Same CDS sequence) | NM_017112.1 | |
Accession Version | NM_017112.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | serine protease hepsin precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X70900.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X70900.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCGAAGG AGGGTGGCCG GACTGCACCA TGCTGTTCCA GACCCAAGGT GGCAGCTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_058808.1 |
CDS | 185..1435 |
Translation |
Target ORF information:
Target ORF information:
|
NM_017112.1 |
1 | ATGGCGAAGG AGGGTGGCCG GACTGCACCA TGCTGTTCCA GACCCAAGGT GGCAGCTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. |
Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol. |
Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period. |
Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice. |
Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. |