Gene Symbol | Hspa9 |
Entrez Gene ID | 291671 |
Full Name | heat shock protein family A member 9 |
Synonyms | Crp40,GRP-75,Hspa9a,PBP74 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Hspa9 cDNA ORF clone
Gene Symbol | Hspa9 |
Entrez Gene ID | 291671 |
Full Name | heat shock protein family A member 9 |
Synonyms | Crp40,GRP-75,Hspa9a,PBP74 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001100658.2 | NP_001094128.2 | stress-70 protein, mitochondrial |
Pan troglodytes (chimpanzee) | HSPA9 | XP_001171426.2 |
Bos taurus (cattle) | HSPA9 | NP_001029696.1 |
Gallus gallus (chicken) | HSPA9 | NP_001006147.1 |
Schizosaccharomyces pombe (fission yeast) | ssc1 | NP_593459.1 |
Arabidopsis thaliana (thale cress) | mtHsc70-1 | NP_195504.2 |
Homo sapiens (human) | HSPA9 | NP_004125.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010876 | XP_309825.4 |
Kluyveromyces lactis | KLLA0E22309g | XP_454960.1 |
HSPA9 | XP_001113234.1 | |
Canis lupus familiaris (dog) | HSPA9 | XP_531923.2 |
Mus musculus (house mouse) | Hspa9 | NP_034611.2 |
Danio rerio (zebrafish) | hspa9 | NP_958483.2 |
Saccharomyces cerevisiae (baker's yeast) | SSC1 | NP_012579.1 |
Neurospora crassa | NCU08693 | XP_961753.2 |
Oryza sativa (rice) | Os09g0491772 | NP_001175918.1 |
Xenopus tropicalis (tropical clawed frog) | hspa9 | NP_001001229.1 |
Rattus norvegicus (Norway rat) | Hspa9 | NP_001094128.2 |
Drosophila melanogaster (fruit fly) | Hsc70-5 | NP_523741.2 |
Caenorhabditis elegans (roundworm) | hsp-6 | NP_504291.1 |
Eremothecium gossypii | AGOS_AFR352C | NP_985899.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_04191 | XP_003719632.1 |
Overexpression of GRP75 inhibits inflammation in a rat model of intracerebral hemorrhage.
Lv LJ, Li J, Qiao HB, Nie BJ, Lu P, Xue F, Zhang ZM
Molecular medicine reports15(3)1368-1372(2017 Mar)
Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.
Shan Y, Cortopassi G
Mitochondrion2694-103(2016 Jan)
GRP75 Involves in Retinal Ganglion Cell Apoptosis After Rat Optic Nerve Crush.
Zhang G, Han M, Wang X, Xiao A
Journal of molecular neuroscience : MN56(2)422-30(2015 Jun)
Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.
Maio N, Rouault TA
Biochimica et biophysica acta1853(6)1493-512(2015 Jun)
Unlocking the presequence import pathway.
Schulz C, Schendzielorz A, Rehling P
Trends in cell biology25(5)265-75(2015 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
GRP75 expression is significantly decreased in brain tissues following ICH, and that overexpression of GRP75 inhibits inflammation and neuronal apoptosis in a rat model of ICH.
Title: Overexpression of GRP75 inhibits inflammation in a rat model of intracerebral hemorrhage.
GRP75 was significantly upregulated in the retina after optic nerve crush.
Title: GRP75 Involves in Retinal Ganglion Cell Apoptosis After Rat Optic Nerve Crush.
Studied polyubiquitinated proteins during inflammatory response in intestinal epithelial cells; found Grp75 and Grp78 differentially ubiquitinated between control and inflammation; results confirmed in HCT-8 cells and in TNBS induced colitis in rats.
Title: Evaluation of ubiquitinated proteins by proteomics reveals the role of the ubiquitin proteasome system in the regulation of Grp75 and Grp78 chaperone proteins during intestinal inflammation.
AKT and extracellular signal-regulated protein kinases 1 and 2 activated by Grp75 inhibited the Bax conformational change and subsequent apoptosis.
Title: Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions.
mortalin plays an essential role in the regulation of dopamine-dependent behavior and plays an even greater role in the pathogenesis of schizophrenia
Title: Knockdown of mortalin within the medial prefrontal cortex impairs normal sensorimotor gating.
The following Hspa9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspa9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa04487 | |
Clone ID Related Accession (Same CDS sequence) | NM_001100658.2 | |
Accession Version | NM_001100658.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2040bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | stress-70 protein, mitochondrial | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC118806.5. On Oct 27, 2012 this sequence version replaced NM_001100658.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## |
1 | ATGATAAGCG CCAGCAGAGC CGCGGCCGCG CGTCTCGTGG GCACCACAGC GTCCCGGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001094128.2 |
CDS | 104..2143 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001100658.2 |
1 | ATGATAAGCG CCAGCAGAGC CGCGGCCGCG CGTCTCGTGG GCACCACAGC GTCCCGGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Overexpression of GRP75 inhibits inflammation in a rat model of intracerebral hemorrhage. |
Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly. |
GRP75 Involves in Retinal Ganglion Cell Apoptosis After Rat Optic Nerve Crush. |
Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. |
Unlocking the presequence import pathway. |