Gene Symbol | Fto |
Entrez Gene ID | 291905 |
Full Name | FTO, alpha-ketoglutarate dependent dioxygenase |
Synonyms | RGD1305121 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Fto cDNA ORF clone
Gene Symbol | Fto |
Entrez Gene ID | 291905 |
Full Name | FTO, alpha-ketoglutarate dependent dioxygenase |
Synonyms | RGD1305121 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001039713.1 | NP_001034802.1 | alpha-ketoglutarate-dependent dioxygenase FTO |
Xenopus tropicalis (tropical clawed frog) | fto | NP_001017273.1 |
Homo sapiens (human) | FTO | NP_001073901.1 |
Pan troglodytes (chimpanzee) | FTO | XP_510968.2 |
Gallus gallus (chicken) | FTO | NP_001172076.1 |
Bos taurus (cattle) | FTO | NP_001091611.1 |
Rattus norvegicus (Norway rat) | Fto | NP_001034802.1 |
FTO | XP_001092038.1 | |
Danio rerio (zebrafish) | fto | XP_001345910.4 |
Canis lupus familiaris (dog) | FTO | XP_535301.4 |
Mus musculus (house mouse) | Fto | NP_036066.2 |
The investigation of the effects of topiramate on the hypothalamic levels of fat mass/obesity-associated protein and neuropeptide Y in obese female rats.
Alkan I, Altunkaynak BZ, Altun G, Erener E
Nutritional neuroscience1-10(2017 Sep)
Nutrition modulates Fto and Irx3 gene transcript levels, but does not alter their DNA methylation profiles in rat white adipose tissues.
Nowacka-Woszuk J, Pruszynska-Oszmalek E, Szydlowski M, Szczerbal I
Gene61044-48(2017 Apr)
Reversible methylation of m
Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS, Elemento O, Debart F, Kiledjian M, Jaffrey SR
Nature541(7637)371-375(2017 01)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Study revealed that diet was an important factor modulating transcription of Fto and Irx3, but its effect is time-dependent. In contrast, the DNA methylation profiles of Fto and Irx3 were not altered by nutrition, which may indicate that the feeding type, when applied postnatally, did not affect DNA methylation of these genes.
Title: Nutrition modulates Fto and Irx3 gene transcript levels, but does not alter their DNA methylation profiles in rat white adipose tissues.
increased levels in the liver are involved in oxidative stress and lipid deposition, which characterize nonalcoholic fatty liver disease
Title: Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease.
demonstrates leptin-induced FTO upregulation in cardiomyocytes via JAK2/STAT3- dependent CUX1 upregulation and suggests an FTO regulatory function of leptin
Title: Identification of fat mass and obesity associated (FTO) protein expression in cardiomyocytes: regulation by leptin and its contribution to leptin-induced hypertrophy.
Both Fto mRNA and catechol-O-methyltransferaze mRNA are upregulated in an identical time-dependent manner in fasting animals.
Title: Fasting induced cytoplasmic Fto expression in some neurons of rat hypothalamus.
Maternal obesity significantly impacted FTO expression in both hypothalamus and liver at weaning.
Title: Early hypothalamic FTO overexpression in response to maternal obesity--potential contribution to postweaning hyperphagia.
The following Fto gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fto cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa13509 | |
Clone ID Related Accession (Same CDS sequence) | NM_001039713.1 | |
Accession Version | NM_001039713.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-23 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | alpha-ketoglutarate-dependent dioxygenase FTO | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AM233906.1. On Mar 16, 2006 this sequence version replaced XM_214652.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AM233906.1, BC168239.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGAAGCGCG TCCAGACCGC GGAGGAACGG GAGCGGGAAG CTAAGAAACT GAGGCTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001034802.1 |
CDS | 1..1509 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001039713.1 |
1 | ATGAAGCGCG TCCAGACCGC GGAGGAACGG GAGCGGGAAG CTAAGAAACT GAGGCTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The investigation of the effects of topiramate on the hypothalamic levels of fat mass/obesity-associated protein and neuropeptide Y in obese female rats. |
Nutrition modulates Fto and Irx3 gene transcript levels, but does not alter their DNA methylation profiles in rat white adipose tissues. |
Reversible methylation of m |