Gene Symbol | Usp14 |
Entrez Gene ID | 291796 |
Full Name | ubiquitin specific peptidase 14 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Usp14 cDNA ORF clone
gRNAs
Gene Symbol | Usp14 |
Entrez Gene ID | 291796 |
Full Name | ubiquitin specific peptidase 14 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001008301.1 | NP_001008302.1 | ubiquitin carboxyl-terminal hydrolase 14 |
XM_006254398.3 | XP_006254460.1 | ubiquitin carboxyl-terminal hydrolase 14 isoform X2 |
XM_006254396.2 | XP_006254458.1 | ubiquitin carboxyl-terminal hydrolase 14 isoform X1 |
Homo sapiens (human) | USP14 | NP_005142.1 |
Canis lupus familiaris (dog) | USP14 | XP_537306.2 |
Gallus gallus (chicken) | USP14 | XP_004939812.1 |
Xenopus tropicalis (tropical clawed frog) | usp14 | NP_001005641.1 |
Bos taurus (cattle) | USP14 | NP_001068657.1 |
Caenorhabditis elegans (roundworm) | usp-14 | NP_497006.1 |
Schizosaccharomyces pombe (fission yeast) | ubp6 | NP_594117.2 |
Pan troglodytes (chimpanzee) | USP14 | NP_001038961.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009348 | XP_310014.4 |
Magnaporthe oryzae (rice blast fungus) | MGG_02970 | XP_003720730.1 |
Neurospora crassa | NCU01919 | XP_965550.1 |
Drosophila melanogaster (fruit fly) | CG5384 | NP_001260321.1 |
Saccharomyces cerevisiae (baker's yeast) | UBP6 | NP_116665.1 |
Kluyveromyces lactis | KLLA0A10791g | XP_451470.1 |
Eremothecium gossypii | AGOS_AEL029W | NP_984832.2 |
Arabidopsis thaliana (thale cress) | UBP7 | NP_566680.2 |
Oryza sativa (rice) | Os01g0550100 | NP_001043299.1 |
USP14 | XP_001090784.1 | |
Mus musculus (house mouse) | Usp14 | NP_067497.2 |
Rattus norvegicus (Norway rat) | Usp14 | NP_001008302.1 |
Danio rerio (zebrafish) | usp14 | NP_956267.1 |
Arabidopsis thaliana (thale cress) | UBP6 | NP_564596.1 |
Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease.
Kiprowska MJ, Stepanova A, Todaro DR, Galkin A, Haas A, Wilson SM, Figueiredo-Pereira ME
Biochimica et biophysica acta1863(6)1157-1170(2017 Jun)
Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3? phosphorylation.
Liu N, Chai R, Liu B, Zhang Z, Zhang S, Zhang J, Liao Y, Cai J, Xia X, Li A, Liu J, Huang H, Liu S
Biochemical and biophysical research communications478(3)1236-41(2016 09)
Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells.
Nakashima A, Ohnuma S, Kodani Y, Kaneko YS, Nagasaki H, Nagatsu T, Ota A
Biochemical and biophysical research communications472(4)598-602(2016 Apr)
Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling.
Jung H, Kim BG, Han WH, Lee JH, Cho JY, Park WS, Maurice MM, Han JK, Lee MJ, Finley D, Jho EH
Oncogenesis2e64(2013 Aug)
USP14 inhibits ER-associated degradation via interaction with IRE1alpha.
Nagai A, Kadowaki H, Maruyama T, Takeda K, Nishitoh H, Ichijo H
Biochemical and biophysical research communications379(4)995-1000(2009 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
mediates the development of cardiac hypertrophy by promoting GSK-3beta phosphorylation.
Title: Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3? phosphorylation.
Activation of proteasome degradation by IU-1, which is an inhibitor for the deubiquitinating activity of USP14, decreased only the quantity of TH molecules phosphorylated at their Ser19.
Title: Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells.
The following Usp14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Usp14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa11224 | |
Clone ID Related Accession (Same CDS sequence) | NM_001008301.1 , XM_006254396.2 | |
Accession Version | NM_001008301.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-12-01 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin carboxyl-terminal hydrolase 14 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085947.1. On Dec 16, 2004 this sequence version replaced XM_214624.2. ##Evidence-Data-START## Transcript exon combination :: BC085947.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCCACTCT ACTCTGTTAC AGTAAAATGG GGAAAGGAGA AATTTGAAGG TGTAGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001008302.1 |
CDS | 123..1604 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCACTCT ACTCTGTTAC AGTAAAATGG GGAAAGGAGA AATTTGAAGG TGTAGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa11224 | |
Clone ID Related Accession (Same CDS sequence) | NM_001008301.1 , XM_006254396.2 | |
Accession Version | XM_006254396.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin carboxyl-terminal hydrolase 14 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006254396.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCACTCT ACTCTGTTAC AGTAAAATGG GGAAAGGAGA AATTTGAAGG TGTAGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006254458.1 |
CDS | 317..1798 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCACTCT ACTCTGTTAC AGTAAAATGG GGAAAGGAGA AATTTGAAGG TGTAGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa38167 | |
Clone ID Related Accession (Same CDS sequence) | XM_006254398.3 | |
Accession Version | XM_006254398.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin carboxyl-terminal hydrolase 14 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005117.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254398.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCACTCT ACTCTGTTAC AGTAAAATGG GGAAAGGAGA AATTTGAAGG TGTAGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006254460.1 |
CDS | 288..1664 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCACTCT ACTCTGTTAC AGTAAAATGG GGAAAGGAGA AATTTGAAGG TGTAGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. |
Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3? phosphorylation. |
Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells. |
Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. |
USP14 inhibits ER-associated degradation via interaction with IRE1alpha. |