Gene Symbol | Pak4 |
Entrez Gene ID | 292756 |
Full Name | p21 (RAC1) activated kinase 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Pak4 cDNA ORF clone
Gene Symbol | Pak4 |
Entrez Gene ID | 292756 |
Full Name | p21 (RAC1) activated kinase 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001106238.1 | NP_001099708.1 | serine/threonine-protein kinase PAK 4 |
XM_008759119.2 | XP_008757341.1 | serine/threonine-protein kinase PAK 4 isoform X1 |
Canis lupus familiaris (dog) | PAK4 | XP_005616659.1 |
Gallus gallus (chicken) | PAK4 | XP_001233796.3 |
Homo sapiens (human) | PAK4 | NP_001014831.1 |
Xenopus tropicalis (tropical clawed frog) | pak4 | NP_001090671.1 |
PAK4 | XP_001085295.1 | |
Mus musculus (house mouse) | Pak4 | NP_081746.1 |
Rattus norvegicus (Norway rat) | Pak4 | NP_001099708.1 |
Bos taurus (cattle) | PAK4 | NP_001069652.1 |
Danio rerio (zebrafish) | pak4 | NP_001002222.1 |
Drosophila melanogaster (fruit fly) | mbt | NP_523375.2 |
Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson's disease.
Won SY, Park MH, You ST, Choi SW, Kim HK, McLean C, Bae SC, Kim SR, Jin BK, Lee KH, Shin EY, Kim EG
Science translational medicine8(367)367ra170(2016 Nov)
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1.
Baskaran Y, Ang KC, Anekal PV, Chan WL, Grimes JM, Manser E, Robinson RC
Nature communications68681(2015 Nov)
p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma.
Liu W, Yang Y, Liu Y, Liu H, Zhang W, Xu L, Zhu Y, Xu J
Urologic oncology33(5)205.e13-21(2015 May)
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PAK4 activity was markedly decreased in postmortem brain tissue from Parkinson's disease (PD) patients and in rodent models of PD. Expression of constitutively active PAK4(S445N/S474E) (caPAK4) protected DA neurons in both the 6-hydroxydopamine and alpha-synuclein rat models of PD and preserved motor function.
Title: Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson's disease.
The following Pak4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pak4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa00513 | |
Clone ID Related Accession (Same CDS sequence) | NM_001106238.1 | |
Accession Version | NM_001106238.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-08-18 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | serine/threonine-protein kinase PAK 4 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473979.2. On or before Oct 4, 2007 this sequence version replaced XM_218388.3, XM_001073872.1, XM_001073813.1, XM_001073846.1. ##Evidence-Data-START## Transcript exon combination :: BC168940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTTGGAA AGAAGAAGAA GCGGGTGGAG ATCTCGGCCC CATCCAACTT CGAGCACCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001099708.1 |
CDS | 244..2025 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001106238.1 |
1 | ATGTTTGGAA AGAAGAAGAA GCGGGTGGAG ATCTCGGCCC CATCCAACTT CGAGCACCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa45060 | |
Clone ID Related Accession (Same CDS sequence) | XM_008759119.2 | |
Accession Version | XM_008759119.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | serine/threonine-protein kinase PAK 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759119.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTGGAA AGAAGAAGAA GCGGGTGGAG ATCTCGGCCC CATCCAACTT CGAGCACCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008757341.1 |
CDS | 2341..4122 |
Translation |
Target ORF information:
Target ORF information:
|
XM_008759119.2 |
1 | ATGTTTGGAA AGAAGAAGAA GCGGGTGGAG ATCTCGGCCC CATCCAACTT CGAGCACCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson's disease. |
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. |
p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma. |
E-cadherin interactome complexity and robustness resolved by quantitative proteomics. |