Gene Symbol | Rbbp8 |
Entrez Gene ID | 291787 |
Full Name | RB binding protein 8, endonuclease |
Synonyms | CtIP,RBBP-8,RGD1308872,RIM,SAE2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Rbbp8 cDNA ORF clone
gRNAs
Gene Symbol | Rbbp8 |
Entrez Gene ID | 291787 |
Full Name | RB binding protein 8, endonuclease |
Synonyms | CtIP,RBBP-8,RGD1308872,RIM,SAE2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017600927.1 | XP_017456416.1 | DNA endonuclease RBBP8 isoform X3 |
XM_008771940.2 | XP_008770162.1 | DNA endonuclease RBBP8 isoform X4 |
XM_006254407.1 | XP_006254469.1 | DNA endonuclease RBBP8 isoform X4 |
XM_008771939.2 | XP_008770161.2 | DNA endonuclease RBBP8 isoform X5 |
XM_017600925.1 | XP_017456414.1 | DNA endonuclease RBBP8 isoform X1 |
NM_001134417.1 | NP_001127889.1 | DNA endonuclease RBBP8 |
XM_017600926.1 | XP_017456415.1 | DNA endonuclease RBBP8 isoform X2 |
XM_006254408.2 | XP_006254470.1 | DNA endonuclease RBBP8 isoform X4 |
Homo sapiens (human) | RBBP8 | NP_002885.1 |
Bos taurus (cattle) | RBBP8 | NP_001095436.1 |
Mus musculus (house mouse) | Rbbp8 | NP_001074692.1 |
Pan troglodytes (chimpanzee) | RBBP8 | XP_001153774.1 |
RBBP8 | XP_001093018.2 | |
Canis lupus familiaris (dog) | RBBP8 | XP_005623065.1 |
Rattus norvegicus (Norway rat) | Rbbp8 | NP_001127889.1 |
Gallus gallus (chicken) | RBBP8 | XP_419158.1 |
Xenopus tropicalis (tropical clawed frog) | rbbp8 | XP_004915272.1 |
CtIP tetramer assembly is required for DNA-end resection and repair.
Davies OR, Forment JV, Sun M, Belotserkovskaya R, Coates J, Galanty Y, Demir M, Morton CR, Rzechorzek NJ, Jackson SP, Pellegrini L
Nature structural & molecular biology22(2)150-157(2015 Feb)
Double-strand break repair: 53BP1 comes into focus.
Panier S, Boulton SJ
Nature reviews. Molecular cell biology15(1)7-18(2014 Jan)
CtIP is required to initiate replication-dependent interstrand crosslink repair.
Duquette ML, Zhu Q, Taylor ER, Tsay AJ, Shi LZ, Berns MW, McGowan CH
PLoS genetics8(11)e1003050(2012)
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.
Huertas P, Jackson SP
The Journal of biological chemistry284(14)9558-65(2009 Apr)
CDK targets Sae2 to control DNA-end resection and homologous recombination.
Huertas P, Cort?s-Ledesma F, Sartori AA, Aguilera A, Jackson SP
Nature455(7213)689-92(2008 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Rbbp8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rbbp8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa02644 | |
Clone ID Related Accession (Same CDS sequence) | NM_001134417.1 | |
Accession Version | NM_001134417.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2682bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | DNA endonuclease RBBP8 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC162012.1. On or before Aug 29, 2008 this sequence version replaced XM_001072535.1, XM_214620.4. ##Evidence-Data-START## Transcript exon combination :: BC162012.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00632250, SAMN01906347 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001127889.1 |
CDS | 263..2944 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa38176 | |
Clone ID Related Accession (Same CDS sequence) | XM_008771940.2 , XM_006254407.1 , XM_006254408.2 | |
Accession Version | XM_008771940.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2655bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | DNA endonuclease RBBP8 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008771940.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008770162.1 |
CDS | 303..2957 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa38176 | |
Clone ID Related Accession (Same CDS sequence) | XM_008771940.2 , XM_006254407.1 , XM_006254408.2 | |
Accession Version | XM_006254407.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2655bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | DNA endonuclease RBBP8 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006254469.1 |
CDS | 407..3061 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa38176 | |
Clone ID Related Accession (Same CDS sequence) | XM_008771940.2 , XM_006254407.1 , XM_006254408.2 | |
Accession Version | XM_006254408.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2655bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | DNA endonuclease RBBP8 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006254408.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006254470.1 |
CDS | 429..3083 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa59251 | |
Clone ID Related Accession (Same CDS sequence) | XM_017600925.1 | |
Accession Version | XM_017600925.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2652bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | DNA endonuclease RBBP8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017456414.1 |
CDS | 332..2983 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa59252 | |
Clone ID Related Accession (Same CDS sequence) | XM_017600926.1 | |
Accession Version | XM_017600926.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2550bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | DNA endonuclease RBBP8 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017456415.1 |
CDS | 332..2881 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa59253 | |
Clone ID Related Accession (Same CDS sequence) | XM_017600927.1 | |
Accession Version | XM_017600927.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2757bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | DNA endonuclease RBBP8 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCCTGTA TTTCAACAAT CCAAAGACAA CGTCACACCT ATGTAAGGAC ACAAAGGTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017456416.1 |
CDS | 387..3143 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTCCTGTA TTTCAACAAT CCAAAGACAA CGTCACACCT ATGTAAGGAC ACAAAGGTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa59254 | |
Clone ID Related Accession (Same CDS sequence) | XM_008771939.2 | |
Accession Version | XM_008771939.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2682bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | DNA endonuclease RBBP8 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008771939.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008770161.2 |
CDS | 331..3012 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCATTT CAGGAAGCAG CTGTGGAAGC CCTAATTCCA CAGATATATC CAGTGACTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CtIP tetramer assembly is required for DNA-end resection and repair. |
Double-strand break repair: 53BP1 comes into focus. |
CtIP is required to initiate replication-dependent interstrand crosslink repair. |
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. |
CDK targets Sae2 to control DNA-end resection and homologous recombination. |