Gene Symbol | Htra2 |
Entrez Gene ID | 297376 |
Full Name | HtrA serine peptidase 2 |
Synonyms | Prss25 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Htra2 cDNA ORF clone
gRNAs
Gene Symbol | Htra2 |
Entrez Gene ID | 297376 |
Full Name | HtrA serine peptidase 2 |
Synonyms | Prss25 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001106599.2 | NP_001100069.1 | serine protease HTRA2, mitochondrial |
Homo sapiens (human) | HTRA2 | NP_037379.1 |
Pan troglodytes (chimpanzee) | HTRA2 | XP_003309140.2 |
Canis lupus familiaris (dog) | HTRA2 | XP_532992.3 |
Danio rerio (zebrafish) | LOC560917 | XP_002663637.2 |
Danio rerio (zebrafish) | zgc:173425 | NP_001098612.1 |
Danio rerio (zebrafish) | si:busm1-sl7.7 | XP_003199743.1 |
Danio rerio (zebrafish) | LOC100003308 | NP_001103205.1 |
Danio rerio (zebrafish) | LOC799006 | XP_001339411.5 |
Danio rerio (zebrafish) | si:dkey-84o3.3 | XP_002665896.3 |
Bos taurus (cattle) | HTRA2 | NP_001071424.1 |
Gallus gallus (chicken) | HTRA2 | XP_423666.3 |
Danio rerio (zebrafish) | LOC100536969 | XP_003199752.2 |
Danio rerio (zebrafish) | si:dkey-84o3.7 | XP_001335201.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000240 | XP_310886.5 |
Danio rerio (zebrafish) | zgc:174193 | NP_001108178.1 |
Danio rerio (zebrafish) | si:dkey-33c12.10 | XP_003199749.2 |
Danio rerio (zebrafish) | si:dkey-33c12.2 | XP_005172803.1 |
Danio rerio (zebrafish) | LOC100329860 | XP_002664149.3 |
Danio rerio (zebrafish) | LOC797876 | XP_001923767.4 |
Danio rerio (zebrafish) | LOC100331049 | XP_002665901.2 |
Danio rerio (zebrafish) | LOC799537 | NP_001103640.1 |
Rattus norvegicus (Norway rat) | Htra2 | NP_001100069.1 |
Danio rerio (zebrafish) | LOC100149563 | NP_001122292.1 |
Danio rerio (zebrafish) | LOC797799 | NP_001103998.1 |
Drosophila melanogaster (fruit fly) | HtrA2 | NP_001262565.1 |
HTRA2 | XP_001110803.1 | |
Mus musculus (house mouse) | Htra2 | NP_062726.3 |
Danio rerio (zebrafish) | LOC793110 | XP_001332804.5 |
Danio rerio (zebrafish) | LOC793521 | XP_001333305.1 |
Danio rerio (zebrafish) | LOC100330919 | XP_005161042.1 |
Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart.
Liu X, Lei J, Wang K, Ma L, Liu D, Du Y, Wu Y, Zhang S, Wang W, Ma X, Liu H
Rejuvenation research20(3)183-192(2017 Jun)
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons.
Patil KS, Basak I, Lee S, Abdullah R, Larsen JP, M?ller SG
Journal of neuroscience research92(9)1167-77(2014 Sep)
The protease Omi regulates mitochondrial biogenesis through the GSK3?/PGC-1? pathway.
Xu R, Hu Q, Ma Q, Liu C, Wang G
Cell death & disease5e1373(2014 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Findings suggest that upregulated HtrA2 played a role in Mn-induced neuronal death in brain striatum
Title: Upregulation of mitochondrial protease HtrA2/Omi contributes to manganese-induced neuronal apoptosis in rat brain striatum.
HtrA2 might exert an important function in regulating caspase-dependent neuronal apoptosis through interacting with XIAP following intracerebral hemorrhage.
Title: The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats.
The protective effect of melatonin is likely mediated, in part, by inhibition of peroxynitrate-mediated nitrosative stress, which in turn relieves imbalance of mitochondrial HtrA2-PED signaling and endothelial cell death.
Title: Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.
caspase-independent events are involved in cardiac apoptosis during the late remodeling stage of pathologic heart failure.
Title: Response of caspase-independent apoptotic factors to high salt diet-induced heart failure.
The following Htra2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Htra2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa12911 | |
Clone ID Related Accession (Same CDS sequence) | NM_001106599.2 | |
Accession Version | NM_001106599.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | serine protease HTRA2, mitochondrial | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC158760.1. On Jan 27, 2008 this sequence version replaced NM_001106599.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC158760.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## |
1 | ATGGCTGCGC TGAAGGCGGG GCGGGGTGCA AACTGGAGCC TTCGGGCATG GCGGGCTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001100069.1 |
CDS | 25..1401 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGCTGCGC TGAAGGCGGG GCGGGGTGCA AACTGGAGCC TTCGGGCATG GCGGGCTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart. |
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons. |
The protease Omi regulates mitochondrial biogenesis through the GSK3?/PGC-1? pathway. |