Best1 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Best1 |
| Entrez Gene ID | 293735 |
| Full Name | bestrophin 1 |
| Synonyms | Vmd2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001011940.1 | NP_001011940.1 | bestrophin-1 |
| XM_017589024.1 | XP_017444513.1 | bestrophin-1 isoform X1 |
| Homo sapiens (human) | BEST1 | NP_004174.1 |
| Bos taurus (cattle) | BEST1 | NP_001073714.1 |
| Mus musculus (house mouse) | Best1 | NP_036043.2 |
| Danio rerio (zebrafish) | LOC560608 | XP_689098.3 |
| Pan troglodytes (chimpanzee) | BEST1 | XP_001151529.1 |
| LOC718993 | XP_001116591.1 | |
| Xenopus tropicalis (tropical clawed frog) | best1 | NP_001155223.1 |
| Canis lupus familiaris (dog) | BEST1 | NP_001091014.1 |
| Rattus norvegicus (Norway rat) | Best1 | NP_001011940.1 |
| Gallus gallus (chicken) | BEST1 | XP_004941545.1 |
Related articles in PubMed
Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats.
Pineda-Farias JB, Barrag?n-Iglesias P, Loeza-Alcocer E, Torres-L?pez JE, Rocha-Gonz?lez HI, P?rez-Severiano F, Delgado-Lezama R, Granados-Soto V
Molecular pain1141(2015 Jul)
Genes and mutations causing retinitis pigmentosa.
Daiger SP, Sullivan LS, Bowne SJ
Clinical genetics84(2)132-41(2013 Aug)
Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries.
Broegger T, Jacobsen JC, Secher Dam V, Boedtkjer DM, Kold-Petersen H, Pedersen FS, Aalkjaer C, Matchkov VV
Cardiovascular research91(4)685-93(2011 Sep)
Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosa.
Davidson AE, Millar ID, Urquhart JE, Burgess-Mullan R, Shweikh Y, Parry N, O'Sullivan J, Maher GJ, McKibbin M, Downes SM, Lotery AJ, Jacobson SG, Brown PD, Black GC, Manson FD
American journal of human genetics85(5)581-92(2009 Nov)
Human disease-causing mutations disrupt an N-C-terminal interaction and channel function of bestrophin 1.
Qu Z, Cheng W, Cui Y, Cui Y, Zheng J
The Journal of biological chemistry284(24)16473-81(2009 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
There is functional anoctamin-1 and bestrophin-1 expression in rats at sites related to nociceptive processing.
Title: Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats.
mRNA levels for bestrophin-1 and -2 were also significantly reduced by bestrophin-3 down-regulation
Title: Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries.
The presence of bestrophin-1 influences kinetics and voltage-dependence of voltage-dependent Ca2+ channels; these effects might open new ways to understand the mechanisms leading to retinal degeneration in Best's disease.
Title: Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells.
The following Best1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Best1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa01642 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001011940.1 | |
| Accession Version | NM_001011940.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1653bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-05-26 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | bestrophin-1 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079048.1. On Feb 11, 2005 this sequence version replaced XM_219573.2. ##Evidence-Data-START## Transcript exon combination :: BC079048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642710, SAMN02642711 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGACTATCA CCTACACAAA CGAAGTGGCC AATGCCCGCC TTGGTTCCTT CTCGTGCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001011940.1 |
| CDS | 153..1805 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001011940.1 |
ORF Insert Sequence:
1 | ATGACTATCA CCTACACAAA CGAAGTGGCC AATGCCCGCC TTGGTTCCTT CTCGTGCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa56516 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017589024.1 | |
| Accession Version | XM_017589024.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | bestrophin-1 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCCCGCCT TGGTTCCTTC TCGTGCCTCC TCCTGCGCTG GCGAGGCAGC ATCTACAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017444513.1 |
| CDS | 218..1744 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017589024.1 |
ORF Insert Sequence:
1 | ATGCCCGCCT TGGTTCCTTC TCGTGCCTCC TCCTGCGCTG GCGAGGCAGC ATCTACAAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. |
|
Genes and mutations causing retinitis pigmentosa. |
|
Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries. |
|
Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosa. |
|
Human disease-causing mutations disrupt an N-C-terminal interaction and channel function of bestrophin 1. |