Gene Symbol | Jag1 |
Entrez Gene ID | 29146 |
Full Name | jagged 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | ligand responsible for activating Notch1 [RGD, Feb 2006]. |
ORF » Species Summary » Rattus norvegicus » Jag1 cDNA ORF clone
Gene Symbol | Jag1 |
Entrez Gene ID | 29146 |
Full Name | jagged 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | ligand responsible for activating Notch1 [RGD, Feb 2006]. |
mRNA | Protein | Name |
---|---|---|
NM_019147.1 | NP_062020.1 | protein jagged-1 precursor |
Canis lupus familiaris (dog) | JAG1 | XP_005634840.1 |
Bos taurus (cattle) | JAG1 | NP_001178107.1 |
Rattus norvegicus (Norway rat) | Jag1 | NP_062020.1 |
Gallus gallus (chicken) | JAG1 | XP_415035.4 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004154 | XP_313038.5 |
Pan troglodytes (chimpanzee) | JAG1 | XP_001169666.1 |
Drosophila melanogaster (fruit fly) | Ser | NP_524527.3 |
JAG1 | XP_001116216.2 | |
Mus musculus (house mouse) | Jag1 | NP_038850.1 |
Xenopus tropicalis (tropical clawed frog) | jag1 | XP_002931784.1 |
Homo sapiens (human) | JAG1 | NP_000205.1 |
Danio rerio (zebrafish) | jag1b | NP_571938.1 |
Potential role of the Jagged1/Notch1 signaling pathway in the endothelial-myofibroblast transition during BLM-induced pulmonary fibrosis.
Yin Q, Wang W, Cui G, Yan L, Zhang S
Journal of cellular physiology233(3)2451-2463(2018 Mar)
Overexpression of Jagged1 Ameliorates Aged Rat-Derived Endothelial Progenitor Cell Functions and Improves Its Transfusion Efficiency for Rat Balloon-Induced Arterial Injury.
Zhu G, Wang J, Song M, Zhou F, Fu D, Ruan G, Bai Y, Yu Z, Zhang L, Zhu X, Huang L, Pang R, Pan X
Annals of vascular surgery41241-258(2017 May)
Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.
Kakuda S, Haltiwanger RS
Developmental cell40(2)193-201(2017 01)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Jagged1/Notch1 signaling pathway is activated in pulmonary microvascular endothelial cells during the pathogenesis of BLM-induced pulmonary fibrosis in rats.
Title: Potential role of the Jagged1/Notch1 signaling pathway in the endothelial-myofibroblast transition during BLM-induced pulmonary fibrosis.
Overexpression of Jagged1 ameliorates aged rat-derived endothelial progenitor cell functions and increases its transfusion efficiency for balloon-induced rat arterial injury.
Title: Overexpression of Jagged1 Ameliorates Aged Rat-Derived Endothelial Progenitor Cell Functions and Improves Its Transfusion Efficiency for Rat Balloon-Induced Arterial Injury.
Jag1 can attenuate restenosis of vein graft by inducing decreased proliferation and increased apoptosis in vivo.
Title: Soluble Jagged-1 inhibits restenosis of vein graft by attenuating Notch signaling.
Nerve regeneration and functional rehabilitation in the recombinant rat jagged1/FC chimera group were advanced significantly due to Notch signaling activation.
Title: Effect of active Notch signaling system on the early repair of rat sciatic nerve injury.
Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1.
Title: ?-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.
The following Jag1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jag1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa03854 | |
Clone ID Related Accession (Same CDS sequence) | NM_019147.1 | |
Accession Version | NM_019147.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3660bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | protein jagged-1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L38483.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L38483.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCGGTCCC CACGGACGCG CGGCCGGCCG GGGCGCCCCT TGAGCCTTCT GCTCGCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_062020.1 |
CDS | 387..4046 |
Translation |
Target ORF information:
Target ORF information:
|
NM_019147.1 |
1 | ATGCGGTCCC CACGGACGCG CGGCCGGCCG GGGCGCCCCT TGAGCCTTCT GCTCGCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Potential role of the Jagged1/Notch1 signaling pathway in the endothelial-myofibroblast transition during BLM-induced pulmonary fibrosis. |
Overexpression of Jagged1 Ameliorates Aged Rat-Derived Endothelial Progenitor Cell Functions and Improves Its Transfusion Efficiency for Rat Balloon-Induced Arterial Injury. |
Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. |